The profoundly moving, day-by-day recounting of her mother’s death “shows the power of compassion when it is allied with acute intelligence” (The Sunday Telegraph). Powerful, touching, and sometimes shocking, this is an end-of-life account that no reader is ever likely to forget.

    He also had severe cerebral palsy and was quadriplegic, unable to speak, and wracked by seizures. He died suddenly at age seventeen.In fiercely honest, surprisingly funny, and sometimes heartbreaking prose, Jesse’s mother, Marianne Leone, chronicles her transformation by the remarkable life and untimely death of her child. An unforgettable memoir of joy, grief, and triumph, Knowing Jesse unlocks the secret of unconditional love and speaks to all families who strive to do right by their children.

    What she did not count on was how much death would be a part of her work. Almost immediately, Chen found herself wrestling with medicine’s most profound paradox, that a profession premised on caring for the ill also systematically depersonalizes dying. Final Exam follows Chen over the course of her education, training, and practice as she grapples at strikingly close range with the problem of mortality, and struggles to reconcile the lessons of her training with her innate knowledge of shared humanity, and to separate her ideas about healing from her fierce desire to cure.From her first dissection of a cadaver in gross anatomy to the moment she first puts a scalpel to a living person; from the first time she witnesses someone flatlining in the emergency room to the first time she pronounces a patient dead, Chen is struck by her own mortal fears: there was a dying friend she could not call; a young patient’s tortured death she could not forget; even the sense of shared kinship with a corpse she could not cast aside when asked to saw its pelvis in two. Gradually, as she confronts the ways in which her fears have incapacitated her, she begins to reject what she has been taught about suppressing her feelings for her patients, and she begins to carve out a new role for herself as a physician and as human being. Chen’s transfixing and beautiful rumination on how doctors negotiate the ineluctable fact of death becomes, in the end, a brilliant questioning of how we should live.Moving and provocative, motored equally by clinical expertise and extraordinary personal grace, this is a piercing and compassionate journey into the heart of a world that is hidden and yet touches all of our lives. A superb addition to the best medical literature of our time.

    Educated at Smith, she had an epically conflict-filled relationship with her mother, Aurelia. She then married the poet Ted Hughes and plunged into the sturm and drang of married life in the full glare of the world of English and American letters. Her poems were fought over, rejected, accepted and, ultimately, embraced by readers everywhere. Dead at thirty, she committed suicide by putting her head in an oven while her children slept. Her poetry collection titled Ariel became a modern classic. Her novel The Bell Jar has a fixed place on student reading lists. American Isis will be the first Plath bio benefitting from the new Ted Hughes archive at the British Library which includes forty one letters between Plath and Hughes as well as a host of unpublished papers. The Sylvia Plath Carl Rollyson brings to us in American Isis is no shrinking Violet overshadowed by Ted Hughes, she is a modern day Isis, a powerful force that embraced high and low culture to establish herself in the literary firmament.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Kramer. But what began as a floppy foot and leg weakness led to a shattering diagnosis: he had amyotrophic lateral sclerosis. ALS is a cruel, unrelenting neurodegenerative disease where the body’s muscles slowly weaken, including those used to move, swallow, talk, and ultimately breathe. There is no cure; ALS is a death sentence.When death is a constant companion, sitting too closely beside you at the dinner table, coloring your thoughts and feelings and words, your outlook on life is utterly transformed. The perspective and insights offered in We Know How This Ends reveal this daily reality and inspire a way forward for anyone who has suffered major loss and for anyone who surely will. Rather than wallowing in sadness and bitterness, anger and denial, Kramer accepted the crushing diagnosis. The educator and musician recognized that if he wanted a meaningful life, embracing his imminent death was his only viable option. His decision was the foundation for profound, personal reflection and growth, even as his body weakened, and inspired Kramer to share and teach the lessons he was learning from ALS about how to live as fully as possible, even in the midst of devastating grief.At the same time Kramer was diagnosed, broadcast journalist Cathy Wurzer was struggling with her own losses, especially the slow descent of her father into the bewildering world of dementia. Mutual friends put this unlikely pair—journalist and educator—together, and the serendipitous result has been a series of remarkable broadcast conversations, a deep friendship, and now this book.Written with wisdom, genuine humor, and down-to-earth observations, We Know How This Ends is far more than a memoir. It is a dignified, courageous, and unflinching look at how acceptance of loss and inevitable death can lead us all to a more meaningful and fulfilling life.

    As she searches for answers nearly thirty years later, Kimball embarks on a journey into the secrets her family has kept for decades. Using old diary entries, hospital records, home videos, and other archives, Margaret pieces together a narrative map of her childhood—her mother's bipolar disorder, her grandmother's institutionalization, and her brother's increasing struggles—in an attempt to understand what no one likes to talk about: the fractures in her family.

    Three weeks later, John's cousin Anthony Radziwill died of cancer. In this moving and candid memoir, Carole Radziwill, Anthony's widow, tells her story.

    And imagine how that would change the outlook of the 5 million Americans who suffer from Alzheimer’s disease and other dementias, not to mention their families, loved ones, and caretakers. A neurologist who’s been specializing in dementia and memory loss for more than 20 years, Dr. Gayatri Devi rewrites the story of Alzheimer’s by defining it as a spectrum disorder—like autism, Alzheimer’s is a disease that affects different people differently. She encourages people who are worried about memory impairment to seek a diagnosis, because early treatment will enable doctors and caregivers to manage the disease more effectively through drugs and other therapies. Told through the stories of Dr. Devi’s patients, The Spectrum of Hope is the kind of narrative medical writing that grips the reader, humanizes the science, and offers equal parts practical advice and wisdom with skillful ease. But beyond the pleasures of great reading, it’s a book that offers real hope. Here are chapters on how to maintain independence and dignity; how to fight depression, anxiety, and apathy; how to communicate effectively with a person suffering from dementia. Plus chapters on sexuality, genetics, going public with the diagnosis, even putting together a bucket list—because through her practice, Dr. Devi knows that the majority of Alzheimer’s patients continue to live and work in their communities. They babysit their grandkids, drive to the store (or own the store), serve their clients, or otherwise live fulfilling lives. That’s news that 5 million people are waiting to hear.

    The critically acclaimed series became America’s most watched—and most talked about—network show, even building on its fan base in the drama’s second season. As Kate Pearson, Chrissy Metz presents a character that has never been seen on television, yet viewers see themselves in her, no matter what they look like or where they come from. Considered a role model just for being her authentic self, Chrissy found herself on magazine covers and talk shows, walking red carpets, and as the subject of endless conversations on social media “I don’t know what you’ve been through to play her,” she is often told by fans, “but it was something.”In This is Me, Chrissy Metz shares her story with a raw honesty that will leave readers both surprised but also inspired. Infused with the same authenticity she brings to her starring role, Chrissy’s This is Me is so much more than your standard Hollywood memoir or collection of personal essays. She embraces the spirit of Shonda Rhimes’ Year of Yes, and shares how she has applied the lessons she learned from both setbacks and successes. A born entertainer, Chrissy finds light in even her darkest moments, and leaves the reader feeling they are spending time with a friend who gets it.Chrissy Metz grew up in a large family, one that always seemed to be moving, and growing. Her father disappeared one day, leaving her mother to work a series of menial jobs and his children to learn to live with the threat of hunger and the electricity being cut off. When her mother remarried, Chrissy hoped for “normal” but instead experienced a form of mental pain that seemed crafted just for her. The boys who showed her attention did so with strings attached as well, and Chrissy accepted it, because for her, love always came with conditions.When she set out for Los Angeles, it was the first time she had been away from her family and from Florida. And for years, she got barely an audition. So how does a woman with the deck stacked against her radiate such love, beauty and joy? This too is at the heart of This is Me. With chapters that alternate from autobiographical to instructional, Chrissy offers practical applications of her hard-won insights in a series of “Bee Mindful” interstitials. There she invites you to embrace gratitude in “Say Thank You” or to be honest with your partner and yourself in “The Shrouded Supreme.” Blending love and experience, Chrissy encourages us all to claim our rightful place in a world that may be trying to knock us down, find our own unique gifts, and pursue our dreams.

    Grace and Grit is the compelling story of the five-year journey of Ken Wilber and his wife Treya Killam Wilber through Treya's illness, treatment, and, finally, death.

    Staff nursing in a ward where she's challenged by an inventory driven ward sister, she reckons it's time to swap such trivialities for life as a district nurse.Independent thinking is one thing, but Jane's about to find that the drama on district can demand instant reaction; and without hospital back up, she's usually the one having to provide it. She meets a rich cast of patients all determined to follow their own individual star, and goes to Edinburgh where Queen Victoria's Jubilee Institute's nurse training is considered the cr me de la cr me of the district nursing world.Call Me Sister recalls Jane's challenging and often hilarious route to realizing her own particular dream.

    During her sophomore year at Brown University, Lindsay received a phone call from her brother that her mother was missing. Forty days later they discover the unthinkable: Their mother’s body had been found in the ocean. Missing is at first a page-turning account of those first forty days, as it chronicles dealings with detectives, false sightings, wild hope, and deep despair. The balance of the story is a candid, emotional exploration of a daughter’s search for solace after tragedy as she tries to understand who her mother truly was, makes peace with her grief, and becomes closer to her father and brothers as her mother’s death forces her to learn more about her mother than she ever knew before.

    It was the pain from that, from feeling ugly, that I always viewed as the great tragedy of my life. The fact that I had cancer seemed minor in comparison.At age nine, Lucy Grealy was diagnosed with a potentially terminal cancer. When she returned to school with a third of her jaw removed, she faced the cruel taunts of classmates. In this strikingly candid memoir, Grealy tells her story of great suffering and remarkable strength without sentimentality and with considerable wit. Vividly portraying the pain of peer rejection and the guilty pleasures of wanting to be special, Grealy captures with unique insight what it is like as a child and young adult to be torn between two warring impulses: to feel that more than anything else we want to be loved for who we are, while wishing desperately and secretly to be perfect.

    Fragmented by drink and dysfunction, the family had avoided assembling under one roof for more than a decade. But when Big Dad, the patriarch, was diagnosed with stomach cancer, the siblings all returned to their childhood home, Four Corner Farm, to help their parents navigate the specialists, treatment options, pain management, and, most difficult of all, their own anguish. "The Things Between Us" is Lee Montgomery's alternately wrenching and riotous story of her family reuniting as one of their own is dying. Even in healthy times, Big Dad moved carefully through life, taking responsibility for the farm, the cars, the house, and his wife. Meanwhile the irrepressible Mumzy drank her first gin each day at 8:45 a.m. and spent her time singing jazz standards and reliving the glory days when she rescued horses from the now defunct hunt club. Prickly and proud, the two tried always to keep their chins up. But Big Dad's cancer rattled their formidable denial, and their habitual coping mechanisms took on heightened meaning when he became sick and the family reconvened. In Big Dad's last months, Montgomery accompanied him on his daily walks as he bade farewell to the places where their lives had unfolded; she and her mother sang old songs, and eventually composed their own jazzy musical called "If You're Dying of Cancer, Do You Want Us to Tell You?"Montgomery's stunning memoir vividly evokes the often unspoken bonds between family members -- bonds made of memory, love, and disappointment. Heartbreaking, lyrical, and often hilarious, "The Things Between Us" hums with a sense of wonder as the author discovers anew the most familiar people in her life, herself among them.