Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    Making remarkable connections across brain function, myth, and anthropology, Dr. Shlain shows why pre-literate cultures were principally informed by holistic, right-brain modes that venerated the Goddess, images, and feminine values. Writing drove cultures toward linear left-brain thinking and this shift upset the balance between men and women, initiating the decline of the feminine and ushering in patriarchal rule. Examining the cultures of the Israelites, Greeks, Christians, and Muslims, Shlain reinterprets ancient myths and parables in light of his theory. Provocative and inspiring, this book is a paradigm-shattering work that will transform your view of history and the mind.

    Spock”-like reference that is both reassuring and realistic—now updated to reflect the many advances in neonatology.Preemies, Second Edition is the only parents’ reference resource of its kind—delivering up-to-the-minute information on medical care in a warm, caring, and engaging voice. Authors Dana Wechsler Linden and Emma Trenti Paroli are parents who have “been there.” Together with neonatologist Mia Wechsler Doron, they answer the dozens of questions that parents will have at every stage—from high-risk pregnancy through preemie hospitalization, to homecoming and the preschool years—imparting a vast, detailed store of knowledge in clear language that all readers can understand. Preemies, Second Edition covers topics related to premature birth, including: What are your risk factors for having a premature baby? Can you do something to delay early labor? What do doctors know about you baby’s outlook during her first minutes and days of life? How will your preemie’s progress be monitored? How do you cope with a long hospitalization? Are there special preparations for you baby’s homecoming? What kind of stimulation during the first year gives your baby the best chance? Will your preemie grow up healthy? Normal?

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    We hurt ourselves, we feel pain, we seek help from a professional or learn to avoid certain behaviors that cause pain. But the story of what goes on in our body is far from simple. Even medical practitioners themselves often fail to grasp the complexities between our minds and bodies and how they interact when dealing with pain stimulus. Throughout history we’ve tried to prevent and mediate the effects of pain—which has only resulted in a highly medicated population and a booming opiates industry. Written by a medical expert trained as an anesthesiologist, An Anatomy of Pain is the first book to clearly explain the current issues and complexities surrounding the treatment of pain and how society deals with those in pain, as well as how our bodies relate to pain. Common conception still equates pain with tissue damage but that is only a very small part of the story—the organ which produces pain is the brain. Case studies show that a woman who has undergone a c-section reports dramatically less pain than a patient who has had kidney stones removed in a similarly invasive operation. The soldier who drags himself or herself to safety after being shot deals with pain in a remarkably different way from someone suffering a similar injury on a street. The truth is that pain is a complex mix of nerve endings, psychological state, social preconceptions, and situational awareness. Filled with case studies and medical history, this enlightening book offers a crash course in all aspects of pain, from chronic to acute, and walks us through the current landscape of pain treatments—from medication (including opioids) to electrical nerve stimulation. Whether it’s a mild ache or severe discomfort, we all encounter pain in our lives and “this splendid book—informative, empathic, and wise—about a universal experience will surely promote healing” (Booklist, starred review).

    Spanning continents and centuries, it is an in-depth look into the history and science of manliness. From speed and strength, to beauty and sex appeal, to bravado and wit, it examines how man today compares to his masculine ancestors. Peter McAllister set out to rebut the claim that man today is suffering from feminization and emasculation. He planned to use his skills as a paleoanthropologist and journalist to write a book demonstrating unequivocally that man today is a triumph---the result of a hard-fought evolutionary struggle toward greatness. As you will see, he failed. In nearly every category of manliness, modern man turned out to be not just matched, but bested, by his ancestors. Stung, McAllister embarked on a new mission. If his book couldn’t be a testament to modern male achievement, he decided, it would be a record of his failures. Manthropology, then, is a globe-spanning tour of the science of masculinity. It kicks off in Ice Age France, where a biomechanical analysis demonstrates that La Ferrassie 2, a Neanderthal woman discovered in the early 1900s, would cream 2004 World Arm Wrestling Federation champion Alexey Voyevoda in an arm wrestle. Then it moves on to medieval Serbia, showing how Slavic guslar poets (who were famously able to repeat a two thousand-line verse after just one hearing) would have destroyed Curtis Jackson, aka 50 Cent, in a battle rap. Finally, it takes the reader to the steaming jungles of modern equatorial Africa, where Aka Pygmy men are such super-dads, they even grow breasts to suckle their children. Now, that’s commitment. For modern man, the results of these investigations aren’t always pretty. But in its look at the history of men, Manthropology is unfailingly smart, informative, surprising, and entertaining.                         *** HOW DOES MODERN MAN STACK UP? Russian arm wrestling champion Alexey Voyevoda has a twenty-two-inch bicep and has curled more than two hundred and fifty pounds---with just one arm. But could he stand up in an arm wrestling match with an average Neanderthal male? Or, for that matter, a female? (p. 10)                       *** Today’s Ultimate Fighters compete in a sport where bouts routinely end with an unconscious loser splayed out on a blood-soaked canvas. But what would a match in the Octagon look like next to the Pankration bouts of the Ancient Greeks: a battleground or a playground? (p. 77)                       *** A modern army goes into battle with state-of-the-art technology and centuries of strategical insight. But for sheer determination, could they have bested Nero’s legions, who marched nearly two marathons a day for six days straight---each legionary carrying hundred-pound packs? (p. 99)                       *** There’s philological evidence that suggests Homer may not have written the Iliad; he may have rapped it. If 50 Cent had to face Homer in a rap battle, would he come out on top? (p. 160)                       *** Wilt Chamberlain is known for scoring on more than just the court. He claimed to have had as many as twenty thousand sexual encounters in his lifetime. Such conquest could only be matched by one of the world’s greatest conquerors: There is the evidence that approximately 32 million people are descended from Genghis Khan. (p. 248)

    Since then, Fisher has conducted pioneering brain research on lust, romantic love, and attachment; gathered data on more than 80,000 people to explain why you love who you love; and collected information on more than 30,000 men and women on sexting, hooking up, friends with benefits, and other current trends in courtship and marriage. And she presents a new, scientifically based and optimistic perspective on relationships in our digital age—what she calls “slow love.”This is a cutting-edge tour de force that traces human family life from its origins in Africa over 20 million years ago to the Internet dating sites and bedrooms of today. And it’s got it all: the copulatory gaze and other natural courting ploys; the who, when, where, and why of adultery; love addictions; her discovery of four broad chemically based personality styles and what each seeks in romance; the newest data on worldwide (biologically based) patterns of divorce; how and why men and women think differently; the real story of women, men, and power; the rise—and fall—of the sexual double standard; and what brain science tells us about how to make and keep a happy partnership.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    It's all what Dr Joshua Wolrich defines as 'nutribollocks' and he is on a mission to set the record straight.As an NHS doctor with personal experience of how damaging diets can be, he believes every one of us deserves to have a happy, healthy relationship with food and with our bodies. His message is clear: we need to fight weight stigma, call out the lies of diet culture and give ourselves permission to eat all foods.Food Isn't Medicine wades through nutritional science (both good and bad) to demystify the common diet myths that many of us believe without questioning. If you have ever wondered whether you should stop eating sugar, try fasting, juicing or 'alkaline water', or struggled through diet after diet (none of which seem to work), this book will be a powerful wake-up call. Drawing on the latest research and delivered with a dose of humour, it not only liberates us from the destructive belief that weight defines health but also explains how to spot the misinformation we are bombarded with every day.Dr Joshua Wolrich will empower you to escape the diet trap and call out the bad health advice for what it really is: complete nutribollocks.

    Khiara M. Bridges investigates how race—commonly seen as biological in the medical world—is socially constructed among women dependent on the public healthcare system for prenatal care and childbirth. Bridges argues that race carries powerful material consequences for these women even when it is not explicitly named, showing how they are marginalized by the practices and assumptions of the clinic staff. Deftly weaving ethnographic evidence into broader discussions of Medicaid and racial disparities in infant and maternal mortality, Bridges shines new light on the politics of healthcare for the poor, demonstrating how the “medicalization” of social problems reproduces racial stereotypes and governs the bodies of poor women of color.

    Its job is to protect us from cancer. This gene--known simply as p53--constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history. p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science's mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, the book reveals the excitement of the hunt for new cures--the hype, the enthusiasm, the lost opportunities, the blind alleys and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is at the cutting edge. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

    Misogyny encompasses the Church, witch hunts, sexual theory, Nazism, pro-life campaigners, and finally, today's developing world, where women are increasingly and disproportionately at risk because of radicalized religious beliefs, famine, war, and disease. Extensively researched, highly readable and provocative, this book chronicles an ancient, pervasive and enduring injustice. The questions it poses deal with the fundamentals of human existence — sex, love, violence — that have shaped the lives of humans throughout history, and ultimately limn an abuse of human rights on a nearly unthinkable scale.

    But music could not be explainedwithout addressing language, and could not be accounted for withoutunderstanding the evolution of the human body and mind. Thus Mithenarrived at the wildly ambitious project that unfolds in this book: anexploration of music as a fundamental aspect of the human condition, encoded into the human genome during the evolutionary history of ourspecies. Music is the language of emotion, common wisdom tells

    Here is a tableau of female self-denial: medieval martyrs who used starvation to demonstrate religious devotion, "wonders of science" whose families capitalized on their ability to survive on flower petals and air, silent screen stars whose strict "slimming" regimens inspired a generation. Here, too, is a fascinating look at how the cultural ramifications of the Industrial Revolution produced a disorder that continues to render privileged young women helpless. Incisive, compassionate, illuminating, Fasting Girls offers real understanding to victims and their families, clinicians, and all women who are interested in the origins and future of this complex, modern and characteristically female disease.