With it has come vast amounts of data in a variety of fields such as medicine, biology, finance, and marketing. The challenge of understanding these data has led to the development of new tools in the field of statistics, and spawned new areas such as data mining, machine learning, and bioinformatics. Many of these tools have common underpinnings but are often expressed with different terminology. This book describes the important ideas in these areas in a common conceptual framework. While the approach is statistical, the emphasis is on concepts rather than mathematics. Many examples are given, with a liberal use of color graphics. It should be a valuable resource for statisticians and anyone interested in data mining in science or industry. The book's coverage is broad, from supervised learning (prediction) to unsupervised learning. The many topics include neural networks, support vector machines, classification trees and boosting—the first comprehensive treatment of this topic in any book. Trevor Hastie, Robert Tibshirani, and Jerome Friedman are professors of statistics at Stanford University. They are prominent researchers in this area: Hastie and Tibshirani developed generalized additive models and wrote a popular book of that title. Hastie wrote much of the statistical modeling software in S-PLUS and invented principal curves and surfaces. Tibshirani proposed the Lasso and is co-author of the very successful An Introduction to the Bootstrap. Friedman is the co-inventor of many data-mining tools including CART, MARS, and projection pursuit.

    Beautifully presented, it introduces the formation and function of blood cells and diseases that arise from dysfunction and disruption of these processes. Basic science, diagnostic tests and clinical features and management are all easily explained. The 5th edition has been reorganized to increase the focus on discrete disorders to show the increased understanding of the causation of blood disorders and improved diagnostic techniques and clinical management. A new standardized approach to describing disease and management has also been introduced. The authors' engaging style and inviting presentation continue to make Essential Haematology the perfect learning and reference text.Fully supported with downloadable figures from the book, along with a PDF of the captions, at www.wiley.com/go/essentialhaematology

    By scale, we mean having numbers of users in the millions and being built by large engineering teams.For mobile engineers, this book is a blueprint for modern app engineering approaches. For non-mobile engineers and managers, it is a resource with which to build empathy and appreciation for the complexity of world-class mobile engineering.

    In each chapter, you will learn programming concepts and apply them immediately as you build an application or enhance one from a previous chapter. These applications have been carefully designed and tested to teach the associated concepts and to provide practice working with the standard development tools Xcode, Interface Builder, and Instruments. The guide’s learn-while-doing approach delivers the practical knowledge and experience you need to design and build real-world applications.

    But what if you could have your computer do them for you?In "Automate the Boring Stuff with Python," you'll learn how to use Python to write programs that do in minutes what would take you hours to do by hand no prior programming experience required. Once you've mastered the basics of programming, you'll create Python programs that effortlessly perform useful and impressive feats of automation to: Search for text in a file or across multiple filesCreate, update, move, and rename files and foldersSearch the Web and download online contentUpdate and format data in Excel spreadsheets of any sizeSplit, merge, watermark, and encrypt PDFsSend reminder emails and text notificationsFill out online formsStep-by-step instructions walk you through each program, and practice projects at the end of each chapter challenge you to improve those programs and use your newfound skills to automate similar tasks.Don't spend your time doing work a well-trained monkey could do. Even if you've never written a line of code, you can make your computer do the grunt work. Learn how in "Automate the Boring Stuff with Python.""

    You'll learn the SPA design approach, and then start exploring new techniques like structured JavaScript and responsive design. And you'll learn how to capitalize on trends like server-side JavaScript and NoSQL data stores, as well as new frameworks that make JavaScript more manageable and testable as a first-class language.About this BookIf your website is a jumpy collection of linked pages, you are behind. Single page web applications are your next step: pushing UI rendering and business logic to the browser and communicating with the server only to synchronize data, they provide a smooth user experience, much like a native application. But, SPAs can be hard to develop, manage, and test.Single Page Web Applications shows how your team can easily design, test, maintain, and extend sophisticated SPAs using JavaScript end-to-end, without getting locked into a framework. Along the way, you'll develop advanced HTML5, CSS3, and JavaScript skills, and use JavaScript as the language of the web server and the database.This book assumes basic knowledge of web development. No experience with SPAs is required.Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications.What's InsideDesign, build, and test a full-stack SPA Best-in-class tools like jQuery, TaffyDB, Node.js, and MongoDB Real-time web with web sockets and Socket.IO Touch controls for tablets and smartphones Common SPA design mistakesAbout the AuthorsThe authors are architects and engineering managers. Michael Mikowski has worked on many commercial SPAs and a platform that processes over 100 billion requests per year. Josh Powell has built some of the most heavily trafficked sites on the web.Table of ContentsPART 1: INTRODUCING SPAS Our first single page application Reintroducing JavaScript PART 2: SPA CLIENT Develop the Shell Add feature modules Build the Model Finish the Model and Data modules PART 3: THE SPA SERVER The web server The server database Readying our SPA for production

    In eight chapters, it provides the most thorough coverage of TCP available. It also covers the newest TCP/IP features, including multicasting, path MTU discovery and long fat pipes. The author describes various protocols, including ARP, ICMP and UDP. He utilizes network diagnostic tools to actually show the protocols in action. He also explains how to avoid silly window syndrome (SWS) by using numerous helpful diagrams. This book gives you a broader understanding of concepts like connection establishment, timeout, retransmission and fragmentation. It is ideal for anyone wanting to gain a greater understanding of how the TCP/IP protocols work.

    Based on Big Nerd Ranch's popular Android Bootcamp course, this guide will lead you through the wilderness using hands-on example apps combined with clear explanations of key concepts and APIs. This book focuses on practical techniques for developing apps compatible with all versions of Android widely used today (Android 2.2 - 4.2). Write and run code every step of the way - creating apps that catalog crime scenes, browse photos, track your jogging route, and more. Each chapter and app has been designed and tested to provide the knowledge and experience you need to get started in Android development. Write and run code every step of the way -- creating apps that catalog crime scenes, browse photos, track your jogging route, and more. Each chapter and app has been designed and tested to provide the knowledge and experience you need to get started in Android development."Big Nerd Ranch provided the training we needed to get hundreds of engineers building skillfully on Android. This book is a great distillation of that training and will be a huge help to anyone looking to ramp up as well." - Mike Shaver, Director of Mobile Engineering, Facebook"...a must-have for the developer just starting in Android or ready for more advanced techniques. I was impressed with this book's content and clarity of presentation. The authors explain simple and complex Android topics with equal ease." - James Steele, author of The Android Developer's Cookbook

    Verification that algorithms work is emphasized more than their complexity. An effective use of examples, and huge number of interesting exercises, demonstrate the topics of trees and distance, matchings and factors, connectivity and paths, graph coloring, edges and cycles, and planar graphs. For those who need to learn to make coherent arguments in the fields of mathematics and computer science.

    Whether you are a student, software developer, tech entrepreneur, or researcher in computer science, this authoritative and self-contained book tells you everything you need to know about the new global money for the Internet age.How do Bitcoin and its block chain actually work? How secure are your bitcoins? How anonymous are their users? Can cryptocurrencies be regulated? These are some of the many questions this book answers. It begins by tracing the history and development of Bitcoin and cryptocurrencies, and then gives the conceptual and practical foundations you need to engineer secure software that interacts with the Bitcoin network as well as to integrate ideas from Bitcoin into your own projects. Topics include decentralization, mining, the politics of Bitcoin, altcoins and the cryptocurrency ecosystem, the future of Bitcoin, and more.An essential introduction to the new technologies of digital currencyCovers the history and mechanics of Bitcoin and the block chain, security, decentralization, anonymity, politics and regulation, altcoins, and much moreFeatures an accompanying website that includes instructional videos for each chapter, homework problems, programming assignments, and lecture slidesAlso suitable for use with the authors' Coursera online courseElectronic solutions manual (available only to professors)

    You might think the problem is your brain. It seems to have a mind of its own, a mind that doesn't always want to take in the dry, technical stuff you're forced to study. The fact is your brain craves novelty. It's constantly searching, scanning, waiting for something unusual to happen. After all, that's the way it was built to help you stay alive. It takes all the routine, ordinary, dull stuff and filters it to the background so it won't interfere with your brain's real work--recording things that matter. How does your brain know what matters? It's like the creators of the Head First approach say, suppose you're out for a hike and a tiger jumps in front of you, what happens in your brain? Neurons fire. Emotions crank up. Chemicals surge. That's how your brain knows.And that's how your brain will learn Java. Head First Java combines puzzles, strong visuals, mysteries, and soul-searching interviews with famous Java objects to engage you in many different ways. It's fast, it's fun, and it's effective. And, despite its playful appearance, Head First Java is serious stuff: a complete introduction to object-oriented programming and Java. You'll learn everything from the fundamentals to advanced topics, including threads, network sockets, and distributed programming with RMI. And the new. second edition focuses on Java 5.0, the latest version of the Java language and development platform. Because Java 5.0 is a major update to the platform, with deep, code-level changes, even more careful study and implementation is required. So learning the Head First way is more important than ever. If you've read a Head First book, you know what to expect--a visually rich format designed for the way your brain works. If you haven't, you're in for a treat. You'll see why people say it's unlike any other Java book you've ever read.By exploiting how your brain works, Head First Java compresses the time it takes to learn and retain--complex information. Its unique approach not only shows you what you need to know about Java syntax, it teaches you to think like a Java programmer. If you want to be bored, buy some other book. But if you want to understand Java, this book's for you.

    The gold standard for attaining security is cryptography because it provides the most reliable tools for storing or transmitting digital information. Written by Niels Ferguson, lead cryptographer for Counterpane, Bruce Schneier's security company, and Bruce Schneier himself, this is the much anticipated follow-up book to Schneier's seminal encyclopedic reference, Applied Cryptography, Second Edition (0-471-11709-9), which has sold more than 150,000 copies. Niels Ferguson (Amsterdam, Netherlands) is a cryptographic engineer and consultant at Counterpane Internet Security. He has extensive experience in the creation and design of security algorithms, protocols, and multinational security infrastructures. Previously, Ferguson was a cryptographer for DigiCash and CWI. At CWI he developed the first generation of off-line payment protocols. He has published numerous scientific papers. Bruce Schneier (Minneapolis, MN) is Founder and Chief Technical Officer at Counterpane Internet Security, a managed-security monitoring company. He is also the author of Secrets and Lies: Digital Security in a Networked World (0-471-25311-1).

    However, most discussions of Bayesian inference rely on intensely complex mathematical analyses and artificial examples, making it inaccessible to anyone without a strong mathematical background. Now, though, Cameron Davidson-Pilon introduces Bayesian inference from a computational perspective, bridging theory to practice-freeing you to get results using computing power. Bayesian Methods for Hackers illuminates Bayesian inference through probabilistic programming with the powerful PyMC language and the closely related Python tools NumPy, SciPy, and Matplotlib. Using this approach, you can reach effective solutions in small increments, without extensive mathematical intervention. Davidson-Pilon begins by introducing the concepts underlying Bayesian inference, comparing it with other techniques and guiding you through building and training your first Bayesian model. Next, he introduces PyMC through a series of detailed examples and intuitive explanations that have been refined after extensive user feedback. You'll learn how to use the Markov Chain Monte Carlo algorithm, choose appropriate sample sizes and priors, work with loss functions, and apply Bayesian inference in domains ranging from finance to marketing. Once you've mastered these techniques, you'll constantly turn to this guide for the working PyMC code you need to jumpstart future projects. Coverage includes - Learning the Bayesian "state of mind" and its practical implications - Understanding how computers perform Bayesian inference - Using the PyMC Python library to program Bayesian analyses - Building and debugging models with PyMC - Testing your model's "goodness of fit" - Opening the "black box" of the Markov Chain Monte Carlo algorithm to see how and why it works - Leveraging the power of the "Law of Large Numbers" - Mastering key concepts, such as clustering, convergence, autocorrelation, and thinning - Using loss functions to measure an estimate's weaknesses based on your goals and desired outcomes - Selecting appropriate priors and understanding how their influence changes with dataset size - Overcoming the "exploration versus exploitation" dilemma: deciding when "pretty good" is good enough - Using Bayesian inference to improve A/B testing - Solving data science problems when only small amounts of data are available Cameron Davidson-Pilon has worked in many areas of applied mathematics, from the evolutionary dynamics of genes and diseases to stochastic modeling of financial prices. His contributions to the open source community include lifelines, an implementation of survival analysis in Python. Educated at the University of Waterloo and at the Independent University of Moscow, he currently works with the online commerce leader Shopify.

    These singularities are places where space-time begins or ends, and the presently known laws of physics break down. They will occur inside black holes, and in the past are what might be construed as the beginning of the universe. To show how these predictions arise, the authors discuss the General Theory of Relativity in the large. Starting with a precise formulation of the theory and an account of the necessary background of differential geometry, the significance of space-time curvature is discussed and the global properties of a number of exact solutions of Einstein's field equations are examined. The theory of the causal structure of a general space-time is developed, and is used to study black holes and to prove a number of theorems establishing the inevitability of singualarities under certain conditions. A discussion of the Cauchy problem for General Relativity is also included in this 1973 book.

    Because the computer gathers knowledge from experience, there is no need for a human computer operator to formally specify all the knowledge that the computer needs. The hierarchy of concepts allows the computer to learn complicated concepts by building them out of simpler ones; a graph of these hierarchies would be many layers deep. This book introduces a broad range of topics in deep learning.The text offers mathematical and conceptual background, covering relevant concepts in linear algebra, probability theory and information theory, numerical computation, and machine learning. It describes deep learning techniques used by practitioners in industry, including deep feedforward networks, regularization, optimization algorithms, convolutional networks, sequence modeling, and practical methodology; and it surveys such applications as natural language processing, speech recognition, computer vision, online recommendation systems, bioinformatics, and videogames. Finally, the book offers research perspectives, covering such theoretical topics as linear factor models, autoencoders, representation learning, structured probabilistic models, Monte Carlo methods, the partition function, approximate inference, and deep generative models.Deep Learning can be used by undergraduate or graduate students planning careers in either industry or research, and by software engineers who want to begin using deep learning in their products or platforms. A website offers supplementary material for both readers and instructors.