By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.Of all diseases, the 1918 flu was by far the worst that has ever afflicted humankind; not even the Black Death of the Middle Ages comes close in terms of the number of lives it took. No war, no natural disaster, no famine has claimed so many. In the space of eighteen months in 1918-1919, about 500 million people--one-third of the global population at the time--came down with influenza. The exact total of lives lost will never be known, but the best estimate is between 50 and 100 million. In this powerful book, filled with black and white photographs, nonfiction master Albert Marrin examines the history, science, and impact of this great scourge--and the possibility for another worldwide pandemic today.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    In The Viral Storm, award-winning biologist Nathan Wolfe tells the story of how viruses and human beings have evolved side by side through history; how deadly viruses like HIV, swine flu, and bird flu almost wiped us out in the past; and why modern life has made our species vulnerable to the threat of a global pandemic.Wolfe's research missions to the jungles of Africa and the rain forests of Borneo have earned him the nickname "the Indiana Jones of virus hunters," and here Wolfe takes readers along on his groundbreaking and often dangerous research trips—to reveal the surprising origins of the most deadly diseases and to explain the role that viruses have played in human evolution.In a world where each new outbreak seems worse than the one before, Wolfe points the way forward, as new technologies are brought to bear in the most remote areas of the world to neutralize these viruses and even harness their power for the good of humanity. His provocative vision of the future will change the way we think about viruses, and perhaps remove a potential threat to humanity's survival.

    Now award-winning writer Carl Zimmer takes us on a fantastic voyage into the secret parasite universe we actually live in but haven't recognized. He reveals not only that parasites are the most successful life-forms on Earth, but that they triggered the development of sex, shape ecosystems, and have driven the engine of evolution. In mapping the parasite universe, Zimmer makes the astonishing observation that most species are parasites, and that almost every animal, including humans, will at one time or another become the home of a parasite. Zimmer shows how highly evolved parasites are and describes the frightening and amazing ingenuity these commando invaders use to devour their hosts from the inside and control their behavior. The sinister Sacculina carcini makes its home in an unlucky crab and proceeds to eat everything but what the crab needs to put food in its mouth, which Sacculina then consumes. When Sacculina finally reproduces, it places its young precisely where the crab would nurture its own progeny, and then has the crab nurture the foster family members. Single-celled Toxoplasma gondi has an even more insidious role, for it can invade the human brain. There it makes men distrustful and less willing to submit to social mores. Women become more outgoing and warm-hearted. Why would a parasite cause these particular personality changes? It seems Toxoplasma wants its host to be less afraid, to be more prone to danger and a violent end -- so that, in the carnage, it will be able to move on to another host. From the steamy jungles of Costa Rica to the fetid parasite heaven of rebel-held southern Sudan, Zimmer tracks the genius of parasitic life and its impact on humanity. We hosts have developed remarkable defenses against the indomitable parasite: our mighty immune system, our culturally enforced habit of keeping clean, and, perhaps most intriguingly, sex. But this is not merely a book about the evil power of parasitism and how we must defend against it. On the contrary, Zimmer concludes that humankind itself is a new kind of parasite, one that preys on the entire Earth. If we are to achieve the sophistication of the parasites on display here in vivid detail, if we are to promote the flourishing of life in all its diversity as they do, we must learn the ways nature lives with itself, the laws of Parasite Rex.

    She focuses on a different danger in each chapter-from the looming risk of lethal influenza to in-depth information on the public health perils posed by bioterrorism. With a novelist's descriptive eye and a thriller writer's sense of tension, she warns us that the most ceaselessly creative bioterrorist is still Mother Nature, whose microbial operatives are all around us, ready to pounce when conditions are right.

    We are now all too aware of how it is applied, but we know far less about how the idea came to be--and where it may yet go.Until Proven Safe tracks the idea of quarantine around the globe, through time and space, chasing the story from the lazarettos and quarantine islands of Venice--built before communicable diseases were really understood--to the hallways of the CDC, NASA, and the cutting-edge labs and conference rooms where the future technology of quarantine is being developed. The result is a tour of an idea that could not be more urgent or relevant, a book full of stories, people, and insights that is as compelling as it is definitive.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    It infected nearly one-third of the world’s population and killed ten percent of those it struck. In its wake, schools and businesses closed, hospitals became overwhelmed, and the sick spilled out into makeshift care centers in public spaces. Policemen, public transportation workers, and everyday citizens in face masks were a common—and eerie—sight. Yet, discussion of this global pandemic often takes a backseat to World War I and other contemporary events.

    As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Alexander von Humboldt (1769 – 1859) was an intrepid explorer and the most famous scientist of his age. In North America, his name still graces four counties, thirteen towns, a river, parks, bays, lakes, and mountains. His restless life was packed with adventure and discovery, whether he was climbing the highest volcanoes in the world or racing through anthrax-infected Siberia or translating his research into bestselling publications that changed science and thinking. Among Humboldt's most revolutionary ideas was a radical vision of nature, that it is a complex and interconnected global force that does not exist for the use of humankind alone. Now Andrea Wulf brings the man and his achievements back into focus: his daring expeditions and investigation of wild environments around the world and his discoveries of similarities between climate and vegetation zones on different continents. She also discusses his prediction of human-induced climate change, his remarkable ability to fashion poetic narrative out of scientific observation, and his relationships with iconic figures such as Simón Bolívar and Thomas Jefferson. Wulf examines how Humboldt's writings inspired other naturalists and poets such as Darwin, Wordsworth, and Goethe, and she makes the compelling case that it was Humboldt's influence that led John Muir to his ideas of natural preservation and that shaped Thoreau's Walden.With this brilliantly researched and compellingly written book, Andrea Wulf shows the myriad fundamental ways in which Humboldt created our understanding of the natural world, and she champions a renewed interest in this vital and lost player in environmental history and science.

    The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern tobacco plantations to the dense immigrant neighborhoods of northern cities to far-flung villages on the edges of the nascent American empire. In Pox, award-winning historian Michael Willrich offers a gripping chronicle of how the nation's continentwide fight against smallpox launched one of the most important civil liberties struggles of the twentieth century.At the dawn of the activist Progressive era and during a moment of great optimism about modern medicine, the government responded to the deadly epidemic by calling for universal compulsory vaccination. To enforce the law, public health authorities relied on quarantines, pesthouses, and "virus squads"-corps of doctors and club-wielding police. Though these measures eventually contained the disease, they also sparked a wave of popular resistance among Americans who perceived them as a threat to their health and to their rights.At the time, anti-vaccinationists were often dismissed as misguided cranks, but Willrich argues that they belonged to a wider legacy of American dissent that attended the rise of an increasingly powerful government. While a well-organized anti-vaccination movement sprang up during these years, many Americans resisted in subtler ways-by concealing sick family members or forging immunization certificates. Pox introduces us to memorable characters on both sides of the debate, from Henning Jacobson, a Swedish Lutheran minister whose battle against vaccination went all the way to the Supreme Court, to C. P. Wertenbaker, a federal surgeon who saw himself as a medical missionary combating a deadly-and preventable-disease.As Willrich suggests, many of the questions first raised by the Progressive-era antivaccination movement are still with us: How far should the government go to protect us from peril? What happens when the interests of public health collide with religious beliefs and personal conscience? In Pox, Willrich delivers a riveting tale about the clash of modern medicine, civil liberties, and government power at the turn of the last century that resonates powerfully today.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    . . If what we want in this moment is insight from this brilliant doctor about pandemics, he wants us to see that they do not occur in isolation. --Carolyn Kellogg, The Boston GlobeIn 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it?Paul Farmer, the internationally renowned doctor and anthropologist, experienced the Ebola outbreak firsthand--Partners in Health, the organization he founded, was among the international responders. In Fevers, Feuds, and Diamonds, he offers the first substantive account of this frightening, fast-moving episode and its implications. In vibrant prose, Farmer tells the harrowing stories of Ebola victims while showing why the medical response was slow and insufficient. Rebutting misleading claims about the origins of Ebola and why it spread so rapidly, he traces West Africa's chronic health failures back to centuries of exploitation and injustice. Under formal colonial rule, disease containment was a priority but care was not - and the region's health care woes worsened, with devastating consequences that Farmer traces up to the present.This thorough and hopeful narrative is a definitive work of reportage, history, and advocacy, and a crucial intervention in public-health discussions around the world.

    Beginning with the above questions, she began informally researching every affliction that she encountered in humans to learn whether it happened with animals, too. And usually, it did: dinosaurs suffered from brain cancer, koalas can catch chlamydia, reindeer seek narcotic escape in hallucinogenic mushrooms, stallions self-mutilate, and gorillas experience clinical depression. Natterson-Horowitz and science writer Kathryn Bowers have dubbed this pan-species approach to medicine zoobiquity. Here, they present a revelatory understanding of what animals can teach us about the human body and mind, exploring how animal and human commonality can be used to diagnose, treat, and heal patients of all species.