Chapters cover cancer, infection, immune disorders, genetics, and disorders of each body system, highlighting pathophysiologic processes, resulting signs and symptoms, diagnostic test findings, and current treatments. Reader-friendly features include illustrations, checklists, and full-color miniguides illustrating the pathophysiology of specific disorders.This edition has new full-color miniguides on cancer pathophysiology and neuropathology. A new Focus on Genetics feature identifies gene-related discoveries and their implications for treatment or diagnosis. Review questions and answers follow current NCLEX-RN® requirements and alternate-format questions are included.

    This is incidental as it is about neither of those industries in particular. It is about the magic and wonderment of those days as seen through the eyes of a child – my eyes! It is about the days when imagination was the biggest plaything that we possessed. The days when a plastic football provided a whole summer's play. It is about the scrapes that I found myself in and the things that I observed around me, and how they made me feel. All the stories are true and I personally experienced every one of them. The names of the characters have been changed. The reason being that I have no idea of the whereabouts of many of the characters contained within my stories, so I have no way of asking them for their permission to include them in this book. Some have possibly passed away, and it would be unfair of me to mention them without their blessing. Anyone who knows me will know who they are though.

    R in a Nutshell provides a quick and practical way to learn this increasingly popular open source language and environment. You'll not only learn how to program in R, but also how to find the right user-contributed R packages for statistical modeling, visualization, and bioinformatics.The author introduces you to the R environment, including the R graphical user interface and console, and takes you through the fundamentals of the object-oriented R language. Then, through a variety of practical examples from medicine, business, and sports, you'll learn how you can use this remarkable tool to solve your own data analysis problems.Understand the basics of the language, including the nature of R objectsLearn how to write R functions and build your own packagesWork with data through visualization, statistical analysis, and other methodsExplore the wealth of packages contributed by the R communityBecome familiar with the lattice graphics package for high-level data visualizationLearn about bioinformatics packages provided by Bioconductor"I am excited about this book. R in a Nutshell is a great introduction to R, as well as a comprehensive reference for using R in data analytics and visualization. Adler provides 'real world' examples, practical advice, and scripts, making it accessible to anyone working with data, not just professional statisticians."

    With this practical book, you'll explore text-mining techniques with tidytext, a package that authors Julia Silge and David Robinson developed using the tidy principles behind R packages like ggraph and dplyr. You'll learn how tidytext and other tidy tools in R can make text analysis easier and more effective.The authors demonstrate how treating text as data frames enables you to manipulate, summarize, and visualize characteristics of text. You'll also learn how to integrate natural language processing (NLP) into effective workflows. Practical code examples and data explorations will help you generate real insights from literature, news, and social media.Learn how to apply the tidy text format to NLPUse sentiment analysis to mine the emotional content of textIdentify a document's most important terms with frequency measurementsExplore relationships and connections between words with the ggraph and widyr packagesConvert back and forth between R's tidy and non-tidy text formatsUse topic modeling to classify document collections into natural groupsExamine case studies that compare Twitter archives, dig into NASA metadata, and analyze thousands of Usenet messages

    The R language provides everything you need to do statistical work, but its structure can be difficult to master. This collection of concise, task-oriented recipes makes you productive with R immediately, with solutions ranging from basic tasks to input and output, general statistics, graphics, and linear regression.Each recipe addresses a specific problem, with a discussion that explains the solution and offers insight into how it works. If you're a beginner, R Cookbook will help get you started. If you're an experienced data programmer, it will jog your memory and expand your horizons. You'll get the job done faster and learn more about R in the process.Create vectors, handle variables, and perform other basic functionsInput and output dataTackle data structures such as matrices, lists, factors, and data framesWork with probability, probability distributions, and random variablesCalculate statistics and confidence intervals, and perform statistical testsCreate a variety of graphic displaysBuild statistical models with linear regressions and analysis of variance (ANOVA)Explore advanced statistical techniques, such as finding clusters in your dataWonderfully readable, R Cookbook serves not only as a solutions manual of sorts, but as a truly enjoyable way to explore the R language--one practical example at a time.--Jeffrey Ryan, software consultant and R package author

    Bill Rawls understands Lyme disease sufferers seeking clarity and relief because, like myself, he has experienced the pain and frustration firsthand. Through this ground-breaking book, he shares everything he has discovered on his journey to reclaiming his health... it may just be the answer you've been waiting for." – Neil Spector, MD, Author of Gone in a Heartbeat Lyme disease is one of the most puzzling illnesses on the planet. Anyone who has suffered from its debilitating symptoms knows the frustrations of trying to find a cure. Many sufferers drag themselves from one doctor or alternative practitioner to the next, getting lost in a maze of lab tests, prescription drugs, and treatments. Thousands of dollars and months (or years) later, they realize they are no better off than where they started. Unlocking Lyme puts an end to this desperate quest. Written by Dr. Bill Rawls, a physician who overcame Lyme disease himself, this book is a comprehensive, practical resource full of solutions that work. What took Dr. Rawls 10 years to learn through intense research and personal experience, you can now learn and implement in a matter of months. DR. RAWLS’ STORY Dr. Rawls was in the middle of a successful OB/GYN career when Lyme disease interrupted his life. In his struggle to overcome it, he explored every treatment option – from conventional medicine to the full range of alternative therapies. Ultimately, he embraced modern herbal therapy as his preferred solution, but he recognizes that the path may be different for each person. INSIDE THE BOOK Unlocking Lyme is the sum of Dr. Rawls’ experience, research, and practical solutions to date. The book is divided into four parts, each part addressing a critical aspect of recovery: PART 1 - Provides an overview of common misconceptions about what Lyme disease is (hint: it’s more than just a tick bite and Borrelia infection) PART 2 - Provides information on how to obtain a diagnosis, despite current limitations in diagnostic testing for Lyme PART 3 - Discusses limitations of long-term antibiotic use, and offers an overview of holistic and non-toxic therapies for healing and symptom control (including pain, depression, insomnia) PART 4 - Explains how to embrace a healthier lifestyle so you can stay well; learn how to strengthen your immune system, microbiome, and balance in your body In the years since his recovery, Dr. Rawls has helped thousands of patients find their path to healing from Lyme disease. Unlocking Lyme brings together Dr. Rawls’ accumulated knowledge and is the key you need to get your life back. TESTIMONIALS “Dr. Rawls understands the misery of chronic Lyme disease firsthand. Unlocking Lyme shares the approaches that he used to successfully recover his own health, and helps the reader understand that there is so much that can be done to regain a state of wellness and optimal health.” – Scott Forsgren Editor & Founder, BetterHealthGuy.com “Dr. Rawls has spoken on his approach to Lyme disease for the past several years; his comprehensive approach and lifestyle guidance has helped many of our members. We heartily endorse his approach to helping deal with the symptoms of Lyme and other tick-borne illnesses.” – John Dorney, President NC Lyme Disease Foundation "Unlocking Lyme delves into the science behind Lyme disease, explaining what it is, but more importantly how it can be overcome. Dr. Rawls carefully explains the various treatments for Lyme, leaving the reader feeling informed and empowered.

    The metric gives unparalleled insight into which teams and players are performing at the highest level.Professional gamblers have used Expected Goals to make millions through football betting. Club scouts have used Expected Goals to identify hidden gems in the transfer market. And the media have recently started using Expected Goals to offer more profound insight in their broadcasts.Despite this, most ordinary fans still don’t understand what the Expected Goals method is – or appreciate the significant impact that it is set to have on the sport in coming years.Expected Goals (otherwise known as xG) was originally conjured up by a small corner of the online football analytics community. It didn’t take long for professional gamblers to begin using xG to predict match outcomes. These bettors utilised the Expected Goals method to turn over hundreds of millions of pounds from the bookmakers.Before long, football clubs had caught on to the ground-breaking insight given by xG. Brentford FC were leaders in this field, managing to assemble a Play-Off-reaching squad on a shoe-string budget. In the last five years, the small West London side have turned over more than £100m in transfer profit from their use of the Expected Goals method in player recruitment.More recently, the Expected Goals method has been adopted by the media as a form of insight. Fans are finally catching on to the pioneering means of football analysis. Soon enough, anyone who doesn’t understand the Expected Goals philosophy will be left behind.“This book will make you watch football differently” – Tobias Pedersen“Possibly the most ground-breaking football book ever written” – Football Impact“A brilliant account of the history and future of Expected Goals” – StatShot

    Baseball Prospectus 2015 brings together an elite group of analysts to provide the definitive look at the upcoming season in critical essays and commentary on the thirty teams, their managers, and more than sixty players and prospects from each team.Baseball Prospectus 2015contains critical essays on each of the thirty teams and player comments for some sixty players for each of those teams; projects each player's stats for the coming season using the groundbreaking PECOTA projection system, which has been called "perhaps the game's most accurate projection model" (Sports Illustrated). Now in its twentieth edition, this New York Times bestselling insider's guide from Baseball Prospectus, America's leading provider of statistical analysis for baseball, remains hands down the most authoritative and entertaining book of its kind.

    Who fights off predators by spraying blood from its eyes? How does the slender, deep-sea gulper swallow prey twice its size? Who sucks out body fluids with its short, sharp mouthparts? Readers will learn everything they ever wanted to know about some of the scariest creatures on the planet.

    Each recipe tackles a specific problem with a solution you can apply to your own project, and includes a discussion of how and why the recipe works.Most of the recipes use the ggplot2 package, a powerful and flexible way to make graphs in R. If you have a basic understanding of the R language, you're ready to get started.Use R's default graphics for quick exploration of dataCreate a variety of bar graphs, line graphs, and scatter plotsSummarize data distributions with histograms, density curves, box plots, and other examplesProvide annotations to help viewers interpret dataControl the overall appearance of graphicsRender data groups alongside each other for easy comparisonUse colors in plotsCreate network graphs, heat maps, and 3D scatter plotsStructure data for graphing

    This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree- based methods, support vector machines, clustering, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform. Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra.

    The book begins by introducing the R language, including the development environment. Focusing on practical solutions, the book also offers a crash course in practical statistics and covers elegant methods for dealing with messy and incomplete data using features of R.About the TechnologyR is a powerful language for statistical computing and graphics that can handle virtually any data-crunching task. It runs on all important platforms and provides thousands of useful specialized modules and utilities. This makes R a great way to get meaningful information from mountains of raw data.About the BookR in Action is a language tutorial focused on practical problems. It presents useful statistics examples and includes elegant methods for handling messy, incomplete, and non-normal data that are difficult to analyze using traditional methods. And statistical analysis is only part of the story. You'll also master R's extensive graphical capabilities for exploring and presenting data visually. Purchase of the print book comes with an offer of a free PDF, ePub, and Kindle eBook from Manning. Also available is all code from the book. What's InsidePractical data analysis, step by stepInterfacing R with other softwareUsing R to visualize dataOver 130 graphsEight reference appendixes================================Table of ContentsPart I Getting startedIntroduction to RCreating a datasetGetting started with graphsBasic data managementAdvanced data managementPart II Basic methodsBasic graphsBasic statisticsPart III Intermediate methodsRegressionAnalysis of variancePower analysisIntermediate graphsRe-sampling statistics and bootstrappingPart IV Advanced methodsGeneralized linear modelsPrincipal components and factor analysisAdvanced methods for missing dataAdvanced graphics

    But what if free will doesn't exist? What if our lives are largely predetermined, hardwired in our brains - and our choices over what we eat, who we fall in love with, even what we believe are not real choices at all? Neuroscience is challenging everything we think we know about ourselves, revealing how we make decisions and form our own reality, unaware of the role of our unconscious minds. Did you know, for example, that:* You can carry anxieties and phobias across generations of your family?* Your genes and pleasure and reward receptors in your brain will determine how much you eat?* We can sniff out ideal partners with genes that give our offspring the best chance of survival?Leading neuroscientist Hannah Critchlow draws vividly from everyday life and other experts in their field to show the extraordinary potential, as well as dangers, which come with being able to predict our likely futures - and looking at how we can alter what's in store for us. Lucid, illuminating, awe-inspiring The Science of Fate revolutionises our understanding of who we are - and empowers us to help shape a better future for ourselves and the wider world.

     All of us WANT to achieve optimum wellness, but not all of us know how. There are some basic levers that drive health in one of two directions: towards perfection, or towards chronic degenerative disease. If you understand the principles that govern your physiology, you can achieve complete mastery over your own body composition and become the best possible version of yourself. The P:E Diet is the SIMPLEST and MOST PRACTICAL diet and exercise book ever written. Once you understand the core tenets of your biology, you will know HOW to increase your lean mass while decreasing your fat mass—and you will know WHY it works. The P:E Diet breaks down every single dietary strategy into one incredibly simple metric: PROTEIN versus ENERGY. The protein to energy ratio explains EVERY SINGLE DIET PHENOMENON. The P:E Diet breaks down the cause of the obesity epidemic and the solution using this one powerful weapon. This is not ‘paleo’ or ‘keto’ or ‘low carb’ or ‘low fat’ or ‘plants versus animals’ or ‘calorie counting’—instead this is one MASTER CONCEPT that explains the success of EVERY SINGLE DIETARY STRATEGY out there. This book completely TRANSCENDS ALL OF THE DIET CAMPS and explains why they ALL offer some value—and once you understand this underlying principle, you unlock EVERY DIET. The P:E Diet explains EXACTLY why FOOD CHOICE is everything — once you choose WHAT to eat, your body will tell you HOW MUCH to eat. This approach teaches you how to eat INTUITIVELY to achieve your goals, without unnecessary tracking or micromanaging quantity.
 The exercise portion of this book is just as revelatory: all you need for the optimum adaptive response to exercise is to generate MAXIMUM TENSION in your muscles for the MAXIMUM TIME possible. All exercise can be broken down into three exercise motions: PUSH, PULL, and LEGS. This requires NO EQUIPMENT WHATSOEVER and can be accomplished with bodyweight only. By maximizing INTENSITY and FREQUENCY you can build muscle with absolute MINIMUM TIME. Packed with hundreds of photos and illustrations, The P:E Diet is a life-changing knowledge bomb that absolutely anyone and everyone should read. PLEASE NOTE: MAY NOT WORK ON ALL KINDLE DEVICES! Will work well on the Kindle App but may not work on all Kindle devices.

    In a world saturated with marketing messages, making your offering relevant is your biggest challenge. Dentsu's Cross Switch model meets it head on.The Dentsu Way shares proven tactics for getting your message to consumers and creating scenarios to move them through calibrated Contact Points to meet whatever specific goal you set.This game-changing book:Explains Dentsu's 110-year history and unique service structure, as well as its broad range of business fieldsIntroduces ten case studies of successful campaigns, which have won international advertising awards at events such as the Cannes Lions International Advertising Festival and ADFESTProvides nine of Dentsu's newest original tools and analysis methodsGain broader, more meaningful customer involvement and penetrate more deeply than ever into your market by following the Dentsu Way.