The colony on Roanoke Island off of the coast of North Carolina-115 men, women, and children-had disappeared without a trace. For four hundred years, the question of what became of the doomed settlers has remained unanswered. Where did they go? What really happened? Why were they on Roanoke Island in the first place, as that was not their destination? Using her consummate skills as an anthropologist and ethnohistorian, Lee Miller casts new light on the previously inexplicable puzzle of Roanoke, unraveling a thrilling web of deceit that can be traced back to the inner circle of Queen Elizabeth's government to finally solve the lasting mystery of the Lost Colony.

    Edward Marriott’s dramatic, gripping new book gives you yet another thing to worry about.” —New York Plague. The very word carries an unholy resonance. No other disease can claim its apocalyptic power: it can lie dormant for centuries, only to resurface with nation-killing force. Here, with the high drama of an adventure tale, Edward Marriott unravels the story of this lethal disease: the historic battle to identify its source, the devastating effects of pandemics, and the prospects for new outbreaks. Marriott begins the trail in Hong Kong in the summer of 1894, when a plague diagnosis brought to the island two top scientists—Alexandre Yersin, a maverick Frenchman, and his Japanese rival, Shibasaburo Kitasato. Marriott interweaves the narrative of their fierce competition with vivid scenes of the scourge’s persistence: California in 1900; Surat, India, in 1994; and New York City sometime in the future.A masterly account of medical and human history, Plague is at once an instructive warning and a chilling read.

    A twenty-eight year old — and not widely famous — Christopher Wren was giving a lecture on astronomy. As his audience listened to him speak, they decided that it would be a good idea to create a Society to promote the accumulation of useful knowledge.With that, the Royal Society was born. Since its birth, the Royal Society has pioneered scientific exploration and discovery. Isaac Newton, Charles Darwin, Albert Einstein, Robert Hooke, Robert Boyle, Joseph Banks, Humphry Davy, Isambard Kingdom Brunel, John Locke, Alexander Fleming — all were fellows.Bill Bryson’s favourite fellow was Reverend Thomas Bayes, a brilliant mathematician who devised Bayes’ theorem. Its complexity meant that it had little practical use in Bayes’ own lifetime, but today his theorem is used for weather forecasting, astrophysics and stock market analysis. A milestone in mathematical history, it only exists because the Royal Society decided to preserve it — just in case. The Royal Society continues to do today what it set out to do all those years ago. Its members have split the atom, discovered the double helix, the electron, the computer and the World Wide Web. Truly international in its outlook, it has created modern science.Seeing Further celebrates its momentous history and achievements, bringing together the very best of science writing. Filled with illustrations of treasures from the Society’s archives, this is a unique, ground-breaking and beautiful volume, and a suitable reflection of the immense achievements of science.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    Gifted Hands will transplace you into the operating room to witness surgeries that made headlines around the world, and into the private mind of a compassionate, God-fearing physician who lives to help others. In 1987, Dr. Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head -- an extremely complex and delicate operation that was five months of planning and twenty-two hours of actual surgery, involving a surgical plan that Carson helped initiate. Gifted Hands reveals a man with humility, decency, compassion, courage, and sensitivity who serves as a role model for young people (and everyone else) in need of encouragement to attempt the seemingly impossible and to excel in whatever they attempt. Dr. Carson also describes the key role that his highly intelligent though relatively uneducated mother played in his metamorphosis from an unmotivated ghetto youngster into one of the most respected neurosurgeons in the world.

    Written by medical students and reviewed by top faculty, this unique book provides practical, tested advice for acing the USMLE Step 2 CK.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    Hall's legendary The Secret Teachings of All Ages is a codex to the ancient occult and esoteric traditions of the world. Students of hidden wisdom, ancient symbols, and arcane practices treasure Hall's magnum opus above all other works.While many thousands of copies have sold since its initial publication in 1928, The Secret Teachings of All Ages has previously been available only in oversized, expensive editions. For the first time, Hall's celebrated classic is now published in an affordable trade paperback volume. Literally hundreds of entries shine a rare light on some of the most fascinating and closely held aspects of myth, religion, and philosophy from throughout the centuries.More than one hundred line drawings and a sixteen-page color insert reproduce some of the finest illustrations of the original book, while reset and reformatted text makes this edition of The Secret Teachings of All Ages newly accessible to readers everywhere.

    They included Lord Byron, John Keats, and Mary Shelley, as well as a host of fascinating lesser-known figures: Mary Shelley’s stepsister and Byron’s mistress, Claire Clairmont; Hunt’s botanist sister-in-law, Elizabeth Kent; the musician Vincent Novello; the painters Benjamin Haydon and Joseph Severn; and writers such as Charles and Mary Lamb, Thomas Love Peacock, and William Hazlitt. They were characterized by talent, idealism, and youthful ardor, and these qualities shaped and informed their politically oppositional stances—as did their chaotic family arrangements, which often left the young women, despite their talents, facing the consequences of the men’s philosophies.In Young Romantics, Daisy Hay follows the group’s exploits, from its inception in Hunt’s prison cell in 1813 to its disintegration after Shelley’s premature death in 1822. It is an enthralling tale of love, betrayal, sacrifice, and friendship, all of which were played out against a background of political turbulence and intense literary creativity.

    or a bit of both.The interests of Athanasius Kircher, the legendary seventeenth-century priest-scientist, knew no bounds. From optics to music to magnetism to medicine, he offered up inventions and theories for everything, and they made him famous across Europe. His celebrated museum in Rome featured magic lanterns, speaking statues, the tail of a mermaid, and a brick from the Tower of Babel. Holy Roman Emperors were his patrons, popes were his friends, and in his spare time he collaborated with the Baroque master Bernini.But Kircher lived during an era of radical transformation, in which the old approach to knowledge - what he called the "art of knowing" - was giving way to the scientific method and modern thought. A Man of Misconceptions traces the rise, success, and eventual fall of this fascinating character as he attempted to come to terms with a changing world.With humor and insight, John Glassie returns Kircher to his rightful place as one of history’s most unforgettable figures.A Scientific American Best Science Book of 2012An Atlantic Wire Best Book of 2012A New York Times Book Review "Editor's Choice”

    In Counting Backwards, pediatric anesthesiologist Dr. Henry Jay Przybylo delivers an unforgettable account of the procedure’s daily dramas and fundamental mysteries. Przybylo has administered anesthesia more than 30,000 times over his thirty-year career: on newborn babies, screaming toddlers, sullen teenagers, even a gorilla. Filled with intense moments of near-disaster, life-saving successes, and simple grace, Counting Backwards is for anyone curious about what happens after we lose consciousness.

    Think of Hamlet, trapped in indecision, or Macbeth’s merciless and ultimately self-destructive ambition, or the Machiavellian rise and short reign of Richard III. They are so vital, so alive and real that we can see aspects of ourselves in them. But their world was at once familiar and nothing like our own. In this brilliant work of historical reconstruction Neil MacGregor and his team at the British Museum, working together in a landmark collaboration with the Royal Shakespeare Company and the BBC, bring us twenty objects that capture the essence of Shakespeare’s universe. A perfect complement to A History of the World in 100 Objects, MacGregor’s landmark New York Times bestseller, Shakespeare’s Restless World highlights a turning point in human history. This magnificent book, illustrated throughout with more than one hundred vibrant color photographs, invites you to travel back in history and to touch, smell, and feel what life was like at that pivotal moment, when humankind leaped into the modern age. This was an exhilarating time when discoveries in science and technology altered the parameters of the known world. Sir Francis Drake’s circumnavigation map allows us to imagine the age of exploration from the point of view of one of its most ambitious navigators. A bishop’s cup captures the most sacred and divisive act in Christendom. With A History of the World in 100 Objects, MacGregor pioneered a new way of telling history through artifacts. Now he trains his eye closer to home, on a subject that has mesmerized him since childhood, and lets us see Shakespeare and his world in a whole new light.

    Brilliant, driven, but haunted by demons, William Stewart Halsted took surgery from a horrific, dangerous practice to what we now know as a lifesaving art. Halsted was born to wealth and privilege in New York City in the mid-1800s. He attended the finest schools, but he was a mediocre student. His academic interests blossomed at medical school and he quickly became a celebrated surgeon. Experimenting with cocaine as a local anesthetic, he became addicted. He was hospitalized and treated with morphine to control his craving for cocaine. For the remaining 40 years of his life he was addicted to both drugs.Halsted resurrected his career at Johns Hopkins, where he became the first chief of surgery. Among his accomplishments, he introduced the residency training system, the use of sterile gloves, the first successful hernia repair, radical mastectomy, fine silk sutures, and anatomically correct surgical technique. Halsted is without doubt the father of modern surgery, and his eccentric behavior, unusual lifestyle, and counterintuitive productivity in the face of lifelong addiction make his story unusually compelling.Gerald Imber, a renowned surgeon himself, evokes Halsted's extraordinary life and achievements and places them squarely in the historical and social context of the late 19th century. The result is an illuminating biography of a complex and troubled man, whose genius we continue to benefit from today.