Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    The Architecture of Happiness starts from the idea that where we are heavily influences who we can be, and it argues that it is architecture's task to stand as an eloquent reminder of our full potential.Whereas many architects are wary of openly discussing the word beauty, this book has at its center the large and naïve question: What is a beautiful building? It is a tour through the philosophy and psychology of architecture that aims to change the way we think about our homes, our streets and ourselves.

    She draws on conversations with hundreds of the world's top scientists and on her own work as a Pulitzer Prize-winning writer for the New York Times to create a thoroughly entertaining guide to scientific literacy. Angier's gifts are on full display in The Canon, an ebullient celebration of science that stands to become a classic. The Canon is vital reading for anyone who wants to understand the great issues of our time -- from stem cells and bird flu to evolution and global warming. And it's for every parent who has ever panicked when a child asked how the earth was formed or what electricity is. Angier's sparkling prose and memorable metaphors bring the science to life, reigniting our own childhood delight in discovering how the world works. "Of course you should know about science," writes Angier, "for the same reason Dr. Seuss counsels his readers to sing with a Ying or play Ring the Gack: These things are fun and fun is good." The Canon is a joyride through the major scientific disciplines: physics, chemistry, biology, geology, and astronomy. Along the way, we learn what is actually happening when our ice cream melts or our coffee gets cold, what our liver cells do when we eat a caramel, why the horse is an example of evolution at work, and how we're all really made of stardust. It's Lewis Carroll meets Lewis Thomas -- a book that will enrapture, inspire, and enlighten.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    It follows the figure of the working man through the daily tedium of the office to the humiliating mandatory team-building exercise, to awkward encounters with the boss who pretends to hate capitalism and tells you to be authentic.

    Addictions to smartphones, sex, games, social media, gambling, money, but most of all to alcohol and drugs. The words 'addict' and 'addiction' are loaded with baggage. Not just in Australia, but the world over, addicts are considered to be sub-human, if not alien. This book aims to reclaim their dignity. It aims to rescue the word 'addiction' from its kidnappers and restore its humanity. It offers personal accounts from inspirational people who have found themselves in the grips of such addictions, and their amazing stories of survival. At the Ted Noffs Foundation, Matt Noffs and Kieran Palmer spend their lives working with young people who have serious and often debilitating drug addictions. This book shares the tools they use every day. It offers insights into why addiction takes place and why it's a natural part of being human. It journeys across the spectrum of addictive behaviors, from social media to drugs like heroin. It questions the assumptions and begins to debunk the myth that all addiction is identical and predictable. Addiction is something that could affect any of us. This is a book that everyone should read.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon.

    When there aren’t enough of them, or they aren’t working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine’s Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they’re the wave of the future. “Neil takes readers on a riveting journey through the past, present and future of stem cell therapy. His well-researched, educational and entertaining book could change your life. I highly recommend it.” Tony Robbins, NY Times #1 Bestselling Author 100 years old will soon become the new 60. Stem cells are a key therapeutic to enable this future. Dr. Riordan’s book is your guide to why this is true and how you will benefit. A must read for anyone who cares about extending their healthy lifespan.” Peter H. Diamandis, MD; Founder, XPRIZE & Singularity University; Co-Founder, Human Longevity, Inc.; Author of NY Times Best Sellers Abundance and Bold

    When the seventh row of the periodic table of elements was completed in June 2016 with the addition of four final elements—nihonium, moscovium, tennessine, and oganesson—we at last could identify all the ingredients necessary to construct our world.In Elemental, chemist and science educator Tim James provides an informative, entertaining, and quirkily illustrated guide to the table that shows clearly how this abstract and seemingly jumbled graphic is relevant to our day-to-day lives.James tells the story of the periodic table from its ancient Greek roots, when you could count the number of elements humans were aware of on one hand, to the modern alchemists of the twentieth and twenty-first centuries who have used nuclear chemistry and physics to generate new elements and complete the periodic table. In addition to this, he answers questions such as: What is the chemical symbol for a human? What would happen if all of the elements were mixed together? Which liquid can teleport through walls? Why is the medieval dream of transmuting lead into gold now a reality?Whether you're studying the periodic table for the first time or are simply interested in the fundamental building blocks of the universe—from the core of the sun to the networks in your brain—Elemental is the perfect guide.

    In July of 1991, he launched Cartoon Books in Columbus, Ohio, to publish his black-and-white comic strip Bone. A tale of three marshmallowy creatures named Bone, adrift in a world of humans, monsters and fantasy creatures, Bone has since been translated into 15 languages and won Smith countless awards. Bone and Beyond is the first volume to offer an overview of Smith's work. Published in conjunction with the Wexner Center and Cartoon Research Library's 2008 exhibition, this catalogue presents work featured in the show, including examples of Smith's original drawings for Bone, plus the more recent Shazam and Rasl, a forthcoming time travel story. Also featured are selected works by cartoonists who have influenced Smith, such as George Herriman, Charles Schulz and Walt Kelly, and essays by comic book and fantasy author Neil Gaiman, comic book artist and scholar Scott McCloud and Wexner Center film/video curator David Filipi, the exhibition's co-curator. Cartoon Research Library curator Lucy Shelton Caswell, the exhibition's other co-curator, provides an introduction.

    For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

    Attitudes Toward History followed it two years later. These were revolutionary texts in the theory of communication, and, as classics, they retain their surcharge of energy. Permanence and Change treats human communication in terms of ideal cooperation, whereas Attitudes Towards History characterizes tactics and patterns of conflict typical of actual human associations. It is in Permanence and Change that Burke establishes in path-breaking fashion that form permeates society just as it does poetry and the arts. Hence, his master idea that forms of art are not exclusively aesthetic: the cycles of a storm, the gradations of a sunrise, the stages of an epidemic, the undoing of Prince Hamlet are all instances of progressive form. This new edition of Permanence and Change reprints Hugh Dalziel Duncan's long sociological introduction and includes a substantial new afterward in which Burke reexamines his early ideas in light of subsequent developments in his own thinking and in social theory.

    There's nothing cool about Céline Dion, and nothing clever. That's part of her appeal as an object of love or hatred — with most critics and committed music fans taking pleasure (or at least geeky solace) in their lofty contempt. This book documents Carl Wilson's brave and unprecedented year-long quest to find his inner Céline Dion fan, and explores how we define ourselves in the light of what we call good and bad, what we love and what we hate.