In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    What explains these far-flung distributions? Why are species found where they are across the Earth? Since the discovery of plate tectonics, scientists have long conjectured that plants and animals were scattered over the globe by riding pieces of ancient supercontinents as they broke up. In the past decade, however, that theory has foundered, as the genomic revolution has made reams of new genetic data available. And the data has revealed an extraordinary, stranger-than-fiction story that has sparked a scientific revolution. In The Monkey's Voyage, biologist Alan de Queiroz introduces a radical new theory of how species as diverse as monkeys, baobab trees, and burrowing lizards made incredible long-distance ocean crossings: pregnant animals and wind-blown plants rode rafts and icebergs and even stowed away on the legs of sea-going birds to create the map of life we see today. In other words, these organisms were not merely victims of continental fate; they were masters of their geographic destiny. And as de Queiroz shows, the effects of oceanic dispersal have been crucial in generating the diversity of life on Earth, from monkeys and guinea pigs in South America to beech trees and kiwi birds in New Zealand. By toppling the idea that the slow process of continental drift drove odd distributions of organisms, this new theory highlights the dynamic and unpredictable nature of the history of life. In the tradition of John McPhee’s Basin and Range, The Monkey's Voyage is a beautifully told narrative of a profound investigation into the importance of contingency in history and the nature of scientific discovery.

    AI is all the rage, and the buzziest AI buzz surrounds adaptive machine learning computer systems that learn intelligent behavior from massive amounts of data. This is what powers a driverless car, for example. In this book, Hector Levesque shifts the conversation to -good old fashioned artificial intelligence, - which is based not on heaps of data but on understanding commonsense intelligence. This kind of artificial intelligence is equipped to handle situations that depart from previous patterns -- as we do in real life, when, for example, we encounter a washed-out bridge or when the barista informs us there's no more soy milk.Levesque considers the role of language in learning. He argues that a computer program that passes the famous Turing Test could be a mindless zombie, and he proposes another way to test for intelligence -- the Winograd Schema Test, developed by Levesque and his colleagues. -If our goal is to understand intelligent behavior, we had better understand the difference between making it and faking it, - he observes. He identifies a possible mechanism behind common sense and the capacity to call on background knowledge: the ability to represent objects of thought symbolically. As AI migrates more and more into everyday life, we should worry if systems without common sense are making decisions where common sense is needed.

    Everything that makes you you, and all your experiences of the world, are somehow conjured up by 1.4 kilograms of grey matter inside your skull. That might seem impossible, but science has advanced so much that we now understand not just its structures and inner workings but also how it can give rise to perception, consciousness, emotions, memories, intelligence, sleep and more.HOW YOUR BRAIN WORKS explores the amazing world inside your head. Discover the evolution and anatomy of the brain. Learn how we can peer inside it and watch it at work, and how the latest technology can allow us to control our minds and those of others.ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

    They evolved from land-roaming, dog-like creatures into animals that move like fish, breathe like us, can grow to 300,000 pounds, live 200 years and roam entire ocean basins. Whales fill us with terror, awe, and affection--yet we know hardly anything about them, and they only enter our awareness when they die, struck by a ship or stranded in the surf. Why did it take whales over 50 million years to evolve to such big sizes, and how do they eat enough to stay that big? How did their ancestors return from land to the sea? Why do they beach themselves? What do their lives tell us about our oceans, and evolution as a whole? Importantly, in the sweepstakes of human-driven habitat and climate change, will whales survive?Nick Pyenson's research has given us the answers to some of our biggest questions about whales. Nick's rich storytelling takes us to the cool halls deep inside the Smithsonian's priceless fossil collection, to the frigid fishing decks on Antarctic whaling stations, and to the blazing hot desert of Chile where scientists race against time to document the largest fossil whalebone site on earth. Spying on Whales is science writing at its best: an author who is an incredible, passionate writer, at the forefront of his field, on a topic that invokes deep fascination.

    And before there were fish in the sea, there were cephalopods - the ancestors of modern squid and Earth’s first truly substantial animals. Cephalopods became the first creatures to rise from the seafloor, essentially inventing the act of swimming. With dozens of tentacles and formidable shells, they presided over an undersea empire for millions of years. But when fish evolved jaws, the ocean’s former top predator became its most delicious snack. Cephalopods had to step up their game. Many species streamlined their shells and added defensive spines, but these enhancements only provided a brief advantage. Some cephalopods then abandoned the shell entirely, which opened the gates to a flood of evolutionary innovations: masterful camouflage, fin-supplemented jet propulsion, perhaps even dolphin-like intelligence. Squid Empire is an epic adventure spanning hundreds of millions of years, from the marine life of the primordial ocean to the calamari on tonight’s menu. Anyone who enjoys the undersea world—along with all those obsessed with things prehistoric—will be interested in the sometimes enormous, often bizarre creatures that ruled the seas long before the first dinosaurs.

    In Denialism, New Yorker staff writer Michael Specter reveals that Americans have come to mistrust institutions and especially the institution of science more today than ever before. For centuries, the general view had been that science is neither good nor bad—that it merely supplies information and that new information is always beneficial. Now, science is viewed as a political constituency that isn’t always in our best interest. We live in a world where the leaders of African nations prefer to let their citizens starve to death rather than import genetically modified grains. Childhood vaccines have proven to be the most effective public health measure in history, yet people march on Washington to protest their use. In the United States a growing series of studies show that dietary supplements and “natural” cures have almost no value, and often cause harm. We still spend billions of dollars on them. In hundreds of the best universities in the world, laboratories are anonymous, unmarked, and surrounded by platoons of security guards—such is the opposition to any research that includes experiments with animals. And pharmaceutical companies that just forty years ago were perhaps the most visible symbol of our remarkable advance against disease have increasingly been seen as callous corporations propelled solely by avarice and greed. As Michael Specter sees it, this amounts to a war against progress. The issues may be complex but the choices are not: Are we going to continue to embrace new technologies, along with acknowledging their limitations and threats, or are we ready to slink back into an era of magical thinking? In Denialism, Specter makes an argument for a new Enlightenment, the revival of an approach to the physical world that was stunningly effective for hundreds of years: What can be understood and reliably repeated by experiment is what nature regarded as true. Now, at the time of mankind’s greatest scientific advances—and our greatest need for them—that deal must be renewed.

    By spinning 28 mathematical tales, Orlin shows us that calculus is simply another language to express the very things we humans grapple with every day -- love, risk, time, and most importantly, change. Divided into two parts, "Moments" and "Eternities," and drawing on everyone from Sherlock Holmes to Mark Twain to David Foster Wallace, Change is the Only Constant unearths connections between calculus, art, literature, and a beloved dog named Elvis. This is not just math for math's sake; it's math for the sake of becoming a wiser and more thoughtful human.

    Now she reveals their secrets in this extraordinary portrait of our most remarkable wild neighbors..For thousands of years myth and folklore have celebrated its cunning intelligence. Today the red fox is the nature’s most populous carnivore, its dancing orange tail a common sight in backyards. Yet who is this wild neighbor, truly? How do we negotiate this uneasy new chapter of an ancient relationship? Join British ecologist Adele Brand on a journey to discover the surprising secrets of the fabled fox, the familiar yet enigmatic creature that has adapted to the human world with astonishing—some say, unsettling—success.

    It discusses new results, along with applications of probability theory to a variety of problems. The book contains many exercises and is suitable for use as a textbook on graduate-level courses involving data analysis. Aimed at readers already familiar with applied mathematics at an advanced undergraduate level or higher, it is of interest to scientists concerned with inference from incomplete information.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    You experience it passing every day when you watch clocks tick, bread toast, and children grow. But most physicists see things differently, from Newton to Einstein to today’s quantum theorists. For them, time isn’t real. You may think you experience time passing, but they say it’s just an illusion.Lee Smolin, author of the controversial bestseller The Trouble with Physics, argues this limited notion of time is holding physics back. It’s time for a major revolution in scientific thought. The reality of time could be the key to the next big breakthrough in theoretical physics.What if the laws of physics themselves were not timeless? What if they could evolve? Time Reborn offers a radical new approach to cosmology that embraces the reality of time and opens up a whole new universe of possibilties. There are few ideas that, like our notion of time, shape our thinking about literally everything, with major implications for physics and beyond—from climate change to the economic crisis. Smolin explains in lively and lucid prose how the true nature of time impacts our world.

    Whether it is a visualization of the Catalan numbers or an explanation of how the Fibonacci numbers occur in nature, there is something in here to delight everyone. The diagrams and pictures, many of which are in color, make this book particularly appealing and fun. A few of the discussions may be confusing to those who are not adept mathematicians; those who are may be irked that certain facts are mentioned without an accompanying proof. Nonetheless, The Book of Numbers will succeed in infecting any reader with an enthusiasm for numbers.

    Although the laws of physics create a powerful impression that time is flowing, in fact there are only timeless `nows'. In The End of Time, the British theoretical physicist Julian Barbour describes the coming revolution in our understanding of the world: a quantum theory of the universe that brings together Einstein's general theory of relativity - which denies the existence of a unique time - and quantum mechanics - which demands one. Barbour believes that only the most radical of ideas can resolve the conflict between these two theories: that there is, quite literally, no time at all. The End of Time is the first full-length account of the crisis in our understanding that has enveloped quantum cosmology. Unifying thinking that has never been brought together before in a book for the general reader, Barbour reveals the true architecture of the universe and demonstrates how physics is coming up sharp against the extraordinary possibility that the sense of time passing emerges from a universe that is timeless. The heart of the book is the author's lucid description of how a world of stillness can appear to be teeming with motion: in this timeless world where all possible instants coexist, complex mathematical rules of quantum mechanics bind together a special selection of these instants in a coherent order that consciousness perceives as the flow of time. Finally, in a lucid and eloquent epilogue, the author speculates on the philosophical implications of his theory: Does free will exist? Is time travel possible? How did the universe begin? Where is heaven? Does the denial of time make life meaningless? Written with exceptional clarity and elegance, this profound and original work presents a dazzlingly powerful argument that all will be able to follow, but no-one with an interest in the workings of the universe will be able to ignore.

    Indeed, most are only barely aware of the diseases caused by them, except, perhaps, for mad cow disease. Yet prions are the stuff of a revolutionary science?a science that might lead to cures for some of humankind?s most devastating diseases.Fatal Flaws is a scientific detective story about this elusive protein, starting with the discovery of kuru, a disease unique to New Guinea in the 1950s that baffled scientists and carried with it whispers of cannibalism. Kuru began a scientific stampede to seek out the agent of this mysterious disease?the prion?a misfolded protein whose existence some of the world?s top scientists still find difficult to accept. Today, the subject of prions remains controversial, yet the proteins might promise new treatments for some of the most intractable brain diseases, ones that affect millions around the planet, including Parkinson?s, ALS and Alzheimer?s.In Fatal Flaws, Jay Ingram unties a complicated interweaving of biology, medicine, human tragedy, surprise and disbelief in the world of prions, and he unravels some of history?s most stunning revelations about disease, the brain and infection.