Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Hazen writes of how the co-evolution of the geosphere and biosphere—of rocks and living matter—has shaped our planet into the only one of its kind in the Solar System, if not the entire cosmos.With an astrobiologist’s imagination, a historian’s perspective, and a naturalist’s passion for the ground beneath our feet, Hazen explains how changes on an atomic level translate into dramatic shifts in Earth’s makeup over its 4.567 billion year existence. He calls upon a flurry of recent discoveries to portray our planet’s many iterations in vivid detail. Through his theory of “co-evolution,” we learn how reactions between organic molecules and rock crystals may have generated Earth’s first organisms, which in turn are responsible for more than two-thirds of the mineral varieties on the planet.The Story of Earth is also the story of the pioneering men and women behind the sciences. Readers will meet black-market meteorite hawkers of the Sahara Desert, the gun-toting Feds who guarded the Apollo missions’ lunar dust, and the World War II Navy officer whose super-pressurized “bomb”—recycled from military hardware—first simulated the molten rock of Earth’s mantle. As a mentor to a new generation of scientists, Hazen introduces the intrepid young explorers whose dispatches from Earth’s harshest landscapes will revolutionize geology.

    Now she builds on those insights to show us how to give our animals the best and happiest life—on their terms, not ours.It’s usually easy to pinpoint the cause of physical pain in animals, but to know what is causing them emotional distress is much harder. rawing on the latest research and her own work,Grandin identifies the core emotional needs of animals. Then she explains how to fulfill them for dogs and cats, horses, farm animals, and zoo animals.Whether it’s how to make the healthiest environment for the dog you must leave alone most of the day, how to keep pigs from being bored, or how to know if the lion pacing in the zoo is miserable or just exercising, Grandin teaches us to challenge our assumptions about animal contentment and honor our bond with our fellow creatures.Animals Make Us Human is the culmination of almost thirty years of research, experimentation, and experience.This is essential reading for anyone who’s ever owned, cared for, or simply cared about an animal.

    But as Stephen Asma shows in Stuffed Animals and Pickled Heads, there is moregoing on in these great institutions than just smart fun. Asma takes us on a wide-ranging tour of natural history museums in New York and Chicago, London and Paris, interviewing curators, scientists, and exhibit designers, and providing a wealth of fascinating observations. We learn how the first museums were little more than high-toned side shows, with such garish exhibits as the pickled head of Peter the Great's lover. In contrast, today's museums are hot-beds of serious science, funding major research in such fields as anthropology and archaeology. Rich in detail, lucid explanation, telling anecdotes, and fascinating characters.... Asma has rendered a fascinating and credible account of how natural history museums are conceived and presented. It's the kind of book that will not only engage a wide and diverse readership, but it should, best of all, send them flocking to see how we look at nature and ourselves in those fabulous legacies of the curiosity cabinet.--The Boston Herald.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Costa takes readers on a journey from Darwin’s childhood through his voyage on the HMS Beagle, where his ideas on evolution began, and on to Down House, his bustling home of forty years. Using his garden and greenhouse, the surrounding meadows and woodlands, and even the cellar and hallways of his home-turned-field-station, Darwin tested ideas of his landmark theory of evolution through an astonishing array of experiments without using specialized equipment. From those results, he plumbed the laws of nature and drew evidence for the revolutionary arguments of On the Origin of Species and other watershed works.This unique perspective introduces us to an enthusiastic correspondent, collaborator, and, especially, an incorrigible observer and experimenter. And it includes eighteen experiments for home, school, or garden.

    Geological Survey, a lively and revealing history of the world's most disruptive natural disasters, their impact on our culture, and new ways of thinking about the ones to comeNatural disasters emerge from the same forces that give our planet life. Earthquakes have provided us with natural springs. Volcanoes have given us fertile soil. A world without floods would be a world without rain. It is only when these forces exceed our ability to withstand them that they become disasters. Together, these colossal events have shaped our cities and their architecture; elevated leaders and toppled governments; influenced the way we reason, feel, fight, unite, and pray. The history of natural disasters is a history of ourselves.The Big Ones is a look at some of the most devastating disasters in human history, whose reverberations we continue to feel today. It considers Pompeii, and how a volcanic eruption in the first century AD challenged and reinforced prevailing views of religion for centuries to come. It explores the California floods of 1862, examining the failures of our collective memory. And it transports us to today, showing what Hurricane Katrina and the 2004 Indian Ocean tsunami can tell us about governance and globalization. With global temperatures rising, natural disasters are striking with greater frequency. More than just history, The Big Ones is a call to action. Natural disasters are inevitable; human catastrophes are not. With this energizing and richly researched book, Jones offers a look at our past, readying us to face down the Big Ones in our future.

    These weren't simply variations on apes, but upright-walking humans who lived side by side, competing, cooperating, sometimes even mating with our direct ancestors. Why did the line of ancient humans who eventually evolved into us survive when the others were shown the evolutionary door? Chip Walter draws on new scientific discoveries to tell the fascinating tale of how our survival was linked to our ancestors being born more prematurely than others, having uniquely long and rich childhoods, evolving a new kind of mind that made us resourceful and emotionally complex; how our highly social nature increased our odds of survival; and why we became self aware in ways that no other animal seems to be. Last Ape Standing also profiles the mysterious "others" who evolved with us-the Neanderthals of Europe, the "Hobbits" of Indonesia, the Denisovans of Siberia and the just-discovered Red Deer Cave people of China who died off a mere eleven thousand years ago. Last Ape Standing is evocative science writing at its best-a witty, engaging and accessible story that explores the evolutionary events that molded us into the remarkably unique creatures we are; an investigation of why we do, feel, and think the things we do as a species, and as people-good and bad, ingenious and cunning, heroic and conflicted.

    Now updated with new material that brings the killer's picture into clearer focus.In the fall of 1888, all of London was held in the grip of unspeakable terror.  An elusive madman calling himself Jack the Ripper was brutally butchering women in the slums of London’s East End.  Police seemed powerless to stop the killer, who delighted in taunting them and whose crimes were clearly escalating in violence from victim to victim.  And then the Ripper’s violent spree seemingly ended as abruptly as it had begun.  He had struck out of nowhere and then vanished from the scene.  Decades passed, then fifty years, then a hundred, and the Ripper’s bloody sexual crimes became anemic and impotent fodder for puzzles, mystery weekends, crime conventions, and so-called “Ripper Walks” that end with pints of ale in the pubs of Whitechapel.  But to number-one New York Times bestselling novelist Patricia Cornwell, the Ripper murders are not cute little mysteries to be transformed into parlor games or movies but rather a series of terrible crimes that no one should get away with, even after death.  Now Cornwell applies her trademark skills for meticulous research and scientific expertise to dig deeper into the Ripper case than any detective before her—and reveal the true identity of this fabled Victorian killer.In Portrait of a Killer: Jack the Ripper, Case Closed, Cornwell combines the rigorous discipline of twenty-first century police investigation with forensic techniques undreamed of during the late Victorian era to solve one of the most infamous and difficult serial murder cases in history.  Drawing on unparalleled access to original Ripper evidence, documents, and records, as well as archival, academic, and law-enforcement resources, FBI profilers, and top forensic scientists, Cornwell reveals that Jack the Ripper was none other than a respected painter of his day, an artist now collected by some of the world’s finest museums: Walter Richard Sickert.It has been said of Cornwell that no one depicts the human capability for evil better than she.   Adding layer after layer of circumstantial evidence to the physical evidence discovered by modern forensic science and expert minds, Cornwell shows that Sickert, who died peacefully in his bed in 1942, at the age of 81, was not only one of Great Britain’s greatest painters but also a serial killer, a damaged diabolical man driven by megalomania and hate.  She exposes Sickert as the author of the infamous Ripper letters that were written to the Metropolitan Police and the press.  Her detailed analysis of his paintings shows that his art continually depicted his horrific mutilation of his victims, and her examination of this man’s birth defects, the consequent genital surgical interventions, and their effects on his upbringing present a casebook example of how a psychopathic killer is created.New information and startling revelations detailed in Portrait of a Killer include:- How a year-long battery of more than 100 DNA tests—on samples drawn by Cornwell’s forensics team in September 2001 from original Ripper letters and Sickert documents—yielded the first shadows of the 75- to 114 year-old genetic evid...

    Rachel Carson's rare ability to combine scientific insight with moving, poetic prose catapulted her book to first place on The New York Times best-seller list, where it enjoyed wide attention for thirty-one consecutive weeks. It remained on the list for more than a year and a half and ultimately sold well over a million copies, has been translated into 28 languages, inspired an Academy Award-winning documentary, and won both the 1952 National Book Award and the John Burroughs Medal.This classic work remains as fresh today as when it first appeared. Carson's writing teems with stunning, memorable images--the newly formed Earth cooling beneath an endlessly overcast sky; the centuries of nonstop rain that created the oceans; giant squids battling sperm whales hundreds of fathoms below the surface; and incredibly powerful tides moving 100 billion tons of water daily in the Bay of Fundy. Quite simply, she captures the mystery and allure of the ocean with a compelling blend of imagination and expertise.Reintroducing a classic work to a whole new generation of readers, this Special Edition features a new chapter written by Jeffrey Levinton, a leading expert in marine ecology, that brings the scientific side of The Sea Around Us completely up to date. Levinton incorporates the most recent thinking on continental drift, coral reefs, the spread of the ocean floor, the deterioration of the oceans, mass extinction of sea life, and many other topics. In addition, acclaimed nature writer Ann Zwinger has contributed a brief foreword.Today, with the oceans endangered by the dumping of medical waste and ecological disasters such as the Exxon oil spill in Alaska, this illuminating volume provides a timely reminder of both the fragility and the importance of the ocean and the life that abounds within it. Anyone who loves the sea, or who is concerned about our natural environment, will want to read this classic work.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    The earthworm may be small, spineless, and blind, but its impact on the ecosystem is profound. It ploughs the soil, fights plant diseases, cleans up pollution, and turns ordinary dirt into fertile land. Who knew? In her witty, offbeat style, Stewart shows that much depends on the actions of the lowly worm. Charles Darwin devoted his last years to the meticulous study of these creatures, praising their remarkable abilities. With the august scientist as her inspiration, Stewart investigates the worm's subterranean realm, talks to oligochaetologists—the unsung heroes of earthworm science—who have devoted their lives to unearthing the complex life beneath our feet, and observes the thousands of worms in her own garden. From the legendary giant Australian worm that stretches to ten feet in length to the modest nightcrawler that wormed its way into the heart of Darwin's last book to the energetic red wigglers in Stewart's compost bin, The Earth Moved gives worms their due and exposes their hidden and extraordinary universe. This book is for all of us who appreciate Mother Nature's creatures, no matter how humble.

    Imprisoned in the Buchenwald concentration camp, they miraculously survive the Nazis’ murderous brutality.Then Gustav learns he is being sent to Auschwitz—and certain death.For Fritz, letting his father go is unthinkable. Desperate to remain together, Fritz makes an incredible choice: he insists he must go too. To the Nazis, one death camp is the same as another, and so the boy is allowed to follow. Throughout the six years of horror they witness and immeasurable suffering they endure as victims of the camps, one constant keeps them alive: their love and hope for the future. Based on the secret diary that Gustav kept as well as meticulous archival research and interviews with members of the Kleinmann family, including Fritz’s younger brother Kurt, sent to the United States at age eleven to escape the war, The Boy Who Followed His Father into Auschwitz is Gustav and Fritz’s story—an extraordinary account of courage, loyalty, survival, and love that is unforgettable.

    Rather, they recruited an elite group of young women who, with only pencil, paper, and mathematical prowess, transformed rocket design, helped bring about the first American satellites, and made the exploration of the solar system possible. For the first time, Rise of the Rocket Girls tells the stories of these women--known as "human computers"--who broke the boundaries of both gender and science. Based on extensive research and interviews with all the living members of the team, Rise of the Rocket Girls offers a unique perspective on the role of women in science: both where we've been, and the far reaches of space to which we're heading.