There have been exhilarating highs and devastating lows, but his love for the practice of neurosurgery has never wavered. Following the publication of his celebrated New York Times bestseller Do No Harm, Marsh retired from his full-time job in England to work pro bono in Ukraine and Nepal. In Admissions, he describes the difficulties of working in these troubled, impoverished countries and the further insights it has given him into the practice of medicine. Marsh also faces up to the burden of responsibility that can come with trying to reduce human suffering. Unearthing memories of his early days as a medical student and the experiences that shaped him as a young surgeon, he explores the difficulties of a profession that deals in probabilities rather than certainties and where the overwhelming urge to prolong life can come at a tragic cost for patients and those who love them. Reflecting on what forty years of handling the human brain has taught him, Marsh finds a different purpose in life as he approaches the end of his professional career and a fresh understanding of what matters to us all in the end.

    Evolution, during the early nineteenth century, was an idea in the air. Other thinkers had suggested it, but no one had proposed a cogent explanation for how evolution occurs. Then, in September 1838, a young Englishman named Charles Darwin hit upon the idea that "natural selection" among competing individuals would lead to wondrous adaptations and species diversity. Twenty-one years passed between that epiphany and publication of "On the Origin of Species," The human drama and scientific basis of Darwin's twenty-one-year delay constitute a fascinating, tangled tale that elucidates the character of a cautious naturalist who initiated an intellectual revolution. "The Reluctant Mr. Darwin" is a book for everyone who has ever wondered about who this man was and what he said. Drawing from Darwin's secret "transmutation" notebooks and his personal letters, David Quammen has sketched a vivid life portrait of the man whose work never ceases to be controversial.

    By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

    Keying Einstein's crucial discoveries to the simple mental images that inspired them, Michio Kaku finds a revealing new way to discuss his ideas, and delivers an appealing and always accessible introduction to Einstein's work.

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    Can our world support that? What kind of world will it be? Those answering these questions generally fall into two deeply divided groups--Wizards and Prophets, as Charles Mann calls them in this balanced, authoritative, nonpolemical new book. The Prophets, he explains, follow William Vogt, a founding environmentalist who believed that in using more than our planet has to give, our prosperity will lead us to ruin. Cut back! was his mantra. Otherwise everyone will lose! The Wizards are the heirs of Norman Borlaug, whose research, in effect, wrangled the world in service to our species to produce modern high-yield crops that then saved millions from starvation. Innovate! was Borlaug's cry. Only in that way can everyone win! Mann delves into these diverging viewpoints to assess the four great challenges humanity faces--food, water, energy, climate change--grounding each in historical context and weighing the options for the future. With our civilization on the line, the author's insightful analysis is an essential addition to the urgent conversation about how our children will fare on an increasingly crowded Earth.

    He constructed a fleet of customized unicycles and a flamethrowing trumpet, outfoxed Vegas casinos, and built juggling robots. He also wrote the seminal text of the digital revolution, which has been called “the Magna Carta of the Information Age.” His discoveries would lead contemporaries to compare him to Albert Einstein and Isaac Newton. His work anticipated by decades the world we’d be living in today—and gave mathematicians and engineers the tools to bring that world to pass.In this elegantly written, exhaustively researched biography, Jimmy Soni and Rob Goodman reveal Claude Shannon’s full story for the first time. It’s the story of a small-town Michigan boy whose career stretched from the era of room-sized computers powered by gears and string to the age of Apple. It’s the story of the origins of our digital world in the tunnels of MIT and the “idea factory” of Bell Labs, in the “scientists’ war” with Nazi Germany, and in the work of Shannon’s collaborators and rivals, thinkers like Alan Turing, John von Neumann, Vannevar Bush, and Norbert Wiener.And it’s the story of Shannon’s life as an often reclusive, always playful genius. With access to Shannon’s family and friends, A Mind at Play brings this singular innovator and creative genius to life.

    This page-turning survey of the whole of terrestrial evolution sheds new light on how nervous systems evolved in animals, how the brain developed, and what it means to be human.In The Deep History of Ourselves LeDoux argues that the key to understanding all human behavior lies in viewing evolution through the prism of the first living organisms. By tracking the chain of the evolutionary timeline he shows how even the earliest single cell organisms had to solve the same problems we and our cells have to solve today in order to survive and thrive. Along the way, LeDoux explores our place in nature, how the evolution of nervous systems enchanced the ability of organisms to survive and thrive, and how the emergence of what we humans understand as consciousness made our greatest and most horrendous achievements as a species possible.

    Caravaggio defied the aesthetic conventions of his time; his use of ordinary people, realistically portrayed—street boys, prostitutes, the poor, the aged—was a profound and revolutionary innovation that left its mark on generations of artists. His insistence on painting from nature, on rendering the emotional truth of experience, whether religious or secular, made him an artist who speaks across the centuries to modern day.Called “racy, intensely imagined, and highly readable” by the New York Times Book Review, Caravaggio includes eight pages of color illustrations, and is sure to appeal to art enthusiasts interested in one of history’s true innovators. Caravaggio is part of the “Eminent Lives” series from HarperCollins, a selection of biographies by distinguished authors on canonical figures.

    Together they changed the course of history.Legendary financier, philanthropist, and society figure Alfred Lee Loomis gathered the most visionary scientific minds of the twentieth century—Albert Einstein, Werner Heisenberg, Niels Bohr, Enrico Fermi, and others—at his state-of-the-art laboratory in Tuxedo Park, New York, in the late 1930s. He established a top-secret defense laboratory at MIT and personally bankrolled pioneering research into new, high-powered radar detection systems that helped defeat the German Air Force and U-boats. With Ernest Lawrence, the Nobel Prize–winning physicist, he pushed Franklin Delano Roosevelt to fund research in nuclear fission, which led to the development of the atomic bomb. Jennet Conant, the granddaughter of James Bryant Conant, one of the leading scientific advisers of World War II, enjoyed unprecedented access to Loomis’ papers, as well as to people intimately involved in his life and work. She pierces through Loomis’ obsessive secrecy and illuminates his role in assuring the Allied victory.

    No one can stop him--but he walks away. A miracle? No...dysentery. Microbes saved the Roman Empire. Nearly a millennium later, the microbes of the Black Death ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Soon after, microbes ravaged the Americas, paving the way for their European conquest. Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species. The "good side" of history's worst epidemics The surprising debt we owe to killer diseases Where diseases came from... ...and where they may be going Children of pestilence: disease and civilization From Egypt to Mexico, the Romans to Attila the Hun STDs, sexual behavior, and culture How microbes may shape cultural cycles of puritanism and promiscuity

    When Michael Crichton -- a Harvard-trained physician, bestselling novelist, and successful movie director -- began to feel isolated in his own life, he decided to widen his horizons. He tracked wild animals in the jungles of Rwanda. He climbed Kilimanjaro and Mayan pyramids. He trekked across a landslide in Pakistan. He swam amid sharks in Tahiti. Fueled by a powerful curiosity and the need to see, feel, and hear firsthand and close-up, Michael Crichton has experienced adventures as compelling as those he created in his books and films. These adventures -- both physical and spiritual -- are recorded here in Travels, Crichton's most astonishing and personal work.

    . . . Jardine takes a complex view, according Hooke with the respect and dignity that eluded him for so long. . . [and] with this compelling and empathetic portrait, she succeeds in making a convincing case for his place in history. . . [as] a founding father in Europe’s scientific revolution.”   — Los Angeles TimesThe brilliant, largely forgotten maverick Robert Hooke was an engineer, surveyor, architect, and inventor who worked tirelessly with his intimate friend Christopher Wren to rebuild London after the Great Fire of 1666. He was the first Curator of Experiments at the Royal Society, and his engravings of natural phenomena seen under the new microscope appeared in his masterpiece, the acclaimed Micrographia, one of the most influential volumes of the day.But Hooke's irascible temper and his passionate idealism proved fatal for his relationships with important political figures, most notably Sir Isaac Newton: their quarrel is legendary. As a result, historical greatness eluded Robert Hooke. Eminent historian Lisa Jardine does this original thinker of indefatigable curiosity and imagination justice and allows him to take his place as a major figure in the seventeenth century intellectual and scientific revolution.

    In my case, blinking my left eyelid is my only means of communication.’In December 1995, Jean-Dominique Bauby, editor-in-chief of French ‘Elle’ and the father of two young children, suffered a massive stroke and found himself paralysed and speechless, but entirely conscious, trapped by what doctors call ‘locked-in syndrome’. Using his only functioning muscle – his left eyelid – he began dictating this remarkable story, painstakingly spelling it out letter by letter.His book offers a haunting, harrowing look inside the cruel prison of locked-in syndrome, but it is also a triumph of the human spirit.