Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the desert island book of all medical pharmacology - if you can own just one pharmacology book, this is it.

    It is intended to demystify ecological models and the mathematics behind them by deriving the models from first principles. The Primer explains in detail basic concepts of exponential and logistic population growth, age-structured demography, metapopulation dynamics, competition, predation, island biogeography, and, in a chapter new to this edition, succession. The book may be used as a self-teaching tutorial by students, as a primary textbook, or as a supplemental text to a general ecology textbook.

    Cave paintings of the giant beasts hint at the profound role they played in early human culture-our Ice Age ancestors built igloo-shaped huts out of mammoth bones and even feasted on mammoth tongues. Eager to uncover more clues to this mystical prehistoric age, explorers since the time of Peter the Great have scoured Siberia for mammoth remains. Now a new generation of explorers has taken to the tundra. Armed with GPS, ground-penetrating radar, and Soviet-era military helicopters, they seek an elusive prize: a mammoth carcass that will help determine how the creature lived, how it died-and how it might be brought back to life.In this adventure-filled narrative, science writer Richard Stone follows two teams of explorers-one Russian/Japanese, the other a French-led consortium-as they battle bitter cold, high winds, supply shortages, and the deeply rooted superstitions of indigenous peoples who fear the consequences of awakening the "rat beneath the ice." Stone travels from St. Petersburg to the Arctic Circle, from the North Sea to high-tech Japanese laboratories, as he traces the sometimes-surreal quest of these intrepid scientists, whose work could well rewrite our planet's evolutionary history. A riveting tale of high-stakes adventure and scientific hubris, Mammoth is also an intellectual voyage through uncharted moral terrain, as we confront the promise and peril of resurrecting creatures from the deep past.

    Following the development of scientific ideas about these dramatic events, Macdougall traces the lives of many of the brilliant and intriguing characters who have contributed to the evolving understanding of how ice ages come about. As it explains how the great Pleistocene Ice Age has shaped the earth's landscape and influenced the course of human evolution, Frozen Earth also provides a fascinating look at how science is done, how the excitement of discovery drives scientists to explore and investigate, and how timing and chance play a part in the acceptance of new scientific ideas. Macdougall describes the awesome power of cataclysmic floods that marked the melting of the glaciers of the Pleistocene Ice Age. He probes the chilling evidence for "Snowball Earth," an episode far back in the earth's past that may have seen our planet encased in ice from pole to pole. He discusses the accumulating evidence from deep-sea sediment cores, as well as ice cores from Greenland and the Antarctic, that suggests fast-changing ice age climates may have directly impacted the evolution of our species and the course of human migration and civilization. Frozen Earth also chronicles how the concept of the ice age has gripped the imagination of scientists for almost two centuries. It offers an absorbing consideration of how current studies of Pleistocene climate may help us understand earth's future climate changes, including the question of when the next glacial interval will occur.

    Thomas Pakenham embarks on a five-year odyssey to most of the temperate and tropical regions of the world to photograph sixty trees of remarkable personality and presence: Dwarfs, Giants, Monuments, and Aliens; the lovingly tended midgets of Japan; the enormous strangler from India; and the 4,700-year "Old Methusalehs." American readers will be fascinated by Pakenham's first examination of North American trees, including the towering Redwoods of Sequoia and Yosemite, the gaunt Joshua Trees of Death Valley and the Bristlecone pines discovered in California's White Mountains.Many of these trees were already famous—champions by girth, height, volume or age—while others had never previously been caught by the camera. Pakenham's five-year odyssey, sweating it out with a 30 pound Linhof camera and tripod, took him to most of the temperate and many of the tropical regions of the world. Although North American trees dominate this book, Pakenham also trekked to remote regions in Mexico, all over Europe, parts of Asia including Japan, northern and southern Africa, Madagascar, Australia and New Zealand.Remarkable Trees of the World is a lavish work that will be treasured for generations by all those who marvel at nature.

    Yet only now, with the publication of Voyaging, the first of two volumes that will constitute the definitive biography, do we have a truly vivid and comprehensive picture of Darwin as man and as scientist. Drawing upon much new material, supported by an unmatched acquaintance with both the intellectual setting and the voluminous sources, Janet Browne has at last been able to unravel the central enigma of Darwin's career: how did this amiable young gentleman, born into a prosperous provincial English family, grow into a thinker capable of challenging the most basic principles of religion and science? The dramatic story of Voyaging takes us from agonizing personal challenges to the exhilaration of discovery; we see a young, inquisitive Darwin gradually mature, shaping, refining, and finally setting forth the ideas that would at last fall upon the world like a thunderclap in The Origin of Species.

    Robin Moore has a passion for frogs and a fascination with finding new and "lost" species. In 2010, he spearheaded the worldwide "Search for Lost Frogs" campaign, which coordinated the efforts of 33 teams of scientists in 19 countries on five continents in a quest to find 100 species of amphibian not seen in over a decade."In Search of Lost Frogs" is a stunning record of Moore's journey and what he and his team did (or did not) find. The book is overflowing with exquisite close-up photographs by Moore that display the frogs' remarkable coloring and camouflage, and reveal their diminutive size -- many of the frogs are less than 5 cm long, if that. Moore's engaging text tells the story of the expedition, its highs and lows, discoveries and failures, and the campaign's ongoing work.The book's first half covers what frogs do for the health of the planet, the slippery slope of extinction, what is being done to monitor frog populations and find lost species, the Lazarus project (which aims to "revive" lost species) and the author's career-long resolve to find the Mesopotamia Beaked Toad.The second half of the book is about the searches. Moore describes the struggles, victories and dangers as well as the science. He takes readers along as his team trudge through rainforest, climb mountains and paddle rivers in search of the lost frogs, some not seen for more than a century. He tells a story of perseverance, disappointment, rediscovery, resilience, but ultimately of hope, written with passion and illustrated with superb photographs. And a surprise ending: they found 15 lost frogs.They include: In Ecuador, the Rio Pescado Stubfoot Toad, not seen since 1995 In Haiti, six rediscoveries, including the Ventriloquial Frog and Mozart's Frog, both lost for 20 years In India, the Dehradun Stream Frog, last seen (and only once) in 1985; the Elegant Tree Frog (1937); the Chalazodes Bubble Nest Frog (1874); the Anamalai Dot-Frog (1938) In Democratic Republic of Congo, the Omaniundu Reed Frog (1979) In Ivory Coast, the Mount Nimba Reed Frog (1967).Naturalists, lovers of all things frog, schools and interested general readers will enjoy the stunning photographs, the science and the adventurous stories of discovery.

    He sees the angler's environment all around him--in New York's Grand Central Station, in the cement-lined pond of a city park, in a shimmering bonefish flat in the Florida Keys, in the trout streams of the Rocky Mountains. He marvels at the fishing in the turbid Ohio River by downtown Cincinnati, where a good bait for catfish is half a White Castle french fry. The incidentals of the angling experience, the who and the where of it, interest him as much as what he catches and how. The essays contain sharply focused observations of the American outdoors, a place filled with human alterations and detritus that somehow remain defiantly unruined. Frazier's simple love of the sport lifts him to a straight-ahead angling description that's among the best contemporary writing on the subject. The Fish's Eye brings together twenty years of heartfelt, funny, and vivid essays on a timeless pursuit where so many mysteries, both human and natural, coincide.

    An exciting revision of this innovative text, Earth: Portrait of a Planet, Third Edition, emphasizes active student learning with a new chapter format, interactive media, and the power and insight of Google Earth .

    Also known as the Yellowstone Earthquake, the disaster caused massive flooding and the worst landslide in the history of the Northwestern United States. In The Night the Mountain Fell author Edmund Christopherson gives us a page-turning, journalistic-style account of how the deadliest earthquake in Montana's history ultimately claimed the lives of twenty-eight people.

    This man was a freediver, and his amphibious abilities inspired Nestor to seek out the secrets of this little-known discipline. In Deep, Nestor embeds with a gang of extreme athletes and renegade researchers who are transforming not only our knowledge of the planet and its creatures, but also our understanding of the human body and mind. Along the way, he takes us from the surface to the Atlantic’s greatest depths, some 28,000 feet below sea level. He finds whales that communicate with other whales hundreds of miles away, sharks that swim in unerringly straight lines through pitch-black waters, and seals who dive to depths below 2,400 feet for up to eighty minutes—deeper and longer than scientists ever thought possible. As strange as these phenomena are, they are reflections of our own species’ remarkable, and often hidden, potential—including echolocation, directional sense, and the profound physiological changes we undergo when underwater. Most illuminating of all, Nestor unlocks his own freediving skills as he communes with the pioneers who are expanding our definition of what is possible in the natural world, and in ourselves.

    A spellbinding look into the natural world's most fascinating and baffling phenomena, with illustrated explanations of rainbows, meteors, sunsets, hurricanes, the northern lights, and dozens of other curiosities of the sky.

    Because of this balance, "Microbiology" is appropriate for microbiology majors and mixed majors courses. The new authors have focused on readability, artwork, and the integration of several key themes (including evolution, ecology and diversity) throughout the text, making an already superior text even better.

    Recent, massive blooms of billions of jellyfish have clogged power plants, decimated fisheries, and caused millions of dollars of damage. Driven by questions about how overfishing, coastal development, and climate change were contributing to a jellyfish population explosion, Juli embarked on a scientific odyssey. She traveled the globe to meet the biologists who devote their careers to jellies, hitched rides on Japanese fishing boats to see giant jellyfish in the wild, raised jellyfish in her dining room, and throughout it all marveled at the complexity of these alluring and ominous biological wonders.

    If it ceased flowing, the water held in its reservoirs might hold out for three to four years, but after that it would be necessary to abandon most of southern California and Arizona, and much of Colorado, New Mexico, Utah and Wyoming. For the entire American Southwest the Colorado is indeed the river of life, which makes it all the more tragic and ironic that by the time it approaches its final destination, it has been reduced to a shadow upon the sand, its delta dry and deserted, its flow a toxic trickle seeping into the sea.   In this remarkable blend of history, science, and personal observation, acclaimed author Wade Davis tells the story of America’s Nile, how it once flowed freely and how human intervention has left it near exhaustion, altering the water temperature, volume, local species, and shoreline of the river Theodore Roosevelt once urged us to “leave it as it is.” Yet despite a century of human interference, Davis writes, the splendor of the Colorado lives on in the river’s remaining wild rapids, quiet pools, and sweeping canyons. The story of the Colorado River is the human quest for progress and its inevitable if unintended effects—and an opportunity to learn from past mistakes and foster the rebirth of America’s most iconic waterway.   A beautifully told story of historical adventure and natural beauty, River Notes is a fascinating journey down the river and through mankind’s complicated and destructive relationship with one of its greatest natural resources.