And certainly no one wants to overeat for years, become overweight, and end up with a high risk of diabetes or heart disease--yet two thirds of Americans do precisely that. Even though we know better, we often eat too much. Why does our behavior betray our own intentions to be lean and healthy? The problem, argues obesity and neuroscience researcher Stephan J. Guyenet, is not necessarily a lack of willpower or an incorrect understanding of what to eat. Rather, our appetites and food choices are led astray by ancient, instinctive brain circuits that play by the rules of a survival game that no longer exists. And these circuits don’t care about how you look in a bathing suit next summer.To make the case, The Hungry Brain takes readers on an eye-opening journey through cutting-edge neuroscience that has never before been available to a general audience. The Hungry Brain delivers profound insights into why the brain undermines our weight goals and transforms these insights into practical guidelines for eating well and staying slim. Along the way, it explores how the human brain works, revealing how this mysterious organ makes us who we are.

    From that day forward his life became a hell of uncontrollable tics, urges, and involuntary utterances. Eventually he is diagnosed with Tourette's Syndrome and Obsessive Compulsive disorder, and Cory embarks on an excruciating journey from specialist to specialist, enduring countless combinations of medications in wildly varying doses. Soon it becomes unclear what tics are symptoms of his disease and what are side effects of the drugs. The only certainty is that it kept getting worse. Despite his lack of control, Cory is aware of every embarrassing movement, and sensitive to every person's reaction to his often aggravating presence. Simply put: Cory Friedman's life is a living hell.Against Medical Advice is the true story of one family's decades-long battle for survival in the face of extraordinary difficulties and a rigid medical establishment.

    In this fully updated and revised edition, diabetes educator Gary Scheiner provides the tools to “think like a pancreas”—to successfully master the art and science of matching insulin to the body’s ever-changing needs. Comprehensive, free of medical jargon, and packed with useful information not readily available elsewhere, this new edition covers the many strides taken in diabetes education and management since the first edition seven years ago. Think Like a Pancreas includes critical information, such as day-to-day blood glucose control and monitoring, designing an insulin program to best match your lifestyle, up-to date medication and technology, and new insulin formulations and combinations.

    In Rats, the critically acclaimed bestseller, Robert Sullivan spends a year investigating a rat-infested alley just a few blocks away from Wall Street. Sullivan gets to know not just the beast but its friends and foes: the exterminators, the sanitation workers, the agitators and activists who have played their part in the centuries-old war between human city dweller and wild city rat. Sullivan looks deep into the largely unrecorded history of the city and its masses-its herds-of-rats-like mob. Funny, wise, sometimes disgusting but always compulsively readable, Rats earns its unlikely place alongside the great classics of nature writing. With an all-new Afterword by the author

    By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

    Jason Fung forever changed the way we think about obesity with his best-selling book, The Obesity Code. Now he has set out to do the same for type 2 diabetes.Today, most doctors, dietitians, and even diabetes specialists consider type 2 diabetes to be a chronic and progressive disease—a life sentence with no possibility of parole. But the truth, as Dr. Fung reveals in this paradigm-shifting book, is that type 2 diabetes is reversible. Writing with clear, persuasive language, he explains why conventional treatments that rely on insulin or other blood-glucose-lowering drugs can actually exacerbate the problem, leading to significant weight gain and even heart disease. The only way to treat type 2 diabetes effectively, he argues, is proper dieting and intermittent fasting—not medication.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

    On the eve of this centenary, journalist Johann Hari set off on an epic three-year, thirty-thousand-mile journey into the war on drugs. What he found is that more and more people all over the world have begun to recognize three startling truths: Drugs are not what we think they are. Addiction is not what we think it is. And the drug war has very different motives to the ones we have seen on our TV screens for so long.In Chasing the Scream, Hari reveals his discoveries entirely through the stories of people across the world whose lives have been transformed by this war. They range from a transsexual crack dealer in Brooklyn searching for her mother, to a teenage hit-man in Mexico searching for a way out. It begins with Hari's discovery that at the birth of the drug war, Billie Holiday was stalked and killed by the man who launched this crusade--and it ends with the story of a brave doctor who has led his country to decriminalize every drug, from cannabis to crack, with remarkable results.Chasing the Scream lays bare what we really have been chasing in our century of drug war--in our hunger for drugs, and in our attempt to destroy them. This book will challenge and change how you think about one of the most controversial--and consequential--questions of our time.

    This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?"The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception.Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.

    The book is an analysis of physical suffering and its relation to the numerous vocabularies and cultural forces--literary, political, philosophical, medical, religious--that confront it. Elaine Scarry bases her study on a wide range of sources: literature and art, medical case histories, documents on torture compiled by Amnesty International, legal transcripts of personal injury trials, and military and strategic writings by such figures as Clausewitz, Churchill, Liddell Hart, and Kissinger, She weaves these into her discussion with an eloquence, humanity, and insight that recall the writings of Hannah Arendt and Jean-Paul Sartre. Scarry begins with the fact of pain's inexpressibility. Not only is physical pain enormously difficult to describe in words--confronted with it, Virginia Woolf once noted, "language runs dry"--it also actively destroys language, reducing sufferers in the most extreme instances to an inarticulate state of cries and moans. Scarry analyzes the political ramifications of deliberately inflicted pain, specifically in the cases of torture and warfare, and shows how to be fictive. From these actions of "unmaking" Scarry turns finally to the actions of "making"--the examples of artistic and cultural creation that work against pain and the debased uses that are made of it. Challenging and inventive, The Body in Pain is landmark work that promises to spark widespread debate.

    In the same period it also produced treatments to control the progress of Parkinson's, rheumatoid arthritis, and schizophrenia. It made realities of open-heart surgery, organ transplants, test-tube babies. Unquestionably, the medical accomplishments of the postwar years stand at the forefront of human endeavor, yet progress in recent decades has slowed nearly to a halt. In this winner of the Los Angeles Times Book Prize, medical doctor and columnist James Le Fanu both surveys the glories of medicine in the postwar years and analyzes the factors that for the past twenty-five years have increasingly widened the gulf between achievement and advancement: the social theories of medicine, ethical issues, and political debates over health care that have hobbled the development of vaccines and discovery of new "miracle" cures. While fully demonstrating the extraordinary progress effected by medical research in the latter half of the twentieth century, Le Fanu also identifies the perils that confront medicine in the twenty-first. 16 pages of black-and-white photographs add to what the Los Angeles Times cited as "a sobering, contrarian challenge" to the "nostrum of medicine as a never-ending font of ‘miracle cures'." "[From] a respected science writer ... important information that ... has been overlooked or ignored by many physicians." —New Republic "Provocative and engrossing and informative." —Houston Chronicle "Marvelously written, meticulously researched ... one of the most thought-provoking and important works to appear in recent years." —Choice

    Best of all, he's a gifted writer who possesses a delightfully devilish sense of humor. In these essays, which range widely but mostly focus on the relationships between biology and human behavior, hard and intricate science is handled with a deft touch that makes it accessible to the general reader. In one memorable piece, Sapolsky compares the fascination with tabloid TV to behavior he's observed among wild African baboons. "Rubber necks," notes the professor, "seem to be a common feature of the primate order." In the title essay of The Trouble with Testosterone, Sapolsky ruminates on the links, real or perceived, between that hormone and aggression.Covering such broad topics as science, politics, history, and nature, the author of Why Zebras Don't Get Ulcers writes accessible and interesting essays that explore the human struggle with moral and ethical problems in today's world. 20,000 first printing.

    But compulsions exist along a broad continuum, and at the opposite end of these mild forms exist life altering disorders. Sharon Begley’s meticulously researched book is the first of its kind to examine all of these behaviors—mild and extreme (OCD, hoarding, acquiring, exercise, even compulsions to do good)—together, as they should be, because while forms of compulsion may look incredibly different, these are actually all coping responses to varying degrees of anxiety. With a focus on personal stories of dozens of interviewees, Begley employs genuine compassion and gives meaningful context to their plight. Along the way she explores the role of compulsion in our fast paced culture, the brain science behind it, and strange manifestations of the behavior throughout history. Can’t Just Stop makes compulsion comprehensible and accessible, exploring how we can realistically grapple with it in ourselves and those we love.

    But a recent groundbreaking discovery revealed them to be capable of terrifying Jekyll and Hyde behavior. When triggered--and anything that stirs up the immune system in the body can activate microglia--they can morph into destroyers, impacting a wide range of issues from memory problems and anxiety to depression and Alzheimer's. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to repair the brain in ways that help alleviate symptoms and hold the promise to one day prevent disease.A fascinating behind-the-scenes account of this cutting-edge science, The Angel and the Assassin also explores the medical implications of these game-changing discoveries. Award-winning journalist Donna Jackson Nakazawa began her investigation with a personal interest--when diagnosed with an autoimmune disorder years ago, she was convinced there was something physical going on in her brain as well as her body, though no doctor she consulted could explain how the two could be interacting in this way. With the compassion born of her own experience, she follows practitioners and patients on the front lines of treatments that help to "reboot" microglia--from neurofeedback and intermittent fasting to transcranial magnetic stimulation and gamma light flicker therapy. She witnesses patients finding significant relief from pressing symptoms--and at least one stunning recovery--offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.Proving once and for all the biological basis for the mind-body connection, the discovery of the true role of microglia stands to rewrite psychiatric and medical texts as we know them. Hailed as "riveting," "stunning," and "visionary," The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.