From its origins in 1738 as an almshouse and pesthouse, Bellevue today is a revered public hospital bringing first-class care to anyone in need. With its diverse, ailing, and unprotesting patient population, the hospital was a natural laboratory for the nation's first clinical research. It treated tens of thousands of Civil War soldiers, launched the first civilian ambulance corps and the first nursing school for women, pioneered medical photography and psychiatric treatment, and spurred New York City to establish the country's first official Board of Health. As medical technology advanced, "voluntary" hospitals began to seek out patients willing to pay for their care. For charity cases, it was left to Bellevue to fill the void. The latter decades of the twentieth century brought rampant crime, drug addiction, and homelessness to the nation's struggling cities problems that called a public hospital's very survival into question. It took the AIDS crisis to cement Bellevue's enduring place as New York's ultimate safety net, the iconic hospital of last resort.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    Includes three previously unpublished stories, and two stories which have been filmed for "The Hunger" TV series: 'The Secret Shih-Tan' and 'Anais.'

    K. C. Cole's "Fun with Physics" is a profile of astrophysicist Janet Conrad that blends her personal life with professional activity. In "Desperate Measures," the doctor and writer Atul Gawande profiles the surgeon Francis Daniels Moore, whose experiments in the 1940s and '50s pushed medicine harder and farther than almost anyone had contemplated. Also included is a poem by the legendary John Updike, "Mars as Bright as Venus." The collection ends with Diane Ackerman's "ebullient" essay "We Are All a Part of Nature."Together these twenty-three articles on a wide range of today's most current topics in science -- from biology, physics, biotechnology, and astronomy, to anthropology, genetics, evolutionary theory, and cognition‚ represent the full spectrum of scientific writing from America's most prominent science authors, proving once again that "good science writing is evidently plentiful" (Scientific American).

    These dramatic first-person essays detail spectacular serendipities, impossible cures, breathtaking resuscitations, extraordinary awakenings, and recovery from unimaginable disasters. Still other essays give voice to cases in which the physical aspects were less dramatic than the emotional aspects, yet miraculous and transformational for everyone involved. Positive impacts left in the wake of even the gravest of tragedies, profound triumphs of heart and spirit. Preeminent physicians in many specialties, including deans and department heads on the faculties of the top university medical schools in the country describe, in everyday language and with moving testimony, their very personal reactions to these remarkable clinical experiences. Among the extraordinary cases poignantly recounted by the physicians witnessing them: A priest visiting a hospitalized patient went into cardiac arrest on the elevator, which opened up on the cardiac floor, right at the foot of the cardiac specialist, at just the right moment.A tiny premature baby dying from irreversible lung disease despite the most intensive care who recovered almost immediately after being taken from his hospital bed and placed on his mother's chest.President John F. Kennedy's son Patrick, who died shortly after birth, and whose disease eventually led to research that saved generations of babies.A nine-year-old boy who was decapitated in a horrific car accident but survived without neurological damage.A woman who conceived and delivered a healthy baby—despite having had both of her fallopian tubes surgically removed.A young man whose only hope for survival was a heart transplant, but just at the moment he developed a potentially fatal complication making a transplant impossible, his own heart began healing itself.A teenage girl near death after contracting full-blown rabies who became the first patient ever to recover from that disease after an unexpected visit by Timothy Dolan, the man who would go on to become the Archbishop of New York.A Manhattan window-washer who fell 47 stories—and not only became the only person ever to survive a fall from that height, but went on to make a full recovery. Miracles We Have Seen is a book of inspiration and optimism, and a compelling glimpse into the lives of physicians—their humanity and determined devotion to their patients and their patients' families. It reminds us that what we don't know or don't understand isn‘t necessarily cause for fear, and can even be reason for hope

    Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 “parrot fever” pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.In The Pandemic Century, a lively account of scares both infamous and less known, Mark Honigsbaum combines reportage with the history of science and medical sociology to artfully reconstruct epidemiological mysteries and the ecology of infectious diseases. We meet dedicated disease detectives, obstructive or incompetent public health officials, and brilliant scientists often blinded by their own knowledge of bacteria and viruses. We also see how fear of disease often exacerbates racial, religious, and ethnic tensions—even though, as the epidemiologists Malik Peiris and Yi Guan write, “‘nature’ remains the greatest bioterrorist threat of all.”Like man-eating sharks, predatory pathogens are always present in nature, waiting to strike; when one is seemingly vanquished, others appear in its place. These pandemics remind us of the limits of scientific knowledge, as well as the role that human behavior and technologies play in the emergence and spread of microbial diseases.

    Ballet dancers and rock musicians, professors and thieves-"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul.

    Many books on the plague rely on statistics to tell the story: how many people died; how farm output and trade declined. But statistics can’t convey what it was like to sit in Siena or Avignon and hear that a thousand people a day are dying two towns away. Or to have to chose between your own life and your duty to a mortally ill child or spouse. Or to live in a society where the bonds of blood and sentiment and law have lost all meaning, where anyone can murder or rape or plunder anyone else without fear of consequence.In The Great Mortality, author John Kelly lends an air of immediacy and intimacy to his telling of the journey of the plague as it traveled from the steppes of Russia, across Europe, and into England, killing 75 million people—one third of the known population—before it vanished.

    His passing on March 6, 1900, would have been unremarkable if a city health officer hadn’t noticed a swollen black lymph node on his groin—a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong’s tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed ten million lives worldwide.To local press, railroad barons, and elected officials, such a possibility was inconceivable—or inconvenient. As they mounted a cover-up to obscure the threat, ending the career of one of the most brilliant scientists in the nation in the process, it fell to federal health officer Rupert Blue to save a city that refused to be rescued. Spearheading a relentless crusade for sanitation, Blue and his men patrolled the squalid streets of fast-growing San Francisco, examined gory black buboes, and dissected diseased rats that put the fate of the entire country at risk.In the tradition of Erik Larson and Steven Johnson, Randall spins a spellbinding account of Blue’s race to understand the disease and contain its spread—the only hope of saving San Francisco, and the nation, from a gruesome fate.

    . . The book soars." --"The San Diego Union-Tribune" Jamie Weisman was a patient long before she was a doctor. She was born with a rare defect in her immune system that leaves her prey to a range of ailments and crises and that, because it is treatable but not curable, will keep her a patient for life. In this probing and inspiring book, she brings her sojourns on both sides of the doctor-patient divide to bear on the issues of the flesh that preoccupy us all. It is a worthy addition to the best that has been written about our physical selves, a meditation on our extraordinary powers of healing and the limitations that leave intact the miracle and tragedy of being.

    This is not true. He is our best critic; he thinks with a sublime ferocity."--Cynthia OzickFollowing the collection The Broken Estate--which established James Wood as the leading critic of his generation--The Irresponsible Self confirms Wood's preeminence, not only as a discerning judge but also as an appreciator of contemporary novels.In twenty-three passionate, sparkling dispatches, he effortlessly connects his encyclopedic, passionate understanding of the literary canon with an equally earnest and appreciative view of the most discussed authors writing today, including Franzen, Pynchon, Rushdie, DeLillo, Naipaul, David Foster Wallace, and Zadie Smith.This collection includes Wood's famous and controversial attack on "hysterical realism", and his sensitive but unsparing examinations of White Teeth and Brick Lane. The Irresponsible Self is indispensable reading for anyone who cares about modern fiction.

    This elegant, humane, and engaging book "captures what we know of the development of what makes us human" (Nature).Visit Armand Marie Leroi on the web: http: //armandleroi.com/index.htmlStepping effortlessly from myth to cutting-edge science,

    Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic; the visionary scientist Gregory Pincus, who was dismissed by Harvard in the 1930s as a result of his experimentation with in vitro fertilization but who, after he was approached by Sanger and McCormick, grew obsessed with the idea of inventing a drug that could stop ovulation; and the telegenic John Rock, a Catholic doctor from Boston who battled his own church to become an enormously effective advocate in the effort to win public approval for the drug that would be marketed by Searle as Enovid.Spanning the years from Sanger’s heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminist politics, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes. Brilliantly researched and briskly written, The Birth of the Pill is gripping social, cultural, and scientific history.

    It proved fatal to at least a half-million Americans. Yet, the Spanish flu pandemic is largely forgotten today. In this vivid narrative, Alfred W. Crosby recounts the course of the pandemic during the panic-stricken months of 1918 and 1919, measures its impact on American society, and probes the curious loss of national memory of this cataclysmic event. In a new edition, with a new preface discussing the recent outbreaks of diseases, including the Asian flu and the SARS epidemic, America's Forgotten Pandemic remains both prescient and relevant. Alfred W. Crosby is a Professor Emeritus in American Studies, History and Geography at the University of Texas at Austin, where he taught for over 20 years. His previous books include Throwing Fire (Cambrige, 2002), the Measure of Reality (Cambridge, 1997) and Ecological Imperialism (cambridge, 1986). Ecological Imperialism was the winner of the 1986 Phi Beta Kappa book prize. The Measure of Reality was chosen by the Los Angeles Times as one of the 100 most important books of 1997.