Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    41 illustrations.

    ENTANGLEMENT. REALITY. Books containing these three words are typically fluff or incomprehensible; this one is not. "Q is for Quantum" teaches a theory at the forefront of modern physics to an audience presumed to already know only basic arithmetic. Topics covered range from the practical (new technologies we can expect soon) to the foundational (old ideas that attempt to make sense of the theory). The theory is built up precisely and quantitatively. Deceptively vague jargon and analogies are avoided, and mysterious features of the theory are made explicit and not skirted. The tenacious reader will emerge with a better technical understanding of why we are troubled by this theory than that possessed by many professional physicists.

    It covers all relevant areas, including molecular spectroscopy, electronic structure computations, molecular beam methods and time-resolved measurements of chemical systems.

    After sampling myths explaining First Light, the story moves on to early philosophers' queries, then through the centuries, from Buddhist temples to Biblical scripture, when light was the soul of the divine.Battling darkness and despair, Gothic architects crafted radiant cathedrals while Dante dreamed a "heaven of pure light." Later, following Leonardo's advice, Renaissance artists learned to capture light on canvas. During the Scientific Revolution, Galileo gathered light in his telescope, Descartes measured the rainbow, and Newton used prisms to solidify the science of optics. But even after Newton, light was an enigma. Particle or wave? Did it flow through an invisible "ether"? Through the age of Edison and into the age of lasers, Light reveals how light sparked new wonders--relativity, quantum electrodynamics, fiber optics, and more.Although lasers now perform everyday miracles, light retains its eternal allure. "For the rest of my life," Einstein said, "I will reflect on what light is." Light explores and celebrates such curiosity.

    To the public he is a figure of tragic dimensions - a brilliant scientist and author of the phenomenal best-seller A Brief History of Time, and yet confined to a wheelchair, unable to speak or write. Hawking has mastered the two great theories of 20th-century physics - Einstein's General Theory of Relativity and Quantum Mechanics - and has made breathtaking discoveris about where they break down or overlap, such as on the edge of a Black Hole or at the Big Bang origin of the Universe. Here is the perfect introduction to Hawking's work by the author, who was helped by several long discussions with Hawking in researching the book.

    Yet as bestselling author and astrophysicist Jeffrey Bennett points out, black holes don't suck. With that simple idea in hand, Bennett begins an entertaining introduction to Einstein's theories, describing the amazing phenomena readers would actually experience if they took a trip through a black hole.The theory of relativity also gives us the cosmic speed limit of the speed of light, the mind-bending ideas of time dilation and curvature of spacetime, and what may be the most famous equation in history: e = mc2. Indeed, the theory of relativity shapes much of our modern understanding of the universe, and it is not "just a theory: " every major prediction of relativity has been tested to exquisite precision and its practical applications include the Global Positioning System (GPS). Bennett proves anyone can understand the basics of Einstein's ideas. His intuitive, nonmathematical approach gives a wide audience its first real taste of how relativity works and why it is so important not only to science but also to the way we view ourselves as human beings.

    When the boy's eyes were healed they removed the bandages and, waving a hand in front of the child's physically perfect eyes, asked him what he saw. "I don't know," was his only reply. What he saw was only a varying brightness in front of him. However, when allowed to touch the hand as it began to move, he cried out in a voice of triumph, "It's moving!" He could feel it move, but he still needed laboriously to learn to see it move. Light and eyes were not enough to grant him sight. How, then, do we see? What's the difference between seeing and perception? What is light?From ancient times to the present, from philosophers to quantum physicists, nothing has so perplexed, so fascinated, so captivated the mind as the elusive definition of light. In Catching the Light, Arthur Zajonc takes us on an epic journey into history, tracing how humans have endeavored to understand the phenomenon of light. Blending mythology, religion, science, literature, and painting, Zajonc reveals in poetic detail the human struggle to identify the vital connection between the outer light of nature and the inner light of the human spirit. He explains the curiousness of the Greeks' blue and green "color blindness": Odysseus gazing longingly at the "wine-dark sea"; the use of chloros (green) as the color of honey in Homer's Odessey; and Euripides' use of the color green to describe the hue of tears and blood. He demonstrates the complexity of perception through the work of Paul Cézanne--the artist standing on the bank of a river, painting the same scene over and over again, the motifs multiplying before his eyes. And Zajonc goes on to show how our quest for an understanding of light, as well as the conclusions we draw, reveals as much about the nature of our own psyche as it does about the nature of light itself. For the ancient Egyptians the nature of light was clear--it simply was the gaze of God. In the hands of the ancient Greeks, light had become the luminous inner fire whose ethereal effluence brought sight. In our contemporary world of modern quantum physics, science plays the greatest part in our theories of light's origin--from scientific perspectives such as Sir Isaac Newton's "corpuscular theory of light" and Michael Faraday's "lines of force" to such revolutionary ideas as Max Planck's "discrete motion of a pendulum" (the basis of quantum mechanics), Albert Einstein's "particles of light" and "theory of relativity," and Niels Bohr's "quantum jumps." Yet the metaphysical aspects of the scientific search, Zajonc shows, still loom large. For the physicist Richard Feynman, a quantum particle travels all paths, eventually distilling to one path whose action is least--the most beautiful path of all. Whatever light is, here is where we will find it.With rare clarity and unmatched lyricism, Zajonc illuminates the profound implications of the relationships between the multifaceted strands of human experience and scientific endeavor. A fascinating search into our deepest scientific mystery, Catching the Light is a brilliant synthesis

    In Gravity, he takes an enlightening look at three of the towering figures of science who unlocked many of the mysteries behind the laws of physics: Galileo, the first to take a close look at the process of free and restricted fall; Newton, originator of the concept of gravity as a universal force; and Einstein, who proposed that gravity is no more than the curvature of the four-dimensional space-time continuum.Graced with the author's own drawings, both technical and fanciful, this remarkably reader-friendly book focuses particularly on Newton, who developed the mathematical system known today as the differential and integral calculus. Readers averse to equations can skip the discussion of the elementary principles of calculus and still achieve a highly satisfactory grasp of a fascinating subject.Starting with a chapter on Galileo’s pioneering work, this volume devotes six chapters to Newton's ideas and other subsequent developments and one chapter to Einstein, with a concluding chapter on post-Einsteinian speculations concerning the relationship between gravity and other physical phenomena, such as electromagnetic fields.

    He was trying to find an equation that explained all physical reality - a theory of everything. He failed, but others have taken up the challenge in a remarkable quest that is shedding light on unsuspected secrets of the cosmos.Experimental physicist and award-winning educator Dr. Don Lincoln of the Fermi National Accelerator Laboratory takes you on this exciting journey in The Theory of Everything: The Quest to Explain All Reality. Suitable for the intellectually curious at all levels and assuming no background beyond basic high-school math, these 24 half-hour lectures cover recent developments at the forefront of particle physics and cosmology, while delving into the history of the centuries-long search for this holy grail of science.You trace the dream of a theory of everything through Newton, Maxwell, Einstein, Bohr, Schrödinger, Feynman, Gell-Mann, Weinberg, and other great physicists, charting their progress toward an all-embracing, unifying theory. Their resulting equations are the masterpieces of physics, which Dr. Lincoln explains in fascinating and accessible detail. Studying them is like touring a museum of great works of art - works that are progressing toward an ultimate, as-yet-unfinished masterpiece.Listening Length: 12 hours and 21 minutes

    On March 14, 2013, physicists at CERN confirmed it. This elusive subatomic particle forms a field that permeates the entire universe, creating the masses of the elementary particles that are the basic building blocks of everything in the known world--from viruses to elephants, from atoms to quasars.     Starting where Nobel Laureate Leon Lederman's bestseller The God Particle left off, this incisive new book explains what's next. Lederman and Hill discuss key questions that will occupy physicists for years to come:      * Why were scientists convinced that something like the "God Particle" had to exist?      * What new particles, forces, and laws of physics lie beyond the "God Particle"?      * What powerful new accelerators are now needed for the US to recapture a leadership role in science and to reach "beyond the God Particle," such as Fermilab's planned Project-X and the Muon Collider?      Using thoughtful, witty, everyday language, the authors show how all of these intriguing questions are leading scientists ever deeper into the fabric of nature. Readers of The God Particle will not want to miss this important sequel.

    Lorentz.

    Bronowski was both a distinguished mathematician and a poet, a philosopher of science and a literary critic who wrote a well-known study of William Blake. Dr. Bronowski's very career was founded on the premise of an intimate connection between science and the humanities, disciplines which are still generally thought to be worlds apart.The Common Sense of Science, a book which remains as topical today as it was when it first appeared twenty-five years ago, articulates and develops Bronowski's provocative idea that the sciences and the arts fundamentally share the same imaginative vision.

    These singularities are places where space-time begins or ends, and the presently known laws of physics break down. They will occur inside black holes, and in the past are what might be construed as the beginning of the universe. To show how these predictions arise, the authors discuss the General Theory of Relativity in the large. Starting with a precise formulation of the theory and an account of the necessary background of differential geometry, the significance of space-time curvature is discussed and the global properties of a number of exact solutions of Einstein's field equations are examined. The theory of the causal structure of a general space-time is developed, and is used to study black holes and to prove a number of theorems establishing the inevitability of singualarities under certain conditions. A discussion of the Cauchy problem for General Relativity is also included in this 1973 book.

    This indispensable collection of forty-eight pieces from his brilliant oeuvre includes selections from classics such as Ever Since Darwin and The Mismeasure of Man, plus articles and speeches never before published in book form.This volume, the last that will bear his name, spotlights his elegance, depth, and sheer pleasure in our world—a true celebration of an extraordinary mind.