But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    "Go ahead, ask your question," her father urged, nudging her forward. She smiled shyly and said, "You're my hero. Who's yours?" Many people - especially girls - have asked us that same question over the years. It's one of our favourite topics.HILLARY: Growing up, I knew hardly any women who worked outside the home. So I looked to my mother, my teachers, and the pages of Life magazine for inspiration. After learning that Amelia Earhart kept a scrapbook with newspaper articles about successful women in male-dominated jobs, I started a scrapbook of my own. Long after I stopped clipping articles, I continued to seek out stories of women who seemed to be redefining what was possible.CHELSEA: This book is the continuation of a conversation the two of us have been having since I was little. For me, too, my mom was a hero; so were my grandmothers. My early teachers were also women. But I grew up in a world very different from theirs. My pediatrician was a woman, and so was the first mayor of Little Rock who I remember from my childhood. Most of my close friends' moms worked outside the home as nurses, doctors, teachers, professors, and in business. And women were going into space and breaking records here on Earth.Ensuring the rights and opportunities of women and girls remains a big piece of the unfinished business of the twenty-first century. While there's a lot of work to do, we know that throughout history and around the globe women have overcome the toughest resistance imaginable to win victories that have made progress possible for all of us. That is the achievement of each of the women in this book.So how did they do it? The answers are as unique as the women themselves. Civil rights activist Dorothy Height, LGBTQ trailblazer Edie Windsor, and swimmer Diana Nyad kept pushing forward, no matter what. Writers like Rachel Carson and Chimamanda Ngozi Adichie named something no one had dared talk about before. Historian Mary Beard used wit to open doors that were once closed, and Wangari Maathai, who sparked a movement to plant trees, understood the power of role modeling. Harriet Tubman and Malala Yousafzai looked fear in the face and persevered. Nearly every single one of these women was fiercely optimistic - they had faith that their actions could make a difference. And they were right.To us, they are all gutsy women - leaders with the courage to stand up to the status quo, ask hard questions, and get the job done. So in the moments when the long haul seems awfully long, we hope you will draw strength from these stories. We do. Because if history shows one thing, it's that the world needs gutsy women.

    In this classic work Anne Sayre, a journalist and close friend of Franklin, puts the record straight.

    Czerski provides the tools to alter the way we see everything around us by linking ordinary objects and occurrences, like popcorn popping, coffee stains, and fridge magnets, to big ideas like climate change, the energy crisis, or innovative medical testing. She provides answers to vexing questions: How do ducks keep their feet warm when walking on ice? Why does it take so long for ketchup to come out of a bottle? Why does milk, when added to tea, look like billowing storm clouds? In an engaging voice at once warm and witty, Czerski shares her stunning breadth of knowledge to lift the veil of familiarity from the ordinary.

    These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, narrated by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using some of today's most controversial creations—e-cigarettes, GMOs, drug treatments for ADHD—as case studies. For every "Aha!" moment that should have been an "Oh no," this book is an engrossing account of how science has been misused disastrously—and how we can learn to use its power for good.

    What happened, how it happened, and what it means to you today. A colorful cast of characters whose discoveries were often driven not only by personal tragedy, curiosity, and hard work, but petty bickering, dumb luck, and a healthy dose of humor. For anyone interested in science, medicine, and beyond... Why are you alive right now? Chances are, you owe your life to one of the remarkable medical discoveries in this book. Maybe it was vaccines. Or antibiotics. Or X-rays. Revolutionary medical breakthroughs like these haven’t just changed the way we treat disease, they’ve transformed how we understand ourselves and the world we live in. In Breakthrough!, Jon Queijo tells the hidden stories behind 10 of history’s most amazing medical discoveries. This isn’t dry history: These are life-and-death mysteries uncovered, tales of passionate, often-mocked individuals who stood their ground and were proven right. From germs to genetics, the ancient Hippocrates to the cutting edge, these are stories that have changed the world—and, quite likely, saved your life.

    But in middle age, he discovered the new anxieties and pleasures of mastering a new culture. When he left fifteen years later to take a teaching position in the U.S., he was fluent enough to broadcast on French radio and TV, and in his work as a journalist, he'd made the acquaintance of everyone from Yves Saint Laurent to Catherine Deneuve to Michel Foucault. He'd also developed a close friendship with an older woman, Marie-Claude, through which he'd come to understand French life and culture in a deeper way.The book's title evokes the Parisian landscape in the eternal mists and the half-light, the serenity of the city compared to the New York White had known (and vividly recalled in City Boy). White fell headily in love with the city and its culture: both intoxicated and intellectually stimulated. He became the definitive biographer of Jean Genet; he wrote lives of Marcel Proust and Arthur Rimbaud; and he became a recipient of the French Order of Arts and Letters. Inside a Pearl recalls those fertile years for White. It's a memoir which gossips and ruminates, and offers a brilliant examination of a city and a culture eternally imbued with an aura of enchantment.

    Inspired by the promise of riches, countless seafarers poured out of the Iberian Peninsula and wider Europe in search of spices, treasure, and land. Many returned with strange tales of the New World.Curiosity began to percolate through Europe as the New World’s people, animals, and plants ruptured prior assumptions about the biblical description of creation. The Church, long fearful of challenges to its authority, could no longer suppress the mantra “Dare to know!”Noblemen began collecting cabinets of curiosities; soon others went from collecting to examining natural objects with fresh eyes. Observation led to experiments; competing conclusions triggered debates. The foundations for the natural sciences were laid as questions became more multifaceted and answers became more complex. Carl Linneaus developed a classification system and sent students around the globe looking for specimens. Museums, botanical gardens, and philosophical societies turned their attention to nature. National governments undertook explorations of the Pacific.Eminent historian Joyce Appleby vividly recounts the explorers’ triumphs and mishaps, including Magellan’s violent death in the Philippines; the miserable trek of the “new Argonauts” across the Andes on their mission to determine the true shape of the earth; and how two brilliant scientists, Alexander Humboldt and Charles Darwin, traveled to the Americas for evidence to confirm their hypotheses about the earth and its inhabitants. Drawing on detailed eyewitness accounts, Appleby also tells of the turmoil created in the all societies touched by the explorations.This sweeping, global story imbues the Age of Discovery with fresh meaning, elegantly charting its stimulation of the natural sciences, which ultimately propelled Western Europe toward modernity.

    They attracted followers ranging from Thomas Jefferson, who laid out mastodon bones on the White House floor, to twentieth-century doctors who used their knowledge of new species to conquer epidemic diseases. Acclaimed science writer Richard Conniff brings these daredevil "species seekers" to vivid life. Alongside their globe-spanning tales of adventure, he recounts some of the most dramatic shifts in the history of human thought. At the start, everyone accepted that the Earth had been created for our benefit. We weren't sure where vegetable ended and animal began, we couldn't classify species, and we didn't understand the causes of disease. But all that changed as the species seekers introduced us to the pantheon of life on Earth—and our place within it.

    No one can stop him--but he walks away. A miracle? No...dysentery. Microbes saved the Roman Empire. Nearly a millennium later, the microbes of the Black Death ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Soon after, microbes ravaged the Americas, paving the way for their European conquest. Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species. The "good side" of history's worst epidemics The surprising debt we owe to killer diseases Where diseases came from... ...and where they may be going Children of pestilence: disease and civilization From Egypt to Mexico, the Romans to Attila the Hun STDs, sexual behavior, and culture How microbes may shape cultural cycles of puritanism and promiscuity

    Long after her grandmother’s death, she found a shoebox tucked in the closet containing photographs of her grandmother with a mysterious stranger, a cryptic telegram from the Red Cross, and a drawing signed by Picasso. This discovery sent Freeman on a decade-long quest to uncover the significance of these keepsakes, taking her from Picasso’s archives in Paris to a secret room in a farmhouse in Auvergne to Long Island to Auschwitz. Freeman pieces together the puzzle of her family’s past, discovering more about the lives of her grandmother and her three brothers, Jacques, Henri, and Alex. Their stories sometimes typical, sometimes astonishing—reveal the broad range of experiences of Eastern European Jews during Holocaust. This thrilling family saga is filled with extraordinary twists, vivid characters, and famous cameos, illuminating the Jewish and immigrant experience in the World War II era. Addressing themes of assimilation, identity, and home, this powerful story about the past echoes issues that remain relevant today.

    At eleven, his grandmother’s cancer diagnosis drove him to investigate new ways to produce medical isotopes. And by fourteen, Wilson had built a 500-million-degree reactor and become the youngest person in history to achieve nuclear fusion. How could someone so young achieve so much, and what can Wilson’s story teach parents and teachers about how to support high-achieving kids? In The Boy Who Played with Fusion, science journalist Tom Clynes narrates Taylor Wilson’s extraordinary journey—from his Arkansas home where his parents fully supported his intellectual passions, to a unique Reno, Nevada, public high school just for academic superstars, to the present, when now nineteen-year-old Wilson is winning international science competitions with devices designed to prevent terrorists from shipping radioactive material into the country. Along the way, Clynes reveals how our education system shortchanges gifted students, and what we can do to fix it.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Six years later they were bitter antagonists, locked in a savage struggle that was as much personal and emotional as it was theoretical and professional. Between them stood a young woman named Sabina Spielrein, who had been both patient and lover to Jung and colleague and confidante to Freud before going on to become an innovative psychoanalyst herself.A solid new interpretation of the short-lived but oft-analyzed collaboration between Freud and Jung, in which the mysterious Sabina Spielrein figures prominently. Using Spielrein's correspondence and journals--discovered in the 1970's and first appearing in Aldo Carotenuto's A Secret Symmetry (1982)--Kerr traces a fascinating, credible web of influence and cross-fertilized ideas that he weaves skillfully into a record of psychoanalytic history.

    W. Brands, twice a finalist for the Pulitzer Prize, comes the riveting story of how President Harry Truman and General Douglas MacArthur squared off to decide America's future in the aftermath of World War II. At the height of the Korean War, President Harry S. Truman committed a gaffe that sent shock waves around the world. When asked by a reporter about the possible use of atomic weapons in response to China's entry into the war, Truman replied testily, "The military commander in the field will have charge of the use of the weapons, as he always has." This suggested that General Douglas MacArthur, the willful, fearless, and highly decorated commander of the American and U.N. forces, had his finger on the nuclear trigger. A correction quickly followed, but the damage was done; two visions for America's path forward were clearly in opposition, and one man would have to make way.Truman was one of the most unpopular presidents in American history. Heir to a struggling economy, a ruined Europe, and increasing tension with the Soviet Union, on no issue was the path ahead clear and easy. General MacArthur, by contrast, was incredibly popular, as untouchable as any officer has ever been in America. The lessons he drew from World War II were absolute: appeasement leads to disaster and a showdown with the communists was inevitable--the sooner the better. In the nuclear era, when the Soviets, too, had the bomb, the specter of a catastrophic third World War lurked menacingly close on the horizon.The contest of wills between these two titanic characters unfolds against the turbulent backdrop of a faraway war and terrors conjured at home by Joseph McCarthy. From the drama of Stalin's blockade of West Berlin to the daring landing of MacArthur's forces at Inchon to the shocking entrance of China into the war, " The General and the President vividly evokes the making of a new American era."