As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    By focusing on the experiences of ordinary villagers as they lived-and died-during the Black Death (1345-50), Hatcher vividly places the reader directly inside those tumultuous times and describes in fascinating detail the day-to-day existence of people struggling with the tragic effects of the plague. Dramatic scenes portray how contemporaries must have felt and thought about these momentous events: what they knew and didn't know about the horrors of the disease, what they believed about death and God's vengeance, and how they tried to make sense of it all despite frantic rumors, frightening tales, and fearful sermons.

    From modest origins, the Habsburgs gained control of the Holy Roman Empire in the fifteenth century. Then, in just a few decades, their possessions rapidly expanded to take in a large part of Europe, stretching from Hungary to Spain, and parts of the New World and the Far East. The Habsburgs continued to dominate Central Europe through the First World War.Historians often depict the Habsburgs as leaders of a ramshackle empire. But Rady reveals their enduring power, driven by the belief that they were destined to rule the world as defenders of the Roman Catholic Church, guarantors of peace, and patrons of learning. The Habsburgs is the definitive history of a remarkable dynasty that forever changed Europe and the world.

    They first came into existence as an idea, before they had a common ruler and before the country they lived in even had a name. They have lasted as a recognizable entity ever since, and their defining national institutions can be traced back to the earliest years of their history.The English have come a long way from those precarious days of invasion and conquest, with many spectacular changes of fortune. Their political, economic and cultural contacts have left traces for good and ill across the world. This book describes their history and its meanings from their beginnings in the monasteries of Northumbria and the wetlands of Wessex to the cosmopolitan energy of today's England. Robert Tombs draws out important threads running through the story, including participatory government, language, law, religion, the land and the sea, and ever-changing relations with other peoples. Not the least of these connections are the ways the English have understood their own history, have argued about it, forgotten it, and yet been shaped by it. These diverse and sometimes conflicting understandings are an inherent part of their identity. Rather to their surprise, as ties within the United Kingdom loosen, the English are suddenly beginning a new period in their long history. Especially at times of change, history can help us to think about the sort of people we are and wish to be. This book, the first single-volume work on this scale for more than half a century, and which incorporates a wealth of recent scholarship, presents a challenging modern account of this immense and continuing story, bringing out the strength and resilience of English government, the deep patterns of division, and yet also the persistent capacity to come together in the face of danger.

    The answers are best found not in jurisprudence but in science: the curious science of human-wildlife conflict, a discipline at the crossroads of human behavior and wildlife biology.Roach tags along with animal-attack forensics investigators, human-elephant conflict specialists, bear managers, and "danger tree" faller blasters. Intrepid as ever, she travels from leopard-terrorized hamlets in the Indian Himalaya to St. Peter’s Square in the early hours before the pope arrives for Easter Mass, when vandal gulls swoop in to destroy the elaborate floral display. She taste-tests rat bait, learns how to install a vulture effigy, and gets mugged by a macaque.Combining little-known forensic science and conservation genetics with a motley cast of laser scarecrows, langur impersonators, and trespassing squirrels, Roach reveals as much about humanity as about nature’s lawbreakers. When it comes to "problem" wildlife, she finds, humans are more often the problem—and the solution. Fascinating, witty, and humane, Fuzz offers hope for compassionate coexistence in our ever-expanding human habitat.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    Wave after wave of Norse ‘sea-wolves’ followed in search of plunder, land, or a glorious death in battle. Much of the British Isles fell before their swords, and the continental capitals of Paris and Aachen were sacked in turn. Turning east, they swept down the uncharted rivers of central Europe, captured Kiev and clashed with mighty Constantinople, the capital of the Byzantine Empire. But there is more to the Viking story than brute force. They were makers of law - the term itself comes from an Old Norse word - and they introduced a novel form of trial by jury to England. They were also sophisticated merchants and explorers who settled Iceland, founded Dublin, and established a trading network that stretched from Baghdad to the coast of North America. In The Sea Wolves, Lars Brownworth brings to life this extraordinary Norse world of epic poets, heroes, and travellers through the stories of the great Viking figures. Among others, Leif the Lucky who discovered a new world, Ragnar Lodbrok the scourge of France, Eric Bloodaxe who ruled in York, and the crafty Harald Hardrada illuminate the saga of the Viking age - a time which “has passed away, and grown dark under the cover of night”.

    His first tunnel trips inspired a lifelong fascination with exploring underground worlds, from the derelict subway stations and sewers of New York City to sacred caves, catacombs, tombs, bunkers, and ancient underground cities in more than twenty countries around the world. Underground is both a personal exploration of Hunt’s obsession and a panoramic study of how we are all connected to the underground, how caves and other dark hollows have frightened and enchanted us through the ages.In a narrative spanning continents and epochs, Hunt follows a cast of subterraneaphiles who have dedicated themselves to investigating underground worlds. He tracks the origins of life with a team of NASA microbiologists a mile beneath the Black Hills, camps out for three days with urban explorers in the catacombs and sewers of Paris, descends with an Aboriginal family into a 35,000-year-old mine in the Australian outback, and glimpses a sacred sculpture molded by Paleolithic artists in the depths of a cave in the Pyrenees.Each adventure is woven with findings in mythology and anthropology, natural history and neuroscience, literature and philosophy. In elegant and graceful prose, Hunt cures us of our “surface chauvinism,” opening our eyes to the planet’s hidden dimension. He reveals how the subterranean landscape gave shape to our most basic beliefs and guided how we think about ourselves as humans. At bottom, Underground is a meditation on the allure of darkness, the power of mystery, and our eternal desire to connect with what we cannot see.

    They never saw her again. Her abduction was one of the most notorious episodes of the vicious conflict known as The Troubles. Everyone in the neighborhood knew the I.R.A. was responsible. But in a climate of fear and paranoia, no one would speak of it. In 2003, five years after an accord brought an uneasy peace to Northern Ireland, a set of human bones was discovered on a beach. McConville's children knew it was their mother when they were told a blue safety pin was attached to the dress--with so many kids, she had always kept it handy for diapers or ripped clothes.Patrick Radden Keefe's mesmerizing book on the bitter conflict in Northern Ireland and its aftermath uses the McConville case as a starting point for the tale of a society wracked by a violent guerrilla war, a war whose consequences have never been reckoned with. The brutal violence seared not only people like the McConville children, but also I.R.A. members embittered by a peace that fell far short of the goal of a united Ireland, and left them wondering whether the killings they committed were not justified acts of war, but simple murders.Patrick Radden Keefe writes an intricate narrative about a notorious killing in Northern Ireland and its devastating repercussions.

    The powerful, voracious Rodrigo Borgia, better known to history as Pope Alexander VI, was the central figure of the dynasty. Two of his seven papal offspring also rose to power and fame—Lucrezia Borgia, his daughter, whose husband was famously murdered by her brother, and that brother, Cesare, who served as the model for Niccolò Machiavelli's The Prince. Notorious for seizing power, wealth, land, and titles through bribery, marriage, and murder, the dynasty's dramatic rise from its Spanish roots to its occupation of the highest position in Renaissance society forms a gripping tale.Erudite, witty, and always insightful, Hibbert removes the layers of myth around the Borgia family and creates a portrait alive with his superb sense of character and place.

    Here, Sunday Times bestselling author Charles Spencer tells the real story behind the legend to show how one cataclysmic shipwreck changed England’s course.In 1120, the White Ship was known as the fastest ship afloat. When it sank sailing from Normandy to England it was carrying aboard the only legitimate heir to King Henry I, William of Ætheling. The raucous, arrogant young prince had made a party of the voyage, carousing with his companions and pushing wine into the eager hands of the crew. It was the middle of the night when the drunken helmsman rammed the ship into rocks.The next day only one of the three hundred who had boarded the ship was alive to describe the horrors of the slow shipwreck. William, the face of England’s future had drowned along with scores of the social elite. The royal line severed and with no obvious heir to the crown, a civil war of untold violence erupted. Known fittingly as ‘The Anarchy’, this game of thrones saw families turned in on each other, with English barons, rebellious Welsh leaders and Scottish invaders all playing a part in the bloody, desperate scrum for power.One incredible shipwreck and two decades of violent uncertainty; England’s course had changed forever.

    Most of the time this math works quietly behind the scenes . . . until it doesn't. All sorts of seemingly innocuous mathematical mistakes can have significant consequences.Math is easy to ignore until a misplaced decimal point upends the stock market, a unit conversion error causes a plane to crash, or someone divides by zero and stalls a battleship in the middle of the ocean.Exploring and explaining a litany of glitches, near misses, and mathematical mishaps involving the internet, big data, elections, street signs, lotteries, the Roman Empire, and an Olympic team, Matt Parker uncovers the bizarre ways math trips us up, and what this reveals about its essential place in our world. Getting it wrong has never been more fun.

    Victoria's matchmaking plans were further complicated by the tumultuous international upheavals of the time: revolution and war were in the air, and kings and queens, princes and princesses were vulnerable targets.Queen Victoria's Matchmaking travels through the glittering, decadent palaces of Russia and Europe, weaving in scandals, political machinations and family tensions to enthralling effect. It is at once an intimate portrait of a royal family and an examination of the conflict caused by the marriages the Queen arranged. At the heart of it all is Victoria herself: doting grandmother one moment; determined Queen Empress the next.

    16 years later, the French Ambassador Hugues de Terlon secretly unearthed Descartes' bones & transported them to France. Why would this devoutly Catholic official care so much about the remains of a philosopher who was hounded from country to country on charges of atheism? Why would Descartes' bones take such a strange, serpentine path over the next 350 years—a path intersecting some of the grandest events imaginable: the birth of science, the rise of democracy, the mind-body problem, the conflict between faith & reason? Their story involves people from all walks of life—Louis XIV, a Swedish casino operator, poets & playwrights, philosophers & physicists, as these people used the bones in scientific studies, stole them, sold them, revered them as relics, fought over them, passed them surreptitiously from hand to hand. The answer lies in Descartes’ famous phrase: Cogito ergo sum—"I think, therefore I am." In his deceptively simple 78-page essay, Discourse on the Method, this small, vain, vindictive, peripatetic, ambitious Frenchman destroyed 2000 years of received wisdom & laid the foundations of the modern world. At the root of Descartes’ method was skepticism: "What can I know for certain?" Like-minded thinkers around Europe passionately embraced the book--the method was applied to medicine, nature, politics & society. The notion that one could find truth in facts that could be proved, & not in reliance on tradition & the Church's teachings, would become a turning point in human history. In an age of faith, what Descartes was proposing seemed like heresy. Yet Descartes himself was a good Catholic, who was spurred to write his incendiary book for the most personal of reasons: He'd devoted himself to medicine & the study of nature, but when his beloved daughter died aged 5, he took his ideas deeper. To understand the natural world one needed to question everything. Thus the scientific method was created & religion overthrown. If the natural world could be understood, knowledge could be advanced, & others might not suffer as his child did. The great controversy Descartes ignited continues to our era: where Islamic terrorists spurn the modern world & pine for a culture based on unquestioning faith; where scientists write bestsellers that passionately make the case for atheism; where others struggle to find a balance between faith & reason. Descartes’ Bonesis a historical detective story about the creation of the modern mind, with twists & turns leading up to the present day—to the science museum in Paris where the philosopher’s skull now resides & to the church a few kilometers away where, not long ago, a philosopher-priest said a mass for his bones.

    In this landmark book, Ronald Hutton traces witchcraft from the ancient world to the early-modern stake.   This book sets the notorious European witch trials in the widest and deepest possible perspective and traces the major historiographical developments of witchcraft. Hutton, a renowned expert on ancient, medieval, and modern paganism and witchcraft beliefs, combines Anglo-American and continental scholarly approaches to examine attitudes on witchcraft and the treatment of suspected witches across the world, including in Africa, the Middle East, South Asia, Australia, and North and South America, and from ancient pagan times to current interpretations. His fresh anthropological and ethnographical approach focuses on cultural inheritance and change while considering shamanism, folk religion, the range of witch trials, and how the fear of witchcraft might be eradicated.