It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    It lasted 3,000 years, longer than any other on the planet. Its Great Pyramid of Cheops was the tallest building in the world until well into the 19th century and remains the only Ancient Wonder still standing. And it was the most technologically advanced of the ancient civilizations, with the medical knowledge that made Egyptian physicians the most famous in the world.Yet even after deciphering its hieroglyphs, and marveling at its scarabs, mummies, obelisks, and sphinxes, Egyptian civilization remains one of history's most mysterious, as "other" as it is extraordinary. This chronological survey presents the complete history of ancient Egypt's three great Kingdoms: the Old Kingdom, when the pyramids were built and Egypt became a nation under the supreme rule of the pharaoh and the rules of Egyptian art were established; the Middle Kingdom, when Egypt was a nation fighting to restore its greatness; and the New Kingdom, when all the names we know today-Hatshepsut, Tutankhamen, Ramses the Great, Cleopatra, and others-first appeared.Listening Length: 24 hours and 25 minutes

    The truth is, while metaphysics is among the oldest strands of philosophical thought—an inquiry into the very nature ofreality—metaphysics is also on the cutting edge of today’s scientific discoveries.

    Over the last two decades, it has emerged as a powerful tool for solving crimes and determining guilt and innocence. But, very recently, an important new aspect of DNA has been revealed—it contains a detailed record of evolution. That is, DNA is a living chronicle of how the marvelous creatures that inhabit our planet have adapted to its many environments, from the freezing waters of the Antarctic to the lush canopy of the rain forest.In the pages of this highly readable narrative, Sean Carroll guides the general reader on a tour of the massive DNA record of three billion years of evolution to see how the fittest are made. And what a eye-opening tour it is—one featuring immortal genes, fossil genes, and genes that bear the scars of past battles with horrible diseases. This book clinches the case for evolution, beyond any reasonable doubt.

    This is a world tour of prehistory with profound links to who we are and how we live today.2.5 Million Years of HistoryThis 36-lecture narrative covers human prehistory from our beginnings more than 2.5 million years ago up to and beyond the advent of the world's first preindustrial civilizations.Due to the large spans of time and geography covered in this series, these lectures are divided into six sections:Section I: BeginningsThis section surveys the archaic world of the first humans, you travel into the remote past, learning why the late Harvard biologist Stephen Jay Gould was probably right to observe that we all come from the same African twig on the bushy tree of human evolution.You examine prehistory from Australopithecus africanus through Homo habilis (the first tool-making hominid), and Homo erectus (whose remains were first found on Java but whose origins lie in Africa) through the hardy Neanderthals who lived and hunted successfully in Europe despite the bitter grip of the last Ice Age 100,000 and more years ago. You focus on the first human settlement of Africa as early as 800,000 years ago.Section II: Modern HumansThis section tells the story of the great diaspora of anatomically modern humans in the late Ice Age. Whether and how these modern humans spread from the African tropics into southwestern Asia and beyond remains one of the great controversies among scholars of prehistory.You follow Homo sapiens sapiens north into Europe some 45,000 years ago. You meet the Cro-Magnons, among the first known artists as well as hunter-gatherers, who exhibited degrees of spiritual awareness, social interaction, and fluid intelligence.You venture into the frigid open plains of the Ukraine and Eurasia, where big-game hunters flourished in spite of nine-month winters. Moving to the Americas, debate over the origins of the first human settlement continues.Section III: Farmers and HerdersThis section describes perhaps the most important development in all human prehistory: the beginnings of agriculture and animal domestication.This defining chapter began about 12,000 years ago, when hunter-gatherers in the Near East broke from the long human tradition of intensely mobile foraging and turned to more settled ways of life built around cultivating cereal grains or tending animals.Section IV: Eastern Mediterranean CivilizationsProfessor Fagan describes early civilizations in an increasingly complex eastern Mediterranean world, discussing many theories accounting for the appearance of urban civilization and overall attributes of preindustrial civilizations.You examine Sumerian civilization in Mesopotamia and the intricate patchwork of city-states between the Tigris and Euphrates Rivers. You explore ancient Egypt, the Minoan civilization of Crete, the Mycenaeans, and the Hittites.You learn about the Uluburun shipwreck of southern Turkey, a sealed capsule of international trade from 3,000 years ago.Section V: Africans and AsiansYou analyze the beginnings of South Asian civilization and the mysterious Harappan civilization of the Indus, which traded with Mesopotamia. Professor Fagan resumes the story of South Asian civilization after the collapse of the Harappan and shows how Mauryan rulers on the Ganges encouraged trading much farther afield.You see the impact of monsoons which revolutionized maritime trading among Africa, India, and Southeast Asia, and explore Meroe, Aksum, and the coastal civilization of East Africa.Several lectures cover the beginnings of civilization in China and Southeast Asia.Section VI: Ancient AmericansProfessor Fagan takes you into sophisticated chiefdoms and civilizations that developed in the Americas over the past 3,500 years, including Pueblo cultures of the North American Southwest and the Mississippian culture of the South and Southeast. You learn about Mesoamerican civilization, primordial Olmec culture of the lowlands, and the spectacular ancient Maya civilization.Moving to the highlands, you visit the city-states of Monte Albán in the Valley of Oaxaca and Teotihuacán near the Valley of Mexico. Professor Fagan also describes the rise of Aztec civilization, followed by a journey to the Andes. Finally, you explore the southern highlands, with the rise of Tiwanaku near Lake Titicaca, the Chimu civilization of the coast, and the huge Inka empire.The series closes by analyzing the closing centuries of prehistoric times during the European age of discovery and summarizing the main issues and themes of the course: * What was involved in the archaic world * The appearance and spread of modern humans * Food production * The development of states.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Course Lecture Titles1. Biology and BehaviorAn Introduction 2. The Basic Cells of the Nervous System 3. How Two Neurons Communicate 4. Learning and Synaptic Plasticity 5. The Dynamics of Interacting Neurons 6. The Limbic System 7. The Autonomic Nervous System (ANS) 8. The Regulation of Hormones by the Brain 9. The Regulation of the Brain by Hormones 10. The Evolution of Behavior 11. The Evolution of BehaviorSome Examples 12. Cooperation, Competition, and Neuroeconomics 13. What Do Genes Do? Microevolution of Genes 14. What Do Genes Do? Macroevolution of Genes 15. Behavior Genetics 16. Behavior Genetics and Prenatal Environment 17. An Introduction to Ethology 18. Neuroethology 19. The Neurobiology of Aggression I 20. The Neurobiology of Aggression II 21. Hormones and Aggression 22. Early Experience and Aggression 23. Evolution, Aggression, and Cooperation 24. A Summary

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    They were hunter-gatherers, consummate foraging experts, but taking the world as they found it. Then a revolution occurred – our ancestors’ interaction with other species changed. They began to tame them. The human population boomed; civilization began.In her new book, Tamed, Alice Roberts uncovers the amazing deep history of ten familiar species with incredible wild pasts: dogs, apples and wheat; cattle; potatoes and chickens; rice, maize, and horses – and, finally, humans. Alice Roberts not only reveals how becoming part of our world changed these animals and plants, but shows how they became our allies, essential to the survival and success of our own species – and to our future.Enlightening, wide-ranging and endlessly fascinating, Tamed is an epic story, encompassing hundreds of thousands of years of history and archaeology alongside cutting-edge genetics and anthropology. Yet it is also a deeply personal journey that will change how we see ourselves and the species on which we have left our mark.

    And with the advent of modern science, great minds have turned to testing and experimentation rather than mere thought as a way of approaching and grappling with some of the universe's most pressing and vexing dilemmas. So what is our latest picture of some of the most inexplicable features of the universe? What still remains to be uncovered? What are some of the next avenues of exploration for today's chemists, physicists, biologists, and astronomers? Pondering the answers to these and other questions is a great way to appreciate the grandeur and complexity of the world around you, better understand and discuss news and developments in science, and spark further interest in some of science's many exciting areas of study. "We know a lot about the universe. But there's even more that we don't know,"says astrophysicist and Professor Neil deGrasse Tyson, director of the Hayden Planetarium, an award-winning lecturer, and one of the world's foremost experts on the secrets of the universe. And his course The Inexplicable Universe: Unsolved Mysteries is the perfect gateway into this mind-bending and eye-opening subject. Each of these six self-contained lectures is a marvelous journey to the frontiers of the known (and unknown) universe and introduces you to tantalizing questions being addressed by the world's top scientists. Undeniably engaging and fascinating, this lecture series is a wonderful entrée to scientific pursuits that lie at the very heart of the history and nature of our universe. An Informed Scientific Conversation Central to The Inexplicable Universe is the way it takes you deep into hidden layers of the universe in a manner that is extremely accessible. Rather than a stern lecture given before a podium complete with confusing mathematics, Professor Tyson's lectures have the feel of an informed conversation that manages to be both thorough and easy to grasp. With each of the inexplicable mysteries he lays bare for you, Professor Tyson introduces you to the history behind it, lays out the science that has helped us grasp it, explains what researchers have discovered to date, and reveals what we have yet to discover. And while the topics explore subjects in everything from quantum mechanics to cosmology to string theory, you'll never feel overwhelmed by what you're learning. In fact, you're more likely to find yourself intrigued by just how much we know-and curious about what the near future will possibly reveal. Explore Fascinating Territory So what territory will you chart in this course? Here are some of the inexplicable ideas you'll investigate in these lectures. Neutrinos: Discovered in 1956, these fast-moving, ghostlike particles are made in abundance in the sun's core. They hardly interact with matter; it takes a light-year's worth of lead (5.8 trillion miles) to stop a neutrino. Not only that, but 65 billion neutrinos pass through every centimeter of your body that's facing the sun every second of every day. String theory: This astounding theory offers the hope of unifying all the particles and forces of physics. In the past several decades since the dawn of string theory, it's been imagined that all the fundamental particles we see and measure are just the manifestation in our dimension of strings vibrating in higher dimensions and at different frequencies. Quantum foam: This idea posits that when the fabric of space and time is so tightly curved on itself, space-time is less a smooth curve and more like the froth on a latte. In this state of matter and energy, quantum fluctuations can spawn entire universes, each with slightly different laws of physics within them! In addition, you'll also get a peek at what it would be like to travel through a black hole, ponder the possibility that life on Earth originated in debris from Mars, probe the supposed existence of multiple universes, and even imagine the possible end of the universe itself. A One-on-One Chat with a Renowned Science Educator Professor Tyson is renowned throughout the scientific community and the media for his vast knowledge, his penetrating insights, and his amazing ability to make even the most intimidating areas of science accessible, engaging, and-most of all-enjoyable. He brings the same inviting tone and sharp intellect to The Inexplicable Universe as he does to his range of media appearances on popular television programs. Due to its unique subject matter The Inexplicable Universe takes a highly visual approach. Many of the fascinating subjects in the course, such as black holes, string theory, and multiple universes are best demonstrated visually and Professor Tyson's lectures feature expertly crafted computer animations, explanatory diagrams, high resolution photographs, and other instructive visual elements. In order to better explain to you some of the grand, intricate ideas being discussed, Professor Tyson personally interacts with many of these animations and graphics using greenscreen technology. Please note that, due to the highly visual nature of The Inexplicable Universe, the course does not come with a guidebook. We did not believe a simple book could adequately convey the information in the course, and rather than make a guidebook that did not do the course justice, we decided to not offer one. However, we believe that you will be very excited by how we produced this course and will find it to be an enriching and fulfilling experience in your educational journey.

    

    But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    Our language even has a word—Machiavellian—that encapsulates the images those responses conjure up: An indistinct figure quietly making his way through the darkest corridors of power, hatching plots to play one rival against another A cold-blooded political liar, ready to justify any duplicity undertaken in the name of a noble end that will ultimately justify the most malignant means A coolly practical leader—amoral at best—willing to do whatever is necessary in a world governed not by ideas of right or wrong, but by solutions dictated by realpolitik.But does the Machiavelli most of us think we know bear any resemblance to the Machiavelli who lived, pondered, and wrote?According to Professor William R. Cook, a reading of Machiavelli that considers only those qualities that we today call "Machiavellian" is incomplete, and Machiavelli himself "certainly would not recognize" such sinister interpretations or caricatures of his writings and beliefs. Indeed, The Prince—on the pages of which so much of this image was built—was not even published in his lifetime.In the 24 lectures that make up Machiavelli in Context, Professor Cook offers the opportunity to meet an extraordinarily thoughtful and sincere student of history and its lessons, and to learn that there is far more to him than can be gleaned from any reading of The Prince, no matter how thorough.Although The Prince is the work by which most of us think we know Machiavelli, and although some have indeed called it the first and most important book of political science ever written, it was not, according to Professor Cook, either Machiavelli's most important work or the one most representative of his beliefs. Those distinctions belong, instead, to his Discourses on the First Ten Books of Livy, a longer work started at about the same time and which would, like The Prince, not be published until well after his death."Everyone who has seriously studied the works of Machiavelli agrees that he ... believed in the superiority of a republican form of government, defined as a mixed constitution with elements of monarchy, aristocracy, and democracy."Once we recover the context of the writing of The Prince, and analyze it along with the Discourses on the First Ten Books of Livy, it will be clear how The Prince can be read as a book designed to guide leaders in the creation—for Machiavelli, restoration—of republican government in Italy."Ultimately, Machiavelli's goal wasn't much different from ours. It was to live in a free and equal participatory society, because he believed that was the greatest way in which human beings could live and flourish."In fact, says Professor Cook, "Machiavelli's republican thought influenced the development of institutions and values both in Europe and in America."To present a complete and well-rounded picture of Machiavelli's ideas on how human societies should be organized and governed, Professor Cook sets aside much of Machiavelli's written output—which included the political work The Art of War, a biography, many letters, and even some plays—to focus on The Prince, the Discourses, and, more briefly, his Florentine Histories.In doing so, Professor Cook draws on the same qualities so evident in his previous courses for The Teaching Company: Tocqueville and the American Experience, Dante's Divine Comedy, Francis of Assisi, and St. Augustine's Confessions.Teaching in the relaxed and informal style of those courses, Professor Cook moves easily among the different disciplines so pertinent to an understanding of Machiavelli's ideas, including history, philosophy, government, and the elements of leadership. He is unfailingly clear, always provides any definitions needed to understand the material at hand, and is always ready with a touch of wit whenever that is appropriate.Because so much of our contemporary misunderstanding of Machiavelli's ideas comes from a lack of context, Professor Cook carefully sets the stage for a complete perspective of Machiavelli's world.Long before he turns to the works themselves, you'll have learned about Florence and its political history, both before and during Machiavelli's lifetime; the developing Renaissance culture of Machiavelli's time, especially as it bears on the use of ancient political thought by writers and political leaders; and Machiavelli's own life story, including his education, service to the Florentine Republic, years spent in exile south of Florence, and the ways each period of his life affected his writings.The result is a thorough grounding in the information one needs to understand and appreciate this stunningly original thinker.You'll learn, for example, what Machiavelli means when he discusses the important ideas of virtù and Fortuna.Though these are today invariably translated as virtue and fortune, Machiavelli's meanings can involve much more. Though he sometimes uses virtù in the sense we would understand today, he often uses the word—which comes from the classical Latin word for Man—as a means of describing the way one practices successful statecraft: aggressively, with no reluctance to use lies, deceit, and cruelty that may be required to maintain power, and hence the stability the people deserve.In a similar way Machiavelli uses Fortuna in a different sense than might have been used by, say, Dante when he describes the vagaries of fate over which we have no control.Instead, Machiavelli uses the adage, "Fortune is like a river." Though we cannot control fortune, which may well choose to make the river flood, a good ruler, practicing virtù, can indeed prepare for it, and thus modify its effects.You'll see how Machiavelli first became exposed to history and one of its earliest great practitioners—the Roman historian, Livy—through his own experience of Fortuna.Though printed books such as Livy's Early History of Rome were too expensive for a family like the young Machiavelli's in the 15th century, his father did own a copy. He had written the index, and a copy of the book had been part of his payment. Thus Machiavelli grew up with the volumes about which he would one day write his own most important work, Discourses on the First Ten Books of Livy.You'll be introduced to Cesare Borgia, the son of Pope Alexander VI and the man regarded as Machiavelli's model for The Prince, especially in the way his actions embodied the virtù so important to Machiavelli.Professor Cook brings this out in a shocking story of Borgia's use of a tough and merciless Spaniard—Ramiro d'Orco—to impose order and stability on the area of north central Italy known as the Romagna that had come under Borgia's rule and was beset by crime and violence.D'Orco's brutal methods had the desired effect. And when the job was completed, the local people emerged from their homes one morning to find the two halves of Ramiro d'Orco's body on opposite sides of the town square of Cesana, because d'Orco had been too tough, and Cesare Borgia needed a way to advertise further his concern for the people whose loyalty he wanted.The story also embodies, for Machiavelli, the idea that cruelty can be "well-used," just as being merciful—withholding such cruelty when a leader deems it needed—may be less than merciful in its long-term impact.Finally, you will get to see, throughout these lectures, the development of Machiavelli's reliance on history for its lessons, his role as a Renaissance Humanist thinker, and the emergence of his republican views, which still have tremendous influence today as we ask how republics start, grow, succeed, or fail.As Professor Cook notes, we are not going to agree with all of Machiavelli's answers. But his commitment to asking the right questions—to thinking, reflecting, and learning everything history has to teach us about the best ways to govern and safeguard the future—was total.

    Among those you'll investigate are the accounts of the creation of the world in Hesiod's Theogony and Ovid's Metamorphoses; the gods Zeus, Apollo, Demeter, Persephone, Hermes, Dionysos, and Aphrodite; the Greek heroes, Theseus and Heracles (Hercules in the Roman version); and the most famous of all classical myths, the Trojan War.Professor Vandiver anchors her presentation in some basics. What is a myth? Which societies use myths? What are some of the problems inherent in studying classical mythology? She also discusses the most influential 19th- and 20th-century thinking about myth's nature and function, including the psychological theories of Freud and Jung and the metaphysical approach of Joseph Campbell. You'll also consider the relationship between mythology and culture (such as the implications of the myth of Demeter, Persephone, and Hades for the Greek view of life, death, and marriage), the origins of classical mythology (including the similarities between the Theogony and Mesopotamian creation myths), and the dangers of probing for distant origins (for example, there's little evidence that a prehistoric "mother goddess" lies at the heart of mythology).Taking you from the surprising "truths" about the Minotaur to Ovid's impact on the works of William Shakespeare, these lectures make classical mythology fresh, absorbing, and often surprising.Disclaimer: Please note that this recording may include references to supplemental texts or print references that are not essential to the program and not supplied with your purchase.©2000 The Teaching Company, LLC (P)2000 The Great Courses

    Central to many spiritual and philosophical traditions and known in English as "meditation," these practices are considered a major means for enhanced awareness and self-mastery. In recent decades, modern science has dramatically confirmed what advanced meditators have long claimed—that meditation, correctly practiced, offers deep and lasting benefits for mental functioning and emotional health, as well as for physical health and well-being.