Engel seamlessly weaves together science, politics, and culture, writing with an even hand—noting the excesses of the more radical edges of the ACT UP movement as well as the conservative religious leaders who thought AIDS victims deserved what they got.The story of AIDS is one of the most compelling human dramas of our time, both in its profound tragedy and in the extraordinary scientific efforts impelled on its behalf. For gay Americans, it has been the story of the past generation, redefining the community and the community's sexuality. For the Third World, AIDS has created endless devastation, toppling economies, social structures, and whole villages and regions. And the worst may yet be to come: AIDS is expanding quickly into India, Russia, China, and elsewhere, while still raging insub-Saharan Africa.A distinguished medical historian, Engel lets his characters speak for themselves. Whether gay activists, government officials, public health professionals, scientists, or frightened parents of schoolchildren, they responded as best they could to tragic happenstance that emerged seemingly from nowhere. There is much drama here, and human weakness and heroism too. Writing with vivid immediacy, Engel allows us to relive the short but tumultuous history of a modern scourge.

    This elegant, humane, and engaging book "captures what we know of the development of what makes us human" (Nature).Visit Armand Marie Leroi on the web: http: //armandleroi.com/index.htmlStepping effortlessly from myth to cutting-edge science,

    In the style of his first book, Andy recalls each event from the detailed documentation recorded at the time, each account written in a way that puts the reader right there next to him so that you live the events in real-time, hear the dialogue between paramedics, patient, their loved ones and other healthcare professionals as it would have been, and share in Andy’s thought processes during each of the ten very different situations he encounters.The term ‘The Dark Side’ describes the frontline emergency aspect of the Ambulance Service, since paramedics frequently experience sombre situations. In ‘The Dark Side, Part 2’ you will share in some truly traumatic, tragic and tearful events involving a seemingly vibrant, healthy young patient, a prison inmate, the victims of an horrific car crash, heart attacks, a frightening epileptic fit, the alarming effects of an allergic reaction, and what can happen when under-strain doctors prescribe the wrong medication. But there’s still room for lighthearted moments and a taste of the sometimes dark humour that allows paramedics to continually deal with events most of us would find too horrific. The detail in the descriptions of the care given to each patient on-scene by Andy and his colleagues will have you marvelling at the ability of these healthcare professionals to work at such speed of thought, buying enough time to deliver a patient into the specialist hands of hospital care and often full recovery. Of course there are inevitably also those times when tears of hope turn to tears of despair for loved ones. You cannot feel that pain until it happens to you, but this book will bring you mighty close to it at times.

    Months later, several health professionals faced criminal allegations that they deliberately injected numerous patients with drugs to hasten their deaths. Five Days at Memorial, the culmination of six years of reporting, unspools the mystery of what happened in those days, bringing the reader into a hospital fighting for its life and into a conversation about the most terrifying form of health care rationing.In a voice at once involving and fair, masterful and intimate, Fink exposes the hidden dilemmas of end-of-life care and reveals just how ill-prepared we are in America for the impact of large-scale disasters—and how we can do better. A remarkable book, engrossing from start to finish, Five Days at Memorial radically transforms your understanding of human nature in crisis.

    Torn from their homes and families, these men, women, and children were loaded into shipboard cattle stalls and abandoned in a lawless place where brutality held sway. Many did not have leprosy, and many who did were not contagious, yet all were ensnared in a shared nightmare. Here, for the first time, John Tayman reveals the complete history of the Molokai settlement and its unforgettable inhabitants. It's an epic of ruthless manhunts, thrilling escapes, bizarre medical experiments, and tragic, irreversible error. Carefully researched and masterfully told, The Colony is a searing tale of individual bravery and extraordinary survival, and stands as a testament to the power of faith, compassion, and the human spirit.

    Smallpox. Incurable and horrifying Ebola-related fevers. For two decades, while a fearful world prepared for nuclear winter, an elite team of Russian bioweaponeers began to till a new killing field: a bleak tract sown with powerful seeds of mass destruction—by doctors who had committed themselves to creating a biological Armageddon. Biohazard is the never-before-told story of Russia’s darkest, deadliest, and most closely guarded Cold War secret.   No one knows more about Russia’s astounding experiments with biowarfare than Ken Alibek. Now the mastermind behind Russia’s germ warfare effort reveals two decades of shocking breakthroughs . . . how Moscow’s leading scientists actually reengineered hazardous microbes to make them even more virulent . . . the secrets behind the discovery of an invisible, untraceable new class of biological agents just right for use in political assassinations . . . the startling story behind Russia’s attempt to turn a sample of the AIDS virus into the ultimate bioweapon. And in a chilling work of real-world intrigue, Biohazard offers us all a rare glimpse into a shadowy scientific underworld where doctors manufacture mass destruction, where witnesses to errors are silenced forever, and where ground zero is closer than we ever dared believe.

    Yet, the one constant in the history of the Apache People is their constant struggle to survive in a world where they are surrounded by various enemies, including other Indian tribes, the Mexicans and finally their brutal nemesis the United States Army. Attacked, tricked, lied to and double crossed by all of those who surround and outnumber them, the Apache people continued their struggle until they were for all intent and purposes almost totally wiped out. One Apache’s name stands out in their brave yet woeful history and it is Geronimo, who at age 30 witnessed the massacre of his mother, wife and two young children.I’ve taken his recollections or accounts of the struggle of the Apache people and intertwined them with some archeological facts about this extraordinary tribe. In addition, I have searched and included some of the best photos of Apaches from that era, which I collected from Library of Congress Archives. What impressed me most about Geronimo was his brevity of words, yet his ability to take a knife to the heart of anyone who reads his verbal history. Like most Apaches, Geronimo said little, but what he did say was profound and truthful. But most powerful is what Geronimo didn’t say in his recollections. It is between this silence one can feel the pain, sorrow, pride and bravery of the Apache People. Chet DembeckPublisher of One

    Women have been giving birth for millennia, so why is it that every culture—and every generation—seems to have its own ideas about the best way to get a baby born? Among the topics that Tina Cassidy looks at are: why birth can be so difficult (blame our ability to walk on two legs, for instance), where women deliver, how the perception of midwives has changed (they were once burned as witches), the lives of some famous obstetricians, and the many ways childbirth has been deadly (lots of blame to go around). Birth is full of quirky details, startling facts, and tales both humorous and disturbing—from men disguised as women to get into delivery rooms to a news flash about a woman giving herself a C-section. From Jessica Mitford’s seminal The American Way of Death to Mary Roach’s Stiff, we’ve witnessed how millions of readers are fascinated by what happens at the end of life. Here is the riveting true story of how it begins.

    If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.The fascinating, true story of the world's deadliest disease.In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for "The New York Times," unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

    Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    She was repeatedly hospitalized in excruciating pain, but the doctors insisted it was a urinary tract infection and sent her home with antibiotics. Unable to get out of bed, much less attend class, Norman dropped out of college and embarked on what would become a years-long journey to discover what was wrong with her. It wasn't until she took matters into her own hands--securing a job in a hospital and educating herself over lunchtime reading in the medical library--that she found an accurate diagnosis of endometriosis.In Ask Me About My Uterus, Norman describes what it was like to have her pain dismissed, to be told it was all in her head, only to be taken seriously when she was accompanied by a boyfriend who confirmed that her sexual performance was, indeed, compromised. Putting her own trials into a broader historical, sociocultural, and political context, Norman shows that women's bodies have long been the battleground of a never-ending war for power, control, medical knowledge, and truth. It's time to refute the belief that being a woman is a preexisting condition.

     This area was dangerous and many who had ventured there alone had never returned. But slowly over the course of this century settlers continued to push further west until regions such as West Virginia were populated with more and more adventurous young men and women. The settlement of these lands did not occur without difficulties and colonizers frequently came into conflict with the local Native American populations. Wills De Hass’s remarkable book History of the Early Settlement and Indian Wars of West Virginia is a fascinating history of how the lands of the west were first settled by white emigrants in the eighteenth century and how these settlers came into frequent strife with the Native American tribes who had previously lived there. Beginning with Columbus’ discovery of this great continent Wills De Hass charts the colonization of this expansive land. He records with brilliant detail the early encounters that Europeans had with the men and women that they found already living across the region and explains how various nations from across the Atlantic made their first tentative footholds on this newly discovered land. De Hass records how settlers were not only conflict with Native Americans but also with each other as this region descended into war, firstly during the French and Indian War and shortly afterwards during the American War of Independence. Particularly fascinating throughout the book are the biographical sketches of various well-known frontiersmen who were particularly influential in the Ohio Valley and northwestern Virginia. This book is perfect for anyone interested in the early settlement of western regions prior to 1795 and how this area was frequently in conflict as settlers attempted to assert their rights against the wishes of the Native American populations. Wills de Hass was a lecturer and writer on archaeological and historical subjects. His book History of the Early Settlement and Indian Wars of Western Virginia was first published in 1851 and De Hass passed away 1910.

    Hornblum releases devastating stories from within the walls of Philadelphia's Holmesburg Prison. For more than two decades, from the mid-1950s through the mid-1970s, inmates were used, in exchange for a few dollars, as guinea pigs in a host of medical experiments. An array of doctors, in conjunction with the University of Pennsylvania and prison officials, established Holmesburg as a laboratory testing ground. Hundreds of prisoners were used to test products from facial creams to far more hazardous, even potentially lethal, substances such chemical warfare agents. Based on in-depth interviews with dozens of prisoners as well as the doctors and prison officials who performed or enforced these experimental tests, Hornblum paints a disturbing portrait of abuse, moral indifference, and greed. Central to this account are the millions of dollars many of America's leading drug and consumer goodscompanies made available for the all too eager doctors seeking fame and fortune through their medical experiments. Acres of Skin is rigorously researched and shocking in its depiction of men treated as laboratory animals.

    The first small cities formed not only the cradle of civilization, but the spawning ground for the earliest viral epidemics, the first opportunity for viruses to find a home in the human herd. This is a story of fear and ignorance, as everything from demons and the wrath of the gods to minority groups have been blamed for epidemics from smallpox to yellow fever to AIDS. It is a story of grief and heartbreak, as hundreds of thousands, sometimes millions, are wiped out in a single year. And it is a story of great bravery and sacrifice, as doctors and nurses put themselves in harm's way to combat yellow fever in Memphis and Ebola in Zaire, and as researchers risk their own lives to test theories of vaccines and the transmission of disease. Now, in Viruses, Plagues, and History, Michael B. A. Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity.Oldstone focuses his tale on a few of the most famous viruses humanity has battled, beginning with some we have effectively defeated, such as smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone -- more than were killed in all the wars of the twentieth century combined. The author presents a vivid account of the long campaign against the virus, the insightful work of Edward Jenner, who created the smallpox vaccine from cowpox virus in 1796, and the monumental efforts of D. A. Henderson and an army of W.H.O. health care workers to finally eradicate smallpox. The smallpox virus remains the only organism that we have deliberately pushed to complete extinction in the wild.Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola and other hemorrhagic fevers, which literally turn their victims' organs to a bloody pulp; the Hantavirus outbreaks in the southwestern United States and elsewhere; mad cow disease, a frightening illness made worse by government mishandling and secrecy; and, of course, AIDS, often called the plague of our time. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the deadly variant from 1918 -- a viral strain that killed over 20 million people in 1918-1919, more than twice the military and civilian casualties of the First World War -- will make a comeback.Viruses have enormous power. They have wiped out cities, brought down dynasties, and helped destroy civilizations. But, as Michael Oldstone reveals, scientific research has given us the power to tame many of these viruses as well. Viruses, Plagues, and History shows us the panorama of humanity's long-standing conflict with our unseen viral enemies, from our successes to our continuing struggles. Oldstone's book is a vivid history of a fascinating field, and a highly reliable dispatch from a worker on the frontiers of this ongoing campaign.