The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

    Once-lush grasslands, the source of precious food and water, are growing dry and bare. Rivers that used to flow year-round now run dry after the rains. Grazing animals want for food. What is causing this “desertification” of the earth, and how can we stop it? In The Grazing Revolution, biologist Allan Savory presents a solution that’s as radical as it is simple: huge herds of livestock, managed to mimic the behavior of the natural herds that once roamed grasslands centuries ago. Tracing his own story of discovery, Savory debunks common misconceptions and provides a vivid chronicle of the process by which he has seen scrubby wasteland revert to robust ecosystems. Our age-old agricultural practices are contributing greatly to the global climate change underway; Savory argues that by re-imagining these practices, we can reverse desertification and save the planet.

    Dozens about lions and tigers and bears. But how many non-scholarly books have been written about giraffes-one of nature's most intriguing and unique animals? None. Until now.You know Lynn Sherr as a veteran journalist and as a leading correspondent for the ABC news magazine 20/20, but you probably didn't know that she has been an avid giraffophile since a visit to the African wilderness nearly twenty-five years ago.The days of the giraffe being overlooked and under-appreciated are over with the publishing of Tall Blondes,a one-of-a-kind book about a one-of-a-kind animal. The giraffe's unusually long neck and legs make it one of the most recognizable creatures on our planet. But it also possesses a wide range of other fascinating and endearing traits and features. And while most giraffes are blondes, they come in beautiful arrays of red, brown, and even white.Sherr traces the cultural history of the giraffe, from it's first appearance in Europe in 46 B.C. (thanks to Julius Caesar) through medieval bestiaries and up to the modern giraffe star of a TV movie. The book is not just about giraffes in the wild: it's about how they have impacted on humans (and visa versa), stirring the imaginations of artists, writers and thinkers. Taking a whimsical approach to her very serious subject, Sherr has filled it with little-known tidbits, awe-inspiring photographs and drawings, and intriguing tales about the world's tallest land animal.Read it, and you'll not only learn about why Sherr (a tall blond herself) has fallen head over heals for this gawky but graceful animal-you'll fall in love too.

    There he met beekeeper Gunter, who showed him the wonders and magic of the beehive. Back in England, Piers decided upon a quest to seek the most wondrous honeys in the world.

    But how the mind works remains one of humankind's greatest mysteries. With boundless curiosity and enthusiasm, Shannon Moffett, a Stanford medical student, takes us down the halls of neuroscience to the front lines of cutting-edge research and medicine to meet some of today's most extraordinary scientists and thinkers, all grappling with provocative questions: Why do we dream? How does memory work? How do we see? What happens when we think? Each chapter delves into a different aspect of the brain, following the experts as they chart new ground. Moffett takes us to a lab where fMRI scans reveal the multitude of stimuli that our brains unconsciously take in; inside an operating room where a neurosurgeon removes a bullet from a patient's skull; to the lab of Christof Koch, a neuroscientist tracking individual neurons in order to crack the code of consciousness; and to a research lab where scientists are investigating the relationship between dreams and waking life. She also takes us beyond the scientific world—to a Zen monk's zendo, where she explores the effects of meditation on the brain; inside the home of a woman suffering from dissociative identity disorder; to a conference with the philosopher Daniel Dennett, who uses illusions, magic, tricks, and logic to challenge our assumptions about the mind; and to the home of the late Nobel Laureate Francis Crick, co-discoverer with James Watson of DNA's double-helix structure. Filled with fascinating case studies and featuring a timeline that tracks the development of the brain from conception to death, The Three Pound Enigma is a remarkable exploration of what it means to be human.

    There is the record-holding husband and wife who cross continents to "twitch" (spot rare birds); the disgraced "stringer" who takes desperate measures to falsify a spotting of the coveted black lark, leading hundreds on a fruitless search; and a group of friends who go birding in America only to be plagued by car trouble, drunk drivers, robbery, and an encounter with the border police.Birders is also an inspiring and heartwarming account of the author's lifelong love for his hobby, and the way it transforms him -- from his fetishistic love affair with his notebook and "bins" (binoculars) to his deep mourning for a friend who went missing when he followed the call of an elusive pheasant in the Himalayan mountains. Informative, touching, and astoundingly funny, here is the layman's invitation to share in an unlikely obsession.

    Amy chronicles her harrowing medical journey from the first misdiagnosis to her astonishing recovery after her heart transplant, which is made all the more dramatic by the romantic bedside courtship with her future husband, and her uncompromising desire to become a mother. She presents a patient's perspective of life after a heart transplant with honesty.

    It considers the diversity and biology of bees, including their peculiar sociosexual arrangements (pity the poor drone), their quirky relationships with flowers, and their startling mental abilities: What are we to make of insects that communicate through symbolic dances? The book also addresses the mysterious syndrome known as colony collapse disorder and identifies opportunities for the conservation of pollinators.Enriched with cultural sidebars and complemented by a stunning collection of images, Bees is a must-read for conservationists, gardeners, and everyone else who cares about the world around them.Published in partnership with the David Suzuki Foundation.Also available in paperback.

    

    Teaches the structure and function of plants and surveys the entire plant kingdom.

    These personal tragedies will, and must, be told and heard. There is, however, also a truthful and objective scientific narrative to be written about how the virus played out and how the world set about dealing with it. Spike is that story - from the inside. Its author, Jeremy Farrar, is one of the UK's leading scientists and a ­­member of the SAGE emergency committee.As head of the Wellcome Trust, and an expert in emerging infectious diseases, Jeremy Farrar was one of the first people in the world to hear about a mysterious new respiratory disease in China - and to learn that it could readily spread between people. Farrar describes how it feels as one of the key scientists at the sharp end of a fast-moving situation, when complex decisions must be made quickly amid great uncertainty. His book casts light on the UK government's claims to be 'following the science' in its response to the virus, and is informed not just by Farrar's views but by interviews with other top scientists and political figures.Farrar, who has spent his career on the frontlines of epidemics including Nipah virus in Malaysia, bird flu in Vietnam and Ebola in West Africa, also reflects on the wider issues of Covid-19: the breath-taking scientific advances in creating tests, treatments and vaccines; the challenge to world leaders to respond for the global good and the need to address inequalities that hold back success against the virus. All these shape how the world ultimately fares not just against Covid-19, but against all the major he­­alth challenges we face globally.

    It develops an understanding of function and evolution into the discussion of anatomy of the various systems.

    The more we notice and listen to what our dogs are trying to tell us, the more we can improve our relationship with our best friends, helping them to feel safe and happy.

    Why does the chestnut-sided warbler sing one song before dawn and another after sunrise? Why does the brown thrasher have a repertoire of two thousand songs when the chipping sparrow has only one? And how is the hermit thrush able to sing a duet with itself, producing two sounds simultaneously to create its beautiful, flutelike melody?Stap's lucid prose distills the complexities of the study of birdsong and unveils a remarkable discovery that sheds light on the mystery of mysteries: why young birds in the suborder oscines -- the "true songbirds" -- learn their songs but the closely related suboscines are born with their songs genetically encoded. As the story unfolds, Stap contemplates our enduring fascination with birdsong, from ancient pictographs and early Greek soothsayers, who knew that bird calls represented the voices of the gods, to the story of Mozart's pet starling.In a modern, noisy world, it is increasingly difficult to hear those voices of the gods. Exploring birdsong takes us to that rare place -- in danger of disappearing forever -- where one hears only the planet's oldest music.