An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    By 1905 they had disappeared from the country. In this spirited and absorbing narrative, Brett Walker takes a deep look at the scientific, cultural, and environmental dimensions of wolf extinction in Japan and tracks changing attitudes toward nature through Japan's long history.Grain farmers once worshiped wolves at shrines and left food offerings near their dens, beseeching the elusive canine to protect their crops from the sharp hooves and voracious appetites of wild boars and deer. Talismans and charms adorned with images of wolves protected against fire, disease, and other calamities and brought fertility to agrarian communities and to couples hoping to have children. The Ainu people believed that they were born from the union of a wolflike creature and a goddess.In the eighteenth century, wolves were seen as rabid man-killers in many parts of Japan. Highly ritualized wolf hunts were instigated to cleanse the landscape of what many considered as demons. By the nineteenth century, however, the destruction of wolves had become decidedly unceremonious, as seen on the island of Hokkaido. Through poisoning, hired hunters, and a bounty system, one of the archipelago's largest carnivores was systematically erased.The story of wolf extinction exposes the underside of Japan's modernization. Certain wolf scientists still camp out in Japan to listen for any trace of the elusive canines. The quiet they experience reminds us of the profound silence that awaits all humanity when, as the Japanese priest Kenko taught almost seven centuries ago, we "look on fellow sentient creatures without feeling compassion."

    But how did the descendants of small primates manage to walk upright, become top predators, and populate the world? How were humans able to develop civilizations and produce a globalized economy? Now, in The Age of Wood, Roland Ennos shows for the first time that the key to our success has been our relationship with wood. “A lively history of biology, mechanics, and culture that stretches back 60 million years” (Nature) The Age of Wood reinterprets human history and shows how our ability to exploit wood’s unique properties has profoundly shaped our bodies and minds, societies, and lives. Ennos takes us on a sweeping journey from Southeast Asia and West Africa where great apes swing among the trees, build nests, and fashion tools; to East Africa where hunter gatherers collected their food; to the structural design of wooden temples in China and Japan; and to Northern England, where archaeologists trace how coal enabled humans to build an industrial world. Addressing the effects of industrialization—including the use of fossil fuels and other energy-intensive materials to replace timber—The Age of Wood not only shows the essential role that trees play in the history and evolution of human existence, but also argues that for the benefit of our planet we must return to more traditional ways of growing, using, and understanding trees. A brilliant blend of recent research and existing scientific knowledge, this is an “excellent, thorough history in an age of our increasingly fraught relationships with natural resources” (Kirkus Reviews, starred review).

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    The consequences of losing beavers were profound: streams eroded, wetlands dried up, and species from salmon to swans lost vital habitat. Today, a growing coalition of “Beaver Believers”―including scientists, ranchers, and passionate citizens―recognizes that ecosystems with beavers are far healthier, for humans and non-humans alike, than those without them. From the Nevada deserts to the Scottish highlands, Believers are now hard at work restoring these industrious rodents to their former haunts. Eager is a powerful story about one of the world’s most influential species, how North America was colonized, how our landscapes have changed over the centuries, and how beavers can help us fight drought, flooding, wildfire, extinction, and the ravages of climate change. Ultimately, it’s about how we can learn to coexist, harmoniously and even beneficially, with our fellow travelers on this planet.

    Humans have "subdued 75 per cent of the land surface, concocted a wizardry of industrial and medical marvels, strung lights all across the darkness." We now collect the DNA of vanishing species in a "frozen ark," equip orangutans with iPads, create wearable technologies and synthetic species that might one day outsmart us. With her distinctive gift for making scientific discovery intelligible to the layperson, Ackerman takes us on an exciting journey to understand this bewildering new reality, introducing us to many of the people and ideas now creating--perhaps saving--the future.The Human Ageis a surprising, optimistic engagement with the dramatic transformations that have shaped, and continue to alter, our world, our relationship with nature and our prospects for the future.

    In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA.There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists. Kean's vibrant storytelling makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    For millions, the Galápagos Islands represent nature at its most unspoiled, an inviolate place famed for its rare flora and fauna. But soon today’s 30,000 human residents could surpass 50,000. Add invasive species, floods of tourists, and unresolved conflicts between Ecuadorian laws and local concerns, and it’s easy to see why the Galápagos were recently added to UNESCO’s World Heritage in Danger list. Each chapter in this provocative, perceptive book focuses on a specific person or group with a stake in the Galápagos’ natural resources—from tour companies whose activities are often illegal and not always green, to creationist guides who lead tours with no mention of evolution, from fishermen up in arms over lobster quotas, to modern-day pirates who poach endangered marine species. Bassett presents a perspective as readable as it is sensible. Told with wit, passion, and grace, the Galápagos story serves as a miniature model of Earth itself, a perfect example of how an environment can be destroyed-- and what is being done to preserve these islands before it's too late.

    But ask a physicist and there’s no doubt that James Clerk Maxwell will be near the top of the list.  Maxwell, an unassuming Victorian Scotsman, explained how we perceive colour. He uncovered the way gases behave. And, most significantly, he transformed the way physics was undertaken in his explanation of the interaction of electricity and magnetism, revealing the nature of light and laying the groundwork for everything from Einstein’s special relativity to modern electronics.   Along the way, he set up one of the most enduring challenges in physics, one that has taxed the best minds ever since. ‘Maxwell’s demon’ is a tiny but thoroughly disruptive thought experiment that suggests the second law of thermodynamics, the law that governs the flow of time itself, can be broken. This is the story of a groundbreaking scientist, a great contributor to our understanding of the way the world works, and his duplicitous demon.

    Alvarez had the first glimmer of that amazing insight when he noticed something odd in a rock outcrop in central Italy. Alvarez now returns to that rich terrain, this time to take the reader on an excavation of the Earth's distant past. We encounter the volcanoes that formed the Seven Hills of Rome; the majestic limestone Apennine mountains that started to develop millions of years ago under water; the evidence that the Mediterranean Sea completely evaporated to a sunken desert, perhaps several times; and the proof that continental plates once overran one another to form the Alps. In Alvarez's telling, all major geologic episodes are as dramatic as the great impact that killed the dinosaurs, even when they happen over eons and without huge creatures to witness them.

    Generating cataclysmic volcanic eruptions and large earthquakes, the hotspot helped lift the Yellowstone Plateau to more than 7,000 feet and pushed the northern Rockies to new heights, forming unusually large glaciers to carve the landscape. It also created the jewel of the U.S. national park system: Yellowstone. Meanwhile, forces stretching apart the western U.S. created the mountainous glory of Grand Teton National Park. These two parks, with their majestic mountains, dazzling geysers, and picturesque hot springs, are windows into the Earth's interior, revealing the violent power of the dynamic processes within. Smith and Siegel offer expert guidance through this awe-inspiring terrain, bringing to life the grandeur of these geologic phenomena as they reveal the forces that have shaped--and continue to shape--the greater Yellowstone-Teton region. Over seventy illustrations--including fifty-two in full color--illuminate the breathtaking beauty of the landscape, while two final chapters provide driving tours of the parks to help visitors enjoy and understand the regions wonders. Fascinating and informative, this book affords us a striking new perspective on Earth's creative forces.

    It stars turtles and shady and heroic human characters both, in settings ranging from luxury redoubts to degraded habitats, during a time when the confluence of easy global trade, limited supply, and inexhaustible demand has accelerated the stress on species. The growth of the middle class in high-population regions like China, where the turtle is particularly valued, feeds this perfect storm into which the turtle finds itself lashed. This is a tale not just of endangered turtles but also one of overall human failings, frailties, and vulnerabilities—all punctuated by optimistic hope for change fueled by dedicated turtle champions.

    Researching private parts was long considered taboo, but scientists are now beginning to understand that the wild diversity of sex organs across species can tell us a lot about evolution. Menno Schilthuizen invites readers to join him as he uncovers the ways the shapes and functions of genitalia have been molded by complex Darwinian struggles: penises that have lost their spines but evolved appendages to displace sperm; female orgasms that select or reject semen from males, in turn subtly modifying the females’ genital shape. We learn why spiders masturbate into miniature webs, discover she dungflies that store sperm from attractive males in their bellies, and see how, when it comes to outlandish appendages and bizarre behaviors, humans are downright boring. Nature’s Nether Regions joyfully demonstrates that the more we learn about the multiform private parts of animals, the more we understand our own unique place in the great diversity of life.

    With stories that entertain as much as they inform, Wilson outlines the basic principles of evolution and shows how, properly understood, they can illuminate the length and breadth of creation, from the origin of life to the nature of religion. Now everyone can move beyond the sterile debates about creationism and intelligent design to share Darwin’s panoramic view of animal and human life, seamlessly connected to each other.Evolution, as Wilson explains, is not just about dinosaurs and human origins, but about why all species behave as they do—from beetles that devour their own young, to bees that function as a collective brain, to dogs that are smarter in some respects than our closest ape relatives. And basic evolutionary principles are also the foundation for humanity’s capacity for symbolic thought, culture, and morality.In example after example, Wilson sheds new light on Darwin’s grand theory and how it can be applied to daily life. By turns thoughtful, provocative, and daringly funny, Evolution for Everyone addresses some of the deepest philosophical and social issues of this or any age. In helping us come to a deeper understanding of human beings and our place in the world, it might also help us to improve that world.