An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    While some scientists tried to create an Aryan physics that excluded any ‘Jewish ideas’, many others made compromises and concessions as they continued to work under the Nazi regime. Among them were three world-renowned physicists:Max Planck, pioneer of quantum theory, regarded it as his moral duty to carry on under the regime.Peter Debye, a Dutch physicist, rose to run the Reich’s most important research institute before leaving for the United States in 1940.Werner Heisenberg, discovered the Uncertainty Principle, and became the leading figure in Germany’s race for the atomic bomb.After the war most scientists in Germany maintained they had been apolitical or even resisted the regime: Debye claimed that he had gone to America to escape Nazi interference in his research; Heisenberg and others argued that they had deliberately delayed production of the atomic bomb.Mixing history, science and biography, Serving the Reich is a gripping exploration of moral choices under a totalitarian regime. Here are human dilemmas, failures to take responsibility, three lives caught between the idealistic goals of science and a tyrannical ideology.

    Transmitted by body lice, it afflicts the dispossessed—refugees, soldiers, and ghettoized peoples—causing hallucinations, terrible headaches, boiling fever, and often death. The disease plagued the German army on the Eastern Front and left the Reich desperate for a vaccine. For this they turned to the brilliant and eccentric Polish zoologist Rudolf Weigl.In the 1920s, Weigl had created the first typhus vaccine using a method as bold as it was dangerous for its use of living human subjects. The astonishing success of Weigl’s techniques attracted the attention and admiration of the world—giving him cover during the Nazi’s violent occupation of Lviv. His lab soon flourished as a hotbed of resistance. Weigl hired otherwise doomed mathematicians, writers, doctors, and other thinkers, protecting them from atrocity. The team engaged in a sabotage campaign by sending illegal doses of the vaccine into the Polish ghettos while shipping gallons of the weakened serum to the Wehrmacht.Among the scientists saved by Weigl, who was a Christian, was a gifted Jewish immunologist named Ludwik Fleck. Condemned to Buchenwald and pressured to re-create the typhus vaccine under the direction of a sadistic Nazi doctor, Erwin Ding-Schuler, Fleck had to make an awful choice between his scientific ideals or the truth of his conscience. In risking his life to carry out a dramatic subterfuge to vaccinate the camp’s most endangered prisoners, Fleck performed an act of great heroism.Drawing on extensive research and interviews with survivors, Arthur Allen tells the harrowing story of two brave scientists—a Christian and a Jew— who put their expertise to the best possible use, at the highest personal danger.

    Doctor, Harvard professor, renowned infectious-disease specialist, anthropologist, the recipient of a MacArthur "genius" grant, world-class Robin Hood, Farmer was brought up in a bus and on a boat, and in medical school found his life’s calling: to diagnose and cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most.Mountains Beyond Mountains takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that "the only real nation is humanity"—a philosophy that is embodied in the small public charity he founded, Partners in Health. He enlists the help of the Gates Foundation, George Soros, the U.N.’s World Health Organization, and others in his quest to cure the world. At the heart of this book is the example of a life based on hope, and on an understanding of the truth of the Haitian proverb "Beyond mountains there are mountains": as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.

    As he would later write in the first of a series of award-winning columns for "Vanity Fair," he suddenly found himself being deported "from the country of the well across the stark frontier that marks off the land of malady." Over the next eighteen months, until his death in Houston on December 15, 2011, he wrote constantly and brilliantly on politics and culture, astonishing readers with his capacity for superior work even in extremis.Throughout the course of his ordeal battling esophageal cancer, Hitchens adamantly and bravely refused the solace of religion, preferring to confront death with both eyes open. In this account of his affliction, he describes the torments of illness, discusses its taboos, and explores how disease transforms experience and changes our relationship to the world around us. By turns personal and philosophical, Hitchens embraces the full panoply of human emotions as cancer invades his body and compels him to grapple with the enigma of mortality.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    It is up to you.Eddie Jaku always considered himself a German first, a Jew second. He was proud of his country. But all of that changed in November 1938, when he was beaten, arrested and taken to a concentration camp.Over the next seven years, Eddie faced unimaginable horrors every day, first in Buchenwald, then in Auschwitz, then on a Nazi death march. He lost family, friends, his country.Because he survived, Eddie made the vow to smile every day. He pays tribute to those who were lost by telling his story, sharing his wisdom and living his best possible life. He now believes he is the 'happiest man on earth'.Published as Eddie turns 100, this is a powerful, heartbreaking and ultimately hopeful memoir of how happiness can be found even in the darkest of times.

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    One truth prevails: the sheer scale of the evils that he unleashed on the world has made him a demonic figure without equal in this century. Kershaw's Hitler brings us closer than ever before to the character of the bizarre misfit in his 30-year ascent from a Viennese shelter for the indigent to uncontested rule over the German nation that had tried & rejected democracy in the crippling aftermath of WWI. With extraordinary vividness, Kershaw recreates the settings that made Hitler's rise possible: the virulent anti-Semitism of prewar Vienna, the crucible of a war with immense casualties, the toxic nationalism that gripped Bavaria in the 20s, the undermining of the Weimar Republic by extremists of the Right & the Left, the hysteria that accompanied Hitler's seizure of power in 1933 & then mounted in brutal attacks by his storm troopers on Jews & others condemned as enemies of the Aryan race. In an account drawing on many previously untapped sources, Hitler metamorphoses from an obscure fantasist, a drummer sounding an insistent beat of hatred in Munich beer halls, to the instigator of an infamous failed putsch &, ultimately, to the leadership of a ragtag alliance of right-wing parties fused into a movement that enthralled the German people. This volume, 1st of two, ends with the promulgation of the infamous Nuremberg laws that pushed German Jews to the outer fringes of society, & with the march of the German army into the Rhineland, Hitler's initial move toward the abyss of war.

    Following his escape from two American POW camps, his retreat into the mountains and out of Europe, and his path to an anonymous life in Buenos Aires, his pursuers are a bulldog West German prosecutor, a blind Argentinean Jew and his beautiful daughter, and a budding, ragtag spy agency called the Mossad, whose operatives have their own scores to settle (and whose rare surveillance photographs are published here for the first time). The capture of Eichmann and the efforts by Israeli agents to secret him out of Argentina to stand trial is the stunning conclusion to this thrilling historical account, told with the kind of pulse-pounding detail that rivals anything you'd find in great spy fiction.

    But aging does not have to mean decline. World-renowned surgeon Dr. Steven Gundry has been treating mature patients for most of his career. He knows that everyone thinks they want to live forever, until they hit middle age and witness the suffering of their parents and even their peers. So how do we solve the paradox of wanting to live to a ripe old age—but enjoy the benefits of youth?This groundbreaking book holds the answer. Working with thousands of patients, Dr. Gundry has discovered that the “diseases of aging” we most fear are not simply a function of age; rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well—one that is based on supporting the health of the “oldest” parts of us: the microorganisms that live within our bodies.Our gut bugs—the bacteria that make up the microbiome—largely determine our health over the years. From diseases like cancer and Alzheimer’s to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver’s seat, controlling our quality of life as we age.The good news is, it’s never too late to support these microbes and give them what they need to help them—and you—thrive. In The Longevity Paradox, Dr. Gundry outlines a nutrition and lifestyle plan to support gut health and live well for decades to come. A progressive take on the new science of aging, The Longevity Paradox offers an action plan to prevent and reverse disease as well as simple hacks to help anyone look and feel younger and more vital.

    

    government faced many difficult decisions, including what to do with the Third Reich’s scientific minds. These were the brains behind the Nazis’ once-indomitable war machine. So began Operation Paperclip, a decades-long, covert project to bring Hitler’s scientists and their families to the United States.Many of these men were accused of war crimes, and others had stood trial at Nuremberg; one was convicted of mass murder and slavery. They were also directly responsible for major advances in rocketry, medical treatments, and the U.S. space program. Was Operation Paperclip a moral outrage, or did it help America win the Cold War?Drawing on exclusive interviews with dozens of Paperclip family members, colleagues, and interrogators, and with access to German archival documents (including previously unseen papers made available by direct descendants of the Third Reich’s ranking members), files obtained through the Freedom of Information Act, and dossiers discovered in government archives and at Harvard University, Annie Jacobsen follows more than a dozen German scientists through their postwar lives and into a startling, complex, nefarious, and jealously guarded government secret of the twentieth century.In this definitive, controversial look at one of America’s most strategic, and disturbing, government programs, Jacobsen shows just how dark government can get in the name of national security.

    The sons of loggers, shipyard workers, and farmers, the boys defeated elite rivals first from eastern and British universities and finally the German crew rowing for Adolf Hitler in the Olympic games in Berlin, 1936.The emotional heart of the story lies with one rower, Joe Rantz, a teenager without family or prospects, who rows not for glory, but to regain his shattered self-regard and to find a place he can call home. The crew is assembled by an enigmatic coach and mentored by a visionary, eccentric British boat builder, but it is their trust in each other that makes them a victorious team. They remind the country of what can be done when everyone quite literally pulls together—a perfect melding of commitment, determination, and optimism.Drawing on the boys' own diaries and journals, their photos and memories of a once-in-a-lifetime shared dream, The Boys in the Boat is an irresistible story about beating the odds and finding hope in the most desperate of times—the improbable, intimate story of nine working-class boys from the American west who, in the depths of the Great Depression, showed the world what true grit really meant. It will appeal to readers of Erik Larson, Timothy Egan, James Bradley, and David Halberstam's The Amateurs.