We visit cutting-edge labs where scientists are working to "hack" the aging process, like purging "senescent" cells from mice to reverse the effects of aging. He'll reveal why some people live past 100 without even trying, what has happened with resveratrol, the "red wine pill" that made headlines a few years ago, how your fat tissue is trying to kill you, and how it's possible to unlock longevity-promoting pathways that are programmed into our very genes. Gifford separates the wheat from the chaff as he exposes hoaxes and scams foisted upon an aging society, and arms readers with the best possible advice on what to do, what not to do, and what life-changing treatments may be right around the corner. An intoxicating mixture of deep reporting, fascinating science, and prescriptive takeaway, Spring Chicken will reveal the extraordinary breakthroughs that may yet bring us eternal youth, while exposing dangerous deceptions that prey on the innocent and ignorant.

    He tells of the large science-steeped family who fostered his early fascination with chemistry. There follow his years at boarding school where, though unhappy, he developed the intellectual curiosity that would shape his later life. And we hear of his return to London, an emotionally bereft ten-year-old who found solace in his passion for learning. Uncle Tungsten radiates all the delight and wonder of a boy’s adventures, and is an unforgettable portrait of an extraordinary young mind.

    Biomedical enhancements, he writes, can make us smarter, have better memories, be stronger, quicker, have more stamina, live much longer, be more resistant to disease and to the frailties of aging, and enjoy richer emotional lives. They can even improve our character, or at least strengthen our powers of self-control. In spite of the benefits that biomedical enhancements may bring, many people instinctively reject them. Some worry that we will lose something important-our appreciation for what we have or what makes human beings distinctively valuable. To think clearly about enhancement, Buchanan argues, we have to acknowledge that nature is a mixed bag and that our species has many design flaws. We should be open to the possibility of becoming better than human, while never underestimating the risk that our attempts to improve may backfire.

    Shattering the myth of muses, higher powers, even creative “types,” Jonah Lehrer demonstrates that creativity is not a single gift possessed by the lucky few. It’s a variety of distinct thought processes that we can all learn to use more effectively.Lehrer reveals the importance of embracing the rut, thinking like a child, daydreaming productively, and adopting an outsider’s perspective (travel helps). He unveils the optimal mix of old and new partners in any creative collaboration, and explains why criticism is essential to the process. Then he zooms out to show how we can make our neighborhoods more vibrant, our companies more productive, and our schools more effective.You’ll learn about Bob Dylan’s writing habits and the drug addictions of poets. You’ll meet a Manhattan bartender who thinks like a chemist, and an autistic surfer who invented an entirely new surfing move. You’ll see why Elizabethan England experienced a creative explosion, and how Pixar’s office space is designed to spark the next big leap in animation.Collapsing the layers separating the neuron from the finished symphony, Imagine reveals the deep inventiveness of the human mind, and its essential role in our increasingly complex world. http://www.jonahlehrer.com/

    Beginning with his family’s odyssey, In a Different Key tells the extraordinary story of this often misunderstood condition, and of the civil rights battles waged by the families of those who have it. Unfolding over decades, it is a beautifully rendered history of ordinary people determined to secure a place in the world for those with autism—by liberating children from dank institutions, campaigning for their right to go to school, challenging expert opinion on what it means to have autism, and persuading society to accept those who are different.  It is the story of women like Ruth Sullivan, who rebelled against a medical establishment that blamed cold and rejecting “refrigerator mothers” for causing autism; and of fathers who pushed scientists to dig harder for treatments. Many others played starring roles too: doctors like Leo Kanner, who pioneered our understanding of autism; lawyers like Tom Gilhool, who took the families’ battle for education to the courtroom; scientists who sparred over how to treat autism; and those with autism, like Temple Grandin, Alex Plank, and Ari Ne’eman, who explained their inner worlds and championed the philosophy of neurodiversity. This is also a story of fierce controversies—from the question of whether there is truly an autism “epidemic,” and whether vaccines played a part in it; to scandals involving “facilitated communication,” one of many treatments that have proved to be blind alleys; to stark disagreements about whether scientists should pursue a cure for autism. There are dark turns too: we learn about experimenters feeding LSD to children with autism, or shocking them with electricity to change their behavior; and the authors reveal compelling evidence that Hans Asperger, discoverer of the syndrome named after him, participated in the Nazi program that consigned disabled children to death.<

    He solidified his standing as the nation's foremost political forecaster with his near perfect prediction of the 2012 election. Silver is the founder and editor in chief of FiveThirtyEight.com. Drawing on his own groundbreaking work, Silver examines the world of prediction, investigating how we can distinguish a true signal from a universe of noisy data. Most predictions fail, often at great cost to society, because most of us have a poor understanding of probability and uncertainty. Both experts and laypeople mistake more confident predictions for more accurate ones. But overconfidence is often the reason for failure. If our appreciation of uncertainty improves, our predictions can get better too. This is the "prediction paradox": The more humility we have about our ability to make predictions, the more successful we can be in planning for the future.In keeping with his own aim to seek truth from data, Silver visits the most successful forecasters in a range of areas, from hurricanes to baseball, from the poker table to the stock market, from Capitol Hill to the NBA. He explains and evaluates how these forecasters think and what bonds they share. What lies behind their success? Are they good-or just lucky? What patterns have they unraveled? And are their forecasts really right? He explores unanticipated commonalities and exposes unexpected juxtapositions. And sometimes, it is not so much how good a prediction is in an absolute sense that matters but how good it is relative to the competition. In other cases, prediction is still a very rudimentary-and dangerous-science.Silver observes that the most accurate forecasters tend to have a superior command of probability, and they tend to be both humble and hardworking. They distinguish the predictable from the unpredictable, and they notice a thousand little details that lead them closer to the truth. Because of their appreciation of probability, they can distinguish the signal from the noise.

    Women have been giving birth for millennia, so why is it that every culture—and every generation—seems to have its own ideas about the best way to get a baby born? Among the topics that Tina Cassidy looks at are: why birth can be so difficult (blame our ability to walk on two legs, for instance), where women deliver, how the perception of midwives has changed (they were once burned as witches), the lives of some famous obstetricians, and the many ways childbirth has been deadly (lots of blame to go around). Birth is full of quirky details, startling facts, and tales both humorous and disturbing—from men disguised as women to get into delivery rooms to a news flash about a woman giving herself a C-section. From Jessica Mitford’s seminal The American Way of Death to Mary Roach’s Stiff, we’ve witnessed how millions of readers are fascinated by what happens at the end of life. Here is the riveting true story of how it begins.

    Through the stories of victims, perpetrators, law enforcement, and reform movements from across the country, Snyder explores not only the dark corners of private violence, but also its far-reaching consequences for society, and what it will take to truly address it.

    In this book, Christine Overall maintains that the burden of proof should be reversed: that the choice to have children calls for more careful justification and reasoning than the choice not to. Arguing that the choice to have children is not just a prudential or pragmatic decision but one with ethical repercussions, Overall offers a wide-ranging exploration of how we might think systematically and deeply about this fundamental aspect of human life. Writing from a feminist perspective, she also acknowledges the inevitably gendered nature of the decision; although both men and women must ponder the issue, the choice has different meanings, implications, and risks for women than it has for men. Overall considers a series of ethical perspectives on procreation, examining approaches that rely on reproductive rights; on fundamental religious, family, or political values; and on the anticipated consequences of the decision for both individuals and society. She examines some of the broader issues relevant to the decision, including population growth, resource depletion, and social policies governing reproduction. Finding the usual approaches to the question inadequate or incomplete, she offers instead a novel argument. Exploring the nature of the biological parent-child relationship--which is not only genetic but also psychological, physical, intellectual, and moral--she argues that the formation of that relationship is the best possible reason for choosing to have a child.

    The pandemic has had a devastating effect on global extreme poverty and harrowing scenes from around the world continue to leave us shocked. As the pandemic rages on, it’s natural to ask: how can I help? Peter Singer – often considered to be the world’s most influential living philosopher– answers this question in The 10th Anniversary Edition of his seminal book, The Life You Can Save. This book will inspire and empower readers to ACT NOW and SAVE LIVES. Moreover, the ebook and the audiobook (narrated by mission–aligned celebrities including Stephen Fry, Kristen Bell, Paul Simon and Michael Schur!) is available to all readers for FREE on The Life You Can Save website. In The Life You Can Save, Peter Singer compellingly lays out the case for why and how we can take action to provide immense benefit to others, at minimal cost to ourselves. Using ethical arguments, illuminating examples, and case studies of charitable giving, he shows that our current response to world poverty is not only insufficient but morally indefensible. And he provides practical recommendations of charities proven to dramatically improve, and even save, the lives of children, women and men living in extreme poverty. The Life You Can Save teaches us to be a part of the solution, helping others as we help ourselves.

    But while this medieval medicine now seems archaic, it also made a critical contribution to modern science.Medieval Bodies guides us on a head-to-heel journey through this era’s revolutionary advancements and disturbing convictions. We learn about the surgeons who dissected a living man’s stomach, then sewed him up again; about the geographers who delineated racial groups by skin color; and about the practice of fasting to gain spiritual renown. Encompassing medicine and mysticism, politics and art—and complete with vivid, full-color illustrations—Medieval Bodies shows us how it felt to live and die a thousand years ago.

      Along the way, he reveals the untold story of Hans Asperger, the father of Asperger’s syndrome, whose “little professors” were targeted by the darkest social-engineering experiment in human history; exposes the covert campaign by child psychiatrist Leo Kanner to suppress knowledge of the autism spectrum for fifty years; and casts light on the growing movement of "neurodiversity" activists seeking respect, support, technological innovation, accommodations in the workplace and in education, and the right to self-determination for those with cognitive differences.

    In defiance of doomsayers, Johnson finds librarians more vital and necessary than ever, as they fuse the tools of the digital age with love for the written word and the enduring values of truth, service to all, and free speech. This Book Is Overdue! is a romp through the ranks of information professionals who organize our messy world and offer old-fashioned human help through the maze.

    In 1960s America, premarital sex was not uncommon, but birth control was hard to get and abortion was illegal. In 1961, sixteen-year-old Margaret Erle became pregnant. Her unsympathetic family sent her to a maternity home. In the hospital, nurses would not even allow her to hold her own newborn. After she was finally badgered into signing away her rights, her son vanished into an adoption agency's hold.Claiming to be acting in the best interests of all, the adoption business was founded on secrecy and lies. American Baby lays out how a lucrative and exploitative industry removed children from their birth mothers and place them with families, fabricating stories about infants' origins and destinations, then closing the door firmly between the parties forever. They struck shady deals with doctors and researchers for pseudoscientific "assessments," and shamed millions of young women into surrendering their children.Gabrielle Glaser dramatically demonstrates the expectations and institutions that Margaret was up against. Though Margaret went on to marry and raise a large family with David's father, she never stopped longing for and worrying about her firstborn. She didn't know he spent the first years of his life living just a few blocks away from her, wondering often about where he came from and why he was given up. Their tale--one they share with millions of Americans--is one of loss, love, and the search for identity.Adoption's closed records are being legally challenged in states nationwide. Open adoption is the rule today, but the identities of many who were adopted or who surrendered a child in the decades this book covers are locked in sealed files. American Baby both illuminates a dark time in our history and shows a path to justice, honesty and reunion that can help heal the wounds inflicted by years of shame and secrecy.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”