It is almost impossible to imagine that prior to the 20th century, there was no reliable way to distinguish between the guilty and the innocent. All that changed in Britain in 1905, when the bloody bodies of an elderly couple were discovered in their shop -- and a solitary fingerprint became the only piece of evidence . . .

    Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    Then a forensic scientist leads police to the peeled skin from two boiled hands--and the fingerprints that will crack the case.The murder weapon was smashed to smithereensA man was killed by a blow from a bottle. Now, determined investigator carefully puts the pieces of glass back together to catch a kiler--and to carry out a crime of his own...What the corpse revealedOnce detectives solved crimes with shoe leather and a gun. Now they use DNA samples, blood splatters, microbes and psychological profilings. This extraordinary book, through details drawn from some of the most baffling cases of the last fifty years, shows how a new generation fo real-life crime busters is catching stalkers, poisoners, mass murderers, and assassins--through the astounding art of forensic science.

    Researchers are delving into the mysteries of stem cells and the human genome, discovering what it means to grow old and how to keep those processes from happening. This isn't science fiction; it's real, it's serious, and it's on track to revolutionize our definitions of life and mortality.In Immortality, Inc., veteran science journalist Chip Walter gains exclusive access to the champions of this radical cause, delivering a book that brings together for the first time the visions of molecular biologist and Apple chairman Arthur Levinson, genomics entrepreneur Craig Venter, futurist Ray Kurzweil, rejuvenation trailblazer Aubrey de Grey, and stem cell expert Robert Hariri. Along the way, Walter weaves in fascinating conversations about life, death, aging, and the future of the human race.

    If you've read Bitch, Bitch Reloaded, The Bitch Is Back, Queen Bitch and Last Bitch Standing, here is an opportunity to have this captivating saga in one book. If you're unfamiliar with the characters get ready to go on a thrilling ride of how one woman's determination took her from having nothing to gaining it all. This is where the journey began for Precious Cummings.The saga continues in Bitch A New Beginning with her daughter Aaliyah.

    

    is the latest blockbuster by Ireland's most respected crime writer and journalist, Paul Williams. Murder Inc. is the definitive account of how organized crime exploded in Limerick from the 1990s and in the noughties. It describes the depravity and decadence of the gangs, their deadly rivaliries, and their reigns of terror over the community in which they lived. Finally, Williams traces the faultlines that eventually led to the implosion of the gangs and their defeat.Drawing on his vast inside knowledge of the criminal underworld, an unparalleled range of contacts and eye witness interviews, Paul Williams provides a chilling insight into the mobsters and events that corroded entire neighbourhoods and devastated countless lives.

    Assuming no prior science knowledge, this book supports main concepts with clinical applications, making them more relevant to students pursuing careers in the allied health field.

    

    Good Old Dog brings their renowned clinic into your living room, arming you with essential advice to see your dog through his golden years. Featuring• Nutritional advice—not every senior diet is right for every senior dog• Emphasis on treating conditions common to older dogs so they live longer• How to evaluate complicated procedures and decide what’s right for your dog• The cost of caring for an older dog and how to shoulder the burden• How to identify cognitive decline and how to manage it• Advice on creating a healthy and comfortable environment• How to determine when “it’s time” and how to cope with the loss• And much more

    Wells begins his work as an inexperienced recent college grad and emerges a caring and beloved veterinarian. Affording the reader an inside glimpse into his daily life, he narrates many uplifting, life-altering, lifethreatening, and hilarious episodes.

    A perfect fit for a lab coat pocket, this book is commonly used as a quick review prior to surgical rounds as well as for board review.Purchasers of this edition will get both the print book and access to MP3 audio files of the entire text. All Q&A material will also be posted online in the form of electronic flashcards for self-quizzing.

    Each case includes an extended discussion, definition of terms, clinical pearls, and USMLE format review questions. This interactive learning system helps you understand essential concepts instead of memorizing facts.

    Every new reader's brain possesses the extraordinary capacity to rearrange itself beyond its original abilities in order to understand written symbols. But how does the brain learn to read? As world-renowned cognitive neuroscientist and scholar of reading Maryanne Wolf explains in this impassioned book, we taught our brain to read only a few thousand years ago, and in the process changed the intellectual evolution of our species.Wolf tells us that the brain that examined tiny clay tablets in the cuneiform script of the Sumerians is configured differently from the brain that reads alphabets or of one literate in today's technology.There are critical implications to such an evolving brain. Just as writing reduced the need for memory, the proliferation of information and the particular requirements of digital culture may short-circuit some of written language's unique contributions—with potentially profound consequences for our future.Turning her attention to the development of the individual reading brain, Wolf draws on her expertise in dyslexia to investigate what happens when the brain finds it difficult to read. Interweaving her vast knowledge of neuroscience, psychology, literature, and linguistics, Wolf takes the reader from the brains of a pre-literate Homer to a literacy-ambivalent Plato, from an infant listening to Goodnight Moon to an expert reader of Proust, and finally to an often misunderstood child with dyslexia whose gifts may be as real as the challenges he or she faces.As we come to appreciate how the evolution and development of reading have changed the very arrangement of our brain and our intellectual life, we begin to realize with ever greater comprehension that we truly are what we read. Ambitious, provocative, and rich with examples, Proust and the Squid celebrates reading, one of the single most remarkable inventions in history. Once embarked on this magnificent story of the reading brain, you will never again take for granted your ability to absorb the written word.