In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    She claims a "husky Negro" did it, and the sheriff, the infamous racist Willis McCall, does not hesitate to round up a herd of suspects. But within days, McCall turns his sights on Jesse Daniels, a gentle, mentally impaired white nineteen-year-old. Soon Jesse is railroaded up to the state hospital for the insane, and locked away without trial. But crusading journalist Mabel Norris Reese cannot stop fretting over the case and its baffling outcome. Who was protecting whom, or what? She pursues the story for years, chasing down leads, hitting dead ends, winning unlikely allies. Bit by bit, the unspeakable truths behind a conspiracy that shocked a community into silence begin to surface.Beneath a Ruthless Sun tells a powerful, page-turning story rooted in the fears that rippled through the South as integration began to take hold, sparking a surge of virulent racism that savaged the vulnerable, debased the powerful, and roils our own times still.

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.

    By combining analysis of the historical evidence with the latest psychiatric research, Ghaemi demonstrates how he thinks these qualities have produced brilliant leadership under the toughest circumstances.individuals and society at large-however high the price for those who endure these illnesses.

    What really happened in 1969? In 1999, when Tom O'Neill was assigned a magazine piece about the thirtieth anniversary of the Manson murders, he worried there was nothing new to say. Weren't the facts indisputable? Charles Manson had ordered his teenage followers to commit seven brutal murders, and in his thrall, they'd gladly complied. But when O'Neill began reporting the story, he kept finding holes in the prosecutor Vincent Bugliosi's narrative, long enshrined in the best-selling Helter Skelter. Before long, O'Neill had questions about everything from the motive to the manhunt. Though he'd never considered himself a conspiracy theorist, the Manson murders swallowed the next two decades of his career. He was obsessed. Searching but never speculative, CHAOS follows O'Neill's twenty-year effort to rebut the "official" story behind Manson. Who were his real friends in Hollywood, and how far would they go to hide their ties? Why didn't law enforcement act on their many chances to stop him? And how did he turn a group of peaceful hippies into remorseless killers? O'Neill's hunt for answers leads him from reclusive celebrities to seasoned spies, from the Summer of Love to the shadowy sites of the CIA's mind-control experiments, on a trail rife with cover-ups and coincidences. Featuring hundreds of new interviews and dozens of never-before-seen documents from the LAPD, the FBI, and the CIA, CHAOS mounts an argument that could be, according to Los Angeles Deputy District Attorney Stephen Kay, strong enough to overturn the verdicts on the Manson murders. In those two dark nights in Los Angeles, O'Neill finds the story of California in the sixties: when charlatans mixed with prodigies, free love was as possible as brainwashing, and utopia-or dystopia-was just an acid trip away.

    Ballet dancers and rock musicians, professors and thieves-"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul.

    After oil was discovered beneath their land, the Osage rode in chauffeured automobiles, built mansions, and sent their children to study in Europe.Then, one by one, they began to be killed off. One Osage woman, Mollie Burkhart, watched as her family was murdered. Her older sister was shot. Her mother was then slowly poisoned. And it was just the beginning, as more Osage began to die under mysterious circumstances.In this last remnant of the Wild West—where oilmen like J. P. Getty made their fortunes and where desperadoes such as Al Spencer, “the Phantom Terror,” roamed – virtually anyone who dared to investigate the killings were themselves murdered. As the death toll surpassed more than twenty-four Osage, the newly created F.B.I. took up the case, in what became one of the organization’s first major homicide investigations. But the bureau was then notoriously corrupt and initially bungled the case. Eventually the young director, J. Edgar Hoover, turned to a former Texas Ranger named Tom White to try to unravel the mystery. White put together an undercover team, including one of the only Native American agents in the bureau. They infiltrated the region, struggling to adopt the latest modern techniques of detection. Together with the Osage they began to expose one of the most sinister conspiracies in American history.A true-life murder mystery about one of the most monstrous crimes in American history.

    The first small cities formed not only the cradle of civilization, but the spawning ground for the earliest viral epidemics, the first opportunity for viruses to find a home in the human herd. This is a story of fear and ignorance, as everything from demons and the wrath of the gods to minority groups have been blamed for epidemics from smallpox to yellow fever to AIDS. It is a story of grief and heartbreak, as hundreds of thousands, sometimes millions, are wiped out in a single year. And it is a story of great bravery and sacrifice, as doctors and nurses put themselves in harm's way to combat yellow fever in Memphis and Ebola in Zaire, and as researchers risk their own lives to test theories of vaccines and the transmission of disease. Now, in Viruses, Plagues, and History, Michael B. A. Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity.Oldstone focuses his tale on a few of the most famous viruses humanity has battled, beginning with some we have effectively defeated, such as smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone -- more than were killed in all the wars of the twentieth century combined. The author presents a vivid account of the long campaign against the virus, the insightful work of Edward Jenner, who created the smallpox vaccine from cowpox virus in 1796, and the monumental efforts of D. A. Henderson and an army of W.H.O. health care workers to finally eradicate smallpox. The smallpox virus remains the only organism that we have deliberately pushed to complete extinction in the wild.Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola and other hemorrhagic fevers, which literally turn their victims' organs to a bloody pulp; the Hantavirus outbreaks in the southwestern United States and elsewhere; mad cow disease, a frightening illness made worse by government mishandling and secrecy; and, of course, AIDS, often called the plague of our time. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the deadly variant from 1918 -- a viral strain that killed over 20 million people in 1918-1919, more than twice the military and civilian casualties of the First World War -- will make a comeback.Viruses have enormous power. They have wiped out cities, brought down dynasties, and helped destroy civilizations. But, as Michael Oldstone reveals, scientific research has given us the power to tame many of these viruses as well. Viruses, Plagues, and History shows us the panorama of humanity's long-standing conflict with our unseen viral enemies, from our successes to our continuing struggles. Oldstone's book is a vivid history of a fascinating field, and a highly reliable dispatch from a worker on the frontiers of this ongoing campaign.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

      We think of the FBI as America’s police force. But secret intelligence is the Bureau’s first and foremost mission. Enemies is the story of how presidents have used the FBI as the most formidable intelligence force in American history.   Here is the hidden history of America’s hundred-year war on terror. The FBI has fought against terrorists, spies, anyone it deemed subversive—and sometimes American presidents. The FBI’s secret intelligence and surveillance techniques have created a tug-of-war between protecting national security and infringing upon civil liberties. It is a tension that strains the very fabric of a free republic.

    Now, as she did in her smash #1 bestseller The Residence, former White House correspondent Kate Andersen Brower draws on a wide array of untapped, candid sources—from residence staff and social secretaries to friends and political advisers—to tell the stories of the ten remarkable women who have defined that role since 1960.Brower offers new insights into this privileged group of remarkable women, including Jacqueline Kennedy, Lady Bird Johnson, Patricia Nixon, Betty Ford, Rosalynn Carter, Nancy Reagan, Barbara Bush, Hillary Clinton, Laura Bush, and Michelle Obama. The stories she shares range from the heartwarming to the shocking and tragic, exploring everything from the first ladies’ political crusades to their rivalries with Washington figures; from their friendships with other first ladies to their public and private relationships with their husbands. She also offers a detailed and insightful new portrait of one of the most-watched first ladies of all time, Hillary Clinton, asking what her tumultuous years in the White House may tell us about her own historic presidential run . . . and what life could be like with the nation’s first First Husband.Candid and illuminating, this first group biography of the modern first ladies provides a revealing look at life upstairs and downstairs at the world’s most powerful address.

    is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. "A whole new crop of chemicals is radically changing the recreational drug landscape," writes Ben Westhoff. "These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs"--and all-too-often tragically lethal. Drugs like fentanyl, K2, and Spice--and those with arcane acronyms like 25i-NBOMe-- were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs' effects impossible to predict. Westhoff has infiltrated this shadowy world, becoming the first journalist to report from inside an illicit Chinese fentanyls lab and providing startling and original reporting on how China's vast chemical industry operates, and how the Chinese government subsidizes it. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Poignantly, Westhoff chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the U.S. and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many.

    They distributed anti-Nazi leaflets, printed subversive newspapers, hid resisters, secreted Jews to safety, transported weapons, and conveyed clandestine messages. The youngest was a schoolgirl of fifteen who scrawled "V" for victory on the walls of her lycée; the eldest, a farmer's wife in her sixties who harbored escaped Allied airmen. Strangers to each other, hailing from villages and cities from across France, these brave women were united in hatred and defiance of their Nazi occupiers.Eventually, the Gestapo hunted down 230 of these women and imprisoned them in a fort outside Paris. Separated from home and loved ones, these disparate individuals turned to one another, their common experience conquering divisions of age, education, profession, and class, as they found solace and strength in their deep affection and camaraderie.In January 1943, they were sent to their final destination: Auschwitz. Only forty-nine would return to France.A Train in Winter draws on interviews with these women and their families; German, French, and Polish archives; and documents held by World War II resistance organizations to uncover a dark chapter of history that offers an inspiring portrait of ordinary people, of bravery and survival—and of the remarkable, enduring power of female friendship.

    Haunting, moving, and beautifully written, Dray and Kamoie used thousands of letters and original sources to tell Eliza’s story as it’s never been told before—not just as the wronged wife at the center of a political sex scandal—but also as a founding mother who shaped an American legacy in her own right.A general’s daughter…Coming of age on the perilous frontier of revolutionary New York, Elizabeth Schuyler champions the fight for independence. And when she meets Alexander Hamilton, Washington’s penniless but passionate aide-de-camp, she’s captivated by the young officer’s charisma and brilliance. They fall in love, despite Hamilton’s bastard birth and the uncertainties of war.A founding father’s wife...But the union they create—in their marriage and the new nation—is far from perfect. From glittering inaugural balls to bloody street riots, the Hamiltons are at the center of it all—including the political treachery of America’s first sex scandal, which forces Eliza to struggle through heartbreak and betrayal to find forgiveness.The last surviving light of the Revolution…When a duel destroys Eliza’s hard-won peace, the grieving widow fights her husband’s enemies to preserve Alexander’s legacy. But long-buried secrets threaten everything Eliza believes about her marriage and her own legacy. Questioning her tireless devotion to the man and country that have broken her heart, she’s left with one last battle—to understand the flawed man she married and the imperfect union he could never have created without her…

    Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.