But what would it look like to study the whole of history, from the big bang through the present day -- and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence?These were the questions David Christian set out to answer when he created the field of "Big History," the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as "history." By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together -- from the creation of the planet to the advent of agriculture, nuclear war, and beyond.With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.

    Eyes wide open. I was standing at an open window, staring at the dizzying curve of Riverside Drive, five floors below. I’d stopped, somehow, poised, about to jump.Growing up the good girl in an Irish American family full of drinkers and terrible sleepers, Kathleen Frazier was twelve when her seemingly innocent sleepwalking turned dangerous. Over the next few years, she was a popular A+ student by day, the star of her high school musical. At night, she both longed for and dreaded sleep.Frazier moved to Manhattan in the 1980s, hoping for a life in the theater but getting a run of sleepwalking performances instead. Efforts to abate her malady with drinking failed miserably. She became promiscuous, looking for nighttime companionship. Could a bed partner save her from flinging herself down a flight of stairs or out an open window? Exhaustion stalked her, and rest and love were seemingly out of reach.This is the journey Frazier illuminates in her intimate memoir. While highlighting her quest to beat her sleep terrors and insomnia, this is ultimately a story of health, hope, and redemption.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    Six eager interns—they saw themselves as modern saviors-to-be.   They came from the top of their medical school class  to the bottom of the hospital staff to serve a  year in the time-honored tradition, racing to answer  the flash of on-duty call lights and nubile  nurses. But only the Fat Man—the Clam, all-knowing resident—could sustain them in their struggle to survive, to stay sane, to love and even to be doctors when their harrowing year was done.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    Jails in New York, Los Angeles, and Chicago each house more people with mental illnesses than any hospital. As many as half of all people in America's jails and prisons have a psychiatric disorder. One in four fatal police shootings involves a person with such disorders.In this revelatory book, journalist Alisa Roth goes deep inside the criminal justice system to show how and why it has become a warehouse where inmates are denied proper treatment, abused, and punished in ways that make them sicker.Through intimate stories of people in the system and those trying to fix it, Roth reveals the hidden forces behind this crisis and suggests how a fairer and more humane approach might look. Insane is a galvanizing wake-up call for criminal justice reformers and anyone concerned about the plight of our most vulnerable.

    We all have one, but most of us will never see one. The heart surgeon now has that privilege but, for centuries, the heart was out of reach even for surgeons. So when a surgeon nowadays opens up a ribcage and mends a heart, it remains something of a miracle, even if, to some, it is merely plumbing. As with plumbers, the quality of surgeons’ work varies. As with plumbers, surgeons’ opinion of their own prowess and their own attitude to risk are not always reliable. Measurement is key. We’ve had a century of effective evidence-based medicine. We’ve had barely a decade of thorough monitoring of clinical outcomes. Thanks to the ground-breaking risk modelling of pioneering surgeons like Samer Nashef, we at last know how to judge whether an operation is in a patient’s best interest, which hospital and surgeon would be best for that operation, when it might best be performed and what the exact level of risk is. We have at last made what is important in surgery measurable. But how should surgeons, and their patients, use these newfound insights? Ever since his days as a medical student, Samer Nashef has challenged the medical profession to be more open and more accurate about the success of surgical procedures, for the sake of the patients. In The Naked Surgeon, he unclothes his own profession to demonstrate to his reader (and prospective patient) many revelations, such as the paradox at the heart of the cardiac surgeon’s craft: the more an operation is likely to kill you, the better it is for you. And he does so with absolute clarity, fluency and not a little wit.

    And unlike dogs, cats offer humans no practical benefit. The truth is they are sadly incompetent mouse-catchers and now pose a threat to many ecosystems. Yet, we love them still.Content:Catacombs Cat's cradle What's the catch? The cats that ate the canaries The cat lobby CAT scan Pandora's litter box Lions and toygers and lykoi Nine likes.

    Decluttering. A parent's death. Sooner or later, all of us are faced with things we no longer need or want. But when we drop our old clothes and other items off at a local donation center, where do they go? Sometimes across the country-or even halfway across the world-to people and places who find value in what we leave behind.In Secondhand, journalist Adam Minter takes us on an unexpected adventure into the often-hidden, multibillion-dollar industry of reuse: thrift stores in the American Southwest to vintage shops in Tokyo, flea markets in Southeast Asia to used-goods enterprises in Ghana, and more. Along the way, Minter meets the fascinating people who handle-and profit from-our rising tide of discarded stuff, and asks a pressing question: In a world that craves shiny and new, is there room for it all?Secondhand offers hopeful answers and hard truths. A history of the stuff we've used and a contemplation of why we keep buying more, it also reveals the marketing practices, design failures, and racial prejudices that push used items into landfills instead of new homes. Secondhand shows us that it doesn't have to be this way, and what really needs to change to build a sustainable future free of excess stuff.

    From blonde to ginger, the brown that changed the way battles were fought to the white that protected against the plague, Picasso's blue period to the charcoal on the cave walls at Lascaux, acid yellow to kelly green, and from scarlet women to imperial purple, these surprising stories run like a bright thread throughout history.In this book, Kassia St. Clair has turned her lifelong obsession with colors and where they come from (whether Van Gogh's chrome yellow sunflowers or punk's fluorescent pink) into a unique study of human civilization. Across fashion and politics, art and war, the secret lives of color tell the vivid story of our culture.

    Those manic blogs from the hospital wards during under-slept call nights (which left a few friends wondering if he had invaded the hospital pharmacy) were the genesis for this book, Playing Doctor. This is a journey through medical training as interpreted by someone who told their college career advisor that the only thing they did not want to be was a doctor-not that medical schools want you believing their training was interpretive, like a modern dance company's version of Grey's Anatomy-and started school with a traumatic brain injury. This entertaining, heartfelt demystification of medical school via the confusion that seemed to litter John's medical trail, takes readers along the studies and clinical wards that miraculously teach students how to care for patients. The follow up books cover residency.

    But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future.

    Grief-stricken, the community mourned what they thought was an isolated loss. Until, a few weeks later, it happened again. And again. And again. In six months, the high school lost five students to suicide at those train tracks.A recent transplant to the community and a new father himself, Lee Daniel Kravetz’s experience as a science journalist kicked in: what was causing this tragedy? More important, how was it possible that a suicide cluster could develop in a community of concerned, aware, hyper-vigilant adults?The answer? Social contagion. We all know that ideas, emotions, and actions are communicable—from mirroring someone’s posture to mimicking their speech patterns, we are all driven by unconscious motivations triggered by our environment. But when just the right physiological, psychological, and social factors come together, we get what Kravetz calls a "strange contagion:" a perfect storm of highly common social viruses that, combined, form a highly volatile condition.Strange Contagion is simultaneously a moving account of one community’s tragedy and a rigorous investigation of social phenomenon, as Kravetz draws on research and insights from experts worldwide to unlock the mystery of how ideas spread, why they take hold, and offer thoughts on our responsibility to one another as citizens of a globally and perpetually connected world.

    In Quirkology, he navigates the backwaters of human behavior, discovering the tell-tale signs that give away a liar, the secret science behind speed-dating and personal ads, and what a person's sense of humor reveals about the innermost workings of their mind- all along paying tribute to others who have carried out similarly weird and wonderful work. Wiseman's research has involved secretly observing people as they go about their daily business, conducting unusual experiments in art exhibitions and music concerts, and even staging fake seances in allegedly haunted buildings. With thousands of research subjects from all over the world, including enamored couples, unwitting pedestrians, and guileless dinner guests, Wiseman presents a fun, clever, and unexpected picture of the human mind.

    At first, she toughed it out through searing pain, taking sick days from work, unable to leave the bathroom or her bed. But when it became undeniable that something was seriously wrong, Miller gave in to family pressure and went to the hospital—beginning a yearslong nightmare of procedures, misdiagnoses, and life-threatening infections. Once she was finally correctly diagnosed with Crohn’s disease, Miller faced another battle: accepting that she will never get better.Today, an astonishing three in five adults in the United States suffer from a chronic disease—a percentage expected to rise post-Covid. Whether the illness is arthritis, asthma, Crohn's, diabetes, endometriosis, multiple sclerosis, ulcerative colitis, or any other incurable illness, and whether the sufferer is a colleague, a loved one, or you, these diseases have an impact on just about every one of us. Yet there remains an air of shame and isolation about the topic of chronic sickness. Millions must endure these disorders not only physically but also emotionally, balancing the stress of relationships and work amid the ever-present threat of health complications.Miller segues seamlessly from her dramatic personal experiences into a frank look at the cultural realities (medical, occupational, social) inherent in receiving a lifetime diagnosis. She offers hard-earned wisdom, solidarity, and an ultimately surprising promise of joy for those trying to make sense of it all.