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    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    The premise for this unique approach is that business initiatives should drive technology choices. Every discussion first addresses the business needs and then addresses the technology that supports those needs. This text provides the foundation that will enable students to achieve excellence in business, whether they major in operations management, manufacturing, sales, marketing, finance, human resources, accounting, or virtually any other business discipline. Business Driven Information Systems is designed to give students the ability to understand how information technology can be a point of strength for an organization.

    Itzik Ben-Gan explains key T-SQL concepts and helps you apply your knowledge with hands-on exercises. The book first introduces T-SQL's roots and underlying logic. Next, it walks you through core topics such as single-table queries, joins, subqueries, table expressions, and set operators. Then the book covers more-advanced data-query topics such as window functions, pivoting, and grouping sets. The book also explains how to modify data, work with temporal tables, and handle transactions, and provides an overview of programmable objects. Microsoft Data Platform MVP Itzik Ben-Gan shows you how to: Review core SQL concepts and its mathematical roots Create tables and enforce data integrity Perform effective single-table queries by using the SELECT statement Query multiple tables by using joins, subqueries, table expressions, and set operators Use advanced query techniques such as window functions, pivoting, and grouping sets Insert, update, delete, and merge data Use transactions in a concurrent environment Get started with programmable objects-from variables and batches to user-defined functions, stored procedures, triggers, and dynamic SQL

    

    You'll also learn about asking the right question: "When do I have to shoot?" The concept of "Don't shoot - Training for the draw is just as effective." Force on force notebook: Revisiting the 21 foot rule in regards to carrying concealed. A special section on 10 seconds to fight. Download your Copy of this report. This report is published by The United States Concealed Carry Association, the biggest community of responsibly-armed Americans.

    Includes discussion of practice techniques, chassis set-up, and working with your pit chief.

    Salesforce.com (more than 50%) and Twitter (more than 75% fall into this category. Ebay gets more than 8 billion API calls a month. Facebook and Google, have dozens of APIs that enable both free services and e-commerce, get more than 5 billion API calls each day. Other companies like NetFlix have expanded their service of streaming movies over the the web to dozens of devices using API. At peak times, more than 20 percent of all traffic is accounted for by Netflix through its APIs. Companies like Sears and E-Trade are opening up their catalogs and other services to allow developers and entrepreneurs to create new marketing experiences. Making an API work to create a new channel is not just a matter of technology. An API must be considered in terms of business strategy, marketing, and operations as well as the technical aspects of programming. This book, written by Greg Brail, CTO of Apigee, and Brian Mulloy, VP of Products, captures the knowledge of all these areas gained by Apigee, the leading company in supporting the rollout of high traffic APIs.

    An exceptional book written by a true professional.

    With the new tablet, I absolutely love its many standard features and capabilities, but have found there is so much more that can be done with this amazing gadget. I’ve learned a lot of great things you can do with a Kindle Fire HD and want to help others get more out of their Kindle Fire HDX and HD devices. I've developed a comprehensive guide book to help users along on their device, including tips and tricks to really unlock and unleash the possibilities with the tablet. Here’s just some of the great info you’ll find in this User’s Guide Book: - Getting to know the various settings of your Kindle Fire HDX or HD - Browsing your Kindle and carousel - How to store your favorite content items on the device - Setting up security options to safeguard your device - Setting up your e-mail, contacts and calendar info - Setting up and using wireless networks - How to print from your Kindle Fire HD - How to install the Dolphin Browser with Adobe Flash - How to install the Google Chrome browser on your tablet - Pairing your Kindle Fire HD with a compatible Bluetooth phone or computer - How to set-up FreeTime for your kids to use your Kindle with restrictions - How to listen to the radio on your tablet - How to use your tablet to make phone calls for free! - How to download YouTube videos to your Kindle Fire HD - How to take photos and videos with your Kindle Fire HD camera - How to sideload apps on your Kindle Fire HD - Some of the best apps you can get for your tablet - Suggested apps to take your tablet to the next level! You’ll learn all of the above and more in this book which features color screenshots straight from the Kindle and step-by-step instructions on the processes involved in unleashing more powerful features for your Kindle Fire HD! There's also helpful links throughout the guide to take you right to the apps and websites being discussed. In all, this is a must-have ebook to get for any Kindle Fire HD user who wants to take their device to the next level! Note: Many of the tips and how-to's covered in this guide will also apply to the previous generation of the Kindle Fire HD, released in 2012. Please note this book is for owners of the American version of the Kindle Fire HDX & Kindle Fire HD tablets sold as of October 2013 in the United States.

    In Understanding ECMAScript 6, expert developer Nicholas C. Zakas provides a complete guide to the object types, syntax, and other exciting changes that ECMAScript 6 brings to JavaScript. Every chapter is packed with example code that works in any JavaScript environment so you'll be able to see new features in action. You'll learn:How ECMAScript 6 class syntax relates to more familiar JavaScript conceptsWhat makes iterators and generators usefulHow arrow functions differ from regular functionsWays to store data with sets, maps, and moreThe power of inheritanceHow to improve asynchronous programming with promisesHow modules change the way you organize codeWhether you're a web developer or a Node.js developer, you'll find Understanding ECMAScript 6 indispensable on your journey from ECMAScript 5 to ECMAScript 6.

    High-profile projects such as the Linux Kernel, Mozilla, Gnome, and Ruby on Rails are now using Distributed Version Control Systems (DVCS) instead of the old stand-bys of CVS or Subversion.Git is a modern, fast, DVCS. But understanding how it fits into your development can be a daunting task without an introduction to the new concepts. Whether you're just starting out as a professional programmer or are an old hand, this book will get you started using Git in this new distributed world. Whether you're making the switch from a traditional centralized version control system or are a new programmer just getting started, this book prepares you to start using Git in your everyday programming.Pragmatic Version Control Using Git starts with an overview of version control systems, and shows how being distributed enables you to work more efficiently in our increasingly mobile society. It then progresses through the basics necessary to get started using Git.You'll get a thorough overview of how to take advantage of Git. By the time you finish this book you'll have a firm grounding in how to use Git, both by yourself and as part of a team.Learn how to use how to use Git to protect all the pieces of your project Work collaboratively in a distributed environment Learn how to use Git's cheap branches to streamline your development Install and administer a Git server to share your repository

    Updated and revised for iPhone SDK 3, many of the discussions in the original book have been clarified to make some of the more complex topics easier to understand. In addition, all of the projects have been rebuilt from scratch using the SDK 3 templates.Assuming only a minimal working knowledge of Objective-C, and written in a friendly, easy-to-follow style, this book offers a complete soup-to-nuts course in iPhone and iPod touch programming. The book starts with the basics, walking you through the process of downloading and installing Apple's free iPhone SDK, and then stepping you though the creation of your first simple iPhone application. From there, you'll learn to integrate all the interface elements iPhone users have come to know and love, such as buttons, switches, pickers, toolbars, and sliders. You'll master a variety of design patterns, from the simplest single view to complex hierarchical drill-downs. The confusing art of table building will be demystified, and you'll see how to save your data using the iPhone file system. You'll also learn how to save and retrieve your data using SQLite, iPhone's built-in database management system. In addition, you'll also learn about Core Data, an important persistence mechanism that has just been added with SDK 3.And there's much more! You'll learn to draw using Quartz 2D and OpenGL ES, add multitouch gestural support (pinches and swipes) to your applications, and work with the camera, photo library, accelerometer, and built-in GPS. You'll discover the fine points of application preferences and learn how to localize your apps for multiple languages. You can discover more about this book, download source code, and find support forums at the book's companion site, at www.iphonedevbook.com.The iPhone 3 update to the best-selling and most recommended book for iPhone developers Packed full of tricks, techniques, and enthusiasm for the new SDK from a developer perspective The most complete, useful, and up-to-date guide to all things having to do with Apple's iPhone SDK

    It will keep you entertained for hours. It's the very unusual story of Paul Henry - from his eventful childhood to his adventurous career in journalism to his recent outrageous comments on television which divided the country.A natural-born story teller, Paul spins many great yarns in this book. It's fascinating insight into his complex character. He's surprising -- he doesn't adhere to any prescribed set of beliefs. He's bold -- he set himself up as an international news correspondent working out of his Masterton lounge. And he's versatile -- turning his hand to running a cafe, running for Parliament and running from terrorists.