As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    Jeff Jarvis tells Gutenberg's story from an entrepreneurial perspective, examining how he overcame technology hurdles, how he operated with the secrecy of a Steve Jobs but then shifted to openness, how he raised capital and mitigated risk, and how, in the end, his cash flow and equity structure did him in. This is also the inspiring story of a great disruptor. That is what makes Gutenberg the patron saint of entrepreneurs.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    However, he observed that fresh vegetables wetted and left outside in the Arctic winds froze in a way that maintained their integrity after thawing. As a result, he developed his patented Birdseye freezing process and started the company that still bears his name. Birdseye forever changed the way we preserve, store, and distribute food, and the way we eat. Mark Kurlansky’s vibrant and affectionate narrative reveals Clarence Birdseye as a quintessential “can-do” American inventor—his other patents include an electric sunlamp, a harpoon gun to tag finback whales, and an improved incandescent lightbulb—and shows how the greatest of changes can come from the simplest of ideas and the unlikeliest of places

    While other nerds were fumbling with password possibilities, this adept break-artist was penetrating the digital secrets of Sun Microsystems, Digital Equipment Corporation, Nokia, Motorola, Pacific Bell, and other mammoth enterprises. His Ghost in the Wires memoir paints an action portrait of a plucky loner motivated by a passion for trickery, not material game. (P.S. Mitnick's capers have already been the subject of two books and a movie. This first-person account is the most comprehensive to date.)

    Rock and roll made it otherwise. From meeting Elvis, to seeing the Beatles on Ed Sullivan, to producing Del Shannon, backing Bob Dylan, putting together a band with George Harrison, Dylan, Roy Orbison, and Jeff Lynne, making records with Johnny Cash, and sending well more than a dozen of his own celebrated recordings high onto the charts, Tom Petty's story has all the drama of a rock and roll epic. Now in his mid-sixties, still making records and still touring, Petty, known for his reclusive style, has shared with Warren Zanes his insights and arguments, his regrets and lasting ambitions, and the details of his life on and off the stage.This is a book for those who know and love the songs, from "American Girl" and "Refugee" to "Free Fallin'" and "Mary Jane's Last Dance," and for those who want to see the classic rock and roll era embodied in one man's remarkable story. Dark and mysterious, Petty manages to come back, again and again, showing us what the music can do and where it can take us.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    But it would take the world some time to believe what had happened: the age of flight had begun, with the first heavier-than-air, powered machine carrying a pilot.Who were these men and how was it that they achieved what they did?David McCullough, two-time winner of the Pulitzer Prize, tells the surprising, profoundly American story of Wilbur and Orville Wright.Far more than a couple of unschooled Dayton bicycle mechanics who happened to hit on success, they were men of exceptional courage and determination, and of far-ranging intellectual interests and ceaseless curiosity, much of which they attributed to their upbringing. The house they lived in had no electricity or indoor plumbing, but there were books aplenty, supplied mainly by their preacher father, and they never stopped reading.When they worked together, no problem seemed to be insurmountable. Wilbur was unquestionably a genius. Orville had such mechanical ingenuity as few had ever seen. That they had no more than a public high school education, little money and no contacts in high places, never stopped them in their mission to take to the air. Nothing did, not even the self-evident reality that every time they took off in one of their contrivances, they risked being killed.In this thrilling book, master historian David McCullough draws on the immense riches of the Wright Papers, including private diaries, notebooks, scrapbooks, and more than a thousand letters from private family correspondence to tell the human side of the Wright Brothers' story, including the little-known contributions of their sister, Katharine, without whom things might well have gone differently for them.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Life remains the only way to make life. Are we still missing a vital ingredient in its creation?      Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences. Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe. Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.

    Having spent years building tanks and airplanes for the army, the car companies would need years more to retool their production to meet the demands of the American public, for whom they had not made any cars since 1942.    And then in stepped Preston Tucker. This salesman extraordinaire from Ypsilanti, Michigan, had built race cars before the war, and had designed prototypes for the military during it. Now, gathering a group of brilliant automotive designers, engineers, and promoters, he announced the creation of a revolutionary new car: the Tucker '48, the first car in almost a decade to be built fresh from the ground up. Tucker's car would include ingenious advances in design and engineering that other car companies could not match. With a rear engine, rear-wheel drive, a safety-glass windshielf that would pop out in case of an accident, a padded dashboard, independent suspension, and automatic transmission, it would be more attractive and aerodynamic—and safer—than any other car on the road.    But as the public eagerly awaited Tucker's car of tomorrow, powerful forces in Washington were trying to bring him down. An SEC commissioner with close ties to Detroit's Big Three automakers deliberately leaked information about an investigation the agency was conducting, suggesting that Tucker was bilking investors with a massive fraud scheme. Headlines accused him a perpetrating a hoax and claimed that his cars weren't real and his factory was a sham.  In fact, the Tucker '48 sedan was genuine, and everyone who saw it was impressed by what this upstart carmaker had achieved. But the SEC's investigation had compounded the company's financial problems and management conflicts, and a superior product was not enough to keep Tucker's dream afloat.  Here, Steve Lehto tackles the story of Tucker's amazing rise and tragic fall, relying on a huge trove of documents that has been used by no other writer to date. It is the first comprehensive, authoritative account of Tucker's magnificent car and his battles with the government. And in this book, Lehto finally answers the questions automobile aficionados have wondered about for decades: Exactly how and why was the production of such an innovative car killed?