The popularity of murder mystery books, TV series, and even board games shows that there is an appetite for death, and the more unusual or macabre the method, the better. With gunshots or stabbings the cause of death is obvious, but poisons are inherently more mysterious. How are some compounds so deadly in such tiny amounts?Agatha Christie used poison to kill her characters more often than any other crime fiction writer. The poison was a central part of the novel, and her choice of deadly substances was far from random; the chemical and physiological characteristics of each poison provide vital clues to the discovery of the murderer. Christie demonstrated her extensive chemical knowledge (much of it gleaned by working in a pharmacy during both world wars) in many of her novels, but this is rarely appreciated by the reader.Written by former research chemist Kathryn Harkup, each chapter takes a different novel and investigates the poison used by the murderer. Fact- and fun-packed, A is for Arsenic looks at why certain chemicals kill, how they interact with the body, and the feasibility of obtaining, administering, and detecting these poisons, both when Christie was writing and today.

    They distill more than 20 years of research and first-hand accounts from the most biodiverse ecosystems on Earth into straightforward principles and guidance for confronting our culture of hyper-novelty.For evolutionary biologists Heather Heying and Bret Weinstein, the cause of our woes is clear: the modern world is out of sync with our ancient brains and bodies. We evolved to live in clans, but today most people don't even know their neighbors' names. Differences between the sexes once served a necessary evolutionary purpose, but today many dismiss the concept of biological sex as offensive. The cognitive dissonance spawned by trying to live in a society we're not built for is killing us.

    If your anxiety about global warming is dominated by fears of sea-level rise, you are barely scratching the surface of what terrors are possible. In California, wildfires now rage year-round, destroying thousands of homes. Across the US, "500-year" storms pummel communities month after month, and floods displace tens of millions annually.This is only a preview of the changes to come. And they are coming fast. Without a revolution in how billions of humans conduct their lives, parts of the Earth could become close to uninhabitable, and other parts horrifically inhospitable, as soon as the end of this century.In his travelogue of our near future, David Wallace-Wells brings into stark relief the climate troubles that await--food shortages, refugee emergencies, and other crises that will reshape the globe. But the world will be remade by warming in more profound ways as well, transforming our politics, our culture, our relationship to technology, and our sense of history. It will be all-encompassing, shaping and distorting nearly every aspect of human life as it is lived today.Like An Inconvenient Truth and Silent Spring before it, The Uninhabitable Earth is both a meditation on the devastation we have brought upon ourselves and an impassioned call to action. For just as the world was brought to the brink of catastrophe within the span of a lifetime, the responsibility to avoid it now belongs to a single generation.

    She's done things I dream of doing."—James CameronEdith Widder's childhood dream of becoming a marine biologist was almost derailed in college, when complications from a surgery gone wrong caused temporary blindness. A new reality of shifting shadows drew her fascination to the power of light—as well as the importance of optimism.As her vision cleared, Widder found the intersection of her two passions in oceanic bioluminescence, a little-explored scientific field within Earth's last great unknown frontier: the deep ocean. With little promise of funding or employment, she leaped at the first opportunity to train as a submersible pilot and dove into the darkness.Widder's first journey into the deep ocean, in a diving suit that resembled a suit of armor, took her to a depth of eight hundred feet. She turned off the lights and witnessed breathtaking underwater fireworks: explosions of bioluminescent activity. Concerns about her future career vanished. She only wanted to know one thing: Why was there so much light down there?Below the Edge of Darkness takes readers deep into our planet's oceans as Widder pursues her questions about one of the most important and widely used forms of communication in nature. In the process, she reveals hidden worlds and a dazzling menagerie of behaviors and animals, from microbes to leviathans, many never before seen or, like the legendary giant squid, never before filmed in their deep-sea lairs. Alongside Widder, we experience life-and-death equipment malfunctions and witness breakthroughs in technology and understanding, all set against a growing awareness of the deteriorating health of our largest and least understood ecosystem.A thrilling adventure story as well as a scientific revelation, Below the Edge of Darkness reckons with the complicated and sometimes dangerous realities of exploration. Widder shows us how when we push our boundaries and expand our worlds, discovery and wonder follow. These are the ultimate keys to the ocean's salvation—and thus to our future on this planet.

    Scientists around the world are currently monitoring the sixth extinction, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. This time around, the cataclysm is us. In prose that is at once frank, entertaining, and deeply informed, The New Yorker writer Elizabeth Kolbert tells us why and how human beings have altered life on the planet in a way no species has before. Interweaving research in half a dozen disciplines, descriptions of the fascinating species that have already been lost, and the history of extinction as a concept, Kolbert provides a moving and comprehensive account of the disappearances occurring before our very eyes. She shows that the sixth extinction is likely to be mankind's most lasting legacy, compelling us to rethink the fundamental question of what it means to be human.

    These vast expanses provide a home to wildlife populations, a vital source of clean air and water, and a haven for recreation.Since its inception, however, America’s public land system has been embroiled in controversy—caught in the push and pull between the desire to develop the valuable resources the land holds or conserve them. Alarmed by rising tensions over the use of these lands, hunter, angler, and outdoor enthusiast Mark Kenyon set out to explore the spaces involved in this heated debate, and learn firsthand how they came to be and what their future might hold.Part travelogue and part historical examination, That Wild Country invites readers on an intimate tour of the wondrous wild and public places that are a uniquely profound and endangered part of the American landscape.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    She had fallen in love and moved to Paris to pursue her dream of becoming a war correspondent. The real world she found, however, would take her into a very different kind of conflict zone.It started with an itch—first on her feet, then up her legs, like a thousand invisible mosquito bites. Next came the exhaustion, and the six-hour naps that only deepened her fatigue. Then a trip to the doctor and, a few weeks shy of her twenty-third birthday, a diagnosis: leukemia, with a 35 percent chance of survival. Just like that, the life she had imagined for herself had gone up in flames. By the time Jaouad flew home to New York, she had lost her job, her apartment, and her independence. She would spend much of the next four years in a hospital bed, fighting for her life and chronicling the saga in a column for The New York Times.When Jaouad finally walked out of the cancer ward—after three and a half years of chemo, a clinical trial, and a bone marrow transplant—she was, according to the doctors, cured. But as she would soon learn, a cure is not where the work of healing ends; it’s where it begins. She had spent the past 1,500 days in desperate pursuit of one goal—to survive. And now that she’d done so, she realized that she had no idea how to live.How would she reenter the world and live again? How could she reclaim what had been lost? Jaouad embarked—with her new best friend, Oscar, a scruffy terrier mutt—on a 100-day, 15,000-mile road trip across the country. She set out to meet some of the strangers who had written to her during her years in the hospital: a teenage girl in Florida also recovering from cancer; a teacher in California grieving the death of her son; a death-row inmate in Texas who’d spent his own years confined to a room. What she learned on this trip is that the divide between sick and well is porous, that the vast majority of us will travel back and forth between these realms throughout our lives. Between Two Kingdoms is a profound chronicle of survivorship and a fierce, tender, and inspiring exploration of what it means to begin again.

    In the aftermath of that six-year old's abduction and slaying in 1981, everything about the nation's regard and response to missing children changed.The shock of the crime and the inability of law enforcement to find Adam's killer put an end to innocence, and altered our very perception of childhood itself - gone forever are the days when young children burst out the doors of American homes with a casual promise to be home by dark. And, due in large part to the efforts of Adam's parents, John and Reve Walsh, the entire mechanism of law enforcement has transformed itself in an effort to protect our children.Before Adam went missing, there were no children's faces on milk cartons and billboards, no Amber Alerts, no national Center for Missing and Abused Children, no national databases for crimes against children, no registration of pedophiles - in fact, it was easier to mobilize the FBI to search for a stolen car or missing horse than for a kidnapped child. Such facts may be sad testimony to the weariness of a modern world, but there is also an uplifting aspect to Adam's story - the 27 years of undaunted effort by decorated Miami Beach Homicide Detective, Joe Matthews, to track down Adam's killer and bring justice to bear at long last.Bringing Adam Home tells the story - the good, the bad, and the ugly - of what it took for one cop to accomplish what an entire system of law enforcement could not. Matthews' achievement is a stirring one, reminding us that such concepts as hard work, dedication, and love, survive, and that goodness can prevail.

    Neither Jefferson nor the other Found­ers could ever have envisioned the modern national security state, with its tens of thousands of "privateers"; its bloated Department of Homeland Security; its rust­ing nuclear weapons, ill-maintained and difficult to dismantle; and its strange fascination with an unproven counterinsurgency doctrine. Written with bracing wit and intelligence, Rachel Maddow's Drift argues that we've drifted away from America's original ideals and become a nation weirdly at peace with perpetual war, with all the financial and human costs that entails. To understand how we've arrived at such a dangerous place, Maddow takes us from the Vietnam War to today's war in Afghanistan, along the way exploring the disturbing rise of executive authority, the gradual outsourcing of our war-making capabilities to private companies, the plummeting percentage of American families whose children fight our constant wars for us, and even the changing fortunes of G.I. Joe. She offers up a fresh, unsparing appraisal of Reagan's radical presidency. Ultimately, she shows us just how much we stand to lose by allowing the priorities of the national security state to overpower our political discourse. Sensible yet provocative, dead serious yet seri­ously funny, Drift will reinvigorate a "loud and jangly" political debate about how, when, and where to apply America's strength and power--and who gets to make those decisions.From the Hardcover edition.

    On that day, astronomer Arthur Eddington and his team observed a solar eclipse and found something extraordinary: gravity bends light, just as Einstein predicted. The finding confirmed the theory of general relativity, fundamentally changing our understanding of space and time.A century later, another group of astronomers is performing a similar experiment on a much larger scale. The Event Horizon Telescope, a globe-spanning array of radio dishes, is examining space surrounding Sagittarius A*, the supermassive black hole at the center of the Milky Way. As Ron Cowen recounts, the foremost goal of the experiment is to determine whether Einstein was right on the details. Gravity lies at the heart of what we don't know about quantum mechanics, but tantalizing possibilities for deeper insight are offered by black holes. By observing starlight wrapping around Sagittarius A*, the telescope will not only provide the first direct view of an event horizon--a black hole's point of no return--but will also enable scientists to test Einstein's theory under the most extreme conditions.Gravity's Century shows how we got from the pivotal observations of the 1919 eclipse to the Event Horizon Telescope, and what is at stake today. Breaking down the physics in clear and approachable language, Cowen makes vivid how the quest to understand gravity is really the quest to comprehend the universe.

    Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

    But it’s also messy, fallible, and about 50,000 years out of date. We cling to superstitions, remember faces but not names, miss things sitting right in front of us, and lie awake at night while our brains endlessly replay our greatest fears. Idiot Brain is for anyone who has ever wondered why their brain appears to be sabotaging their life—and what on earth it is really up to.A Library Journal Science Bestseller and a Finalist for the Goodreads Choice Award in Science Technology.

    Lara, a superstar nurse who tries to battle her way back from a near-ruinous prescription-drug addiction. The outspoken but compassionate Juliette, a fierce advocate for her patients. And Sam, a first-year nurse, struggling to find her way in a gossipy mean-girl climate she likens to “high school, except for the dying people.”The result is a riveting page-turner, insightful and thought-provoking, that will leave readers feeling smarter about their healthcare and undeniably appreciative of the incredible nurses who provide it.

    In this book, he expands the points he has made, and claims that this debate is not so much about religion versus science, as about the nature of science itself. With infectious enthusiasm, he reveals the mechanics of evolutionary theory, explains how it is rooted in the testable and verifiable scientific method, and why it is therefore a sound explanation of our beginning. He argues passionately that to continue to assert otherwise, to continue to insist that creationism has a place in the science classroom is harmful not only to our children, but to the future of the greater world as well.