But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Sergio Vieira de Mello was born in 1948, just as the post-World War II order was taking shape, and died in a terrorist attack on UN Headquarters in Iraq in 2003, just as the battle lines in the 21st century's great struggle were being drawn.

    Now the director of the Heart Failure Program at a Long Island hospital, Jauhar uses his own story as a scalpel to lay open the American health-care system.The patient is ill indeed. A perverse system forces doctors to prescribe unnecessary tests and participate in an elaborate system of cronyism just to cover costs and protect themselves from malpractice suits. Jauhar reports cases where a single patient might see fifteen specialists in one hospital stay, fail to receive a full picture of his actual condition, and leave with a bill for hundreds of thousands of dollars. Jauhar himself wrestles with his conscience as, struggling to make ends meet, he moonlights for a practitioner who charges exorbitant fees for tests of questionable value.Doctored is a cry for reform; a fascinating look at what really goes on in examining rooms, ORs, and your own doctor’s mind; and, most of all, a deeply personal and unsparing act of introspection by a physician who wants to return meaning and moral grounding to a noble profession that has lost its way. It is certain to kick off controversy and heated debate at a time when the dysfunctionalities of our health-care system remain at the top of the nation’s agenda.

    Phiona has been out of school most of her life because her mother cannot afford it, so she is only now learning to read and write. Phiona Mutesi is also one of the best chess players in the world.One day in 2005, while searching for food, nine-year-old Phiona followed her brother to a dusty veranda where she met Robert Katende, who had also grown up in the Kampala slums. Katende, a war refugee turned missionary, had an improbable dream: to empower kids through chess—a game so foreign there is no word for it in their native language. Laying a chessboard in the dirt of the Katwe slum, Robert painstakingly taught the game each day. When he left at night, slum kids played on with bottlecaps on scraps of cardboard. At first they came for a free bowl of porridge, but many grew to love chess, a game that—like their daily lives—means persevering against great obstacles. Of these kids, one stood out as an immense talent: Phiona.By the age of eleven Phiona was her country’s junior champion and at fifteen, the national champion. In September 2010, she traveled to Siberia, a rare journey out of Katwe, to compete in the Chess Olympiad, the world’s most prestigious team-chess event. Phiona’s dream is to one day become a Grandmaster, the most elite title in chess. But to reach that goal, she must grapple with everyday life in one of the world’s most unstable countries, a place where girls are taught to be mothers, not dreamers, and the threats of AIDS, kidnapping, and starvation loom over the people.Like Katherine Boo’s Behind the Beautiful Forevers and Gayle Tzemach Lemmon’s The Dressmaker of Khair Khana, The Queen of Katwe is an intimate and heartrending portrait of human life on the poor fringes of the twenty-first century.

    Dr. Manheimer describes the plights of twelve very different patients--from dignitaries at the nearby UN, to supermax prisoners at Riker's Island, to illegal immigrants, and Wall Street tycoons.Manheimer was not only the medical director of the country's oldest public hospital for over 13 years, but he was also a patient. As the book unfolds, the narrator is diagnosed with cancer, and he is forced to wrestle with the end of his own life even as he struggles to save the lives of others.

    Now cancer-free, Deanna is one of breast can

    Having studied at Yale and Dartmouth, Dr. Emily Transue arrives in Seattle to start her internship in Internal Medicine just after graduating from medical school. This series of loosely interconnected scenes from the author's medical training concludes her residency three years later.During her first week as a student on the medical wards, Dr. Transue watched someone come into the emergency room in cardiac arrest and die. Nothing like this had ever happened to her before-it was a long way from books and labs. So she began to record her experiences as she gained confidence putting her book knowledge to work.The stories focus on the patients Dr. Transue encountered in the hospital, ER and clinic; some are funny and others tragic. They range in scope from brief interactions in the clinic to prolonged relationships during hospitalization. There is a man newly diagnosed with lung cancer who is lyrical about his life on a sunny island far away, and a woman, just released from a breathing machine after nearly dying, who sits up and demands a cup of coffee.Though the book has a great deal of medical content, the focus is more on the stories of the patients' lives and illnesses and the relationships that developed between the patients and the author, and the way both parties grew in the course of these experiences.Along the way, the book describes the life of a resident physician and reflects on the way the medical system treats both its patients and doctors. On Call provides a window into the experience of patients at critical junctures in life and into the author's own experience as a new member of the medical profession.

    Americans Tsh and Kyle met and married in Kosovo. They lived as expats for most of a decade. They’ve been back in the States—now with three kids under ten—for four years, and while home is nice, they are filled with wanderlust and long to answer the call, so a trip—a nine-months-long trip—is planned.At Home in the World follows their journey from China to New Zealand, Ethiopia to England, and more. And all the while Tsh grapples with the concept of home, as she learns what it means to be lost—yet at home—in the world.

    At eight, still too small to mount her horse unaided, she was galloping miles, alone, across Coorain, her parents' thirty thousand windswept, drought-haunted acres in the Australian outback, doing a "man's job" of helping herd the sheep because World War II had taken away the able-bodied men. She loved (and makes us see and feel) the vast unpeopled landscape, beautiful and hostile, whose uncertain weathers tormented the sheep ranchers with conflicting promises of riches and inescapable disaster. She adored (and makes us know) her large-visioned father and her strong, radiant mother, who had gone willingly with him into a pioneering life of loneliness and bone-breaking toil, who seemed miraculously to succeed in creating a warmly sheltering home in the harsh outback, and who, upon her husband's sudden death when Jill was ten, began to slide—bereft of the partnership of work and love that had so utterly fulfilled her—into depression and dependency.We see Jill, staggered by the loss of her father, catapulted to what seemed another planet—the suburban Sydney of the 1950s and its crowded, noisy, cliquish school life. Then the heady excitement of the University, but with it a yet more demanding course of lessons—Jill embracing new ideas, new possibilities, while at the same time trying to be mother to her mother and resenting it, escaping into drink, pulling herself back, striking a balance. We see her slowly gaining strength, coming into her own emotionally and intellectually and beginning the joyous love affair that gave wings to her newfound self.Worlds away from Coorain, in America, Jill Conway became a historian and the first woman president of Smith College. Her story of Coorain and the road from Coorain startles by its passion and evocative power, by its understanding of the ways in which a total, deep-rooted commitment to place—or to a dream—can at once liberate and imprison. It is a story of childhood as both Eden and anguish, and of growing up as a journey toward the difficult life of the free.

    But joy often gave way to sorrow as she invested her heart fully in walking alongside people in the grip of poverty, addiction, desperation, and disease.After unexpected tragedy shook her family, for the first time Katie began to wonder, Is God really good? Does He really love us? When she turned to Him with her questions, God spoke truth to her heart and drew her even deeper into relationship with Him.Daring to Hope is an invitation to cling to the God of the impossible--the God who whispers His love to us in the quiet, in the mundane, when our prayers are not answered the way we want or the miracle doesn't come. It's about a mother discovering the extraordinary strength it takes to be ordinary. It's about choosing faith no matter the circumstance and about encountering God's goodness in the least expected places.Though your heartaches and dreams may take a different shape, you will find your own questions echoed in these pages. You'll be reminded of the gifts of joy in the midst of sorrow. And you'll hear God's whisper: Hold on to hope. I will meet you here.

    Together they began Show Hope, a nonprofit organization dedicated to caring for the world's most vulnerable children by providing financial assistance to families wishing to adopt, as well as increasing awareness of the orphan crisis and funneling resources to orphans domestically and internationally. Mary Beth serves as president of Show Hope and is a speaker for Women of Faith 2010 with her husband. She is also coauthor with Steven of the Shaoey and Dot series of children's picture books. Mary Beth and Steven have six children: Emily, Caleb, Will Franklin, and adopted daughters Shaohannah Hope, Stevey Joy, and Maria Sue, who is now with Jesus. The Chapmans live in Tennessee.www.MaryBethChapman.comEllen Vaughn is a bestselling author and inspirational speaker. Her recent books include It's All About Him with Denise Jackson (wife of Alan Jackson), which debuted at #1 on the New York Times nonfiction list. She is also coauthor with Chuck Colson of Being the Body. In addition to her nonfiction work, Vaughn is an award-winning novelist. She lives in the Washington, D.C., area with her husband, Lee.

    Imagine being thousands of miles away while your family and friends are brutally and methodically slaughtered. Imagine being entrusted by your parents with the mission of leaving everything you know and finding some way to survive, in the name of your family and your people.Scholastique Mukasonga's Cockroaches is the story of growing up a Tutsi in Hutu-dominated Rwanda--the story of a happy child, a loving family, all wiped out in the genocide of 1994. A vivid, bitterwsweet depiction of family life and bond in a time of immense hardship, it is also a story of incredible endurance, and the duty to remember that loss and those lost while somehow carrying on. Sweet, funny, wrenching, and deeply moving, Cockroaches is a window onto an unforgettable world of love, grief, and horror.

    Juniper French was born four months early, at 23 weeks' gestation. She weighed 1 pound, 4 ounces, and her twiggy body was the length of a Barbie doll. Her head was smaller than a tennis ball, her skin was nearly translucent, and through her chest you could see her flickering heart. Babies like Juniper, born at the edge of viability, trigger the question: Which is the greater act of love -- to save her, or to let her go? Kelley and Thomas French chose to fight for Juniper's life, and this is their incredible tale. In one exquisite memoir, the authors explore the border between what is possible and what is right. They marvel at the science that conceived and sustained their daughter and the love that made the difference. They probe the bond between a mother and a baby, between a husband and a wife. They trace the journey of their family from its fragile beginning to the miraculous survival of their now thriving daughter.

    Throughout her life, Elizabeth Lesser has sought understanding about what it means to be true to oneself and, at the same time, truly connected to the ones we love. But when her sister Maggie needs a bone marrow transplant to save her life, and Lesser learns that she is the perfect match, she faces a far more immediate and complex question about what it really means to love—honestly, generously, and authentically.Hoping to give Maggie the best chance possible for a successful transplant, the sisters dig deep into the marrow of their relationship to clear a path to unconditional acceptance. They leave the bone marrow transplant up to the doctors, but take on what Lesser calls a "soul marrow transplant," examining their family history, having difficult conversations, examining old assumptions, and offering forgiveness until all that is left is love for each other’s true selves. Their process—before, during, and after the transplant—encourages them to take risks of authenticity in other aspects their lives.But life does not follow the storylines we plan for it. Maggie’s body is ultimately too weak to fight the relentless illness. As she and Lesser prepare for the inevitable, they grow ever closer as their shared blood cells become a symbol of the enduring bond they share. Told with suspense and humor, Marrow is joyous and heartbreaking, incandescent and profound. The story reveals how even our most difficult experiences can offer unexpected spiritual growth. Reflecting on the multifaceted nature of love—love of other, love of self, love of the world—Marrow is an unflinching and beautiful memoir about getting to the very center of ourselves.

    It started out as a simple hike in the Utah canyonlands on a warm Saturday afternoon. For Aron Ralston, a twenty-seven-year-old mountaineer and outdoorsman, a walk into the remote Blue John Canyon was a chance to get a break from a winter of solo climbing Colorado's highest and toughest peaks. He'd earned this weekend vacation, and though he met two charming women along the way, by early afternoon he finally found himself in his element: alone, with just the beauty of the natural world all around him. It was 2:41 P.M. Eight miles from his truck, in a deep and narrow slot canyon, Aron was climbing down off a wedged boulder when the rock suddenly, and terrifyingly, came loose. Before he could get out of the way, the falling stone pinned his right hand and wrist against the canyon wall. And so began six days of hell for Aron Ralston. With scant water and little food, no jacket for the painfully cold nights, and the terrible knowledge that he'd told no one where he was headed, he found himself facing a lingering death -- trapped by an 800-pound boulder 100 feet down in the bottom of a canyon. As he eliminated his escape options one by one through the days, Aron faced the full horror of his predicament: By the time any possible search and rescue effort would begin, he'd most probably have died of dehydration, if a flash flood didn't drown him before that. What does one do in the face of almost certain death? Using the video camera from his pack, Aron began recording his grateful good-byes to his family and friends all over the country, thinking back over a life filled with adventure, and documenting a last will and testament with the hope that someone would find it. (For their part, his family and friends had instigated a major search for Aron, the amazing details of which are also documented here for the first time.) The knowledge of their love kept Aron Ralston alive, until a divine inspiration on Thursday morning solved the riddle of the boulder. Aron then committed the most extreme act imaginable to save himself. Between a Rock and a Hard Place -- a brilliantly written, funny, honest, inspiring, and downright astonishing report from the line where death meets life -- will surely take its place in the annals of classic adventure stories.