For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    It is 4 a.m. I have run arrest calls, treated life-threatening bleeding, held the hand of a young woman dying of cancer, scuttled down miles of dim corridors wanting to sob with sheer exhaustion, forgotten to eat, forgotten to drink, drawn on every fibre of strength that I possess to keep my patients safe from harm.'How does it feel to be spat out of medical school into a world of pain, loss and trauma that you feel wholly ill-equipped to handle? To be a medical novice who makes decisions which - if you get them wrong - might forever alter, or end, a person's life?In 'Your Life in My Hands', television journalist turned junior doctor Rachel Clarke captures the extraordinary realities of life on the NHS frontline. During last year's historic junior doctor strikes, Rachel was at the forefront of the campaign against the government's imposed contract upon young doctors. Her heartfelt, deeply personal account of life as a junior doctor in today's NHS is both a powerful polemic on the degradation of Britain's most vital public institution and a love letter of optimism and hope to that same health service.

    In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone. Yet, as we obsess over sterilizing our homes and separating our spaces from nature, we are unwittingly cultivating an entirely new playground for evolution. These changes are reshaping the organisms that live with us -- prompting some to become more dangerous, while undermining those species that benefit our bodies or help us keep more threatening organisms at bay. No one who reads this engrossing, revelatory book will look at their homes in the same way again.

    . . Park uses science, compassion, humor, diverse stories and examples of her own shame-free living to take the stigma out of these infections." —The New York TimesWith curiosity and wit, Strange Bedfellows rips back the bedsheets to expose what really happens when STDs enter the sack.Sexually transmitted diseases have been hidden players in our lives for the whole of human history, with roles in everything from World War II to the growth of the Internet to The Bachelor. But despite their prominence, STDs have been shrouded in mystery and taboo for centuries, which begs the question: why do we know so little about them?Enter Ina Park, MD, who has been pushing boundaries to empower and inform others about sexual health for decades. With Strange Bedfellows, she ventures far beyond the bedroom to examine the hidden role and influence of these widely misunderstood infections and share their untold stories.Covering everything from AIDS to Zika, Park explores STDs on the cellular, individual, and population-level. She blends science and storytelling with historical tales, real life sexual escapades, and interviews with leading scientists—weaving in a healthy dose of hilarity along the way.The truth is, most of us are sexually active, yet we’re often unaware of the universe of microscopic bedfellows inside our pants. Park aims to change this by bringing knowledge to the masses in an accessible, no-nonsense, humorous way—helping readers understand the broad impact STDs have on our lives, while at the same time erasing the unfair stigmas attached to them.A departure from the cone of awkward silence and shame that so often surrounds sexual health, Strange Bedfellows is the straight-shooting book about the consequences of sex that all curious readers have been looking for.

    From childhood onward, we learn how big a "portion" is and how sweet is too sweet. We learn to enjoy green vegetables -- or not. But how does this education happen? What are the origins of taste? In First Bite, award-winning food writer Bee Wilson draws on the latest research from food psychologists, neuroscientists, and nutritionists to reveal that our food habits are shaped by a whole host of factors: family and culture, memory and gender, hunger and love. Taking the reader on a journey across the globe, Wilson introduces us to people who can only eat foods of a certain color; prisoners of war whose deepest yearning is for Mom's apple pie; a nine year old anosmia sufferer who has no memory of the flavor of her mother's cooking; toddlers who will eat nothing but hotdogs and grilled cheese sandwiches; and researchers and doctors who have pioneered new and effective ways to persuade children to try new vegetables. Wilson examines why the Japanese eat so healthily, whereas the vast majority of teenage boys in Kuwait have a weight problem -- and what these facts can tell Americans about how to eat better. The way we learn to eat holds the key to why food has gone so disastrously wrong for so many people. But Wilson also shows that both adults and children have immense potential for learning new, healthy eating habits. An exploration of the extraordinary and surprising origins of our tastes and eating habits, First Bite also shows us how we can change our palates to lead healthier, happier lives.

    Forty-five million called him emperor, and he commanded a nation that was the richest, most cultured, and advanced on earth. No army could stand against his impeccably trained, brilliantly led forces, and his continued sweep across Europe seemed inevitable. Early that year, bolstered by his successes, Napoleon turned his attentions toward Moscow, helming the largest invasion in human history. Surely, Tsar Alexander’s outnumbered troops would crumble against this mighty force. But another powerful and ancient enemy awaited Napoleon’s men in the Russian steppes. Virulent and swift, this microscopic foe would bring the emperor to his knees. Even as the Russians retreated before him in disarray, Napoleon found his army disappearing, his frantic doctors powerless to explain what had struck down a hundred thousand soldiers. The emperor’s vaunted military brilliance suddenly seemed useless, and when the Russians put their own occupied capital to the torch, the campaign became a desperate race through the frozen landscape as troops continued to die by the thousands. Through it all, with tragic heroism, Napoleon’s disease-ravaged, freezing, starving men somehow rallied, again and again, to cries of “Vive l’Empereur!”Yet Talty’s sweeping tale takes us far beyond the doomed heroics and bloody clashes of the battlefield. The Illustrious Dead delves deep into the origins of the pathogen that finally ended the mighty emperor’s dreams of world conquest and exposes this “war plague’s” hidden role throughout history. A tale of two unstoppable forces meeting on the road to Moscow in an epic clash of killer microbe and peerless army, The Illustrious Dead is a historical whodunit in which a million lives hang in the balance.

    They’re detectives who solve mysteries about the human body.Diagnosing patients is about looking for clues, whether a persistent tickle in the back of the throat or confusion and memory loss. Just like detectives, good doctors sift through information until they arrive at the medical solution that fits best.Think you have what it takes to keep up with medical detective work? Find out with this second installment of Dr. Roy Benaroch’s thrilling look at medical mysteries from across history. Continuing the excitement of his earlier Audible Original, Medical Mysteries Across History, Pt.2 features cases involving ancient kings and military leaders, beloved philosophers and popular entertainers. You may know who some of these patients are - but you’ve almost certainly never heard their stories told from a doctor’s point of view.In each instance, you’ll learn about the medicine that was practiced during the patient’s life, and you’ll discover how modern medicine can shed light on the past. You’ll see how every life (and every disease) is a story and that these stories reveal the clues doctors need to make an accurate diagnosis. And you’ll discover that while a lot in medicine has certainly changed, the way doctors approach patients hasn’t changed very much at all.Think you can guess who these 10 mystery patients are? Pay attention. The medical and historical hints are there and waiting for you.©2020 Audible Originals, LLC (P)2020 Audible Originals, LLC.

    There have been other books on Dr Morell's cocktail of treatments for Hitler and Goering's reliance on drugs, but Ohler's book is the first to show how the entire Nazi regime was permeated with drugs - cocaine, heroin, morphine and methamphetamines, the last of these crucial to troops' resilience and partly explaining German victory in 1940. Ohler is explicit that drugs cannot explain Third Reich ideology, but their promiscuous use impaired and confused decision-making, with drastic effects on Hitler and his entourage, who, as the war turned against Germany, took refuge in ever more poorly understood cocktails of stimulants. This chemical euphoria changes how we should think about the Nazi high command and its ability to understand the situation it found itself in by 1944-45. As such Blitzed will force a wider reinterpretation of several key events during the Second World War.

    Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    In Will My Cat Eat My Eyeballs?, best-selling author and mortician Caitlin Doughty answers the most intriguing questions she’s ever received about what happens to our bodies when we die. In a brisk, informative, and morbidly funny style, Doughty explores everything from ancient Egyptian death rituals and the science of skeletons to flesh-eating insects and the proper depth at which to bury your pet if you want Fluffy to become a mummy. Now featuring an interview with a clinical expert on discussing these issues with young people—the source of some of our most revealing questions about death—Will My Cat Eat My Eyeballs? confronts our common fear of dying with candid, honest, and hilarious facts about what awaits the body we leave behind.

    For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony.Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.