Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    In The Woman with a Worm in Her Head, Dr. Pamela Nagami reveals-through real-life cases-the sobering facts about some of the world's most horrific diseases: the warning signs, the consequences, treatments, and most compellingly, what it feels like to make medical and ethical decisions that can mean the difference between life and death.Unfailingly precise, calmly instructive, and absolutely engrossing, The Woman with the Worm in Her Head offers both useful information and enjoyable reading.

    Original essays by leading researchers such as Christof Koch, George Church, Olaf Sporns, and May-Britt and Edvard Moser describe the spectacular technological advances that will enable us to map the more than eighty-five billion neurons in the brain, as well as the challenges that lie ahead in understanding the anticipated deluge of data and the prospects for building working simulations of the human brain. A must-read for anyone trying to understand ambitious new research programs such as the Obama administration's BRAIN Initiative and the European Union's Human Brain Project, The Future of the Brain sheds light on the breathtaking implications of brain science for medicine, psychiatry, and even human consciousness itself.Contributors include: Misha Ahrens, Ned Block, Matteo Carandini, George Church, John Donoghue, Chris Eliasmith, Simon Fisher, Mike Hawrylycz, Sean Hill, Christof Koch, Leah Krubitzer, Michel Maharbiz, Kevin Mitchell, Edvard Moser, May-Britt Moser, David Poeppel, Krishna Shenoy, Olaf Sporns, Anthony Zador.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    And we know that another global disaster is eventually headed our way. Can we survive it? How?As a species, Homo sapiens is at a crossroads. Study of our planet’s turbulent past suggests that we are overdue for a catastrophic disaster, whether caused by nature or by human interference.It’s a frightening prospect, as each of the Earth’s past major disasters—from meteor strikes to bombardment by cosmic radiation—resulted in a mass extinction, where more than 75 percent of the planet’s species died out. But in Scatter, Adapt, and Remember, Annalee Newitz, science journalist and editor of the science Web site io9.com explains that although global disaster is all but inevitable, our chances of long-term species survival are better than ever. Life on Earth has come close to annihilation—humans have, more than once, narrowly avoided extinction just during the last million years—but every single time a few creatures survived, evolving to adapt to the harshest of conditions.      This brilliantly speculative work of popular science focuses on humanity’s long history of dodging the bullet, as well as on new threats that we may face in years to come. Most important, it explores how scientific breakthroughs today will help us avoid disasters tomorrow. From simulating tsunamis to studying central Turkey’s ancient underground cities; from cultivating cyanobacteria for “living cities” to designing space elevators to make space colonies cost-effective; from using math to stop pandemics to studying the remarkable survival strategies of gray whales, scientists and researchers the world over are discovering the keys to long-term resilience and learning how humans can choose life over death.     Newitz’s remarkable and fascinating journey through the science of mass extinctions is a powerful argument about human ingenuity and our ability to change. In a world populated by doomsday preppers and media commentators obsessively forecasting our demise, Scatter, Adapt, and Remember is a compelling voice of hope. It leads us away from apocalyptic thinking into a future where we live to build a better world—on this planet and perhaps on others. Readers of this book will be equipped scientifically, intellectually, and emotionally to face whatever the future holds.

    As he did so masterfully in Prime Obsession, Derbyshire brings the evolution of mathematical thinking to dramatic life by focusing on the key historical players. Unknown Quantity begins in the time of Abraham and Isaac and moves from Abel's proof to the higher levels of abstraction developed by Galois through modern-day advances. Derbyshire explains how a simple turn of thought from this plus this equals this to this plus what equals this? gave birth to a whole new way of perceiving the world. With a historian's narrative authority and a beloved teacher's clarity and passion, Derbyshire leads readers on an intellectually satisfying and pleasantly challenging historical and mathematical journey.

    In Tales from the Underground, Cornell ecologist David Wolfe takes us on a tour through current scientific knowledge of the subterranean world. We follow the progress of discovery from Charles Darwin's experiments with earthworms, to Lewis and Clark's first encounter with prairie dogs, to the use of new genetic tools that are revealing an astonishingly rich ecosystem beneath our feet. Wolfe plunges us deep into the earth's rocky crust, where life may have begun-a world devoid of oxygen and light but safe from asteroid bombardment. Primitive microbes found there are turning our notion of the evolutionary tree of life on its head: amazingly, they represent perhaps a full third of earth's genetic diversity. As Wolfe explains, creatures of the soil can work for us, by providing important pharmaceuticals and recycling the essential elements of life, or against us, by spreading disease and contributing to global climate change. The future of our species may well depend on how we manage our living soil resources. Tales from the Underground will forever alter our appreciation of the natural world around-and beneath-us.

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    Her twenty- five-year career conducting experiments that involve rats has led her to a surprising conclusion: Through their adaptive strategies and good habits, these unassuming little animals can teach us some essential lessons about how we, as humans, can lead successful lives. From emotional resilience and a strong work ethic to effective parenting and staying healthy, the lab rat is an unlikely but powerful role model for us all. This is a surprising and engaging guided tour into the sophisticated mental, emotional, and behavioral worlds of these frequently maligned and often misunderstood little creatures.

    lifelike detail... this easily readable book should appeal to dinosaur enthusiasts of all ages." -Science NewsThe Complete Guide to Prehistoric Life. The book's concise, jargon-free text and full color illustrations bring the primordial world to vivid photo-realistic life. In-depth profiles of 112 kinds of beasts cover physical characteristics, lifestyle, habitat and behavior. Throughout, "fascinating fact" sidebars offer additional bits of "dinotrivia." But there is more than dinosaurs here. Readers will find creatures from triobites to early human beings. At the heart of the book are 350 richly detailed and lifelike color illustrations -- accompanied by comprehensive text -- which are the result of pioneering work by the Emmy award-winning creative team at Framestore CFC. Using animation, graphic effects and filmmaking, they recreated awe-inspiring prehistoric creatures and the world they lived in. These images are now reproduced to thrill readers.The Complete Guide to Prehistoric Life was published to accompany two BBC TV prime-time programs, Life Before Dinosaurs and Walking with Life, both part of the Discovery Channel's award-winning Walking with Dinosaurs series.

    He is as passionate about swamps, bogs, and vernal ponds and the creatures who live in them as most of us are about our families and closest friends. He knows frogs and snakes, muskrats and minks, dragonflies, water lilies, cattails, sedges--everything that swims, flies, trudges, slithers, or sinks its roots in wet places. In this "intimate and wise book" (Sue Hubbell), Carroll takes us on a lively, unforgettable yearlong journey, illustrated with his own elegant drawings, through the wetlands and reveals why they are so important to his life and ours -- and to all life on Earth.

    Here he tackles all the "big questions," including the biggest of them all: Why does the universe seem so well adapted for life? In his characteristically clear and elegant style, Davies shows how recent scientific discoveries point to a perplexing fact: many different aspects of the cosmos, from the properties of the humble carbon atom to the speed of light, seem tailor-made to produce life. A radical new theory says it's because our universe is just one of an infinite number of universes, each one slightly different. Our universe is bio-friendly by accident -- we just happened to win the cosmic jackpot. While this "multiverse" theory is compelling, it has bizarre implications, such as the existence of infinite copies of each of us and Matrix-like simulated universes. And it still leaves a lot unexplained. Davies believes there's a more satisfying solution to the problem of existence: the observations we make today could help shape the nature of reality in the remote past. If this is true, then life -- and, ultimately, consciousness -- aren't just incidental byproducts of nature, but central players in the evolution of the universe. Whether he's elucidating dark matter or dark energy, M-theory or the multiverse, Davies brings the leading edge of science into sharp focus, provoking us to think about the cosmos and our place within it in new and thrilling ways.

    The pages take the reader on a wild narrative ride through the world of squid science and adventure, along the way addressing some riddles about what intelligence is, and what monsters lie in the deep. In addition to squid, both giant and otherwise, Kraken examines other equally enthralling cephalopods, including the octopus and the cuttlefish, and explores their otherworldly abilities, such as camouflage and bioluminescence. Accessible and entertaining, Kraken is also the first substantial volume on the subject in more than a decade and a must for fans of popular science.

    The lion was not always king. From antiquity to the Middle Ages, the bear's centrality in cults and mythologies left traces in European languages, literatures, and legends from the Slavic East to Celtic Britain. Historian Michel Pastoureau considers how this once venerated creature was deposed by the advent of Christianity and continued to sink lower in the symbolic bestiary before rising again in Pyrrhic triumph as a popular toy.The early Church was threatened by pagan legends of the bear's power, among them a widespread belief that male bears were sexually attracted to women and would violate them, producing half-bear, half-human beings--invincible warriors who founded royal lines. Marked for death by the clergy, bears were massacred. During the Renaissance, the demonic prestige bears had been assigned in biblical allegory was lost to the goat, ass, bat, and owl, who were the devil's new familiars, while the lion was crowned as the symbol of nobility. Once the undefeated champions of the Roman arena, prized in princely menageries, bears became entertainers in the marketplace, trained to perform humiliating tricks or muzzled and devoured by packs of dogs for the amusement of humans. By the early twentieth century, however, the bear would return from exile, making its way into the hearts of children everywhere as the teddy bear.This compelling history reminds us that men and bears have always been inseparable, united by a kinship that gradually moved from nature to culture--a bond that continues to this day.