Millennia ago, when we first began puzzling over the mysteries of the human body, one organ stood out as vital. The heart was warm, it was central, and it moved as it pumped blood. The ancient Egyptians treated it with reverence, mummifying it separately from the body so that the soul inside it could be weighed. Aristotle believed that it was the seat of consciousness. Over the centuries, science has dispelled the myths, but our fascination with the heart has endured.     From the origins of circulation, still evident in some microorganisms today, to the enormous hearts of blue whales, we journey with Bill to beaches where horseshoe crabs are being harvested for their life-saving blood, and under the sea to learn about the world’s most natural antifreeze, flowing through the veins of icefish. And we follow him through human history, too, as scientists hypothesize wrongly and rightly about what is arguably our most important organ, ultimately developing the technologies that have helped us study the heart—and now, in the most cutting-edge labs, the tools that will help us regenerate it.   Deeply researched and engagingly told, Pump is a fascinating natural history sure to be loved by readers of Mary Roach and Bill Bryson.

    Sapolsky's storytelling concept is delightful but it also has a powerful intrinsic logic: he starts by looking at the factors that bear on a person's reaction in the precise moment a behavior occurs, and then hops back in time from there, in stages, ultimately ending up at the deep history of our species and its evolutionary legacy.And so the first category of explanation is the neurobiological one. A behavior occurs--whether an example of humans at our best, worst, or somewhere in between. What went on in a person's brain a second before the behavior happened? Then Sapolsky pulls out to a slightly larger field of vision, a little earlier in time: What sight, sound, or smell caused the nervous system to produce that behavior? And then, what hormones acted hours to days earlier to change how responsive that individual is to the stimuli that triggered the nervous system? By now he has increased our field of vision so that we are thinking about neurobiology and the sensory world of our environment and endocrinology in trying to explain what happened.Sapolsky keeps going: How was that behavior influenced by structural changes in the nervous system over the preceding months, by that person's adolescence, childhood, fetal life, and then back to his or her genetic makeup? Finally, he expands the view to encompass factors larger than one individual. How did culture shape that individual's group, what ecological factors millennia old formed that culture? And on and on, back to evolutionary factors millions of years old.The result is one of the most dazzling tours d'horizon of the science of human behavior ever attempted, a majestic synthesis that harvests cutting-edge research across a range of disciplines to provide a subtle and nuanced perspective on why we ultimately do the things we do...for good and for ill. Sapolsky builds on this understanding to wrestle with some of our deepest and thorniest questions relating to tribalism and xenophobia, hierarchy and competition, morality and free will, and war and peace. Wise, humane, often very funny, Behave is a towering achievement, powerfully humanizing, and downright heroic in its own right.

    The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    the real Hugh Hefner BOY GEORGE Tony created the concept of the boutique hotel. PAUL OAKENFOLD Roguish and very appealing. I like ebullient, charming characters. GRACE JONES I found extraordinary peace at Pikes, and Tony Pike is the best host... the number one ! JOAN BAEZ There's no place like Pikes. You arrive... then a few days later you come round again without fully knowing quite what happened... but you know it was great. KYLE SIMMONS (BASTILLE) I have never seen a man so happy in a leopard skin thong as Tony ! SHIRLEY KEMP (WHAM) Thanks for a fab time, Tony FREDDIE MERCURY

    No understanding of Western civilization is possible without it. Inevitably, Left-wing academics want to introduce gender studies and race theory to the field—and punish those who refuse to conform. When one University of Chicago professor dared to publicly celebrate the Christian identity of the Middle Ages, she was branded a ‘violent fascist’ and ‘white supremacist’ by her colleagues. Now Medieval Studies scholars are tearing their own discipline apart with witch-hunts, name-calling, boycotts and intimidation. The damage done to academia could be incalculable. In this influential essay, originally published to widespread online acclaim, New York Times-bestselling author and award-winning journalist Milo Yiannopoulos explains why we should all care about the newest front in the cultural war, the academic battle for the Middle Ages.

    The complete story of the actor's career, including his secret gay life. Raymond Burr (1917-1993) was an enigma. A film noir star regularly known for his villainous roles in movies like Rear Window, he delighted millions of viewers each week with the top-rated shows Perry Mason and Ironside, which ran virtually uninterrupted for 20 years. But Burr was leading a secret gay life at a time in Hollywood when such a lifestyle was akin to career suicide. He invented a tragic biography for himself in which he was mythologized as a heartbroken husband and father. There was even an invented affair with a teenage Natalie Wood, 21 years his junior. He fought for truth as Perry Mason and Robert T. Ironside, yet he couldn't admit his own deception. Burr met his partner, struggling actor Robert Benevides, on the set of Perry Mason, and they remained together for over 35 years until Burr's death. Together, they built a business empire, traveled the world, and shared their passion for orchids and fine wine keeping the true nature of their relationship a secret from all but their closest friends a secret revealed here for the first time in depth.

    We have all benefited from the medical discoveries of primate research--vaccines for polio, rubella, and hepatitis B are just a few. But we have also learned more in recent years about how intelligent apes and monkeys really are: they can speak to us with sign language, they can even play video games (and are as obsessed with the games as any human teenager). And activists have also uncovered widespread and unnecessarily callous treatment of animals by researchers (in 1982, a Silver Spring lab was charged with 17 counts of animal cruelty). It is a complex issue, made more difficult by the combative stance of both researchers and animal activists. In The Monkey Wars, Deborah Blum gives a human face to this often caustic debate--and an all-but-human face to the subjects of the struggle, the chimpanzees and monkeys themselves. Blum criss-crosses America to show us first hand the issues and personalities involved. She offers a wide-ranging, informative look at animal rights activists, now numbering some twelve million, from the moderate Animal Welfare Institute to the highly radical Animal Liberation Front (a group destructive enough to be placed on the FBI's terrorist list). And she interviews a wide variety of researchers, many forced to conduct their work protected by barbed wire and alarm systems, men and women for whom death threats and hate mail are common. She takes us to Roger Fouts's research center in Ellensburg, Washington, where we meet five chimpanzees trained in human sign language, and we visit LEMSIP, a research facility in New York State that has no barbed wire, no alarms--and no protesters chanting outside--because its director, Jan Moor-Jankowski, listens to activists with respect and treats his animals humanely. And along the way, Blum offers us insights into the many side-issues involved: the intense battle to win over school kids fought by both sides, and the danger of transplanting animal organs into humans. As it stands now, Blum concludes, the research community and its activist critics are like two different nations, nations locked in a long, bitter, seemingly intractable political standoff....But if you listen hard, there really are people on both sides willing to accept and work within the complex middle. When they can be freely heard, then we will have progressed to another place, beyond this time of hostilities. In The Monkey Wars, Deborah Blum gives these people their voice.

    Readers will find excerpts from bestsellers such as Douglas R. Hofstadter's Gödel, Escher, Bach, Francis Crick's Life Itself, Loren Eiseley's The Immense Journey, Daniel Dennett's Darwin's Dangerous Idea, and Rachel Carson's The Sea Around Us. There are classic essays ranging from J.B.S. Haldane's "On Being the Right Size" and Garrett Hardin's "The Tragedy of the Commons" to Alan Turing's "Computing Machinery and Intelligence" and Albert Einstein's famed New York Times article on "Relativity." And readers will also discover lesser-known but engaging pieces such as Lewis Thomas's "Seven Wonders of Science," J. Robert Oppenheimer on "War and Physicists," and Freeman Dyson's memoir of studying under Hans Bethe.A must-read volume for all science buffs, The Oxford Book of Modern Science Writing is a rich and vibrant anthology that captures the poetry and excitement of scientific thought and discovery.One of New Scientist's Editor's Picks for 2008.

    Letters. Postcards. Photographs. Each memento plays a role in the secret story that's always in her thoughts. A story that can't remain hidden forever.When Orla is handed an envelope by her father, she is perplexed by what she finds - a photograph of her parents, taken the summer she was born. Her heavily expectant mother, unusually, is smiling. Between her parents stands a teenage boy, her mother's arm lovingly around him.Orla later asks her father about the boy's identity, but he refuses to be drawn. Her mother's mood is low again and he doesn't want her upset. So begins the daughter's investigation, back to the summer of 1983, and the story of a young English boy on holidays in rural Ireland. As the circle closes on a web of tragedy and deceit, the truth that emerges will impact on all their lives. The Boy Between is an expertly crafted, suspenseful and ultimately hopeful story of family secrets, a fateful summer, and the long-buried events of a distant past.

    Now in paperback for the first time, this captivating memoir covers the first twenty-five years of an inspiring life, including these historic moments: Gruber's unprecedented academic career, which reached its zenith in 1932, when at twenty she became the world's youngest Ph.D. as a visiting American student at Cologne University, her return to Nazi Germany in 1935, and the rallies she attended where Hitler inveighed against "international Jews" like her; and her first stint as a foreign correspondent, when she became the only journalist to report from the Soviet Arctic, traveled in open cockpit seaplanes, met utopians who extolled Stalin's system, and gulag inmates who told her the bitter truth about his terrible schemes. Gruber writes with warmth, compassion, and humor, offering a life story that will be long remembered by all history lovers, adventurers, and women and men of all ages.

    Most conservationists and environmentalists share this view. But what if the traditional view of ecology is wrong—what if true environmentalists should be applauding the invaders? In The New Wild, Pearce goes on a journey across six continents to rediscover what conservation in the twenty-first century should be about. Pearce explores ecosystems from remote Pacific islands to the United Kingdom, from San Francisco Bay to the Great Lakes, as he digs into questionable estimates of the cost of invader species and reveals the outdated intellectual sources of our ideas about the balance of nature. Pearce acknowledges that there are horror stories about alien species disrupting ecosystems, but most of the time, the tens of thousands of introduced species usually swiftly die out or settle down and become model eco-citizens. The case for keeping out alien species, he finds, looks increasingly flawed. As Pearce argues, mainstream environmentalists are right that we need a rewilding of the earth, but they are wrong if they imagine that we can achieve that by reengineering ecosystems. Humans have changed the planet too much, and nature never goes backward. But a growing group of scientists is taking a fresh look at how species interact in the wild. According to these new ecologists, we should applaud the dynamism of alien species and the novel ecosystems they create. In an era of climate change and widespread ecological damage, it is absolutely crucial that we find ways to help nature regenerate. Embracing the new ecology, Pearce shows us, is our best chance. To be an environmentalist in the twenty-first century means celebrating nature’s wildness and capacity for change.

    Yet it is also one of the most puzzling, with an intriguing and sometimes violent history, from the sixth century BCE to the present day. Destroyed by Vesuvius in 79 CE, the ruins of Pompeii offer the best evidence we have of life in the Roman Empire. But the eruptions are only part of the story. In The Fires of Vesuvius, acclaimed historian Mary Beard makes sense of the remains. She explores what kind of town it was--more like Calcutta or the Costa del Sol?--and what it can tell us about ordinary life there. From sex to politics, food to religion, slavery to literacy, Beard offers us the big picture even as she takes us close enough to the past to smell the bad breath and see the intestinal tapeworms of the inhabitants of the lost city. She resurrects the Temple of Isis as a testament to ancient multiculturalism. At the Suburban Baths we go from communal bathing to hygiene to erotica. Recently, Pompeii has been a focus of pleasure and loss: from Pink Floyd's memorable rock concert to Primo Levi's elegy on the victims. But Pompeii still does not give up its secrets quite as easily as it may seem. This book shows us how much more and less there is to Pompeii than a city frozen in time as it went about its business on 24 August 79.

    By deliberately avoiding the hindsight knowledge that he will lose the Battle of Bosworth Field, this book presents a new Richard—no passive victim, awaiting defeat and death, but a king actively pursuing his own policies and agenda. It also reexamines the aftermath of Bosworth—the treatment of Richard’s body, his burial, and the construction of his tomb. Based on newly discovered evidence and wider insights it explores the motives underlying these events. And there is the fascinating story of why and how Richard III’s DNA was rediscovered, alive and well, and living in Canada. This is a stimulating and thought-provoking account of the end of Richard’s life—even readers very familiar with his short life will discover a new and fascinating picture of him.

    His usurpation of the throne from his nephew Edward V and then subsequent generations of pro-Tudor historians ensured his fame as the disfigured murderer portrayed by Shakespeare. In the twentieth century, Richard found his apologists, those who saw him as more sinned against than sinning. This biography—by the leading expert on Richard—strips away the propaganda of the centuries to rescue Richard from his critics and supporters alike, providing a balanced and compelling portrait of this most infamous of kings.

     Marvel at the thief who steals electrical wires without shutting off the current. Gape at the lawnchair jockey who floats to a height of 16,000 feet suspended by helium balloons. Learn from the man who peers into a gasoline can using a cigarette lighter. All three -- and many more -- contend for Darwin Awards when their choices culminate in magnificent misadventures. These tales of trial and awe-inspiring error--verified by the author and endorsed by website readers--illustrate the ongoing saga of survival of the fittest in all its selective glory.