Incorporating biological, medicinal, and environmental applications, it builts an art program. Highlighting the art program are micro-to-macro art pieces that visually guide students to conceptually understand organic chemistry.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Cameron Webb’s brief but biting assault on the wide spectrum of religiosity that dominates 21st century America, from the hateful and anti-intellectual dogma of the Christian Right to the whitewashed progressivism of religious moderates. It is also a fascinating and humbling journey into the heart of the universe's most mind-numbing wonders.Drawing on recent insights from cosmology and evolution, Despicable Meme paints a vivid portrait of a cosmos unlike anything ever imagined by the provincial, human-centered faiths of the past – a universe of countless worlds spread across unfathomable distances and times, and where, on at least one of those worlds, the slow march of time would combine with the purposeless mechanisms of chemistry and physics to create a being capable of believing that he alone is the reason for it all.With piercing intelligence and candor, Despicable Meme exposes the folly of that conceit and dispenses with the widespread but utterly improbable notion of a personal creator. But it saves its harshest criticism for the vapid accommodationism of religious liberals, those who unknowingly or uncaringly give cover to the misogynistic, racist, homophobic paranoia of the fanatics by refusing to condemn, or quietly tolerating, the outlandish and immoral doctrines that lie festering at the center of their own “moderate” faiths.Despicable Meme is not only a blistering condemnation of radical fundamentalism, it is an impassioned appeal to the rest of us to once and for all abandon the superstitions of the religion we were raised in and embrace the beauty of an endlessly wondrous, but godless, universe.Show less

    Admittedly real life wasn’t like that. But only, they argued, because we didn’t have enough data to be certain.Then the cracks began to appear. It proved impossible to predict exactly how three planets orbiting each other would move. Meteorologists discovered that the weather was truly chaotic – so dependent on small variations that it could never be predicted for more than a few days out. And the final nail in the coffin was quantum theory, showing that everything in the universe has probability at its heart.That gives human beings a problem. We understand the world through patterns. Randomness and probability will always be alien to us. But it’s time to plunge into this fascinating, shadowy world, because randomness crops up everywhere. Probability and statistics are the only way to get a grip on nature’s workings. They may even seal the fate of free will and predict how the universe will end.Forget Newton’s clockwork universe. Welcome to Dice World.

    In this unconventional introduction, physicist Leonard Susskind and hacker-scientist George Hrabovsky offer a first course in physics and associated math for the ardent amateur. Unlike most popular physics books—which give readers a taste of what physicists know but shy away from equations or math—Susskind and Hrabovsky actually teach the skills you need to do physics, beginning with classical mechanics, yourself. Based on Susskind's enormously popular Stanford University-based (and YouTube-featured) continuing-education course, the authors cover the minimum—the theoretical minimum of the title—that readers need to master to study more advanced topics.An alternative to the conventional go-to-college method, The Theoretical Minimum provides a tool kit for amateur scientists to learn physics at their own pace.

    But Max Leonard, himself an accomplished amateur cyclist, does not forget the pain, the glory, the sweat, and the tears that go into these grueling climbs.  After all, cycling up a mountain is hard.  So hard that, to many, it can seem absurd. But for others, climbing a mountain gracefully (and beating your competitors up the slope) represents the pinnacle of cycling achievement. It is where legends are forged.Many books tell you where the mountains are, or how long and how high. None of them ask why. Why are mountain ranges professional cycling’s Coliseum? Why do amateurs also make pilgrimages to these high, remote roads? Why are the roads even there in the first place to lure us on to these obsession inducing climbs?   Just why are mountains so enthralling? “This is real cycling, where the glory is and where dreams come true,” according to Bradley Wiggins. Mountains are where cycling's greatest heroes have made their names. Every amateur rider wishes they could climb better, too.  Are all these people addicted to the pain? To the achievement? Or to the allure of the peaks? Some spend their weekends and holidays cycling up mountains from start to finish. But how does a rider push themselves beyond their limits to get up a 10% gradient on pedal power alone? What is happening when they do?A Higher Calling explores the central place of mountains in the folklore of road cycling. Blending adventure and travel writing with the rich narrative of racing, Max Leonard takes the reader from the battles that created the Alpine roads to the shepherds tending their flocks on the peaks, and to a Grand Tour climax on the “highest road in Europe.” And he tells stories of courage and sacrifice, war and love, obsession and even elephants, along the way.

    They wanted to discover how the world worked, but they also wanted credit for making those discoveries, and their personalities often affected how that credit was assigned. Gilbert Lewis, for example, could be reclusive and resentful, and his enmity with Walther Nernst may have cost him the Nobel Prize; Irving Langmuir, gregarious and charming, rediscovered Lewis's theory of the chemical bond andreceived much of the credit for it. Langmuir's personality smoothed his path to the Nobel Prize over Lewis.Coffey deals with moral and societal issues as well. These same scientists were the first to be seen by their countries as military assets. Fritz Haber, dubbed the father of chemical warfare, pioneered the use of poison gas in World War I-vividly described-and Glenn Seaborg and Harold Urey wereleaders in World War II's Manhattan Project; Urey and Linus Pauling worked for nuclear disarmament after the war. Science was not always fair, and many were excluded. The Nazis pushed Jewish scientists like Haber from their posts in the 1930s. Anti-Semitism was also a force in American chemistry, and few women were allowed in; Pauling, for example, used his influence to cut off the funding and block the publications of his rival, Dorothy Wrinch.Cathedrals of Science paints a colorful portrait of the building of modern chemistry from the late 19th to the mid-20th century.

    - This is the best kind of popular science: informed, impassioned, and highly accessible.- Compare it to Stephen Hawking's The Universe in a Nutshell, but broader in scope and much more readable.- A crossover for the Young Adult market, now in the perfect format.

    This essay by Copernicus (1473-1543), revolutionized the way we look at the earth's placement in the universe, and paved the way for many great scientists, including Galileo and Isaac Newton, whose theories stemmed from this model. Featuring a biography of Copernicus and an accessible, enlightening introduction, both written by the renowned physicist Stephen Hawking, On the Revolution of Heavenly Spheres provides a fascinating look at the theories which shaped our modern understanding of astronomy and physics.

    This is Nick's story of his world record-breaking adventure and the extraordinary people who joined him along the way. On January 6th 2018, Nick Butter tied his laces and stepped out on to an icy pavement in Toronto, where he began to take the first steps of an epic journey that would see him run 196 marathons in every one of the world's 196 countries. Spending almost two years on the road and relying on the kindness of strangers to keep him moving, Nick's odyssey allowed him to travel slowly, on foot, immersing himself in the diverse cultures and customs of his host nations. Running through capital cities and deserts, around islands and through spectacular landscapes, Nick dodges bullets in Guinea-Bissau, crosses battlefields in Syria, survives a wild dog attack in Tunisia and runs around an erupting volcano in Guatemala. Along the way, he is often joined by local supporters and fellow runners, curious children and bemused passers-by. Telling their stories alongside his own, Nick captures the unique spirit of each place he visits and forges a new relationship with the world around him. Running the World captures Nick's journey as he sets three world records and covers over five thousand miles. As he recounts his adventures, he shares his unique perspective on our glorious planet, celebrates the diversity of human experience, and reflects on the overwhelming power of running.

    More than 500 solved Examples to make concepter very clear. Exhautive Exercises for Each topic.

    

    Czerski provides the tools to alter the way we see everything around us by linking ordinary objects and occurrences, like popcorn popping, coffee stains, and fridge magnets, to big ideas like climate change, the energy crisis, or innovative medical testing. She provides answers to vexing questions: How do ducks keep their feet warm when walking on ice? Why does it take so long for ketchup to come out of a bottle? Why does milk, when added to tea, look like billowing storm clouds? In an engaging voice at once warm and witty, Czerski shares her stunning breadth of knowledge to lift the veil of familiarity from the ordinary.

    His conception of the universe pervades Christian theology. Knowledge of his thought is necessary to understand Bacon, Galileo, and the modern scientific view of nature, as well as Dante and many passages from Chaucer, Shakespeare, and Milton. Many phrases such as liberal education and theory contrasted with practice originated with this student of Plato and tutor of Alexander the Great.Writing to inform the beginner and stimulate the expert, eminent scholar A. E. Taylor presents a searching analysis of Aristotle's thought, including classification of the sciences; formal logic; theory of knowledge; matter and form; the four causes; God; physics; biology; sensation; ethics; theory of the state; and the fine arts. He also considers Aristotle's provincialism, errors regarding the nervous system and astronomy, and defense of slavery.The Giants of Philosophy is a series of dramatic presentations, in understandable language, of the concerns, questions, interests, and overall world view of history's greatest philosophers. Special emphasis on clear and relevant explanations gives you a new arsenal of insights toward living a better life.

    But, Alex Bellos says, "math can be inspiring and brilliantly creative. Mathematical thought is one of the great achievements of the human race, and arguably the foundation of all human progress. The world of mathematics is a remarkable place."Bellos has traveled all around the globe and has plunged into history to uncover fascinating stories of mathematical achievement, from the breakthroughs of Euclid, the greatest mathematician of all time, to the creations of the Zen master of origami, one of the hottest areas of mathematical work today. Taking us into the wilds of the Amazon, he tells the story of a tribe there who can count only to five and reports on the latest findings about the math instinct--including the revelation that ants can actually count how many steps they've taken. Journeying to the Bay of Bengal, he interviews a Hindu sage about the brilliant mathematical insights of the Buddha, while in Japan he visits the godfather of Sudoku and introduces the brainteasing delights of mathematical games.Exploring the mysteries of randomness, he explains why it is impossible for our iPods to truly randomly select songs. In probing the many intrigues of that most beloved of numbers, pi, he visits with two brothers so obsessed with the elusive number that they built a supercomputer in their Manhattan apartment to study it. Throughout, the journey is enhanced with a wealth of intriguing illustrations, such as of the clever puzzles known as tangrams and the crochet creation of an American math professor who suddenly realized one day that she could knit a representation of higher dimensional space that no one had been able to visualize. Whether writing about how algebra solved Swedish traffic problems, visiting the Mental Calculation World Cup to disclose the secrets of lightning calculation, or exploring the links between pineapples and beautiful teeth, Bellos is a wonderfully engaging guide who never fails to delight even as he edifies. "Here's Looking at Euclid "is a rare gem that brings the beauty of math to life.