Bill Gates, Bono, and Laura Bush are only a few of the personalities who have lent their names--and opened their pocketbooks--in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren't we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we've known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them? In "The Fever," the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, "The Fever" captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.

    In The Ends of the World, Peter Brannen dives into deep time, exploring Earth’s past dead ends, and in the process, offers us a glimpse of our possible future.Many scientists now believe that the climate shifts of the twenty-first century have analogs in these five extinctions. Using the visible clues these devastations have left behind in the fossil record, The Ends of the World takes us inside “scenes of the crime,” from South Africa to the New York Palisades, to tell the story of each extinction. Brannen examines the fossil record—which is rife with creatures like dragonflies the size of sea gulls and guillotine-mouthed fish—and introduces us to the researchers on the front lines who, using the forensic tools of modern science, are piecing together what really happened at the crime scenes of the Earth’s biggest whodunits.Part road trip, part history, and part cautionary tale, The Ends of the World takes us on a tour of the ways that our planet has clawed itself back from the grave, and casts our future in a completely new light.

    Regarded as the world’s first geneticist, Mendel overcame poverty and obscurity to discover one of the fundamental aspects of genetic science: animals, plants, and people all inherit and pass down traits through the same process, following the same rules. Living the slow-paced, contemplative life of a friar, Gregor Mendel was able to conceive and put into practice his great experiment: growing multiple generations of peas. From observing yellow peas, green peas, smooth peas, and wrinkled peas, Mendel crafted his theory of heredity—years before scientists had any notion of genes. Children will be inspired by Gregor’s neverending search for knowledge, and his famous experiments are easy to understand as an introduction to genetics. F&P level: Q

    Curious about what had prompted a young urban artist to suddenly embrace nature she decided to follow him for a year to find out.Observing two artists through seasonal shifts and migrations, Birds Art Life celebrates the particular madness of chasing after birds in a big city, and explores what happens when the principles of birdwatching are applied to other aspects of art and life. It looks at the ecology of urban spaces and the creative and liberating effects of keeping your eyes and ears wide open. Far from seeking the exotic, Kyo discovers joy in the birds she spots in city parks and harbours, along eaves and on wires. In a world that values big and fast, Kyo begins to look to the small, steady, slow accumulations of knowledge, and the lulls that give way to contemplation.Moving between the granular and the grand, peering into the inner landscape as much as the outer one, Birds Art Life asks how we are shaped and nurtured by our passions, and how we might come to love and protect not only the world’s natural places but also the challenging urban spaces where so many of us live.

    Clark's clear-eyed sympathy for Hughes, his lover Assia Wevill, and other demonized players in the arena of Plath's suicide promotes a deeper understanding of her final days, with their outpouring of first-rate poems. Along with illuminating readings of the poems themselves, Clark's meticulous, compassionate research brings us closer than ever to the spirited woman and visionary artist who blazed a trail that still lights the way for women poets the world over.

    In an era when women were rarely permitted any serious schooling, this twenty-seven-year-old’s nimble conversation and unusual brilliance led Voltaire, then in his late thirties, to wonder, “Why did you only reach me so late?” They fell immediately and passionately in love.Through the prism of their tumultuous fifteen-year relationship we see the crumbling of an ancient social order and the birth of the Enlightenment. Together the two lovers rebuilt a dilapidated and isolated rural chateau at Cirey where they conducted scientific experiments, entertained many of the leading thinkers of the burgeoning scientific revolution, and developed radical ideas about the monarchy, the nature of free will, the subordination of women, and the separation of church and state. But their time together was filled with far more than reading and intellectual conversation. There were frantic gallopings across France, sword fights in front of besieged German fortresses, and a deadly burning of Voltaire’s books by the public executioner at the base of the grand stairwell of the Palais de Justice in Paris. The pair survived court intrigues at Versailles, narrow escapes from agents of the king, a covert mission to the idyllic lakeside retreat of Frederick the Great of Prussia, forays to the royal gambling tables (where Emilie put her mathematical acumen to lucrative use), and intense affairs that bent but did not break their bond.Along with its riveting portrait of Voltaire as a vulnerable romantic, Passionate Minds at last does justice to the supremely unconventional life and remarkable achievements of Emilie du Châtelet—including her work on the science of fire and the nature of light. Long overlooked, her story tells us much about women’s lives at the time of the Enlightenment. Equally important, it demonstrates how this graceful, quick-witted, and attractive woman worked out the concepts that would lead directly to the “squared” part of Einstein’s revolutionary equation: E=mc2.Based on a rich array of personal letters, as well as writings from houseguests, neighbors, scientists, and even police reports, Passionate Minds is both panoramic and intimate in feeling. It is an unforgettable love story and a vivid rendering of the birth of modern ideas.

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Darwin wondered why these birds were confined to remote islands at the tip of South America, sensing a larger story, but he set this mystery aside and never returned to it. Almost two hundred years later, Jonathan Meiburg takes up this chase. He takes us through South America, from the fog-bound coasts of Tierra del Fuego to the tropical forests of Guyana, in search of these birds: striated caracaras, which still exist, though they're very rare. He reveals the wild, fascinating story of their history, origins, and possible futures. And along the way, he draws us into the life and work of William Henry Hudson, the Victorian writer and naturalist who championed caracaras as an unsung wonder of the natural world, and to falconry parks in the English countryside, where captive caracaras perform incredible feats of memory and problem-solving. A Most Remarkable Creature is a hybrid of science writing, travelogue, and biography, as generous and accessible as it is sophisticated, and absolutely riveting.

    It’s so bound up with our deepest feelings that emotional trauma causes it to change shape.Practising cardiologist Sandeep Jauhar beautifully weaves his own experiences with the defining discoveries of the past to tell the story of our most vital organ. He looks at some of the pioneers who risked their careers and their patients’ lives to better understand the heart. People like Daniel Hale Williams, who performed the world’s first documented heart surgery, and Wilson Greatbatch, who accidentally invented the pacemaker.Amid gripping scenes from the operating theatre, Jauhar interweaves stories about the patients he’s treated with the moving tale of his family’s own history of heart problems, from his grandfather’s sudden death in India – an event that sparked his life-long obsession – to the ominous signs of how he himself might die.He also confronts the limits of medical technology and argues that future progress will be determined more by how we choose to live rather than by any device we invent.

    As head of the Los Alamos Laboratory, he oversaw the successful effort to beat the Nazis in the race to develop the first atomic bomb—a breakthrough that was to have eternal ramifications for mankind and that made Oppenheimer the “Father of the Atomic Bomb.” But with his actions leading up to that great achievement, he also set himself on a dangerous collision course with Senator Joseph McCarthy and his witch-hunters. In Robert Oppenheimer: A Life Inside the Center, Ray Monk, author of peerless biographies of Ludwig Wittgenstein and Bertrand Russell, goes deeper than any previous biographer in the quest to solve the enigma of Oppenheimer’s motivations and his complex personality.      The son of German-Jewish immigrants, Oppenheimer was a man of phenomenal intellectual attributes, driven by an ambition to overcome his status as an outsider and penetrate the heart of political and social life. As a young scientist, his talent and drive allowed him to enter a community peopled by the great names of twentieth-century physics—men such as Niels Bohr, Max Born, Paul Dirac, and Albert Einstein—and to play a role in the laboratories and classrooms where the world was being changed forever, where the secrets of the universe, whether within atomic nuclei or collapsing stars, revealed themselves.     But Oppenheimer’s path went beyond one of assimilation, scientific success, and world fame. The implications of the discoveries at Los Alamos weighed heavily upon this fragile and complicated man. In the 1930s, in a climate already thick with paranoia and espionage, he made suspicious connections, and in the wake of the Allied victory, his attempts to resist the escalation of the Cold War arms race led many to question his loyalties.     Through compassionate investigation and with towering scholarship, Ray Monk’s Robert Oppenheimer tells an unforgettable story of discovery, secrecy, impossible choices, and unimaginable destruction.

    At her death in 1817, Jane Austen left the world six of the most beloved novels written in English—but her shortsighted family destroyed the bulk of her letters; and if she kept any diaries, they did not survive her.  Now acclaimed biographer Claire Tomalin has filled the gaps in the record, creating a remarkably fresh and convincing portrait of the woman and the writer. While most Austen biographers have accepted the assertion of Jane's brother Henry that "My dear Sister's life was not a life of events," Tomalin shows that, on the contrary, Austen's brief life was fraught with upheaval.  Tomalin provides detailed and absorbing accounts of Austen's ill-fated love for a young Irishman, her frequent travels and extended visits to London, her close friendship with a worldly cousin whose French husband met his death on the guillotine, her brothers' naval service in the Napoleonic wars and in the colonies, and thus shatters the myth of Jane Austen as a sheltered and homebound spinster whose knowledge of the world was limited to the view from a Hampshire village.

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.