In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    And as outbreaks of COVID-19, Ebola, MERS, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza or coronavirus pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.

    That edition was on the cutting edge of what was then known about the origins and nature of the universe. But the intervening years have seen extraordinary advances in the technology of observing both the micro- and the macrocosmic worlds. These observations have confirmed many of Professor Hawking's theoretical predictions in the first edition of his book, including the recent discoveries of the Cosmic Background Explorer satellite (COBE), which probed back in time to within 300,000 years of the universe's beginning and revealed wrinkles in the fabric of space-time that he had projected. Eager to bring to his original text the new knowledge revealed by these observations, as well as his own recent research, Professor Hawking has prepared a new introduction to the book, written an entirely new chapter on wormholes and time travel, and updated the chapters throughout.

    From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, the history of disease is the history of humankind. With the identification of AIDS in the early 1980s, another chapter has been added to this chronicle of events, which William McNeill explores in his new introduction to this updated editon.Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening. "A brilliantly conceptualized and challenging achievement" (Kirkus Reviews), it is essential reading, offering a new perspective on human history.

    Told by a geologist with a novelist's sense of language and narrative, Sand examines the science—sand forensics, the physics of granular materials, sedimentology, paleontology and archaeology, planetary exploration—and at the same time explores the rich human context of sand. Interwoven with tales of artists, mathematicians, explorers, and even a vampire, the story of sand is an epic of environmental construction and destruction, an adventure in staggering scales of time and distance, yet a tale that encompasses the ordinary and everyday. Sand, in fact, is all around us—it has made possible our computers, buildings and windows, toothpaste, cosmetics, and paper, and it has played dramatic roles in human history, commerce, and imagination. In this luminous, kinetic, revelatory account, we do indeed find the world in a grain of sand.

    Readers of "The New Yorker" may be familiar with the author's suspenseful tales of strange illnesses, rare diseases, poisons and parasites.

    Otto’s subjects include the pioneering dentist who made Shirley Temple and Judy Garland’s teeth sparkle on the silver screen and helped create the all-American image of “pearly whites”; Deamonte Driver, the young Maryland boy whose tragic death from an abscessed tooth sparked congressional hearings; and a marketing guru who offers advice to dentists on how to push new and expensive treatments and how to keep Medicaid patients at bay.In one of its most disturbing findings, Teeth reveals that toothaches are not an occasional inconvenience, but rather a chronic reality for millions of people, including disproportionate numbers of the elderly and people of color. Many people, Otto reveals, resort to prayer to counteract the uniquely devastating effects of dental pain.Otto also goes back in time to understand the roots of our predicament in the history of dentistry, showing how it became separated from mainstream medicine, despite a century of growing evidence that oral health and general bodily health are closely related.Muckraking and paradigm-shifting, Teeth exposes for the first time the extent and meaning of our oral health crisis. It joins the small shelf of books that change the way we view society and ourselves—and will spark an urgent conversation about why our teeth matter.This is an alternate cover edition of ISBN 9781620971444.

    Forced to remain inside until they'd "proven" themselves sane, all eight emerged with alarming diagnoses and even more troubling stories of their treatment. Rosenhan's study broke open the field of psychiatry, closing down institutions and changing mental health diagnosis forever. But, as Cahalan's new research shows, very little in this saga is exactly as it seems. What really happened behind those closed asylum doors, and what does it mean for our understanding of mental illness today?

    In addition to offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its effects, she suggests concrete steps we can take to cure it.

    She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.

    It is too bad, write scientist-historian couple Robert and Michèle Root-Bernstein, who deplore the loss of proven methods developed without the blessing of the academy, noting that "formal academic systems are only one of many ways in which knowledge is discovered, accumulated, and transmitted." Many scientists are now coming to agree with this view, they write in this fascinating collection of case studies. Researchers have showed that black tea, for instance, has powerful antibiotic properties and that maggots do an extraordinary job of cleaning wounds--as traditional healers have known all along.

    This new edition includes an all-embracing and incisive afterword that examines the current state of health care and our relationship with life as it approaches its terminus. It also discusses how we can take control of our own final days and those of our loved ones.Shewin Nuland's masterful How We Die is even more relevant than when it was first published.

    A contemporary of Luther, an enemy of the medical establishment, a scourge of the universities, an alchemist, an army surgeon, and a radical theologian, he attracted myths even before he died. His fantastic journeys across Europe and beyond were said to be made on a magical white horse, and he was rumored to carry the elixir of life in the pommel of his great broadsword. His name was linked with Faust, who bargained with the devil.Who was the man behind these stories? Some have accused him of being a charlatan, a windbag who filled his books with wild speculations and invented words. Others claim him as the father of modern medicine. Philip Ball exposes a more complex truth in The Devil's Doctor—one that emerges only by entering into Paracelsus’s time. He explores the intellectual, political, and religious undercurrents of the sixteenth century and looks at how doctors really practiced, at how people traveled, and at how wars were fought. For Paracelsus was a product of an age of change and strife, of renaissance and reformation. And yet by uniting the diverse disciplines of medicine, biology, and alchemy, he assisted, almost in spite of himself, in the birth of science and the emergence of the age of rationalism.

    The science of element discovery is a truly fascinating field, and is constantly rewriting the laws of chemistry and physics as we know them. Superheavy is the first book to take an in-depth look at how synthetic elements are discovered, why they matter and where they will take us. From the Cold War nuclear race to the present day, scientists have stretched the periodic table to 118 elements. They have broken the rules of the periodic table, rewriting the science we're taught in school, and have the potential to revolutionize our lives.Kit Chapman takes us back to the very beginning, with the creation of the atomic bomb. He tells the story of the major players, such as Ernest Lawrence who revolutionized the field of particle physics with the creation of the cyclotron; Yuri Oganessian, the guerilla scientist who opened up a new era of discovery in the field and is the only living scientists to have an element named after him; and Victor Ninov, the disgraced physicist who almost pulled off the greatest fraud in nuclear science. This book will bring us in a full circle back to Oak Ridge National Laboratory, where the first atomic bomb was developed, and that has more recently been an essential player in creating the new superheavy element 117.Throughout, Superheavy explains the complex science of element discovery in clear and easy-to-follow terms. It walks through the theories of atomic structure, discusses the equipment used and explains the purpose of the research. By the end of the book readers will not only marvel at how far we've come, they will be in awe of where we are going and what this could mean for the worlds of physics and chemistry as we know them today.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.