This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    In fact, your body is actually endowed with many self-defense measures to hold on to fat. For example, fat can use stem cells to regenerate; increase our appetite if it feels threatened; and use bacteria, genetics, and viruses to expand itself. The secret to losing twenty pounds? You have to work with your fat, not against it. Tara explains how your fat influences your appetite and willpower, how it defends itself when attacked, and why it grows back so quickly. The Secret Life of Fat brings cutting-edge research together with historical perspectives to reveal fat’s true identity: an endocrine organ that, in the right amount, is critical to our health. Fat triggers puberty, enables our reproductive and immune systems, and even affects brain size.Although we spend $60 billion annually fighting fat, our efforts are often misinformed and misdirected. Tara expertly illustrates the complex role that genetics, hormones, diet, exercise, and history play in our weight, and The Secret Life of Fat sets you on the path to beat the bulge once and for all.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

     Although one in five Americans now takes at least one psychotropic drug, the fact remains that nearly seventy years after doctors first began prescribing them, we still don't know exactly how or why these drugs work--or don't work--on what ails our brains. Blue Dreams offers the explosive story of the discovery, invention, people, and science behind our licensed narcotics, as told by a riveting writer and psychologist who shares her own intimate experience with the highs and lows of psychiatry's drugs. Lauren Slater's account ranges from the earliest, Thorazine and lithium, up through Prozac and other antidepressants, as well as Ecstasy, "magic mushrooms," the most cutting-edge memory drugs, and even neural implants. Along the way, she narrates the history of psychiatry itself, illuminating the imprint its colorful little capsules have left on millions of brains worldwide, and demonstrating how these wonder drugs may heal us or hurt us.

    In the same down-to-earth, friendly tone that makes her videos so popular, licensed marriage and family therapist and YouTube sensation Kati Morton clarifies and destigmatizes the struggles so many of us go through and encourages readers to reach out for help.

    In late 2004, leading Western scientists joined the Dalai Lama at his home in Dharamsala, India, to address this very question–and in the process brought about a revolution in our understanding of the human mind. In this fascinating and far-reaching book, Wall Street Journal science writer Sharon Begley reports on how cutting-edge science and the ancient wisdom of Buddhism have come together to show how we all have the power to literally change our brains by changing our minds. These findings hold exciting implications for personal transformation.For decades, the conventional wisdom of neuroscience held that the hardware of the brain is fixed and immutable–that we are stuck with what we were born with. As Begley shows, however, recent pioneering experiments in neuroplasticity, a new science that investigates whether and how the brain can undergo wholesale change, reveal that the brain is capable not only of altering its structure but also of generating new neurons, even into old age. The brain can adapt, heal, renew itself after trauma, and compensate for disability. Begley documents how this fundamental paradigm shift is transforming both our understanding of the human mind and our approach to deep-seated emotional, cognitive, and behavioral problems. These breakthroughs show that it is possible to reset our happiness meter, regain the use of limbs disabled by stroke, train the mind to break cycles of depression and OCD, and reverse age-related changes in the brain. They also suggest that it is possible to teach and learn compassion, a key step in the Dalai Lama’s quest for a more peaceful world. But as we learn from studies performed on Buddhist monks, an important component in changing the brain is to tap the power of mind and, in particular, focused attention. This is the classic Buddhist practice of mindfulness, a technique that has become popular in the West and that is immediately available to everyone. With her extraordinary gift for making science accessible, meaningful, and compelling, Sharon Begley illuminates a profound shift in our understanding of how the brain and the mind interact. This tremendously hopeful book takes us to the leading edge of a revolution in what it means to be human.

    They speak their own language, they abide by their own rules, and they seem to exist to drive adults crazy. But adolescence is a typical stage of human development that is the essential preparation for success in the adult world. The more you understand about your teen’s brain, the better prepared you will be to handle this turbulent time in your child’s life.Professor Abigail Baird has devoted the majority of her career to studying adolescence, and in this Audible Original, she shares the latest perspectives on this amazing time of cognitive and behavioral growth. The 10 lectures in this series will reveal that adolescent behavior is much easier to understand than most people think. Rather than seeing the teen years as a crucible to be endured by parents and young people alike, this series offers a practical perspective for adults who hope to help teens truly thrive in their personal journeys to adulthood—not merely to survive their adolescence.Whether you are a parent, someone who works with teens, or even a teen yourself, this course will shed new light on a period of human development that is all too often incorrectly described as a time where psychological peril is inevitable.

    A successful journalist and mother to four children, she had spent her whole life feeling as if she were running a different operating system to those around her. This book charts a year in her life and offers a unique insight into the autistic mind and the journey from diagnosis to acceptance. Drawing on personal experience, research and conversations with experts, she learns how 'different' doesn't need to mean 'less' and how it's never too late for any of us to find our place in the world. Laura explores how and why female autism is so under-diagnosed and very different to that seen in men and boys and explores difficulties and benefits neurodiversity can bring.

    From Zoroastrian sky burials to wish-granting Bolivian skulls, she investigates the world’s funerary customs and expands our sense of what it means to treat the dead with dignity. Her account questions the rituals of the American funeral industry—especially chemical embalming—and suggests that the most effective traditions are those that allow mourners to personally attend to the body of the deceased. Exquisitely illustrated by artist Landis Blair, From Here to Eternity is an adventure into the morbid unknown, a fascinating tour through the unique ways people everywhere confront mortality.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    In her work for New York, The Baffler, The New York Times Magazine, and The Atlantic, as well as in her advice column for The Cut, "Ask Polly," she dispenses a singular, cutting wisdom--an ability to inspire, provoke, and put a name to our most insidious cultural delusions.What If This Were Enough? is a mantra and a clarion call. In its chapters--many of them original to the book, others expanded from their initial publication--Havrilesky takes on those cultural forces that shape us. From the enforced cheer of American life to the celebration of survivalism, from the allure of materialism to our misunderstandings of romance and success, Havrilesky deconstructs some of the most poisonous and misleading messages we ingest today, all the while suggesting new ways we might navigate our increasingly bewildering world.Through her incisive and witty inquiries, Havrilesky emphasizes the importance of locating the miraculous within the mundane. In these timely, provocative, and often hilarious chapters, she urges readers to embrace the flawed--to connect with what already is, who we already are, what we already have. She asks us to consider: What if this were enough? Our salvation, Havrilesky asserts, can be found right here, right now, in this imperfect moment.The smile factory --The happiest place on earth --To infinity and beyond --Playing house --Delusion at the gastropub --Adults only --Stuffed --Running on empty --Lost treasure --Land of heroic villains --The popularity contest --Tag and release --Haunted --Bravado --Survival fantasies --True romance --A scourge of gurus --My mother's house --Miracle of the mundane

    Yalom describes his patients' struggles -- as well as his own -- to come to terms with the two great challenges of existence: how to have a meaningful life yet reckon with its inevitable end. We meet a nurse who must stifle the pain of losing her son in order to comfort her patients' pains, a newly minted psychologist whose studies damage her treasured memories of a lost friend, and a man whose rejection of psychological inquiry forces even Yalom himself into a crisis of confidence. Creatures of a Day is a radically honest statement about the difficulties of human life, but also a celebration of some of the finest fruits -- love, family, friendship -- it can offer. Marcus Aurelius has written that "we are all creatures of a day." With Yalom as our guide, we will find the means to make our own day not only bearable, but also meaningful and joyful.

    With humor and insight, Melissa Mohr takes readers on a journey to discover how "swearing" has come to include both testifying with your hand on the Bible and calling someone a *#$&!* when they cut you off on the highway. She explores obscenities in ancient Rome and unearths the history of religious oaths in the Middle Ages, when swearing (or not swearing) an oath was often a matter of life and death. Holy Sh*t also explains the advancement of civility and corresponding censorship of language in the 18th century, considers the rise of racial slurs after World War II, examines the physiological effects of swearing and answers a question that preoccupies the FCC, the US Senate, and anyone who has recently overheard little kids at a playground: are we swearing more now than people did in the past?A gem of lexicography and cultural history, Holy Sh*t is a serious exploration of obscenity.

    By digging into the data, Oster found that much of the conventional pregnancy wisdom was wrong. In CRIBSHEET, she now tackles an even great challenge: decision making in the early years of parenting. As any new parent knows, there is an abundance of often-conflicting advice hurled at you from doctors, family, friends, and the internet. From the earliest days, parents get the message that they must make certain choices around feeding, sleep, and schedule or all will be lost. There's a rule--or three--for everything. But the benefits of these choices can be overstated, and the tradeoffs can be profound. How do you make your own best decision?