Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    Our sense of its age was vague and vastly off the mark, and much of the knowledge of our own species’ history was a set of fantastic myths and fairy tales. In the tradition of The Microbe Hunters and Gods, Graves, and Scholars, Sean Carroll leads a rousing voyage that recounts the most important discoveries in two centuries of natural history: from Darwin’s trip around the world to Charles Walcott’s discovery of pre-Cambrian life in the Grand Canyon; from Louis and Mary Leakey’s investigation of our deepest past in East Africa to the trailblazers in modern laboratories who have located a time clock in our DNA.

    This book gives a lucid, exciting, and accessible account of the surprising and counterintuitive ideas that shape our understanding of the sub-atomic world. It does not disguise the problems of interpretation that still remain unsettled 75 years after the initial discoveries. The main text makes no use of equations, but there is a Mathematical Appendix for those desiring stronger fare. Uncertainty, probabilistic physics, complementarity, the problematic character of measurement, and decoherence are among the many topics discussed. This volume offers the reader access to one of the greatest discoveries in the history of physics and one of the outstanding intellectual achievements of the twentieth century.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    How did the table fork acquire a fourth tine?  What advantage does the Phillips-head screw have over its single-grooved predecessor? Why does the paper clip look the way it does? What makes Scotch tape Scotch?   In this delightful book Henry Petroski takes a microscopic look at artifacts that most of us count on but rarely contemplate, including such icons of the everyday as pins, Post-its, and fast-food "clamshell" containers.  At the same time, he offers a convincing new theory of technological innovation as a response to the perceived failures of existing products—suggesting that irritation, and not necessity, is the mother of invention.

    But Shep Doeleman and a global coalition of scientists are on the cusp of doing just that.With exclusive access to the team, journalist Seth Fletcher spent five years following Shep and an extraordinary cast of characters as they assembled the Event Horizon Telescope, a virtual radio observatory the size of the Earth. He witnessed their struggles, setbacks, and breakthroughs, and along the way, he explored the latest thinking on the most profound questions about black holes. Do they represent a limit to our ability to understand reality? Or will they reveal the clues that lead to the long-sought Theory of Everything?Fletcher transforms astrophysics into something exciting, accessible, and immediate, taking us on an incredible adventure to better understand the complexity of our galaxy, the boundaries of human perception and knowledge, and how the messy human endeavor of science really works.Weaving a compelling narrative account of human ingenuity with excursions into cutting-edge science, Einstein’s Shadow is a tale of great minds on a mission to change the way we understand our universe—and our place in it.

    Nature’s many innovations—some uncannily perfect—call for natural principles that accelerate life’s ability to innovate.”Darwin’s theory of natural selection explains how useful adaptations are preserved over time. But the biggest mystery about evolution eluded him. As genetics pioneer Hugo de Vries put it, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest.”Can random mutations over a mere 3.8 billion years really be responsible for wings, eyeballs, knees, camouflage, lactose digestion, photosynthesis, and the rest of nature’s creative marvels? And if the answer is no, what is the mechanism that explains evolution’s speed and efficiency?In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over fifteen years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.Consider the Arctic cod, a fish that lives and thrives within six degrees of the North Pole, in waters that regularly fall below 0 degrees. At that temperature, the internal fluids of most organisms turn into ice crystals. And yet, the arctic cod survives by producing proteins that lower the freezing temperature of its body fluids, much like antifreeze does for a car’s engine coolant. The invention of those proteins is an archetypal example of nature’s enormous powers of creativity. Meticulously researched, carefully argued, evocatively written, and full of fascinating examples from the animal kingdom, Arrival of the Fittest offers up the final puzzle piece in the mystery of life’s rich diversity.

     This innovative history proves once and for all that the roots of modern science were established centuries, and in some instances millennia, before the births of Copernicus, Galileo, and Newton. In this enlightening, entertaining, and important book, Teresi describes many discoveries from all over the non-Western world -- Sumeria, Babylon, Egypt, India, China, Africa, Arab nations, the Americas, and the Pacific islands -- that equaled and often surpassed Greek and European learning in the fields of mathematics, astronomy, cosmology, physics, geology, chemistry, and technology. The first extensive and authoritative multicultural history of science written for a popular audience, Lost Discoveries fills a critical void in our scientific, cultural, and intellectual history and is destined to become a classic in its field.

    The passage of nine days, which is how long a drop of water typically stays in Earth's atmosphere, is something we can easily grasp. But spans of hundreds of years--the time a molecule of carbon dioxide resides in the atmosphere--approach the limits of our comprehension. Our everyday lives are shaped by processes that vastly predate us, and our habits will in turn have consequences that will outlast us by generations. Timefulness reveals how knowing the rhythms of Earth's deep past and conceiving of time as a geologist does can give us the perspective we need for a more sustainable future.Marcia Bjornerud shows how geologists chart the planet's past, explaining how we can determine the pace of solid Earth processes such as mountain building and erosion and comparing them with the more unstable rhythms of the oceans and atmosphere. These overlapping rates of change in the Earth system--some fast, some slow--demand a poly-temporal worldview, one that Bjornerud calls "timefulness." She explains why timefulness is vital in the Anthropocene, this human epoch of accelerating planetary change, and proposes sensible solutions for building a more time-literate society.This compelling book presents a new way of thinking about our place in time, enabling us to make decisions on multigenerational timescales. The lifespan of Earth may seem unfathomable compared to the brevity of human existence, but this view of time denies our deep roots in Earth's history--and the magnitude of our effects on the planet.

    It is a ‘ must’ book for those in every branch of science . . . in addition, economists, politicians, statesmen, and businessmen cannot afford to overlook cybernetics and its tremendous, even terrifying implications. "It is a beautifully written book, lucid, direct, and despite its complexity, as readable by the layman as the trained scientist." -- John B. Thurston, "The Saturday Review of Literature" Acclaimed one of the "seminal books . . . comparable in ultimate importance to . . . Galileo or Malthus or Rousseau or Mill," "Cybernetics" was judged by twenty-seven historians, economists, educators, and philosophers to be one of those books published during the "past four decades", which may have a substantial impact on public thought and action in the years ahead." -- Saturday Review

    Far less well-known is a much greater catastrophe that took place at the end of the Permian period 251 million years ago: 90 percent of life was destroyed, including saber-toothed reptiles and their rhinoceros-sized prey on land, as well as vast numbers of fish and other species in the sea.This book documents not only what happened during this gigantic mass extinction but also the recent rekindling of the idea of catastrophism. Was the end-Permian event caused by the impact of a huge meteorite or comet, or by prolonged volcanic eruption in Siberia? The evidence has been accumulating through the 1990s and into the new millennium, and Michael Benton gives his verdict at the very end. From field camps in Greenland and Russia to the laboratory bench, When Life Nearly Died involves geologists, paleontologists, environmental modelers, geochemists, astronomers, and experts on biodiversity and conservation. Their working methods are vividly described and explained, and the current disputes are revealed. The implications of our understanding of crises in the past for the current biodiversity crisis are also presented in detail. 46 b/w illustrations.

    Deep down, a human brain is a chaotic seething soup of particles, on a higher level it is a jungle of neurons, and on a yet higher level it is a network of abstractions that we call "symbols." The most central and complex symbol in your brain or mine is the one we both call "I." The "I" is the nexus in our brain where the levels feed back into each other and flip causality upside down, with symbols seeming to have free will and to have gained the paradoxical ability to push particles around, rather than the reverse. For each human being, this "I" seems to be the realest thing in the world. But how can such a mysterious abstraction be real--or is our "I" merely a convenient fiction? Does an "I" exert genuine power over the particles in our brain, or is it helplessly pushed around by the all-powerful laws of physics? These are the mysteries tackled in I Am a Strange Loop, Douglas R. Hofstadter's first book-length journey into philosophy since Godel, Escher, Bach. Compulsively readable and endlessly thought-provoking, this is the book Hofstadter's many readers have long been waiting for.

    And with good reason. Our biology is set up to work in partnership with the sun. From our sleep cycles to our immune systems and our mental health, access to sunlight is crucial for living a happy and fulfilling life. New research suggests that our sun exposure over a lifetime - even before we were born - may shape our risk of developing a range of different illnesses, from depression to diabetes. Bursting with cutting-edge science and eye-opening advice, Chasing the Sun explores the extraordinary significance of sunlight - from ancient solstice celebrations to modern sleep labs, and from the unexpected health benefits of sun exposure to what the Amish know about sleep that the rest of us don't. As more of us move into light-polluted cities, spending our days in dim offices and our evenings watching brightly lit screens, we are in danger of losing something vital: our connection to the star that gave us life. It's a loss that could have far-reaching consequences that we're only just beginning to grasp.

    Yet unlike Einstein, with whom he formed a warm and abiding friendship, Gödel has long escaped all but the most casual scrutiny of his life.Stephen Budiansky’s Journey to the Edge of Reason is the first biography to fully draw upon Gödel’s voluminous letters and writings—including a never-before-transcribed shorthand diary of his most intimate thoughts—to explore Gödel’s profound intellectual friendships, his moving relationship with his mother, his troubled yet devoted marriage, and the debilitating bouts of paranoia that ultimately took his life. It also offers an intimate portrait of the scientific and intellectual circles in prewar Vienna, a haunting account of Gödel’s and Jewish intellectuals’ flight from Austria and Germany at the start of the Second World War, and a vivid re-creation of the early days of Princeton’s Institute for Advanced Study, where Gödel and Einstein both worked.Eloquent and insightful, Journey to the Edge of Reason is a fully realized portrait of the odd, brilliant, and tormented man who has been called the greatest logician since Aristotle, and illuminates the far-reaching implications of Gödel’s revolutionary ideas for philosophy, mathematics, artificial intelligence, and man’s place in the cosmos.