From the woman suffering from "painful foot and moving toe syndrome" to the Indiana farmer who contacted a variant of mad cow disease from his herds of livestock, Klawans deduced a great deal from his patients, not only about the immediate causes of their ailments, but about the evolutionary underpinnings of their behavior.

    They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization, ' it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Daviesexplores the profound and fascinating impacts of our newfound knowledge.

     Ever wondered what modified starch is and why it's in so much of the food we buy? What do instant mash and freeze-dried coffee have in common? What's the real truth behind the five-second rule? And as the world population grows and the pressure on agriculture to produce more cost-effective and sustainable products increases, what could the future hold for both farmers and consumers?From mindboggling microbiology to ingenious food processing techniques and gadgets, The Science of Food takes a look at the details that matter when it comes to what we eat and how we cook, and lays bare the science behind how it all works. By understanding the chemistry, physics and biology of the food we cook, buy and prepare, we can all become better consumers and happier cooks!

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    When solving problems, it’s easy to get caught up in the complexities whilst ignoring the obvious, simple solutions. Atul Gawande suggests that every business sector can take some tips from the commercial aviation industry’s emphasis on checklists: "Avoidable failures are common and persistent, not to mention demoralizing and frustrating, across many fields… the volume and complexity of what we know has exceeded our individual ability to deliver its benefits correctly, safely, or reliably. Knowledge has both saved us and burdened us. That means we need a different strategy for overcoming failure… And there is such a strategy – though it will seem almost ridiculous in its simplicity. It is a checklist."Atul Gawande has case studies in both arenas to demonstrate its brilliant commonsense. We have developed such sophisticated, complex systems, that we cannot prevent error by memory alone. Despite the growth of superspecialisation, steps are sometimes missed, which demonstrates that problems often exist not because of a lack of knowledge, but just because routine can create complacency. One especially compelling case is the construction industry, which by using checklists has reduced building failures to 0.00002 percent: given such statistics, why would any business not follow suit?

    The Other Brain is the story of glia, which make up approximately 85 percent of the cells in the brain. Long neglected as little more than cerebral packing material ("glia" means glue), glia are sparking a revolution in brain science.Glia are completely different from neurons, the brain cells that we are familiar with. Scientists are discovering that glia have their own communication network, which operates in parallel to the more familiar communication among neurons. Glia provide the insulation for the neurons, and glia even regulate the flow of information between neurons.But it is the potential breakthroughs for medical science that are the most exciting frontier in glia research today. Diseases such as brain cancer and multiple sclerosis are caused by diseased glia. Glia are now believed to play an important role in such psychiatric illnesses as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson's and Alzheimer's. They are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. Scientists have discovered that glia repair the brain and spinal cord after injury and stroke. The more we learn about these cells that make up the "other" brain, the more important they seem to be.Written by a neuroscientist who is a leader in the research to reveal the secrets of these brain cells, The Other Brain offers a firsthand account of science in action. It takes us into the laboratories where important discoveries are being made, and it explains how scientists are learning that glial cells come in different types, with different capabilities. It tells the story of glia research from its origins to the most recent discoveries and gives readers a much more complete understanding of how the brain works and where the next breakthroughs in brain science and medicine are likely to come.

    In 2005, Maimonides Hospital in Brooklyn, New York, unveiled a new state-of-theart, multimillion-dollar cancer center. Determined to understand the whole spectrum of factors that determine what kind of medical care people receive in this country, bestselling author Julie Salamon spent one year tracking the progress of the center and getting to know the characters who make the hospital run. Located in a community where sixty-seven different languages are spoken, Maimonides is a case study for the particular kinds of concerns that arise in institutions that serve an increasingly multicultural American demographic. Granted an astonishing “warts and all” level of access by the hospital higher-ups, Salamon followed the doctors, patients, administrators, nurses, ambulance drivers, cooks, and cleaning staff. She explored not just the action on the ground—what happens between doctors and patients—but also the financial, ethical, technological, sociological, and cultural matters that the hospital community encounters every day. Drawing on her skills as interviewer, observer, and social critic, Salamon presents the story of modern medicine, uniquely viewed from the vantage point of those who make it run. She draws out the internal and external political machinations that exist between doctors and staff as well as between hospital and community. And she grounds the science and emotion of medical drama in the financial realities of operating a huge, private institution that must contend with issues like adapting to the specific needs of immigrant groups that make up a large and growing portion of our society. Salamon exposes struggles of both the profound and humdrum variety. There are bitter internal feuds, warm personal connections, comedy, egoism, greed, love, and loss. There are rabbinic edicts to contend with as well as imams and herbalists and local politicians. There are system foul-ups that keep blood test results from being delivered on time, careless record keepers, shortages of everything except forms to fill, recalcitrant and greedy insurance reimbursement systems, and the surprising difficulty of getting doctors to wash their hands. This is the dynamic universe of small and large concerns and personalities that, taken together, determine the nature of our care and assume the utmost importance. As Martin Payson—chairman of the board at Maimonides and ex-Time-Warner vice chairman—puts it: “Hospitals have a lot in common with the movie business. You’ve got your talent, entrepreneurs, ambition, ego stroking, the business versus the creative part. The big difference is that in the hospital you don’t get second takes. Movies are make-believe. This is real life.”

    Too bad. Because medicine isn't an industry, it's practically witchcraft. Despite the growth of big pharma, HMOs, and hospital chains, medicine remains the isolated work of individual doctors—and the system is going broke fast.So why is Andy Kessler—the man who told you outrageous stories of Wall Street analysts gone bad in Wall Street Meat and tales from inside a hedge fund in Running Money—poking around medicine for the next big wave of technology?It's because he smells change coming. Heart attacks, strokes, and cancer are a huge chunk of medical spending, yet there's surprisingly little effort to detect disease before it's life threatening. How lame is that—especially since the technology exists today to create computer-generated maps of your heart and colon?Because it's too expensive—for now. But Silicon Valley has turned computing, telecom, finance, music, and media upside down by taking expensive new technologies and making them ridiculously cheap. So why not the $1.8 trillion health care business, where the easiest way to save money is to stop folks from getting sick in the first place?Join Kessler's bizarre search for the next big breakthrough as he tries to keep from passing out while following cardiologists around, cracks jokes while reading mammograms, and watches twitching mice get injected with radioactive probes. Looking for a breakthrough, Kessler even selflessly pokes, scans, and prods himself.CT scans of your heart will identify problems before you have a heart attack or stroke; a nanochip will search your blood for cancer cells--five years before they grow uncontrollably and kill you; and baby boomers can breathe a little easier because it's all starting to happen now.Your doctor can't be certain what's going on inside your body, but technology will. Embedding the knowledge of doctors in silicon will bring a breakout technology to health care, and we will soon see an end of medicine as we know it.

    DSM-5 Insanely Simplified provides a summary of key concepts of the new diagnostic schema including a section on the upcoming ICD-10. DSM-5 Insanely Simplified utilizes a variety of devices to help clinicians memorize complex criteria and ideas about the different diagnoses. Cartoons, mnemonic devices, and summary tables allow clinicians and students to quickly grasp and retain broad concepts and subtle nuances related to psychiatric diagnosis. DSM-5 Insanely Simplified fosters quick mastery of the most important concepts introduced in DSM-5 while offering an entirely new way of looking at mental health along a continuum. This new approach avoids simply "labeling" clients by placing them along spectrums that range from normal to problematic symptoms. Mental health professionals as well as laymen interested in a deeper understanding of emotional well-being will appreciate the synthesis of deep psychology and modern approaches to diagnosis. Steven Buser trained in medicine at Duke University and served 12 years as a physician in the US Air Force. He is a graduate of the two-year Clinical Training Program at the CG Jung Institute of Chicago and is a co-founder of the Asheville Jung Center. In addition to a busy psychiatric private practice he serves as Publisher for Chiron Publications. He is active in the community and strives to integrate faith and spirituality into psychotherapy. He resides in the mountains in Asheville, NC with his wife and two children. Len Cruz is the Editor-in-Chief of Chiron Publications, a book publishing company specializing in psychology, mythology, religion, and culture and a co-founder of the Asheville Jung Center. He is a psychiatrist who resides in Western North Carolina. Luke Sloan was a 5th grade student in Asheville, NC when he completed the illustrations for this book. When he's not drawing, Luke enjoys playing soccer, reading books, snow-skiing, and just plain having fun!

    It covers treatment of common diseases as well as other medical, therapeutic and patient related issues. Written by both pharmacists and clinicians to reflect a team approach, it offers an in-depth analysis of drug therapy in the treatment of disease, relying on input from the pharmacist as a member of the team in hospital and community settings. Information is easy to locate in a logical format organized primarily by systems and disorders.A logical organization and format for each chapter provides consistent features including key points, epidemiology, aetiology, disease, clinical manifestations, investigations and treatment, drugs used in treatment.Convenient tables and boxes highlight supplementary information in the text such as risk factors and dietary guidelines.All chapters close with an evidence-based practice box and case studies that solidify applications of chapter content.More up-to-date information is provided on: rational antibiotic prescribing and the institution of policies; advances in therapy for chronic renal failure and transplants; changes in asthma treatment; and new drugs for epilepsy and Parkinson's.The neurology section has been expanded to include a new chapter on multiple sclerosis, dementia and Alzheimer's disease, and treatment.More information has been added related to infertility treatment and menopause.New two-color illustrations make the text more readable and accessible.A greater emphasis on treatment of the patient rather than the diagnosis reflects a shift in focus toward patient-centered care.

     Free History BONUS Inside! The Black Death was the first recorded pandemic in Europe after the fall of the Roman Empire. All across the continent, people learned just how gruesome and horrific disease could be as the plague crossed the boundaries of countries and the lines established by society, killing everyone equally. It showed that no one—not even archbishops and kings—were immune from its grasp. The ferocity with which the plague swept across the continent, even reaching the shores of England, demonstrated how unprepared they were for something on such a large scale. It was the first time that a major disease would strike the continent after the fall of the Roman Empire, but it would not be the last. Over the next few centuries, the bubonic plague would return several times. Although it was incredibly deadly, it never again had the same catastrophic effect on the European population. People began to study it from a scientific perspective instead of the same superstitious angle or religious fatalism, making it possible to understand exactly what was causing the deaths. Today, those in the medical profession can easily treat the bubonic plague if they realize what it is early enough. With examples of the illness occurring in many nations during the last decade, including the US, the Black Death is not gone, but it is no longer the death sentence that it once was. In The Black Death: A Captivating Guide to the Deadliest Pandemic in Medieval Europe and Human History, you will discover topics such as The First Pandemics The Black Death The Unlikely Use of the Black Death Rumors and Arrival Perceptions Vs. The Reality The Ultimate Equalizer Stealing the Future – Princess Joan Decline of the Catholic Church and the Rise of Mysticism Art of the Black Death The First Quarantine and Successful Containment Beyond the Human Toll Lasting Effects on Europe’s Future And much, much more! So if you want to learn more about The Black Death, scroll up and click the "add to cart" button!

    

    In this delightful and compelling exploration of our most neglected sense, veteran science reporter Bob Holmes shows us just how much we’re missing.Considering every angle of flavor from our neurobiology to the science and practice of modern food production, Holmes takes readers on a journey to uncover the broad range of factors that can affect our appreciation of a fine meal or an exceptional glass of wine. He peers over the shoulders of some of the most fascinating food professionals working today, from cutting-edge chefs to food engineers to mathematicians investigating the perfect combination of pizza toppings. He talks with flavor and olfactory scientists, who describe why two people can experience remarkably different sensations from the same morsel of food, and how something as seemingly unrelated as cultural heritage can actually impact our sense of smell.Along the way, even more surprising facts are revealed: that cake tastes sweetest on white plates; that wine experts’ eyes can fool their noses; and even that language can affect our sense of taste. Flavor expands our curiosity and understanding of one of our most intimate sensations, while ultimately revealing how we can all sharpen our senses and our enjoyment of the things we taste.Certain to fascinate everyone from gourmands and scientists to home cooks and their guests, Flavor will open your mind—and palette—to a vast, exciting sensory world.

    Do you want more from life? Have you ever thought you’re capable of so much more, but don’t know how to get there?  Do you feel overwhelmed with an ever-increasing flow of information? Are you unable to identify what can really improve your life? In Upgrade Yourself, you’ll learn simple habits and strategies to transform your mindset and change your life for the better. You’ll be introduced to the core of what you need to know to become the best version of yourself—nothing less!You’ll discover:  how to reprogram your mind to overcome self-defeating behaviors  what a holocaust survivor and a man without arms or legs have in common, and what you can learn from them how an anonymous call changed Tim Ferris’s life, and how this information can change yours, too how to sharpen your skills the Benjamin Franklin way  how a simple strategy can turbocharge your productivity, and  much, much more  By the time you reach the end of Upgrade Yourself, you’ll have a stronger mindset, you’ll develop better habits, you’ll have more discipline and a more exciting vision, and you’ll be able to design a better life for yourself.So, if you want to become the best possible version of yourself, don’t hesitate, scroll to the top of this page, click the download link, and start today.