Mann radically alters our understanding of the Americas before the arrival of Columbus in 1492.Contrary to what so many Americans learn in school, the pre-Columbian Indians were not sparsely settled in a pristine wilderness; rather, there were huge numbers of Indians who actively molded and influenced the land around them. The astonishing Aztec capital of Tenochtitlan had running water and immaculately clean streets, and was larger than any contemporary European city. Mexican cultures created corn in a specialized breeding process that it has been called man’s first feat of genetic engineering. Indeed, Indians were not living lightly on the land but were landscaping and manipulating their world in ways that we are only now beginning to understand. Challenging and surprising, this a transformative new look at a rich and fascinating world we only thought we knew.

    North America was settled by people with distinct religious, political, and ethnographic characteristics, creating regional cultures that have been at odds with one another ever since. Subsequent immigrants didn't confront or assimilate into an "American" or "Canadian" culture, but rather into one of the eleven distinct regional ones that spread over the continent each staking out mutually exclusive territory.In American Nations, Colin Woodard leads us on a journey through the history of our fractured continent, and the rivalries and alliances between its component nations, which conform to neither state nor international boundaries. He illustrates and explains why "American" values vary sharply from one region to another. Woodard reveals how intranational differences have played a pivotal role at every point in the continent's history, from the American Revolution and the Civil War to the tumultuous sixties and the "blue county/red county" maps of recent presidential elections. American Nations is a revolutionary and revelatory take on America's myriad identities and how the conflicts between them have shaped our past and are molding our future.

    Yet under the right circumstances, it is the single most dangerous germ on the planet.Orent reveals how Soviet scientists created genetically-altered forms of this terrible affliction, knowing exactly how to convert plague into a deadly weapon.She shows how scientists are still unable to defend against it, and how plague could be visited upon humanity again.

    The depth below is hot, much warmer than the surface and this book tunnels down through the geological layers, meeting the creatures that dwell in darkness, real and fictional -- rats and eels, monsters and ghosts. There is a bronze-age trackway under the Isle of Dogs, Wren found Anglo-Saxon graves under St Paul's, and the monastery of Whitefriars lies beneath Fleet Street. In Kensal Green cemetery there was a hydraulic device to lower bodies into the catacombs below -- "Welcome to the lower depths". A door in the plinth of statue of Boadicea on Westminster Bridge leads to a huge tunnel, packed with cables -- gas, water, telephone. When the Metropolitan Line was opened in 1864 the guards asked for permission to grow beards to protect themselves against the sulphurous fumes, and called their engines by the names of tyrants -- Czar, Kaiser, Mogul -- and even Pluto, god of the underworld.Going under London is to penetrate history, to enter a hidden world. "The vastness of the space, a second earth," writes Peter Ackroyd, "elicits sensations of wonder and of terror. It partakes of myth and dream in equal measure."

    Updated to include the most recent breakthroughsFirst published in 1998, here are the surprisingly fascinating stories of seven diseases that changed the course of human history - updated to reflect new medical and social developments such as: - the ravages of AIDS in Africa, Asia, and other locations - the bioterror threat posed by smallpox eradication- a primitive yet effective new measure for fighting cholera in India- an important new drug to treat malaria- and moreIllustrated with over fifty reproductions of photographs, newspaper cartoons, public health posters, and the like, Invisible Enemies is an intense and intriguing mix of history, biography, and biology.

    Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes.Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics.Author Dr. Alexandra Levitt is an expert on emerging diseases and other public health threats. Here she shares insider accounts she’s collected that go behind the alarming headlines we’ve seen in the media: mysterious food poisonings, unexplained deaths at a children’s hospital, a strange neurologic disease afflicting slaughterhouse workers, flocks of birds dropping dead out of the sky, and drug-resistant malaria running rampant in a refugee camp. Meet the resourceful investigators—doctors, veterinarians, and research scientists—and discover the truth behind these cases and more.

    But in eagerly pursuing what would a century later become known as the "American dream," this optimistic-yet-motley crew of emigrants was met with a chilling nightmare; in the following months, their jingoistic excitement would be replaced by desperate cries for help that would fall silent in the deadly snow-covered mountains of the Sierra Nevada.We know these early pioneers as the Donner Party, a name that has elicited horror since the late 1840s. Now, celebrated historian Michael Wallis—beloved for his myth-busting portraits of legendary American figures—continues his life’s work of parsing fact from fiction to tell the true story of one of the most embroidered sagas in Western history.Wallis begins the story in 1846, a momentous "year of decision" for the nation, when incredible territorial strides were being made in Texas, New Mexico, and California. Against this dramatic backdrop, an unlikely band of travelers appeared, stratified in age, wealth, education and ethnicity. At the forefront were the Donners: brothers George and Jacob, true sons of the soil determined to tame the wild land of California; and the Reeds, headed by adventurous, business-savvy patriarch James. In total, the Donner-Reed group would reach eighty-seven men, women, and children, and though personal motives varied—bachelors thirsting for adventure, parents wanting greater futures for their children—everyone was linked by the same unwavering belief that California was theirs for the taking.Skeptical of previous accounts of how the group ended up in peril, Wallis has spent years retracing its ill-fated journey, uncovering hundreds of new documents that illuminate how a combination of greed, backbiting, and recklessness led the group to become hopelessly snowbound at the infamous Donner Pass in present-day California. Climaxing with the grim stories of how the party’s paltry rations soon gave way to unimaginable hunger, Wallis not only details the cannibalism that has in perpetuity haunted their legacy but also the heroic rescue parties that managed to reach the stranded, only to discover that just forty-eight had survived the ordeal.An unflinching and historically invaluable account of the darkest side of Manifest Destiny, The Best Land Under Heaven offers a brilliant, revisionist examination of one of America's most calamitous and sensationalized catastrophes.

    But these tiny insects, once merely a seasonal annoyance, now are capturing headlines worldwide as new information emerges about the diseases they carry, their migratory population, and their growing resistance to pesticides.Harvard professor Andrew Spielman has dedicated his life to understanding this insect, a passion that makes him the perfect guide to their amazing world and the perfect author of this lively, accessible book that offers an intriguing and horrifying mosquito-eye view of nature and man. He explains where mosquitoes breed, and how they die, showing us their natural foes and man-made enemies while explaining the myriad diseases they bring to all corners of the world. Spielman offers colorful examples of how the mosquito has insinuated itself into human history, from the defeat of Sir Francis Drake's fleet to the death of thousands of Frenchmen working on the Panama Canal to the recent widespread West Nile panic in New York City. Filled with little-known facts and illuminating anecdotes that bring this tiny being into larger focus, Mosquito offers fascinating, alarming, and convincing evidence that the sooner we get to know this little creature, the better off we'll be.

    He was bound for a New Jersey dueling ground to settle his bitter dispute with Aaron Burr. Hamilton took just two men with him: his “second” for the duel, and Dr. David Hosack.As historian Victoria Johnson reveals in her groundbreaking biography, Hosack was one of the few points the duelists did agree on. Summoned that morning because of his role as the beloved Hamilton family doctor, he was also a close friend of Burr. A brilliant surgeon and a world-class botanist, Hosack—who until now has been lost in the fog of history—was a pioneering thinker who shaped a young nation.Born in New York City, he was educated in Europe and returned to America inspired by his newfound knowledge. He assembled a plant collection so spectacular and diverse that it amazes botanists today, conducted some of the first pharmaceutical research in the United States, and introduced new surgeries to American. His tireless work championing public health and science earned him national fame and praise from the likes of Thomas Jefferson, James Madison, Alexander von Humboldt, and the Marquis de Lafayette.One goal drove Hosack above all others: to build the Republic’s first botanical garden. Despite innumerable obstacles and near-constant resistance, Hosack triumphed when, by 1810, his Elgin Botanic Garden at last crowned twenty acres of Manhattan farmland. “Where others saw real estate and power, Hosack saw the landscape as a pharmacopoeia able to bring medicine into the modern age” (Eric W. Sanderson, author of Mannahatta). Today what remains of America’s first botanical garden lies in the heart of midtown, buried beneath Rockefeller Center.Whether collecting specimens along the banks of the Hudson River, lecturing before a class of rapt medical students, or breaking the fever of a young Philip Hamilton, David Hosack was an American visionary who has been too long forgotten. Alongside other towering figures of the post-Revolutionary generation, he took the reins of a nation. In unearthing the dramatic story of his life, Johnson offers a lush depiction of the man who gave a new voice to the powers and perils of nature.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In

    It is a tour through a now unrecognizable city of abysmal poverty and habitual violence cobbled, as Luc Sante has written, "from legend, memory, police records, the self-aggrandizements of aging crooks, popular journalism, and solid historical research." Asbury presents the definitive work on this subject, an illumination of the gangs of old New York that ultimately gave rise to the modern Mafia and its depiction in films like The Godfather.

    With a tremendous cracking and splintering of oak, it struck the ship just beneath the anchor secured at the cat-head on the port bow..." In the Heart of the Sea brings to new life the incredible story of the wreck of the whaleship Essex - an event as mythic in its own century as the Titanic disaster in ours, and the inspiration for the climax of Moby-Dick. In a harrowing page-turner, Nathaniel Philbrick restores this epic story to its rightful place in American history.In 1820, the 240-ton Essex set sail from Nantucket on a routine voyage for whales. Fifteen months later, in the farthest reaches of the South Pacific, it was repeatedly rammed and sunk by an eighty-ton bull sperm whale. Its twenty-man crew, fearing cannibals on the islands to the west, made for the 3,000-mile-distant coast of South America in three tiny boats. During ninety days at sea under horrendous conditions, the survivors clung to life as one by one, they succumbed to hunger, thirst, disease, and fear.Philbrick interweaves his account of this extraordinary ordeal of ordinary men with a wealth of whale lore and with a brilliantly detailed portrait of the lost, unique community of Nantucket whalers. Impeccably researched and beautifully told, the book delivers the ultimate portrait of man against nature, drawing on a remarkable range of archival and modern sources, including a long-lost account by the ship's cabin boy.At once a literary companion and a page-turner that speaks to the same issues of class, race, and man's relationship to nature that permeate the works of Melville, In the Heart of the Sea will endure as a vital work of American history.

    Police captains took hefty bribes to see nothing while reformers writhed in frustration.     In Island of Vice, bestselling author Richard Zacks paints a vivid picture of the lewd underbelly of 1890s New York, and of Theodore Roosevelt, the cocksure crusading police commissioner who resolved to clean up the bustling metropolis, where the silk top hats of Wall Street bobbed past teenage prostitutes trawling Broadway.     Writing with great wit and zest, Zacks explores how Roosevelt went head-to-head with corrupt Tammany Hall, took midnight rambles with muckraker Jacob Riis, banned barroom drinking on Sundays, and tried to convince 2 million New Yorkers to enjoy wholesome family fun. In doing so, Teddy made a ruthless enemy of police captain “Big Bill” Devery, who grew up in the Irish slums and never tired of fighting “tin soldier” reformers. Roosevelt saw his mission as a battle of good versus evil; Devery saw prudery standing in the way of fun and profit.     When righteous Roosevelt’s vice crackdown started to succeed all too well, many of his own supporters began to turn on him. Cynical newspapermen mocked his quixotic quest, his own political party abandoned him, and Roosevelt discovered that New York loves its sin more than its salvation.     Zacks’s meticulous research and wonderful sense of narrative verve bring this disparate cast of both pious and bawdy New Yorkers to life. With cameos by Stephen Crane, J. P. Morgan, and Joseph Pulitzer, plus a horde of very angry cops, Island of Vice is an unforgettable portrait of turn-of-the-century New York in all its seedy glory, and a brilliant portrayal of the energetic, confident, and zealous Roosevelt, one of America’s most colorful public figures.From the Hardcover edition.

    Edward Marriott’s dramatic, gripping new book gives you yet another thing to worry about.” —New York Plague. The very word carries an unholy resonance. No other disease can claim its apocalyptic power: it can lie dormant for centuries, only to resurface with nation-killing force. Here, with the high drama of an adventure tale, Edward Marriott unravels the story of this lethal disease: the historic battle to identify its source, the devastating effects of pandemics, and the prospects for new outbreaks. Marriott begins the trail in Hong Kong in the summer of 1894, when a plague diagnosis brought to the island two top scientists—Alexandre Yersin, a maverick Frenchman, and his Japanese rival, Shibasaburo Kitasato. Marriott interweaves the narrative of their fierce competition with vivid scenes of the scourge’s persistence: California in 1900; Surat, India, in 1994; and New York City sometime in the future.A masterly account of medical and human history, Plague is at once an instructive warning and a chilling read.

    Ellis focuses the conversation on the often-asked question "What would the Founding Fathers think?" He examines four of our most seminal historical figures through the prism of particular topics, using the perspective of the present to shed light on their views and, in turn, to make clear how their now centuries-old ideas illuminate the disturbing impasse of today's political conflicts. He discusses Jefferson and the issue of racism, Adams and the specter of economic inequality, Washington and American imperialism, Madison and the doctrine of original intent. Through these juxtapositions--and in his hallmark dramatic and compelling narrative voice--Ellis illuminates the obstacles and pitfalls paralyzing contemporary discussions of these fundamentally important issues.8 Hours and 30 Minutes