An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    It was the last time anyone would see her alive. By the next day, Shanann and her two young daughters, Bella and Celeste, had been reported missing, and her husband, Chris Watts, was appearing on the local news, pleading for his family's safe return.But Chris Watts already knew that he would never see his family again. Less than 24 hours after his desperate plea, Watts made a shocking confession to police: he had strangled his pregnant wife to death and smothered their daughters, dumping their bodies at a nearby oil site. Heartbroken friends and neighbors watched in shock as the movie-star handsome, devoted family man they knew was arrested and charged with first degree murder. The perfect mask Chris had presented to the world in his TV interviews and the family's Facebook accounts was slipping--and what lay beneath was a horrifying image of instability, infidelity, sexual ambivalence, and boiling rage.In this first major account of the case, bestselling author and journalist John Glatt reveals the truth behind the tragedy and constructs a chilling portrait of one of the most shocking family annihilator cases of the 21st century.

    But what would it look like to study the whole of history, from the big bang through the present day -- and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence?These were the questions David Christian set out to answer when he created the field of "Big History," the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as "history." By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together -- from the creation of the planet to the advent of agriculture, nuclear war, and beyond.With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.

    You might even be worried that these lapses in memory could be an early sign of Alzheimer's or dementia. In reality, for the vast majority of us, these examples of forgetting are completely normal. Why? Because while memory is amazing, it is far from perfect. Our brains aren't designed to remember every name we hear, plan we make, or day we experience. Just because your memory sometimes fails doesn't mean it's broken or succumbing to disease. Forgetting is actually part of being human. In Remember, neuroscientist and acclaimed novelist Lisa Genova delves into how memories are made and how we retrieve them. You'll learn whether forgotten memories are temporarily inaccessible or erased forever and why some memories are built to exist for only a few seconds (like a passcode) while others can last a lifetime (your wedding day). You'll come to appreciate the clear distinction between normal forgetting (where you parked your car) and forgetting due to Alzheimer's (that you own a car). And you'll see how memory is profoundly impacted by meaning, emotion, sleep, stress, and context. Once you understand the language of memory and how it functions, its incredible strengths and maddening weaknesses, its natural vulnerabilities and potential superpowers, you can both vastly improve your ability to remember and feel less rattled when you inevitably forget. You can set educated expectations for your memory, and in doing so, create a better relationship with it. You don't have to fear it anymore. And that can be life-changing.

    It’s love at first sight, a threat to them both, and a moment of self-discovery. Challenged by society’s rejection and Morise’s return to the US, Mortada takes to the page to understand himself.In his deeply affecting memoir, Mortada interweaves tales of his childhood work as a scrap-metal collector in a war zone and the indignities faced by openly gay artists in Iraq with his impossible love story and journey to the US. Marginalized by his own society, he is surprised to discover the racism he finds in a new one. At its heart, I’m in Seattle, Where Are You? is a moving tale of love and resilience.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

      We swim in freezing Arctic waters and piranha-infested rivers to test our limits. We swim for pleasure, for exercise, for healing. But humans, unlike other animals that are drawn to water, are not natural-born swimmers. We must be taught. Our evolutionary ancestors learned for survival; now, in the twenty-first century, swimming is one of the most popular activities in the world.Why We Swim is propelled by stories of Olympic champions, a Baghdad swim club that meets in Saddam Hussein’s palace pool, modern-day Japanese samurai swimmers, and even an Icelandic fisherman who improbably survives a wintry six-hour swim after a shipwreck. New York Times contributor Bonnie Tsui, a swimmer herself, dives into the deep, from the San Francisco Bay to the South China Sea, investigating what about water—despite its dangers—seduces us and why we come back to it again and again.

    Most of the time this math works quietly behind the scenes . . . until it doesn't. All sorts of seemingly innocuous mathematical mistakes can have significant consequences.Math is easy to ignore until a misplaced decimal point upends the stock market, a unit conversion error causes a plane to crash, or someone divides by zero and stalls a battleship in the middle of the ocean.Exploring and explaining a litany of glitches, near misses, and mathematical mishaps involving the internet, big data, elections, street signs, lotteries, the Roman Empire, and an Olympic team, Matt Parker uncovers the bizarre ways math trips us up, and what this reveals about its essential place in our world. Getting it wrong has never been more fun.

    We own radiation-emitting phones, regularly get diagnostic x-rays, such as mammograms, and submit to full-body security scans at airports. We worry and debate about the proliferation of nuclear weapons and the safety of nuclear power plants. But how much do we really know about radiation? And what are its actual dangers? An accessible blend of narrative history and science, Strange Glow describes mankind's extraordinary, thorny relationship with radiation, including the hard-won lessons of how radiation helps and harms our health. Timothy Jorgensen explores how our knowledge of and experiences with radiation in the last century can lead us to smarter personal decisions about radiation exposures today.Jorgensen introduces key figures in the story of radiation--from Wilhelm Roentgen, the discoverer of x-rays, and pioneering radioactivity researchers Marie and Pierre Curie, to Thomas Edison and the victims of the recent Fukushima Daiichi nuclear power plant accident. Tracing the most important events in the evolution of radiation, Jorgensen explains exactly what radiation is, how it produces certain health consequences, and how we can protect ourselves from harm. He also considers a range of practical scenarios such as the risks of radon in our basements, radiation levels in the fish we eat, questions about cell-phone use, and radiation's link to cancer. Jorgensen empowers us to make informed choices while offering a clearer understanding of broader societal issues.Investigating radiation's benefits and risks, Strange Glow takes a remarkable look at how, for better or worse, radiation has transformed our society.

    Beginning with the publication of Albert Einstein's theory of relativity, through the wild revolution of quantum mechanics, and up until the physics of the modern day (including the astonishing revelation, in 1998, that the Universe is not only expanding, but doing so at an ever-quickening pace), much of what physicists have seen in our Universe suggests that much of our Universe is unseen—that we live in a dark cosmos.Everyone knows that there are things no one can see—the air you're breathing, for example, or, to be more exotic, a black hole. But what everyone does not know is that what we can see—a book, a cat, or our planet—makes up only 5 percent of the Universe. The rest—fully 95 percent—is totally invisible to us; its presence discernible only by the weak effects it has on visible matter around it.This invisible stuff comes in two varieties—dark matter and dark energy. One holds the Universe together, while the other tears it apart. What these forces really are has been a mystery for as long as anyone has suspected they were there, but the latest discoveries of experimental physics have brought us closer to that knowledge. Particle physicist Dan Hooper takes his readers, with wit, grace, and a keen knack for explaining the toughest ideas science has to offer, on a quest few would have ever expected: to discover what makes up our dark cosmos.

    Kate Biberdorf, aka "Kate the Chemist," reveals the fascinating science we experience every day Have you ever wondered what makes dough rise? Or how your morning coffee gives you that energy boost? Or why your shampoo is making your hair look greasy? The answer is chemistry. From the moment we wake up until the time we go to sleep (and even while we sleep), chemistry is at work—and it doesn't take a PhD in science to understand it. Dr. Biberdorf has appeared on TV programs from the Today show to The Late Show with Stephen Colbert, lighting the world on fire and changing the face of chemistry as we know it. In It's Elemental, she demystifies the fundamental principles of the science that may have eluded you in high school and shows how chemistry comes alive in everything we do. With wry wit and infectious enthusiasm, this entertaining guide will ignite your passion for science and change the way you experience the world.

    Childhood tells the story of a misfit child's single-minded determination to become a poet; Youth describes her early experiences of sex, work, and independence. Dependency picks up the story as the narrator embarks on the first of her four marriages and goes on to describe her horrible descent into drug addiction, enabled by her sinister, gaslighting doctor-husband.Throughout, the narrator grapples with the tension between her vocation as a writer and her competing roles as daughter, wife, mother, and drug addict, and she writes about female experience and identity in a way that feels very fresh and pertinent to today's discussions around feminism. Ditlevsen's trilogy is remarkable for its intensity and its immersive depiction of a world of complex female friendships, family and growing up--in this sense, it's Copenhagen's answer to Elena Ferrante's Neapolitan Novels. She can also be seen as a spiritual forerunner of confessional writers like Karl Ove Knausgaard, Annie Ernaux, Rachel Cusk and Deborah Levy. Her trilogy is drawn from her own experiences but reads like the most compelling kind of fiction.Born in a working-class neighborhood in Copenhagen in 1917, Ditlevsen became famous for her poetry while still a teenager, and went on to write novels, stories and memoirs before committing suicide in 1976. Having been dismissed by the critical establishment in her lifetime as a working-class, female writer, she is now being rediscovered and championed as one of Denmark's most important modern authors, with Tove fever gripping readers.

    Stargazing is a pursuit that continues to fascinate us: from Copernicus to Carl Sagan, astronomers throughout history have spent their lives trying to answer the biggest questions in the universe. Now, award-winning astronomer Emily Levesque shares the stories of modern-day stargazers, the people willing to adventure across high mountaintops and to some of the most remote corners of the planet, all in the name of science.From the lonely quiet of midnight stargazing to tall tales of wild bears loose in the observatory, The Last Stargazers is a love letter to astronomy and an affirmation of the crucial role that humans can and must play in the future of scientific discovery.In this sweeping work of narrative science, Levesque shows how astronomers in this scrappy and evolving field are going beyond the machines to infuse creativity and passion into the stars and inspires us all to peer skyward in pursuit of the universe's secrets.

    Coffee. Sunscreen. Vapes. George Zaidan reveals what will kill you, what won't, and why--explained with high-octane hilarity, hysterical hijinks, and other things that don't begin with the letter H. INGREDIENTS offers the perspective of a chemist on the stuff we eat, drink, inhale, and smear on ourselves. Apart from the burning question of whether you should eat that Cheeto, Zaidan explores a range of topics. Here's a helpful guide:Stuff in this book: - How bad is processed food? How sure are we?- Is sunscreen safe? Should you use it?- Is coffee good or bad for you?- What's your disease horoscope?- What is that public pool smell made of?- What happens when you overdose on fentanyl in the sun?- What do cassava plants and Soviet spies have in common?- When will you die?Stuff in other books: - Your carbon footprint- Food sustainability- GMOs- CEO pay- Science funding- Politics- Football- Baseball- Any kind of ball reallyZaidan, an MIT-trained chemist who cohosted CNBC's hit Make Me a Millionaire Inventor and wrote and voiced several TED-Ed viral videos, makes chemistry more fun than Hogwarts as he reveals exactly what science can (and can't) tell us about the packaged ingredients sold to us every day. Sugar, spinach, formaldehyde, cyanide, the ingredients of life and death, and how we know if something is good or bad for us--as well as the genius of aphids and their butts--are all discussed in exquisite detail at breakneck speed.

    So little, in fact, that scientists and philosophers have, for centuries, been obsessed with what has become known as the “eel question”: Where do eels come from? What are they? Are they fish or some other kind of creature altogether? Even today, in an age of advanced science, no one has ever seen eels mating or giving birth, and we still don’t understand what drives them, after living for decades in freshwater, to swim great distances back to the ocean at the end of their lives. They remain a mystery.Drawing on a breadth of research about eels in literature, history, and modern marine biology, as well as his own experience fishing for eels with his father, Patrik Svensson writes a book about this unusual animal. In The Book of Eels, we meet renowned historical thinkers, from Aristotle to Sigmund Freud to Rachel Carson, for whom the eel was a singular obsession. And we meet the scientists who spearheaded the search for the eel’s point of origin, including Danish marine biologist Johannes Schmidt, who led research efforts in the early twentieth century, catching thousands upon thousands of eels, in the hopes of proving their birthing grounds in the Sargasso Sea.Blending memoir and nature writing, Svensson’s journey to understand the eel becomes an exploration of the human condition that delves into overarching issues about our roots and destiny, both as humans and as animals, and, ultimately, how to handle the biggest question of all: death.