He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain’s memory machine has begun to pay off. Award-winning journalist Terry McDermott spent nearly two years observing Lynch at work and now gives us a fascinating and dramatic account of daily life in his lab—the highs and lows, the drudgery and eureka moments, the agonizing failures. He provides detailed, lucid explanations of the cutting-edge science that enabled Lynch to reveal the inner workings of the molecular machine that manufactures memory. After establishing the building blocks, Lynch then set his sights on uncovering the complicated structure of memory as it is stored across many neurons. Adding practical significance to his groundbreaking work, Lynch discovered a class of drugs that could fix the memory machine when it breaks, drugs that would enhance brain function during the memory process and that hold out the possibility of cures for a wide range of neurological conditions, including Alzheimer’s disease, Parkinson’s disease, and attention deficit hyperactivity disorder. Here is an essential story of science, scientists, and scientific achievement—galvanizing in the telling and thrilling in its far-reaching implications.

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    Why does music evoke such powerful moods? The answers are at last be- coming clear, thanks to revolutionary neuroscience and the emerging field of evolutionary psychology. Both a cutting-edge study and a tribute to the beauty of music itself, This Is Your Brain on Music unravels a host of mysteries that affect everything from pop culture to our understanding of human nature, including: • Are our musical preferences shaped in utero? • Is there a cutoff point for acquiring new tastes in music? • What do PET scans and MRIs reveal about the brain’s response to music? • Is musical pleasure different from other kinds of pleasure?This Is Your Brain on Music explores cultures in which singing is considered an essential human function, patients who have a rare disorder that prevents them from making sense of music, and scientists studying why two people may not have the same definition of pitch. At every turn, this provocative work unlocks deep secrets about how nature and nurture forge a uniquely human obsession.

    We can now pin down the neurons that fire when a person reports becoming aware of a piece of information and understand the crucial role unconscious computations play in how we make decisions. The emerging theory enables a test of consciousness in animals, babies, and those with severe brain injuries.A joyous exploration of the mind and its thrilling complexities, Consciousness and the Brain will excite anyone interestedin cutting-edge science and technology and the vast philosophical, personal, and ethical implications of finally quantifyingconsciousness.

    In " An Introduction to the Event-Related Potential Technique," Steve Luck offers the first comprehensive guide to the practicalities of conducting ERP experiments in cognitive neuroscience and related fields, including affective neuroscience and experimental psychopathology. The book can serve as a guide for the classroom or the laboratory and as a reference for researchers who do not conduct ERP studies themselves but need to understand and evaluate ERP experiments in the literature. It summarizes the accumulated body of ERP theory and practice, providing detailed, practical advice about how to design, conduct, and interpret ERP experiments, and presents the theoretical background needed to understand why an experiment is carried out in a particular way. Luck focuses on the most fundamental techniques, describing them as they are used in many of the world's leading ERP laboratories. These techniques reflect a long history of electrophysiological recordings and provide an excellent foundation for more advanced approaches.The book also provides advice on the key topic of how to design ERP experiments so that they will be useful in answering questions of broad scientific interest. This reflects the increasing proportion of ERP research that focuses on these broader questions rather than the "ERPology" of early studies, which concentrated primarily on ERP components and methods. Topics covered include the neural origins of ERPs, signal averaging, artifact rejection and correction, filtering, measurement and analysis, localization, and the practicalities of setting up the lab.

    Its organization and thoroughness are unsurpassed, putting it above similar review books. Students who thoroughly read this book should have no trouble successfully completing their psychiatry clerkship and passing the shelf exam. As course director for the core psychiatry clerkship at my institution, I will recommend this book to students."--Doody's Review Service"First Aid for the Psychiatry Clerkship" gives you the core information needed to impress on the wards and pass the psychiatry clerkship exam. Written by students who know what it takes to succeed, and based on the national guidelines for the psychiatry clerkship, the book is filled with mnemonics, ward and exam tips, tables, clinical images, algorithms, and newly added mini-cases.Features Completely revised based on the psychiatry clerkship's core competencies Written by medical students who passed and reviewed by faculty for accuracy NEW integrated mini-cases illustrate classic patient presentations and/or commonly tested scenarios NEW illustrations and management algorithms Updated throughout with enhanced sections on medications, depression/anxiety, and child psychiatry Helps students hone in on the most important concepts for the clerkship and the examThe content you need to ace the clerkship: Section I: How to Succeed in the Psychiatry Clerkship Section II: High-Yield Facts; Examination and Diagnosis; Psychotic Disorders; Mood Disorders; Anxiety and Adjustment Disorders; Personality Disorders; Substance-Related Disorders; Cognitive Disorders; Geriatric Disorders; Psychiatric Disorders in Children; Dissociative Disorders; Somataform and Factitious Disorders; Impulse Control Disorders; Eating Disordes; Disorders; Sleep Disorders; Sexual Disorders; Psychtherapies; Psychopharmacology; Legal Issues; Section III: Awards and Opportunities.

    The information is stuck on the tip of your tongue. It's an experience so frustrating that it seems like it must be a brain malfunction. In fact, it's actually a hallmark of our greatest power: self-awareness. As cognitive neuroscientist Stephen M. Fleming shows in Know Thyself,self-awareness shapes our intelligence, memory, and conscious experience. It's integral to how we teach and learn. We use it every time we weigh difficult questions, such as assessing how we'd respond in a crisis. Drawing on psychology and neuroscience, Fleming provides deep insight into how self-awareness works, and how we can enhance our ability to know our strengths and weaknesses. In the end, this book isn'tjust about psychology: it's about the science of human excellence.

    Drawing on the treasure trove of information from Scientific American and Scientific American Mind magazines as well as original material written specifically for this book, Judith Horstman weaves together a compelling description of your brain at work and at play. The Scientific American Day in the Life of Your Brain reveals what's going on in there while you sleep and dream, how your brain makes memories and forms addictions and why we sometimes make bad decisions. The book also offers intriguing information about your emotional brain, and what's happening when you're feeling love, lust, fear and anxiety--and how sex, drugs and rock and roll tickle the same spots.Based on the latest scientific information, the book explores your brain's remarkable ability to change, how your brain can make new neurons even into old age and why multitasking may be bad for you.Your brain is uniquely yours - but research is showing many of its day-to-day cycles are universal. This book gives you a look inside your brain and some insights into why you may feel and act as you do.The Scientific American Day in the Life of Your Brain is written in the entertaining, informative and easy-to-understand style that fans of Scientific American and Scientific American Mind magazine have come to expect.

    Now they can stop worrying, take charge of their brain health, and begin enjoying a sharper mind quickly and for years to come. In 2 Weeks to a Younger Brain, Dr. Gary Small and Gigi Vorgan translate the latest brain science into practical strategies and exercises that everyone can use to get immediate and long-lasting benefits. Dr. Small's studies have found that the sooner each of us gets started on a younger brain program, the greater the potential benefits. Following the authors' advice will not only improve your memory, but will also strengthen your physical health by reducing your risk for diabetes, heart disease, and stroke. In a new study published by the journal Psychological Science, researchers at MIT and Massachusetts General Hospital reported that the ability to reason, learn, and remember information ebbs and flows over our lifespan Although some forms of rapid recall peak in our late teens, our ability to evaluate another person's emotions by just viewing their eyes is strongest in midlife. And, vocabulary skills may not decline until well into our 60s. Remarkably, their data showed that since the late-1970s and early 1980s, our peak-ability to define words has gradually increased from age 40 to age 60. After three decades of helping thousands of patients improve their mental acuity, Dr. Small has shown that our daily lifestyle habits are directly linked to brain health. 2 Weeks to a Younger Brain reveals how you can rapidly form new habits that bolster cognitive abilities and help prevent, and reverse, brain aging. 2 Weeks to a Younger Brain makes sense of the latest scientific discoveries showing that: • Brain aging starts as young as age 20 • Sex is good for your brain • Memory exercises can erase senior moments from your brain scan • Aerobic conditioning can overcome even a genetic risk for Alzheimer's disease

    They shirk everyday responsibilities, abuse drugs and alcohol, take up criminal careers, and lash out at family members. In the worst cases, they commit rape, murder, and other acts of extreme violence as though they lack a conscience. What makes these men--men we all know, whether as faces in the news or as people close to us--behave the way they do?Bad Boys, Bad Men examines antisocial personality disorder or ASP, the mysterious mental condition that underlies this lifelong penchant for bad behavior. Psychiatrist and researcher Donald W. Black, MD, draws on case studies, scientific data, and current events to explore antisocial behavior and to chart the history, nature, and treatment of a misunderstood disorder that affects up to seven million Americans. Citing new evidence from genetics and neuroscience, Black argues that this condition is tied to biological causes and that some people are simply born bad. Bad Boys, Bad Men introduces us to people like Ernie, the quintessential juvenile delinquent who had an incestuous relationship with his mother and descended into crime and alcoholism; and John Wayne Gacy, the notorious serial killer whose lifelong pattern of misbehavior escalated to the rape and murder of more than 30 young men and boys. These compelling cases read like medical detective stories as Black tries to separate the lies these men tell from the facts of their lives. Bad Boys, Bad Men not only describes the warning signs that predict which troubled children are more likely to become dangerous adults, but also details progress toward treatment for ASP. This volume will be an essential resource for psychiatrists, psychologists, criminologists, victims of crime, families of individuals afflicted with ASP, and anyone else interested in understanding antisocial behavior.

    The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    Created primarily for medical and premedical students, 'Neuroscience' emphasizes the structure of the nervous system, the correlation of structure and function, and the structure/function relationships particularly pertinent to the practice of medicine.

    Original essays by leading researchers such as Christof Koch, George Church, Olaf Sporns, and May-Britt and Edvard Moser describe the spectacular technological advances that will enable us to map the more than eighty-five billion neurons in the brain, as well as the challenges that lie ahead in understanding the anticipated deluge of data and the prospects for building working simulations of the human brain. A must-read for anyone trying to understand ambitious new research programs such as the Obama administration's BRAIN Initiative and the European Union's Human Brain Project, The Future of the Brain sheds light on the breathtaking implications of brain science for medicine, psychiatry, and even human consciousness itself.Contributors include: Misha Ahrens, Ned Block, Matteo Carandini, George Church, John Donoghue, Chris Eliasmith, Simon Fisher, Mike Hawrylycz, Sean Hill, Christof Koch, Leah Krubitzer, Michel Maharbiz, Kevin Mitchell, Edvard Moser, May-Britt Moser, David Poeppel, Krishna Shenoy, Olaf Sporns, Anthony Zador.

    Schacter explores instances of what we would consider memory failure—absent-mindedness, transience, blocking, misattribution, suggestibility, bias, and persistence—and suggests instead that these miscues are actually indications that memory is functioning as designed. Drawing from vivid scientific research and creative literature, as well as high-profile events in which memory has figured significantly (Bill Clinton's grand jury testimony, for instance), The Seven Sins of Memory provides a more nuanced understanding of how memory and the mind influence each other and shape our lives.

     Auditory hallucination is one of the most awe-inspiring, terrifying, and ill-understood tricks the human psyche is capable of. Muses, Madmen, and Prophets reevaluates the popular conception of the phenomenon today and through the ages, and reveals the roots of the medical understanding and treatment of it. It probes history, literature, anthropology, psychology, and neurology to explain and demystify the experience of hearing voices, in a fascinating and at times funny quest for understanding. Daniel B. Smith's personal experience with the phenomenon-his father heard voices, and it was the great torment and shame of his father's life-and his discovery that some people learn to live in peace with their voices fuels this contemplative, brilliantly researched, and inspired book. Science has not been able to fully explain the phenomenon of auditory hallucination. It is a condition that has existed perhaps as long as we have-there is evidence of it in literature and even pre-literate oral histories from across all times and cultures. Smith presents the sophisticated and radical argument that a negative side effect of living as we do in this great age of medical science is that we have come to limit this phenomenon to nothing more than a biochemical glitch for which the only proper response is medical, pharmaceutical treatment. This "pathological assumption" can inflict great harm on the people who hear voices by ignoring the meaning and reality of the experience for them. But it also obscures from the rest of us a rich wellspring of knowledge about the essential source of faith and inspiration. As Smith examines the many incidences of people who have famously heard voices throughout history-Moses, Mohammed, Teresa of Avila, Joan of Arc, Rilke, William Blake, Socrates, and others-he considers the experience of auditory hallucination in light of its relationship to the nature of pure faith and as the key to the source of artistic inspiration. At the heart of Smith's exploration into the many extraordinary, strange, sometimes frightening and sometimes almost supernatural aspects of auditory hallucination is his driving personal need to comprehend an experience that, when considered in good faith, is as profound and complex as human consciousness itself.