In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences.In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility.A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

    In Turing’s Cathedral, George Dyson focuses on a small group of men and women, led by John von Neumann at the Institute for Advanced Study in Princeton, New Jersey, who built one of the first computers to realize Alan Turing’s vision of a Universal Machine. Their work would break the distinction between numbers that mean things and numbers that do things—and our universe would never be the same. Using five kilobytes of memory (the amount allocated to displaying the cursor on a computer desktop of today), they achieved unprecedented success in both weather prediction and nuclear weapons design, while tackling, in their spare time, problems ranging from the evolution of viruses to the evolution of stars. Dyson’s account, both historic and prophetic, sheds important new light on how the digital universe exploded in the aftermath of World War II. The proliferation of both codes and machines was paralleled by two historic developments: the decoding of self-replicating sequences in biology and the invention of the hydrogen bomb. It’s no coincidence that the most destructive and the most constructive of human inventions appeared at exactly the same time.  How did code take over the world? In retracing how Alan Turing’s one-dimensional model became John von Neumann’s two-dimensional implementation, Turing’s Cathedral offers a series of provocative suggestions as to where the digital universe, now fully three-dimensional, may be heading next.

    Far less well-known is a much greater catastrophe that took place at the end of the Permian period 251 million years ago: 90 percent of life was destroyed, including saber-toothed reptiles and their rhinoceros-sized prey on land, as well as vast numbers of fish and other species in the sea.This book documents not only what happened during this gigantic mass extinction but also the recent rekindling of the idea of catastrophism. Was the end-Permian event caused by the impact of a huge meteorite or comet, or by prolonged volcanic eruption in Siberia? The evidence has been accumulating through the 1990s and into the new millennium, and Michael Benton gives his verdict at the very end. From field camps in Greenland and Russia to the laboratory bench, When Life Nearly Died involves geologists, paleontologists, environmental modelers, geochemists, astronomers, and experts on biodiversity and conservation. Their working methods are vividly described and explained, and the current disputes are revealed. The implications of our understanding of crises in the past for the current biodiversity crisis are also presented in detail. 46 b/w illustrations.

    In his delightfully down-to-earth style, he explores & explains a mind-boggling future of intelligent robots, extraterrestrial life & its consquences, & other provocative, fascinating quandries of the future we want to see today.

    At a summer tea party in Cambridge, England, a guest states that tea poured into milk tastes different from milk poured into tea. Her notion is shouted down by the scientific minds of the group. But one man, Ronald Fisher, proposes to scientifically test the hypothesis. There is no better person to conduct such an experiment, for Fisher is a pioneer in the field of statistics.The Lady Tasting Tea spotlights not only Fisher's theories but also the revolutionary ideas of dozens of men and women which affect our modern everyday lives. Writing with verve and wit, David Salsburg traces breakthroughs ranging from the rise and fall of Karl Pearson's theories to the methods of quality control that rebuilt postwar Japan's economy, including a pivotal early study on the capacity of a small beer cask at the Guinness brewing factory. Brimming with intriguing tidbits and colorful characters, The Lady Tasting Tea salutes the spirit of those who dared to look at the world in a new way.

    The threat of the disease kept ships close to home and doomed those vessels that ventured too far from port. The willful ignorance of the royal medical elite, who endorsed ludicrous medical theories based on speculative research while ignoring the life-saving properties of citrus fruit, cost tens of thousands of lives and altered the course of many battles at sea. The cure for scurvy ranks among the greatest of human accomplishments, yet its impact on history has, until now, been largely ignored.From the earliest recorded appearance of the disease in the sixteenth century, to the eighteenth century, where a man had only half a chance of surviving the scourge, to the early nineteenth century, when the British conquered scurvy and successfully blockaded the French and defeated Napoleon, Scurvy is a medical detective story for the ages, the fascinating true story of how James Lind (the surgeon), James Cook (the mariner), and Gilbert Blane (the gentleman) worked separately to eliminate the dreaded affliction.Scurvy is an evocative journey back to the era of wooden ships and sails, when the disease infiltrated every aspect of seafaring life: press gangs "recruit" mariners on the way home from a late night at the pub; a terrible voyage in search of riches ends with a hobbled fleet and half the crew heaved overboard; Cook majestically travels the South Seas but suffers an unimaginable fate. Brimming with tales of ships, sailors, and baffling bureaucracy, Scurvy is a rare mix of compelling history and classic adventure story.

    Civilization, we are told, could be achieved only by sacrificing those original freedoms or, alternatively, by taming our baser instincts. David Graeber and David Wengrow show how such theories first emerged in the eighteenth century as a conservative reaction to powerful critiques of European society posed by Indigenous observers and intellectuals. Revisiting this encounter has startling implications for how we make sense of human history today, including the origins of farming, property, cities, democracy, slavery, and civilization itself.Drawing on pathbreaking research in archaeology and anthropology, the authors show how history becomes a far more interesting place once we learn to throw off our conceptual shackles and perceive what's really there. If humans did not spend 95 percent of their evolutionary past in tiny bands of hunter-gatherers, what were they doing all that time? If agriculture, and cities, did not mean a plunge into hierarchy and domination, then what kinds of social and economic organization did they lead to? The answers are often unexpected, and suggest that the course of human history may be less set in stone, and more full of playful, hopeful possibilities, than we tend to assume.The Dawn of Everything fundamentally transforms our understanding of the human past and offers a path toward imagining new forms of freedom, new ways of organizing society. This is a monumental book of formidable intellectual range, animated by curiosity, moral vision, and a faith in the power of direct action.

    Strevens calls this scientific code the iron rule of explanation, and reveals the way in which the rule, precisely because it is unreasonably close-minded, overcomes individual prejudices to lead humanity inexorably toward the secrets of nature.“With a mixture of philosophical and historical argument, and written in an engrossing style” (Alan Ryan), The Knowledge Machine provides captivating portraits of some of the greatest luminaries in science’s history, including Isaac Newton, the chief architect of modern science and its foundational theories of motion and gravitation; William Whewell, perhaps the greatest philosopher-scientist of the early nineteenth century; and Murray Gell-Mann, discoverer of the quark. Today, Strevens argues, in the face of threats from a changing climate and global pandemics, the idiosyncratic but highly effective scientific knowledge machine must be protected from politicians, commercial interests, and even scientists themselves who seek to open it up, to make it less narrow and more rational—and thus to undermine its devotedly empirical search for truth.Rich with illuminating and often delightfully quirky illustrations, The Knowledge Machine, written in a winningly accessible style that belies the import of its revisionist and groundbreaking concepts, radically reframes much of what we thought we knew about the origins of the modern world.

    He begins with Copernicus, during the Renaissance, when science replaced mysticism as a means of explaining the workings of the world, and he continues through the centuries, creating an unbroken genealogy of not only the greatest but also the more obscure names of Western science, a dot-to-dot line linking amateur to genius, and accidental discovery to brilliant deduction.By focusing on the scientists themselves, Gribbin has written an anecdotal narrative enlivened with stories of personal drama, success and failure. A bestselling science writer with an international reputation, Gribbin is among the few authors who could even attempt a work of this magnitude. Praised as “a sequence of witty, information-packed tales” and “a terrifi c read” by The Times upon its recent British publication, The Scientists breathes new life into such venerable icons as Galileo, Isaac Newton, Albert Einstein and Linus Pauling, as well as lesser lights whose stories have been undeservedly neglected. Filled with pioneers, visionaries, eccentrics and madmen, this is the history of science as it has never been told before.From the Hardcover edition.

    Gonzalez-Crussi, from the Introduction An international bestseller, translated into eighteen languages, Paul de Kruif’s classic account of the first scientists to see and learn about the microscopic world continues to fascinate new readers. This is a timeless dramatization of the scientists, bacteriologists, doctors, and medical technicians who discovered the microbes and invented the vaccines to counter them. De Kruif writes about how seemingly simple but really fundamental discovers of science—for instance, how a microbe was first viewed in a clear drop of rain water, and when, for the first time, Louis Pasteur discovered that a simple vaccine could save a man from the ravages of rabies by attacking the microbes that cause it.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

      In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    For among the finches of Daphne Major, natural selection is neither rare nor slow: it is taking place by the hour, and we can watch.In this dramatic story of groundbreaking scientific research, Jonathan Weiner follows these scientists as they watch Darwin's finches and come up with a new understanding of life itself. The Beak of the Finch is an elegantly written and compelling masterpiece of theory and explication in the tradition of Stephen Jay Gould.With a new preface.

    This book engaged some of the hardest questions in the evolution debate, and it showed the ever-cautious Darwin at his boldest. If Darwin had one goal with Expression , it was to demonstrate the power of his theories for explaining the origin of our most cherished human qualities: morality and intellect. As Darwin explained, "He who admits, on general grounds, that the structure and habits of all animals have been gradually evolved, will look at the whole subject of Expression in a new and interesting light." Table Of Contents: Table of contents The Expression of the Emotions in Man and Animals Acknowledgements Chronology Introduction Further Reading Note on the Text The Expression of the Emotions in Man and Animals Appendix 1: Translation of French quotations Appendix 2: Darwin's 'Queries About Expression' Appendix 3: List of supplementary images Index