Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Reynolds provides a general overview of the history of the subject as it has developed in English, at the same time introducing key debates, developments, and figures in the field. Reynolds demonstrates how writing for children--whether on page or screen--has helped in shaping ideas about culture, society and childhood. She also raises questions about the future of children's literature generally and discusses the shape that it might take.

    The style is lively and accessible without sacrificing detail or depth. An introductory chapter discusses Sade's life and the links between that and his work. Relying on the many letters he wrote to his wife and lawyer from prison and on other authentic, contemporary evidence, it attempts to disentangle this life from the various myths that Sade's demonic reputation has engendered throughout the nineteenth and twentieth centuries. This initial chapter also reviews the critical corpus or reception of the work since Sade's times up to the present, and reassesses his status as an extra-canonical writer. The following six chapters provide broad coverage of Sade's main intellectual and creative activities, showing how all can be seen as the expression of a veritable cult of the body, a veneration of the physical, and the sexual as channels of transcendence.

    Politicians of all stripes stress its importance, as do church leaders, captains of industry and every kind of campaigning group--from those supporting global causes, such as tackling world poverty, to others with a largely local focus, such as combating neighborhood crime. In this brilliant, compact introduction, Richard Bellamy offers an eye-opening look at an idea that is as important as it is rare--the prospect of influencing government policy according to reasonably fair rules and on a more or less equal basis with others. Bringing together the most recent scholarship, the book sheds light on how ideas of citizenship have changed through time from ancient Greece to the present, looks at concepts such as membership and belonging, and highlights the relation between citizenship, rights, and democracy. Bellamy also examines the challenges confronting the very possibility of citizenship today, the impact of globalization, the desirability of "global citizenship," the teaching of citizenship in schools, citizenship tests for immigrants, and the many different definitions and types of citizenship in modern society.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    In this Very Short Introduction, engineer David Muir Wood turns a spotlight on a field that we often take for granted. He sheds light on the nature and importance of civil engineering in the history of civilization and urbanization, outlines its many accomplishments in the modern era, and points to the hurdles that civil engineering will face in the future. Beginning with the task of creating a settlement on a deserted island, Muir Wood sets out the problems that civil engineers face every day, highlighting the social and environmental challenges as well as the grasp of science and technology needed to craft buildings, bridges, tunnels, houses, and areas of recreation. The author also profiles the lives of some of the major civil engineers, such as Isambard Kingdom Brunel, the acclaimed builder of steamships, railways, and tunnels, and Sir Joseph Bazalgette, whose sewer system in central London was instrumental in relieving the city from cholera epidemics. Finally, Muir Wood considers the growing difficulty of managing our water and energy supplies, and he looks at the engineering profession's increased sensitivity to building and the environment.

    Their archaeological record is both substantial and fascinating, including tomb paintings, sculpture, jewelry, and art. In this Very Short Introduction, Christopher Smith explores Etruscan history, culture, language, and customs. Examining the controversial debates about their origins, he explores how they once lived, placing them within the geographical, economic, and political context of the time. Smith concludes by demonstrating how the Etruscans have been studied and perceived throughout the ages, and the impact this has had on our understanding of their place in history.About the Series: Oxford's Very Short Introductions series offers concise and original introductions to a wide range of subjects--from Islam to Sociology, Politics to Classics, Literary Theory to History, and Archaeology to the Bible. Not simply a textbook of definitions, each volume in this series provides trenchant and provocative--yet always balanced and complete--discussions of the central issues in a given discipline or field. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how the subject has developed and how it has influenced society. Eventually, the series will encompass every major academic discipline, offering all students an accessible and abundant reference library. Whatever the area of study that one deems important or appealing, whatever the topic that fascinates the general reader, the Very Short Introductions series has a handy and affordable guide that will likely prove indispensable.

    Wilson Literary Science Writing AwardShort-listed for Physics World 's Book of the Year The Sunday Times (UK) Best Science Book of 2014 A Publishers Weekly Top 10 Science Book of Fall 2014An NBC News Top Science and Tech Book of 2014A Politics & Prose 2014 Staff PickIn the sixteenth century, Nicolaus Copernicus dared to go against the establishment by proposing that Earth rotates around the Sun. Having demoted Earth from its unique position in the cosmos to one of mediocrity, Copernicus set in motion a revolution in scientific thought. This perspective has influenced our thinking for centuries. However, recent evidence challenges the Copernican Principle, hinting that we do in fact live in a special place, at a special time, as the product of a chain of unlikely events. But can we be significant if the Sun is still just one of a billion trillion stars in the observable universe? And what if our universe is just one of a multitude of others-a single slice of an infinity of parallel realities?In The Copernicus Complex, the renowned astrophysicist Caleb Scharf takes us on a scientific adventure, from tiny microbes within the Earth to distant exoplanets, probability theory, and beyond, arguing that there is a solution to this contradiction, a third way of viewing our place in the cosmos, if we weigh the evidence properly. As Scharf explains, we do occupy an unusual time in a 14-billion-year-old universe, in a somewhat unusual type of solar system surrounded by an ocean of unimaginable planetary diversity: hot Jupiters with orbits of less than a day, planet-size rocks spinning around dead stars, and a wealth of alien super-Earths. Yet life here is built from the most common chemistry in the universe, and we are a snapshot taken from billions of years of biological evolution. Bringing us to the cutting edge of scientific discovery, Scharf shows how the answers to fundamental questions of existence will come from embracing the peculiarity of our circumstance without denying the Copernican vision.With characteristic verve, Scharf uses the latest scientific findings to reconsider where we stand in the balance between cosmic significance and mediocrity, order and chaos. Presenting a compelling and bold view of our true status, The Copernicus Complex proposes a way forward in the ultimate quest: determining life's abundance, not just across this universe but across all realities.

    In this Very Short Introduction, Michael Cook provides a lucid and direct account of the significance of the Koran both in the modern world and inthat of traditional Islam. He gives vivid accounts of its role in Muslim civilization, illustrates the diversity of interpretations championed by traditional and modern commentators, discusses the processes by which the book took shape, and compares it to other scriptures and classics of thehistoric cultures of Eurasia.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundredsof key topics, from philosophy to Freud, quantum theory to Islam.

    Titan Unveiled is one of the first general interest books to reveal the startling new discoveries that have been made since the arrival of the Cassini-Huygens mission to Saturn and Titan.Ralph Lorenz and Jacqueline Mitton take readers behind the scenes of this mission. Launched in 1997, Cassini entered orbit around Saturn in summer 2004. Its formidable payload included the Huygens probe, which successfully parachuted down through Titan's atmosphere in early 2005, all the while transmitting images and data--and scientists were startled by what they saw. One of those researchers was Lorenz, who gives an insider's account of the scientific community's first close encounter with an alien landscape of liquid methane seas and turbulent orange skies. Amid the challenges and frayed nerves, new discoveries are made, including methane monsoons, equatorial sand seas, and Titan's polar hood. Lorenz and Mitton describe Titan as a world strikingly like Earth and tell how Titan may hold clues to the origins of life on our own planet and possibly to its presence on others.Generously illustrated with many stunning images, Titan Unveiled is essential reading for anyone interested in space exploration, planetary science, or astronomy.-- "Lunar and Planetary Information Bulletin"

    The term has become something of a catch-all, a convenient way to encompass numerous issues and developments which pertain to the political, social, and economic history of modern Ireland. It is a question which refuses to go away, but it is also a question whose inconstant meaning is rarely anatomized and still less often denied. One of the main aims of this book is to explore the complicated and shifting nature of the Irish Question, and to assess what it has meant to various political minds and agendas. The book is arranged both thematically and chronologically; each of the eight chapters takes as its focus a particular period, and each period is discussed within the context of one or more questions which informed and shaped that particular period.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam

    She draws on conversations with hundreds of the world's top scientists and on her own work as a Pulitzer Prize-winning writer for the New York Times to create a thoroughly entertaining guide to scientific literacy. Angier's gifts are on full display in The Canon, an ebullient celebration of science that stands to become a classic. The Canon is vital reading for anyone who wants to understand the great issues of our time -- from stem cells and bird flu to evolution and global warming. And it's for every parent who has ever panicked when a child asked how the earth was formed or what electricity is. Angier's sparkling prose and memorable metaphors bring the science to life, reigniting our own childhood delight in discovering how the world works. "Of course you should know about science," writes Angier, "for the same reason Dr. Seuss counsels his readers to sing with a Ying or play Ring the Gack: These things are fun and fun is good." The Canon is a joyride through the major scientific disciplines: physics, chemistry, biology, geology, and astronomy. Along the way, we learn what is actually happening when our ice cream melts or our coffee gets cold, what our liver cells do when we eat a caramel, why the horse is an example of evolution at work, and how we're all really made of stardust. It's Lewis Carroll meets Lewis Thomas -- a book that will enrapture, inspire, and enlighten.

    But learning about his life and understanding his importance has always proven difficult, as our only source of knowledge comes from the biography of him written by his followers, the reliability of which has been questioned by Western scholars. This Very Short Introduction provides a superb introduction to the major aspects of Muhammad's life and its importance, providing both Muslim and Western historical perspectives. It explains the prominent roles that Muhammad's persona has played in the Islamic world throughout history, from the medieval to the modern period. The book also sheds light on modern controversies such as the Satanic Verses, for which author Salman Rushdie was condemned for blasphemy, and the uproar over Danish cartoons of Muhammad, which triggered violent protests around the world. As these recent events show, whatever the truth about Muhammad's life, his persona still plays a crucial role in Muslim life and civilization.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Taking a thematic rather than strictly chronological approach, W.F. Bynum, explores the key turning points in the history of Western medicine-such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines. Covering a vast amount of information, this Very Short Introduction sheds new light on medicine's past, while at the same time engaging with contemporary issues, discoveries, and controversies, such as the spiraling costs of health care, lack of health insurance for millions, breakthrough treatments, and much more. For readers who wish to understand the how we have arrived at our current state of medical practice and knowledge, this book is essential reading.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Taking an international perspective, and focusing on highly topical issues such as torture, arbitrary detention, privacy, health, and discrimination, this Very Short Introduction will help readers to understand for themselves the controversies and complexities behind this vitally relevant issue. Looking at the philosophical justification for rights, the historical origins of human rights and how they are formed in law, Andrew Clapham explains what our human rights actually are, what they might be, and where the human rights movement is heading.

    Looking at the reality behind these images, this Very Short Introduction illuminates the historical background against which the silk road flourished, shedding light on the importance of old-world cultural exchange to Eurasian and world history.On the one hand, historian James A. Millward treats the silk road broadly, to stand in for the cross-cultural communication between peoples across the Eurasian continent since at least the Neolithic era. On the other, he highlights specific examples of goods and ideas exchanged between the Mediterranean, Persia, India, and China, along with the significance of these exchanges. While including silks, spices, and travelers' tales of colorful locales, the book explains the dynamics of Central Eurasian history that promoted Silk Road interactions--especially the role of nomad empires--highlighting the importance of the biological, technological, artistic, intellectual, and religious interchanges across the continent. Millward shows that these exchanges had a profound effect on the old world that was akin to, if not on the scale of, modern globalization. He also disputes the idea that the silk road declined after the collapse of the Mongol empire or the opening of direct sea routes from Europe to Asia, showing how silk road phenomena continued through the early modern and modern expansion of the Russian and Chinese states across Central Asia.Millward concludes that the idea of the silk road has remained powerful, not only as a popular name for boutiques and restaurants, but also in modern politics and diplomacy, such as U.S. Secretary of State Hilary Clinton's Silk Road Initiative for India, Pakistan, and Afghanistan.