13 extraordinary essays shed new light on the mysteries of the universe & on one of the most brilliant thinkers of our time.In his phenomenal bestseller A Brief History of Time, Stephen Hawking literally transformed the way we think about physics, the universe, reality itself. In these thirteen essays and one remarkable extended interview, the man widely regarded as the most brilliant theoretical physicist since Einstein returns to reveal an amazing array of possibilities for understanding our universe. Building on his earlier work, Hawking discusses imaginary time, how black holes can give birth to baby universes, and scientists’ efforts to find a complete unified theory that would predict everything in the universe. With his characteristic mastery of language, his sense of humor and commitment to plain speaking, Stephen Hawking invites us to know him better—and to share his passion for the voyage of intellect and imagination that has opened new ways to understanding the very nature of the cosmos.

    Now award-winning writer Carl Zimmer takes us on a fantastic voyage into the secret parasite universe we actually live in but haven't recognized. He reveals not only that parasites are the most successful life-forms on Earth, but that they triggered the development of sex, shape ecosystems, and have driven the engine of evolution. In mapping the parasite universe, Zimmer makes the astonishing observation that most species are parasites, and that almost every animal, including humans, will at one time or another become the home of a parasite. Zimmer shows how highly evolved parasites are and describes the frightening and amazing ingenuity these commando invaders use to devour their hosts from the inside and control their behavior. The sinister Sacculina carcini makes its home in an unlucky crab and proceeds to eat everything but what the crab needs to put food in its mouth, which Sacculina then consumes. When Sacculina finally reproduces, it places its young precisely where the crab would nurture its own progeny, and then has the crab nurture the foster family members. Single-celled Toxoplasma gondi has an even more insidious role, for it can invade the human brain. There it makes men distrustful and less willing to submit to social mores. Women become more outgoing and warm-hearted. Why would a parasite cause these particular personality changes? It seems Toxoplasma wants its host to be less afraid, to be more prone to danger and a violent end -- so that, in the carnage, it will be able to move on to another host. From the steamy jungles of Costa Rica to the fetid parasite heaven of rebel-held southern Sudan, Zimmer tracks the genius of parasitic life and its impact on humanity. We hosts have developed remarkable defenses against the indomitable parasite: our mighty immune system, our culturally enforced habit of keeping clean, and, perhaps most intriguingly, sex. But this is not merely a book about the evil power of parasitism and how we must defend against it. On the contrary, Zimmer concludes that humankind itself is a new kind of parasite, one that preys on the entire Earth. If we are to achieve the sophistication of the parasites on display here in vivid detail, if we are to promote the flourishing of life in all its diversity as they do, we must learn the ways nature lives with itself, the laws of Parasite Rex.

    But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In his new book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable. Gawande's gripping stories of diligence, ingenuity, and what it means to do right by people take us to battlefield surgical tents in Iraq, to labor and delivery rooms in Boston, to a polio outbreak in India, and to malpractice courtrooms around the country. He discusses the ethical dilemmas of doctors participation in lethal injections, examines the influence of money on modern medicine, and recounts the astoundingly contentious history of hand washing. And as in all his writing, Gawande gives us an inside look at his own life as a practicing surgeon, offering a searingly honest firsthand account of work in a field where mistakes are both unavoidable and unthinkable. At once unflinching and compassionate, Better is an exhilarating journey narrated by arguably the best nonfiction doctor-writer around (Salon). Gawande's investigation into medical professionals and how they progress from merely good to great provides rare insight into the elements of success, illuminating every area of human endeavor.

    How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    For more than two centuries, our understanding of the laws of nature expanded rapidly. But today, despite our best efforts, we know nothing more about these laws than we knew in the 1970s. Why is physics suddenly in trouble? And what can we do about it?One of the major problems, according to Smolin, is string theory: an ambitious attempt to formulate a “theory of everything” that explains all the particles and forces of nature and how the universe came to be. With its exotic new particles and parallel universes, string theory has captured the public’s imagination and seduced many physicists.But as Smolin reveals, there’s a deep flaw in the theory: no part of it has been tested, and no one knows how to test it. In fact, the theory appears to come in an infinite number of versions, meaning that no experiment will ever be able to prove it false. As a scientific theory, it fails. And because it has soaked up the lion’s share of funding, attracted some of the best minds, and effectively penalized young physicists for pursuing other avenues, it is dragging the rest of physics down with it.With clarity, passion, and authority, Smolin charts the rise and fall of string theory and takes a fascinating look at what will replace it. A group of young theorists has begun to develop exciting ideas that, unlike string theory, are testable. Smolin not only tells us who and what to watch for in the coming years, he offers novel solutions for seeking out and nurturing the best new talent—giving us a chance, at long last, of finding the next Einstein.

    Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA.We learn that Neanderthal genes offer a unique window into the lives of our hominin relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Drawing on genetic and fossil clues, Pääbo explores what is known about the origin of modern humans and their relationship to the Neanderthals and describes the fierce debate surrounding the nature of the two species’ interactions. His findings have not only redrawn our family tree, but recast the fundamentals of human history—the biological beginnings of fully modern Homo sapiens, the direct ancestors of all people alive today.A riveting story about a visionary researcher and the nature of scientific inquiry, Neanderthal Man offers rich insight into the fundamental question of who we are.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    Explaining the truth behind the screening statistics and investigating the evidence behind the hype, Margaret McCartney, an award-winning writer and doctor, argues that this patient paradox - too much testing of well people and not enough care for the sick - worsens health inequalities and drains professionalism.

    Kaku skillfully guides us through the latest innovations in string theory and its latest iteration, M-theory, which posits that our universe may be just one in an endless multiverse, a singular bubble floating in a sea of infinite bubble universes. If M-theory is proven correct, we may perhaps finally find answer to the question, “What happened before the big bang?” This is an exciting and unforgettable introduction into the new cutting-edge theories of physics and cosmology from one of the pre-eminent voices in the field.

    That moral fire, argue authors Desmond and Moore, was a passionate hatred of slavery. They draw on a wealth of fresh manuscripts, correspondence, notebooks, diaries, and even ships' logs to show how Darwin's abolitionism had deep roots in his mother's family and was reinforced by his voyage on the Beagle as well as by events in America. Leading apologists for slavery in Darwin's time argued that blacks and whites were separate species, with whites created superior. Darwin believed that the races belonged to the same human family, and slavery was therefore a sin.

    While they're at it, they helpfully demystify many complicated things we do know about, from quarks and neutrinos to gravitational waves and exploding black holes. With equal doses of humor and delight, they invite us to see the universe as a vast expanse of mostly uncharted territory that's still ours to explore.This entertaining illustrated science primer is the perfect book for anyone who's curious about all the big questions physicists are still trying to answer.

    He was one of the leading pioneers of the greatest revolution in twentieth-century science: quantum mechanics. The youngest theoretician ever to win the Nobel Prize for Physics, he was also pathologically reticent, strangely literal-minded and legendarily unable to communicate or empathize. Through his greatest period of productivity, his postcards home contained only remarks about the weather.Based on a previously undiscovered archive of family papers, Graham Farmelo celebrates Dirac's massive scientific achievement while drawing a compassionate portrait of his life and work. Farmelo shows a man who, while hopelessly socially inept, could manage to love and sustain close friendship.The Strangest Man is an extraordinary and moving human story, as well as a study of one of the most exciting times in scientific history.'A wonderful book . . . Moving, sometimes comic, sometimes infinitely sad, and goes to the roots of what we mean by truth in science.' Lord Waldegrave, Daily Telegraph

    The Survivors Club: The Secrets and Science that Could Save Your Life

    It was to last five years and transform him from an amiable and somewhat aimless young man into a scientific celebrity. Even more vitally, it was to set in motion the intellectual currents that culminated in the arrival of The Origin of Species in Victorian drawing-rooms in 1859. His journal, reprinted here in a shortened version, is vivid and immediate, showing us a naturalist making patient observations, above all in geology. As well as a profusion of natural history detail, it records many other things that caught Darwin’s eye, from civil war in Argentina to the new colonial settlements of Australia. The editors have provided an excellent introduction and notes for this Penguin Classics edition, which also contains maps and appendices, including an essay on scientific geology and the Bible by Robert FitzRoy, Darwin’s friend and captain of the Beagle.

    Comparing gene sequences, examining atomic structures of proteins, and looking into the geochemistry of rocks have helped explain evolution in more detail than ever before. Nick Lane expertly reconstructs the history of life by describing the ten greatest inventions of evolution (including DNA, photosynthesis, sex, and sight), based on their historical impact, role in organisms today, and relevance to current controversies. Who would have guessed that eyes started off as light-sensitive spots used to calibrate photosynthesis in algae? Or that DNA’s building blocks form spontaneously in hydrothermal vents? Lane gives a gripping, lucid account of nature’s ingenuity, and the result is a work of essential reading for anyone who has ever pondered or questioned the science underlying evolution’s greatest gifts to man.