Bundled (ISBN 9780534633622) textbook with InfoTrac CD-ROM.

    The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    She entered Ah-gwah-ching State Sanatorium at Walker, Minnesota, for what she thought would be a short stay. In January, her tuberculosis spread, and she nearly died. Her recovery required many months of bed rest and medical care.Marilyn loved to write, and the story of her three-year residency at the sanatorium is preserved in hundreds of letters that she mailed back home to her parents, who could visit her only occasionally and whom she missed terribly. The letters functioned as a diary in which Marilyn articulately and candidly recorded her reactions to roommates, medical treatments, Native American nurses, and boredom. She also offers readers the singular perspective of a bed-bound teenager, gossiping about boys, requesting pretty new pajamas, and enjoying Friday evening popcorn parties with other patients.Selections from this cache of letters are woven into an informative narrative that explores the practices and culture of a midcentury tuberculosis sanatorium and fills in long-forgotten details gleaned from recent conversations with Marilyn, who "graduated" from the sanatorium and went on to lead a full, productive life.

    With a focus on the big picture of human evolution, the text helps students master the basic principles of the subject and arrive at an understanding of the human species and its place in the biological world. This book continues to keep pace with changes in the field by including thorough coverage of cutting-edge advances in molecular biology and genomics, expanded material on modern human biology, and the latest in new fossil finds.

    Decades ago, astronauts brought back 850 pounds of rocks from their lunar journeys; the U.S. gave some away as “goodwill” gifts to the world’s nations. Over time, many of them disappeared, stolen or lost in the aftermath of political turmoil, and offered for millions on the black market. Gutheinz, first as a NASA investigator and then the leader of a intrepid group of students, has dedicated his life to getting them back. Author Joe Kloc tells a wild story of geopolitics, crime, science, and one man’s obsession with keeping the moon out of the wrong hands.

    Morgan

    As a young ornithology instructor at the Hog Island Audubon Camp, Dr. Stephen W. Kress learned that puffins had nested on nearby islands until extirpated by hunters in the late 1800s. To right this environmental wrong, he resolved to bring puffins back to one such island—Eastern Egg Rock. Yet bringing the plan to reality meant convincing skeptics, finding resources, and inventing restoration methods at a time when many believed in “letting nature take its course.” Today, Project Puffin has restored more than 1,000 puffin pairs to three Maine islands. But even more exciting, techniques developed during the project have helped to restore rare and endangered seabirds worldwide. Further, reestablished puffins now serve as a window into the effects of global warming. The success of Dr. Kress’s project offers hope that people can restore lost wildlife populations and the habitats that support them. The need for such inspiration has never been greater.

    Winner of the Francis Parkman PrizeIn this landmark work of environmental history, William Cronon offers an original and profound explanation of the effects European colonists' sense of property and their pursuit of capitalism had upon the ecosystems of New England. Reissued here with an updated afterword by the author and a new preface by the distinguished colonialist John Demos, Changes in the Land, provides a brilliant inter-disciplinary interpretation of how land and people influence one another. With its chilling closing line, "The people of plenty were a people of waste," Cronon's enduring and thought-provoking book is ethno-ecological history at its best.

    

    Jonathan Reiner, share the story of Cheney’s thirty-five-year battle with heart disease—providing insight into the incredible medical breakthroughs that have changed cardiac care over the last four decades. For as long as he has served at the highest levels of business and government, Vice President Dick Cheney has also been one of the world’s most prominent heart patients. Now, for the first time ever, Cheney, together with his longtime cardiologist, Jonathan Reiner, MD, shares the very personal story of his courageous thirty-five-year battle with heart disease, from his first heart attack in 1978 to the heart transplant he received in 2012.In 1978, when Cheney suffered his first heart attack, he received essentially the same treatment President Eisenhower had had in 1955. Since then, cardiac medicine has been revolutionized, and Cheney has benefitted from nearly every medical breakthrough. At each juncture, when Cheney faced a new health challenge, the technology was one step ahead of his disease. Cheney’s story is in many ways the story of the evolution of modern cardiac care.Heart is the riveting, singular memoir of both doctor and patient. Like no US politician has before him, Cheney opens up about his health struggles, sharing harrowing, never-before-told stories about the challenges he faced during a perilous time in our nation’s history. Dr. Reiner provides his perspective on Cheney’s case and also gives readers a fascinating glimpse into his own education as a doctor and the history of our understanding of the human heart. He masterfully chronicles the important discoveries, radical innovations, and cutting-edge science that have changed the face of medicine and saved countless lives.Powerfully braiding science with story and the personal with the political, Heart is a sweeping, inspiring, and ultimately optimistic book that will give hope to the millions of Americans affected by heart disease.

    “I smoked in my twenties. I preferred red wine to sparkling water. I ate too much milk chocolate. I liked limericks. I know all the wrong I’ve done. But also, more than any of that, I’ve always longed for children.” Yet there she was: successful, social, mostly happy, and not a mother. Knowing that her chances of becoming pregnant naturally were quickly fading, Finn decided to gamble: she—like some 85,000 other women in the U.S. each year—would attempt in vitro fertilization. Almost three years later, she’s still trying, and in the process has become an accidental pioneer (and, at times, a guinea pig) in the ever-evolving science of IVF.“The Baby Chase” is a primer for anyone contemplating or undergoing IVF. More than that, it’s a story of longing, hope—and hormones—that will appeal to all parents, present and future.Finn’s engaging and honest account sheds light on a subject that few people who undergo IFV are willing to talk about: what happens when the science doesn’t work. “Usually, it’s only the people who come out on the other side, beaming, with a baby on one hip, who speak up about IVF,” she writes. “We never hear from those IVF has failed - it’s too crushing to talk about. We don’t hear from men and women in the middle of treatment, either.... People like me.”

    Leeuwenhoek proceeded to examine the microscopic activity of his spittle, teeth plaque, and feces, and as the result of his findings the field of bacteriology was born. Some two hundred years later, Wilhelm Conrad Roentgen, a professor of theoretical physics at the University of Wurzburg, invited his wife to his laboratory, asked her to place her hand on an unexposed photographic plate, turned on an electric current, and showed this terrified woman a picture of the bones of her hand. And so came the discovery of the X-ray.This absorbing book is the first to describe these and eight other monumental medical discoveries throughout history, bringing to life the scientific pioneers responsible for them and the excitement, frustrations, and jealousies that surrounded the final achievements. Two distinguished physicians, Meyer Friedman and Gerald W. Friedland, have drawn on their many years of experience as well as on that of world-renowned antiquarian book dealers, physician collectors of old and new medical publications, and medical school professors to single out these medical breakthroughs from thousands of candidates, and, in several cases, to provide information never before available. Their engrossing stories of the ten most significant discoveries will be read with enjoyment by anyone fascinated by the mysteries of medicine.

    These personal tragedies will, and must, be told and heard. There is, however, also a truthful and objective scientific narrative to be written about how the virus played out and how the world set about dealing with it. Spike is that story - from the inside. Its author, Jeremy Farrar, is one of the UK's leading scientists and a ­­member of the SAGE emergency committee.As head of the Wellcome Trust, and an expert in emerging infectious diseases, Jeremy Farrar was one of the first people in the world to hear about a mysterious new respiratory disease in China - and to learn that it could readily spread between people. Farrar describes how it feels as one of the key scientists at the sharp end of a fast-moving situation, when complex decisions must be made quickly amid great uncertainty. His book casts light on the UK government's claims to be 'following the science' in its response to the virus, and is informed not just by Farrar's views but by interviews with other top scientists and political figures.Farrar, who has spent his career on the frontlines of epidemics including Nipah virus in Malaysia, bird flu in Vietnam and Ebola in West Africa, also reflects on the wider issues of Covid-19: the breath-taking scientific advances in creating tests, treatments and vaccines; the challenge to world leaders to respond for the global good and the need to address inequalities that hold back success against the virus. All these shape how the world ultimately fares not just against Covid-19, but against all the major he­­alth challenges we face globally.

    Edgar, like many other people, has synesthesia - a fascinating condition in which music can have color, words can have taste, and time and numbers float through space.Everyone will be closely acquainted with at least 6 or 7 people who have synesthesia but you may not yet know who they are because, until very recently, synesthesia was largely hidden and unknown. Now science is uncovering its secrets and the findings are leading to a radical rethink about how our senses are organized. In this timely and thought-provoking book, Jamie Ward argues that sensory mixing is the norm even though only a few of us cross the barrier into the realms of synesthesia.How is it possible to experience color when no color is there? Why do some people experience touch when they see someone else being touched? Can blind people be made to see again by using their other senses? Why do scientists no longer believe that there are five senses? How does the food industry exploit the links that exist between our senses? Does synesthesia have a function? The Frog Who Croaked Blue explores all these questions in a lucid and entertaining way, making it fascinating reading for anyone with an interest in the intriguing workings of the mind.

    Enhanced with carefully crafted learning tools, its warm narrative style and emphasis on diverse lives and universal themes that speak directly to students.With this new edition, that tradition is brought forward in a captivating new way. Cutting-edge research, electronic tools, and comprehensive insight combine to make The Developing Person Through the Life Span, Seventh Edition, the text that instructors need. With this edition, the ideal life-span text is better than ever.