At the same time, he was immersed in street life. Today he is a cutting-edge neuroscientist—Columbia University's first tenured African American professor in the sciences—whose landmark, controversial research is redefining our understanding of addiction.In this provocative and eye-opening memoir, he recalls his journey of self-discovery and weaves his past and present. Hart goes beyond the hype of the antidrug movement as he examines the relationship among drugs, pleasure, choice, and motivation, both in the brain and in society. His findings shed new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.Though Hart escaped neighborhoods that were dominated by entrenched poverty and the knot of problems associated with it, he has not turned his back on his roots. Determined to make a difference, he tirelessly applies his scientific research to help save real lives. But balancing his former street life with his achievements today has not been easy—a struggle he reflects on publicly for the first time.A powerful story of hope and change, of a scientist who has dedicated his life to helping others, High Price will alter the way we think about poverty, race, and addiction—and how we can effect change.

    He was Stalin’s closest henchman. At one time he had a million armed men under his direct personal command. He was a sadist and a mass murderer. And he was also a vicious rapist with a compulsive appetite for young girls. This is possible: Beria may have kept a private diary in which he lovingly recorded his sexual activities, his murders, various scandals involving men now highly placed in the Soviet hierarchy — and the true facts of Stalin’s death. This is certain: The publication of Beria’s diary would cause the greatest political scandal the world has ever known — and set off a deadly manhunt for those responsible for its release … The private diaries of Beria — Stalin’s notorious chief of secret police — are a lurid, shattering indictment of Russian political methods and contain a new account of what really happened at Stalin’s death. They confirm Beria as one of the greatest human monsters of our time, both in his personal life and in his political manipulations of top Soviet politicians, some of whom are in power today. The Beria Papers are sold to an American publisher for three million dollars. On publication they are an immediate, sensational bestseller. They cause panic in Moscow and outrage everywhere — even in the upper echelons of the U.S. government, where there is fear that such revelations will create a dangerous precedent in smear campaigns against world leaders. So the world’s two most powerful secret services — the Soviet KGB and the American CIA — are ordered to track down the book’s origin. Their investigations range from New York to Washington, to London, Moscow, Munich, Budapest, Vienna and finally to a small island in the Indian Ocean where the activities of the two secret agencies come horrifically together. But can The Beria Papers possibly be a hoax? Praise for The Beria Papers: ‘Intriguing and gripping … compulsively exciting’ - Sunday Express ‘Both exciting and really convincing … fascinating. Part adventure, part thriller, part a documentary of might-have-been history, The Beria Papers is the best thing of its kind for a long time.’ - Sunday Times ‘The most interesting and original thriller since The Odessa File … a sharp and intelligent thriller that cries out for filming.’ - Daily Mail ‘Intriguing and gripping … not merely compulsively exciting entertainment, it is also so well researched and the background appears so absolutely authentic that the whole fantastic story could just be true.’ - Sunday Express Alan Emlyn Williams(born 1935) is an ex-foreign correspondent, novelist and writer of thrillers. He was educated at Stowe, Grenoble and Heidelberg Universities, and at King's College, Cambridge where he graduated in 1957 with a B.A. in modern languages. His father was the actor and writer Emlyn Williams.

    In prehistoric caves, drummers used natural acoustics to recreate natural sound. In classical Europe, orators turned the human voice into a lyrical instrument. In Buddhist temples, the icons' ears were exaggerated to represent their spiritual power. And in modern metropolises we are battered by the roar of sound that surrounds us. In the first narrative history of the subject which puts humans at its centre, and coinciding with the author's major Radio 4 series on the same subject, acclaimed historian David Hendy describes the history of noise - which is also the history of listening. As he puts it himself: 'By thinking about sound and listening, I want to get closer to what it felt like to live in the past or be caught up in the major events of history. The book is a chance for readers to discover more of the personal and social background to those stories featured in the radio series.' This unusual book reveals fascinating changes in how we have understood our fellow human humans and the world around us. For although we might see ourselves inhabiting a visual world, our lives are shaped by our need to hear and be heard.

    He demonstrates how the explosion of rational thought and scientific innovation during the Enlightenment began to change our understanding of the flesh and its relation to the soul. No longer simply a "mortal coil," the body eventually became the location, and source, of our conscious selves. Porter examines this paradigm shift through the eyes of the great thinkers of history, from Descartes to Voltaire to Lord Byron, summarizing and explicating their beliefs "in a prose that leaps resplendently from the page" (Harper's).

    He shows how many intellectuals have denied the existence of human nature by embracing three linked dogmas: the Blank Slate (the mind has no innate traits), the Noble Savage (people are born good and corrupted by society), and the Ghost in the Machine (each of us has a soul that makes choices free from biology). Each dogma carries a moral burden, so their defenders have engaged in desperate tactics to discredit the scientists who are now challenging them.Pinker injects calm and rationality into these debates by showing that equality, progress, responsibility, and purpose have nothing to fear from discoveries about a rich human nature. He disarms even the most menacing threats with clear thinking, common sense, and pertinent facts from science and history.Despite its popularity among intellectuals during much of the twentieth century, he argues, the doctrine of the Blank Slate may have done more harm than good. It denies our common humanity and our individual preferences, replaces hardheaded analyses of social problems with feel-good slogans, and distorts our understanding of government, violence, parenting, and the arts.Pinker shows that an acknowledgement of human nature that is grounded in science and common sense, far from being dangerous, can complement insights about the human condition made by millennia of artists and philosophers. All this is done in the style that earned his previous books many prizes and worldwide acclaim: wit, lucidity, and insight into matters great and small.

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    A brilliant tale of ineptitude, self-righteousness, and human folly, it combines the mordant wit of W. Somerset Maugham with a sense of humor reminiscent of P.G. Wodehouse.When Dr. Sydney Prout is named the head of the United Nations mission to Elephant Island, he believes he is more than ready to meet the challenge of guiding its primitive inhabitants into the post-Colonial era, and eventually, full independence. But neither his many academic credentials nor the Journal of Race Relations have prepared Dr. Prout to reckon with the unrepentant bloody-mindedness of the natives, or anticipate the inventive ways their tribal philosophers will incorporate the most unlikely aspects of modern civilization into their religious lore and traditional way of life.Author Owen Stanley is an Australian explorer, a philosopher, and a poet who speaks seven languages. He is at much at home in the remote jungles of the South Pacific as flying his Staudacher aerobatic plane, deep-sea diving, or translating the complete works of Charles Darwin into Tok Pisin.

    The tipping point, Mirbat, South Oman, 19 July 1972 is one of the least-known yet most crucial battles of modern times. If the SAS had been defeated at Mirbat, the Russian and Chinese plan for a communist foothold in the Middle East would have succeeded, with catastrophic consequences for the oil-hungry West. OPERATION STORM is a page-turning account of courage and resilience. Mirbat was a battle fought and won by nine SAS soldiers and a similar number of brave local people - some as young as ten years old - outnumbered by at least twenty-five to one. Roger Cole, one of the SAS soldiers who took part, and writer Richard Belfield have interviewed every SAS survivor who fought in the battle from the beginning to the end - the first time every single one of them has revealed their experience. OPERATION STORM is a classic story of bravery against impossible odds, minute by minute, bullet by bullet.

    In How to Grow Old, the great Roman orator and statesman eloquently describes how you can make the second half of life the best part of all--and why you might discover that reading and gardening are actually far more pleasurable than sex ever was.Filled with timeless wisdom and practical guidance, Cicero's brief, charming classic—written in 44 BC and originally titled On Old Age—has delighted and inspired readers, from Saint Augustine to Thomas Jefferson, for more than two thousand years. Presented here in a lively new translation with an informative new introduction and the original Latin on facing pages, the book directly addresses the greatest fears of growing older and persuasively argues why these worries are greatly exaggerated--or altogether mistaken.Montaigne said Cicero's book "gives one an appetite for growing old." The American founding father John Adams read it repeatedly in his later years. And today its lessons are more relevant than ever in a world obsessed with the futile pursuit of youth.

    And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    Simpson to get away with murder, an innocent cop - a brilliant detective - had to he destroyed. That was the cynical strategy of the Simpson "Dream Team, " and it worked. But as certainty about Simpson's guilt grows, so does outrage about the scapegoating of Mark Fuhrman. Now the former LAPD detective tells his side of the story in a damning expose. The veteran detective gives the inside story of why and how Simpson's interrogation was bungled; how police criminalists made previously unrevealed errors that torpedoed the prosecution's case; why Marcia Clark foolishly suppressed evidence of an affair between Ron and Nicole; and why Clark refused to call a key police witness who could have corroborated Fuhrman's testimony and blown away the defense team's claim of planted evidence. Fuhrman's own hand-drawn maps of the crime scene and his reconstruction of the murders leave no doubt about what really happened on June 12, 1994. New revelations about the incompetence and corruption that pervaded the "Trial of the Century" will exonerate this decent, loyal detective, the innocent cop who was sacrificed so a rich, guilty celebrity could go free.

    From the Middle Ages onwards the island of Britain has been shaped by the unique dynamic between Edinburgh and London, exchanging inhabitants, monarchs, money and ideas, sometimes in a spirit of friendship and at others in a spirit of murderous dislike.Tom Devine's seminal new book explores this extraordinary history in all its ambiguity, from the seventeenth century to the present. When not undermining each other with invading armies, both Scotland and England have broadly benefitted from each other's presence - indeed for long periods of time nobody questioned the union which joined them. But as Devine makes clear, it has for the most part been a relationship based on consent, not force, on mutual advantage, rather than antagonism - and it has always held the possibility of a political parting of the ways.With the United Kingdom under a level of scrutiny unmatched since the eighteenth century Independence or Union is the essential guide.

    How can it be possible that the world we see is not objective reality? And how can our senses be useful if they are not communicating the truth? Hoffman grapples with these questions and more over the course of this eye-opening work.Ever since Homo sapiens has walked the earth, natural selection has favored perception that hides the truth and guides us toward useful action, shaping our senses to keep us alive and reproducing. We observe a speeding car and do not walk in front of it; we see mold growing on bread and do not eat it. These impressions, though, are not objective reality. Just like a file icon on a desktop screen is a useful symbol rather than a genuine representation of what a computer file looks like, the objects we see every day are merely icons, allowing us to navigate the world safely and with ease.The real-world implications for this discovery are huge. From examining why fashion designers create clothes that give the illusion of a more “attractive” body shape to studying how companies use color to elicit specific emotions in consumers, and even dismantling the very notion that spacetime is objective reality, The Case Against Reality dares us to question everything we thought we knew about the world we see.

    Shirer's new book - written in his ninth decade - explores the passionate, highly charged, and extraordinary lives of Leo and Sonya Tolstoy. It is a compelling illumination both of the nature of genius and of the universal problems of love, sex, and marriage - themes that Tolstoy played out in his great fiction and that haunted him in his tangled domestic life. Rich in anecdotes, wise, full of sweeping history, and imbued with Shirer's profound knowledge of literature and life, Love and Hatred ranks beside such works as Robert Massie's Nicholas and Alexandra and Nigel Nicolson's Portrait of a Marriage as a masterly, intuitive, and sympathetic exploration of the love/hate relationship between two famous, bigger-than-life people. Beginning in 1862, when Tolstoy committed the blunder of asking his young bride to read his diaries of his bachelor life so there should be no secrets between them, and ending with his tragic flight from home (and marriage) in 1910 while the whole world waited for news of him, Love and Hatred tells the story of a great romance between two people who could live neither together nor apart - a romance that exhausted and obsessed them both, and that forms the basis for much of Tolstoy's work. The final book of William L. Shirer's long and brilliant career, it is - appropriately - a masterly re-creation of a time, of two extraordinary people, and of the very nature of love, marriage, and old age.