Drawing on their diverse interests, they provide authoritative, broad-based, and in-depth coverage of current research and clinical practice in neuropsychology. They have not, however, changed the book's overall organization. The first eight chapters present the knowledge base for understanding the principles and practice of patient-oriented, hypothesis-testing neuropsychological assessment. The last 12 chapters review nearly all tests and assessment techniques discussed in previous editions plus many new ones and recent revisions of older tests. The extent of the updating is apparent from the fact that approximately half of the more than 7,000 references cited appeared since the last edition was published.Many new topics relevant to current assessment practices have been added to the 4th edition. The chapter on examination procedures, for example, now contains sections on cognitive functioning in pain and PTSD patients. The chapter on brain disorders includes new material on electrical/lighting injuries, migraine, Alzheimer's disease and other dementing disorders, and both medical and psychological treatments. The discussion of assessment procedures has been updated throughout to cover recently published test batteries used in general neuropsychological assessment (e.g., mental abilities, memory), newly developed batteries for specific issues (e.g., frontal lobe evaluation), and recent research on older neuropsychological assessment batteries. The fully revised chapter on assessing response bias describes and evaluates more than 60 tests, test combinations, and other measures for detecting questionable effort within the context of forensic neuropsychological assessment.

    Studies of synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioral data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviors. The uniform framework for each chapter enables the authors to higlight the principles that are common to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behavior.