It provides a wealth of information on normal and abnormal morphogenesis * minor anomalies and their relevance * clinical approaches to specific diagnoses * and normal standards of measurement for the entire spectrum of disorders. Each chapter includes a description of the specific abnormality-including occasional associated abnormalities-natural history, etiology, and references. On opposing pages are several descriptive photographs and line drawings of either an individual with the abnormality or specific features of the abnormality.Provides over 1,450 photographs and illustrations to depict each malformation-many from the personal collections of Drs. Smith and Jones-to aid readers in diagnosis.Uses a consistent chapter format to help readers quickly and easily find information on any given disorderOffers the most current coverage available on existing disorders and their molecular basis, plus the very latest information on virtually any genetic or physiological malformation.Offers a clearer understanding of abnormalities through the use of more than 1,000 new full-color figures and photographs.Includes updates for every disorder, with extensive new information on the molecular basis of malformations as well as new clinical information for many disorders.Covers 16 additional commonly seen disorders, including Deletion 1p36 syndrome * Deleletion 22q13 syndrome * Meier-Gorlin Syndrome * Short Syndrome * 3-C Syndrome * GAPO Syndrome * Lenz Microphthalmia Syndrome * Muenke Craniosynostosis * Torriello-Carey Syndrome * Mandibulo-Acral Syndrome * Mowat-Wilson Syndrome * Ulnar-Mammary Syndrome * Kaufman-McKusick Syndrome * Smith-Maginess Syndrome * Wiedeman-Rautenstrauch Syndrome * and Shprintzen-Golberg Syndrome.Presents a wealth of new Growth Charts, plus complete revisions to existing Growth Charts.

    Focusing on heredity, which Jacob considers the fundamental feature of living things, he shows how, since the sixteenth century, the scientific understanding of inherited traits has moved not in a linear, progressive way, from error to truth, but instead through a series of frameworks. He reveals how these successive interpretive approaches--focusing on visible structures, internal structures (especially cells), evolution, genes, and DNA and other molecules--each have their own power but also limitations. Fundamentally challenging how the history of biology is told, much as Thomas Kuhn's Structure of Scientific Revolutions did for the history of science as a whole, The Logic of Life has greatly influenced the way scientists and historians view the past, present, and future of biology.

    It extends these concepts to the segregation of genes that cause genetic variation in quantitative traits. Key techniques and methods are also covered.

    It presents the field of population genetics, starting with elementary concepts and leading the reader well into the field. It is concerned mainly with population genetics in a strict sense and deals primarily with natural populations and less fully with the rather similar problems that arise in breading livestock and cultivated plans. The emphasis is on the behavior of genes and population attributes under natural selection where the most important measure is Darwinian fitness. This text is intended for graduate students and advanced undergraduates in genetics and population biology This book steers a middle course between completely verbal biological arguments and the rigor of the mathematician. The first two-thirds of the book do not require advanced mathematical background. An ordinary knowledge of calculus will suffice. The latter parts of the book, which deal with population stochastically, use more advanced methods. Chapter Titles: 1.Models of population growth. 2.Randomly mating populations. 3.Inbreeding. 4.Correlation between relatives and assertive mating. 5.Selection. 6.Populations in approximate equilibrium. 7.Properties of a finite population. 8.Stochastic processes in the change of gene frequencies. 9.Distribution of gene frequencies in populations. Appendix. Some statistical and mathematical methods frequently used in population genetics. Bibliography. Glossary. Index.

    In his extraordinary book, Mayr fully explored, synthesized, and evaluated man's knowledge about the nature of animal species and the part they play in the process of evolution.In this long-awaited abridged edition, Mayr's definitive work is made available to the interested nonspecialist, the college student, and the general reader. The author has retained the dominant themes of his original study--themes now more widely accepted than they were in 1963: the species is the most important unit of evolution; individuals (and not genes) are the targets of natural selection, hence the fitness of a gene is a nebulous if not misleading concept; and the most important genetic phenomena in species are species-specific regulatory systems that give species internal cohesion.Each of the twenty chapters of the original edition has been revised; six have been extensively reworked. Discussions of peripheral subjects and massive citations of the literature have been eliminated, but the glossary has been greatly expanded. The focal point of the volume is, naturally, the species--a reproductively isolated aggregate of interbreeding populations. Presenting an overview of evolutionary biology in Chapter 1, Mayr then considers the nature of species, their population structure, their biological interactions, the multiplication of species, and their role in evolution.Because of the impossibility of experimenting with man and because an understanding of man's biology is indispensable for safeguarding his future, emphasis throughout the book is placed on those findings from higher animals which are directly applicable to man. The last chapter, Man as a Biological Species, is of particular interest to the general reader. Mayr concludes that while modern man appears to be as well adapted for survival purposes as were his ancestors, there is much evidence to suggest that he is threatened by the loss of his most typically human characteristics.