It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.*A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab, allowing for fast retrieval of tried and tested techniques for synthesizing bioconjugates. *Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates. *Includes more than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates, giving researchers a better understanding of how the commercially available reagents facilitate the crosslinking of peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. *Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticles Silane coupling agents Dendrimers and dendrons Chemoselective ligation Quantum dots Lanthanide chelates Cyanine dyes Discrete PEG compounds Buckyballs, fullerenes, and carbon nanotubes Mass tags and isotope tags Bioconjugation in the study of protein interactions

    Nicolaou - Winner of the Nemitsas Prize 2014 in ChemistryThis book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

    Computer simulators are continuously confronted with questions concerning the choice of a particular technique for a given application. A wide variety of tools exist, so the choice of technique requires a good understanding of the basic principles. More importantly, such understanding may greatly improve the efficiency of a simulation program. The implementation of simulation methods is illustrated in pseudocodes and their practical use in the case studies used in the text.Since the first edition only five years ago, the simulation world has changed significantly -- current techniques have matured and new ones have appeared. This new edition deals with these new developments; in particular, there are sections on:Transition path sampling and diffusive barrier crossing to simulaterare events Dissipative particle dynamic as a course-grained simulation technique Novel schemes to compute the long-ranged forces Hamiltonian and non-Hamiltonian dynamics in the context constant-temperature and constant-pressure molecular dynamics simulations Multiple-time step algorithms as an alternative for constraints Defects in solids The pruned-enriched Rosenbluth sampling, recoil-growth, and concerted rotations for complex molecules Parallel tempering for glassy HamiltoniansExamples are included that highlight current applications and the codes of case studies are available on the World Wide Web. Several new examples have been added since the first edition to illustrate recent applications. Questions are included in this new edition. No prior knowledge of computer simulation is assumed.

    The photographs are outstanding.... The brief text compresses many details into a few sentences, The vocabulary is scholarly...and charts combined with the text give a clear overview of the subject s]". -- RQ

    Totally revised and expanded, Color Atlas of Biochemistry presents the fundamentals of human and mammalian biochemistry on 215 stunning color plates.Alongside a short introduction to chemistry and the classical topics of biochemistry, the second edition covers new approaches and aspects in biochemistry, such as links between chemical structure and biological function or pathways for information transfer, as well as recent developments and discoveries, such as the structures of many new important molecules.Key features include:The unique combination of highly effective color graphics and comprehensive figure legendsUnified color-coding of atoms, coenzymes, chemical classes, and cell organelles that allows quick recognition of all involved systemsComputer graphics provide simulated 3D representation of many important moleculesThis Flexibook is ideal for students of medicine and biochemistry and a valuable source of reference for practitioners.

    Nitrogen plays a key role in all areas of organic chemistry, from DNA and proteins through pharmaceuticals to man-made drugs and new material. Despite this large application, there are just a few key principles which underpin the chemistry. This concise primer covers these principles in a discussion of all the main organonitrogen functional groups. It develops the themes logically under three specific sections, providing a clear overview of the synthesis, reactions and properties of organonitrogen compounds.

    It builds on a knowledge of elementary thermodynamics, giving the reader an appreciation of the origin of electrode potentials and shows how these are used to deduce a wealth of chemically important information such as equilibrium constants, free energy, enthalpy and entrophy changes of chemical reactions, activity coefficients, and the selective sensing of ions. The emphasis throughout is on understanding the foundations of the subject and how it may be used to study problems of chemical interest. The authors have minimized the mathematical aspects of the subject without any sacrifices in clarity, so as to enhance the accessibility of this volume.

    It also features first-hand accounts and descriptions of the social, cultural, and religious milieus in which man y psychotropic plants are used, and discusses historical allusions to many literary and scientific figures who used or wrote of mind-altering drugs, including Freud, Dickens, Yeats, and Huxley. Intended for a wide audience of general readers seeking unbiased information, the book gives an accessible explanation of drug-receptor interaction and organic chemical structures, as well as descriptions of the discovery, isolation, and syntheses of the chemical substances responsible for drug activity. Written by an experienced chemist, the book nevertheless keeps technical information to a minimum.

    This primer describes how stereoelectronic effects control this behavior. It is the only concise text on this topic at the undergraduate level. This is an important subject area and the comprehensive yet concise coverage in this book shows students how to build up a powerful but simple way of thinking about chemistry.

    It explains in accessible, non-technical language the science behind sugar and artificial sweeteners; cholesterol, animal fats and fibre; painkillers; plastics and PVC; and the risks associated with taking drugs. It also exposes the misinformation and disinformation that surrounds many of the controversial chemicals we meet in daily life.

    In the developed world, specialty chemicals have gained increasing significance. Although the fundamentals of organic chemical and polymer production have remained largely constant, one needs to be aware of the economic, structural, and political changes in the industry in order to understand its current state. This much-expanded Second Edition of Industrial Organic Chemicals presents the various technologies and processes involved in the organic chemicals industry as an organized body of knowledge. It describes the chemistry of the seven basic building block chemicals and their derivatives, how they are manufactured, their economic importance, uses, and associated environmental issues. Also covered are two topics essential to an understanding of modern industrial chemistry-catalysis and polymer synthesis. Key additions to this Second Edition include discussion of: * Sustainability and "green" chemistry * Dendrimers * Metallocenes * Chemicals in biotechnology * Specialty chemicals for pharmaceuticals, electronics, fire retardation, fuel additives, foods, and other uses * Economic, political, and social concepts for understanding future directions of the industry Industrial Organic Chemicals, Second Edition presents the chemistry of both large-scale and specialty products while taking into account important political, environmental, and economic considerations. It provides both a narrative account of the evolution of today's industry from the viewpoint of authors intimately involved with the changes, and an essential reference for chemists, chemical engineers, plastics engineers, petroleum engineers, managers, executives, and policy makers working in and with the organic chemical industry.