Frizzle's birthday and the class tries to bake a cake but winds up inside it, learning about mixtures and reactions that occur when ingredients are put together.

    He decried the internment of Japanese-Americans in World War Two, agitated against nuclear weapons, promoted vitamin C as a cure for the common cold and researched the idea of DNA.

    But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaginginsight into the one field of chemistry that arguably has the greatest impact on our quality of life than any other.Newly structured into four parts, the book opens in Part A with an introduction to pharmacodynamics and pharmacokinetics. Pharmacodynamics considers the types of molecular targets used by drugs, the interactions which are involved when a drug meets that target, and the consequences of thoseinteractions. Pharmacokinetics considers the issues involved in a drug reaching its target in the first place. Part B goes on to examine the general principles and strategies involved in discovering and designing new drugs and developing them for the marketplace, while Part C looks at particular'tools of the trade' which are invaluable in those processes. Finally, Part D covers a selection of specific topics within medicinal chemistry. Reflecting a change in emphasis in medicinal chemistry research, this Part takes us from the largely trial-and-error approach to drug design to the rationalapproach, and explores the most recent advances in molecular biology and genetics which have revolutionised drug design.With a striking new two-colour text design, and greatly enriched learning features, the third edition conveys the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, physiology, microbiology, cell biology, and pharmacology. A must-have textbook for anystudent of medicinal chemistry.Companion Web Site- Figures available to download, to facilitate lecture preparation - 3D molecular structures, to enable students to visualise key structures in an interactive way - Multiple choice questions with answers, to support and encourage independent learning

    (Part 7--on gunpowder and all aspects of explosive weapons--has already been published, while Part 8--on cavalry techniques and signaling--is still in preparation.) The present volume opens with an introduction on Chinese attitudes to warfare in general. Four major sections follow: on the making and use of simple bows; on the crossbow, the standard weapon of the Han armies, and its introduction to the Western world; on the pre-gunpowder forms of artillery, including the invention of the trebuchet; and on the art of siege warfare in which the Mohists were particularly interested. There is a good deal of material on siege-warfare available, and this final section is a substantial one, covering all aspects in detail.

    It includes only the core topics necessary for a good foundation in general chemistry but without sacrificing clarity and comprehension.

    

    This second edition of Thermodynamics continues to provide an accessible introduction to thermodynamics, which maintains an appropriate rigor to prepare newcomers for subsequent, more advanced topics.The book presents a logical methodology for solving problems in the context of conservation laws and property tables or equations. The authors elucidate the terms around which thermodynamics has historically developed, such as work, heat, temperature, energy, and entropy. Using a pedagogical approach that builds from basic principles to laws and eventually corollaries of the laws, the text enables students to think in clear and correct thermodynamic terms as well as solve real engineering problems.For those just beginning their studies in the field, Thermodynamics, Second Edition provides the core fundamentals in a rigorous, accurate, and accessible presentation.

    This new bookbridges these two areas in order to give the reader a newperspective on the nature of organic reactivity. A key element ofthis new approach is the author's extensive nonmathematicaldescription of the recently developed curve-crossing model thatdescribes why chemical reactions have an activation barrier, andspecifies the factors that govern the barrier heights. In addition, the author draws from physical chemistry and transition-metalchemistry to present an original and detailed description ofelectron transfer theory, and covers the recent discovery that theelectron transfer process is intimately related to many basicorganic processes.This book has been divided into three parts to facilitate itsmixture of classical organic chemistry with new and establishedtheoretical ideas. Part A presents an introductory description ofmolecular orbital and valence bond theories with emphasis on thequalitative aspects that can be applied to practical problems inorganic structure and reactivity. Part B describes the keyprinciples of physical organic chemistry and incorporates a mainlyqualitative description of the Marcus theory of electrontransfer.Building on the theoretical framework developed in parts A and B, part C offers an overview of the basic reactions of organicchemistry: nucleophilic and electrophilic substitution, and radicaland pericyclic reactivity. In addition, part C clearly explains themost recent unifying description of organic reactivity for organicchemists and for graduate and advanced undergraduate students.

    It emphasizes physical models as well as mathematical techniques, along with both rigorous and approximate (order-of-magnitude) problem-solving. Designed to progress beyond a numerical answer, problems expose the physical significance of the situation and teach students how to pose a problem in the first place. In addition, modern molecular concepts, currently unanswered problems in research, experimental techniques, and new directions in the field are introduced wherever appropriate. An orderly progression of thermodynamics carefully builds students' knowledge without covering too much too early on. Chemical reaction thermodynamics is covered in Chapter 7, after the culmination of thermodynamics, with advanced material in Chapter 10.